Integrin beta 2/CD18 Antibody [Unconjugated] Summary
Mouse myeloma cell line NS0-derived recombinant human Integrin beta 2
Gln23-Asn700 Accession # AAA59490
Detects human Integrin beta 2 in direct ELISAs and Western blots.
<0.10 EU per 1 μg of the antibody by the LAL method.
Test in a species/application not listed above to receive a full credit towards a future purchase.
Adhesion Blockade CyTOF-ready Flow Cytometry 2.5 ug/10^6 cells Immunocytochemistry 5-15 ug/mL
Packaging, Storage & Formulations
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Reconstitute at 0.2 mg/mL in sterile PBS.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Integrin beta 2/CD18 Antibody [Unconjugated]
959 beta subunit precursor)10 CD18 antigen CD18 CD18beta 2 cell surface adhesion glycoprotein (LFA-1 CR3 Integrin beta 2 integrin beta-2 integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1;macrophage antigen 1 (mac-1) beta subunit) integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) ITGB2 LAD LCAMB leukocyte cell adhesion molecule CD18 leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C LFA-1 beta LFA-1 MAC-1 beta MF17 MFI7 P150 p150,95 beta Background
Integrin beta 2 is a transmembrane protein expressed by all leukocytes. It occurs in heterodimeric complexes with Integrin subunits alpha D, alpha L (complex also known as LFA‑1), alpha M (Mac-1), or alpha X (CR-4). These complexes are important in adhesion and leukocyte trafficking.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
for 1 year from date of receipt.
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Applications: B/N, Flow, IHC, IHC-Fr, WB
Applications: B/N, CyTOF-ready, Flow, ICC/IF, IHC, IHC-Fr, IP, WB
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Publications for Integrin beta 2/CD18 Antibody (AF1730)(9)
We have publications tested in 1 confirmed species: Human.
We have publications tested in 5 applications: ICC, IF, Migration Assay, Neutralization, Western Blot.
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Publications using AF1730
SP Davies, GM Reynolds, AL Wilkinson, X Li, R Rose, M Leekha, YS Liu, R Gandhi, E Buckroyd, J Grove, NM Barnes, RC May, SG Hubscher, DH Adams, Y Huang, O Qureshi, Z Stamataki Hepatocytes Delete Regulatory T Cells by Enclysis, a CD4+ T Cell Engulfment Process Cell Rep, 2019;29(6):1610-1620.e4. 2019 [PMID: 31693899] (IF, Human) IF
LC Ristow, V Tran, KJ Schwartz, L Pankratz, A Mehle, JD Sauer, RA Welch The Extracellular Domain of the Î²2 Integrin Î² Subunit (CD18) Is Sufficient for Escherichia coli Hemolysin and Aggregatibacter actinomycetemcomitans Leukotoxin Cytotoxic Activity MBio, 2019;10(4):. 2019 [PMID: 31289186] (Western Blot, Human) Western Blot
BL Benson, L Li, JT Myers, RD Dorand, UA Gurkan, AY Huang, RM Ransohoff Biomimetic post-capillary venule expansions for leukocyte adhesion studies Sci Rep, 2018;8(1):9328. 2018 [PMID: 29921896]
SS Lavoie, E Dumas, B Vulesevic, PE Neagoe, M White, MG Sirois Synthesis of Human Neutrophil Extracellular Traps Contributes to Angiopoietin-Mediated In Vitro Proinflammatory and Proangiogenic Activities J. Immunol., 2018;0(0):. 2018 [PMID: 29686052] (Neutralization, Human) Neutralization
X Zhou, R Zhao, K Schwarz, M Mangeat, EC Schwarz, M Hamed, I Bogeski, V Helms, H Rieger, B Qu Bystander cells enhance NK cytotoxic efficiency by reducing search time Sci Rep, 2017;7(0):44357. 2017 [PMID: 28287155] (Migration Assay, Human) Migration Assay
Smeekens S, Gresnigt M, Becker K, Cheng S, Netea S, Jacobs L, Jansen T, van de Veerdonk F, Williams D, Joosten L, Dinarello C, Netea M An anti-inflammatory property of Candida albicans beta-glucan: Induction of high levels of interleukin-1 receptor antagonist via a Dectin-1/CR3 independent mechanism. Cytokine, 2015;71(2):215-22. 2015 [PMID: 25461401] (Neutralization, Human) Neutralization
Dotterweich J, Ebert R, Kraus S, Tower R, Jakob F, Schutze N Mesenchymal stem cell contact promotes CCN1 splicing and transcription in myeloma cells. Cell Commun Signal, 2014;12(0):36. 2014 [PMID: 24965524] (Neutralization, Human) Neutralization
Jerke U, Rolle S, Dittmar G, Bayat B, Santoso S, Sporbert A, Luft F, Kettritz R Complement Receptor Mac-1 Is an Adaptor for NB1 (CD177)-mediated PR3-ANCA Neutrophil Activation. J. Biol. Chem., 2011;286(9):7070-81. 2011 [PMID: 21193407] (Western Blot, Human) Western Blot
van Grevenstein WM, Hofland LJ, van Rossen ME, van Koetsveld PM, Jeekel J, van Eijck CH Inflammatory cytokines stimulate the adhesion of colon carcinoma cells to mesothelial monolayers. Dig. Dis. Sci., 2007;52(10):2775-83. 2007 [PMID: 17394066] (ICC, Human) ICC
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