CD11b/CD18 and Neutrophil-Epithelial Interactions as Targets for Anti-Inflammatory Therapies

Tue, 09/04/2012 - 12:38

The beta-2 integrins, a family of four cell surface transmembrane glycoproteins expressed only on leukocytes, include CD11a/CD18, CD11b/CD18, CD11c/CD18, and CD11d/CD18. They consist of a common beta subunit (CD18) and homologous alpha subunits (CD11a-d) that bind noncovalently to form an alpha/beta heterodimer. Studies with functionally inhibitory monoclonal antibodies to CD11b/CD18 demonstrate the role of CD11b/CD18 in inflammatory processes, including polymorpho nuclear leukocyte (PMN) adhesion and migration across the endo and epithelium (1).

Immunohistochemistry: CD11b Antibody

Moreover, PMN of patients with leukocyte adhesion deficiency, characterized by lack of surface expression of beta-2 integrins, fail to adhere to and migrate across both endothelium and epithelium (2). PMN migrate across intestinal epithelia in many disease states. Although such migration serves as a histological index of disease activity, little is known concerning the molecular events underlying PMN-intestinal epithelial interactions PMN-epithelial interactions were found to be unaffected by monoclonal antibodies recognizing either of the remaining two alpha subunits CD11a or CD11c. It is important to note that CD11b/CD18, plays an important role in the PMN migration in a variety of intestinal diseases (3). These findings add a new element to a multistep model of PMN trans-epithelial migration and may provide new targets for anti-inflammatory therapies.

  1. PMID: 1682344
  2. PMID: 1973407
  3. PMID: 15800062

Novus Biologicals offers CD11b/CD18 reagents for your research needs including:


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