Western Blot: Survivin Antibody [NB100-56168] - Analysis of normal Prostate Epithelium (NPE) and Prostate Cancer using this antibody. 100 ug/lane of each human tissue lysate was loaded per lane. Survivin was detected in ...read more
Immunohistochemistry-Paraffin: Survivin Antibody [NB100-56168] - Analysis of Human Esophageal Cancer at 1:2000. A1 is a high magnification of A. Hematoxylin-eosin counterstain.
Immunohistochemistry-Paraffin: Survivin Antibody [NB100-56168] - Analysis of Human Prostate Cancer array IMG-5755 at 1:2000. A1 is a high magnification of A. Differential expression of Survivin is seen in tissue cores ...read more
Hu, Mu, RtSpecies Glossary
WB, IHC, IHC-P, IP
This product is unpurified. The exact concentration of antibody is not quantifiable.
Apoptosis inhibitor 4 baculoviral IAP repeat-containing protein 5
Apoptosis inhibitor survivin
baculoviral IAP repeat-containing 5
Survivin is a member of the family of inhibitor of apoptosis proteins (IAP), and is involved in both the control of apoptosis and regulation of cell division. IAPs suppress mitochondria-dependent and independent apoptosis by binding to and inhibiting caspases through their BIR domains (reviewed in Liston et al, 2003; Wright and Duckett, 2005). Resistance towards apoptosis is a hallmark of cancer cells, and overexpression of IAPs can contribute to the development of cancer though inhibiting apoptosis. In addition to at least one BIR domain, some IAP members also have a RING-type finger motif at their carboxyl-terminal. Structurally, survivin is composed of a single BIR domain and an extended COOH-terminal a-helical coiled-coil domain; survivin does not contain a RING-finger domain. Survivin is highly expressed in embryonic and fetal organs, and is cell cycle regulated with a marked increase in the G2M phase where it plays a role in facilitating cell division (reviewed in Li, 2005 and Zaffaroni et al, 2005). Survivin is undetectable in most normal differentiated and non-proliferating tissues, but is highly expressed in cancer. Expression has been described in the majority of human tumor types including lung, breast, colon, gastric, leukemias, neuroblastoma, brain tumors, pheochromocytoma, soft tissue sarcomas, melanomas and other skin tumors. Additionally, survivin expression has been detected in a variety of preneoplastic or benign leisons, suggesting that re-expression of survivin may occur early during malignant transformation or following a disruption in the balance between cell division and apoptosis. Human survivin is a 142 amino acid protein which migrates at approx. 16.5 kDa on SDS-PAGE gels. Multiple surviving splice variants have been described and therefore the molecular weight may vary according to the isoform(s) expressed. Described splice variants include: 1. Survivin-2B results insertion of an alternative exon. 2. Survivin-deltaEx3 results from the removal of exon 3. 3. Survivin-3B results from the addition of a novel exon 3B. 4. Survivin 2alpha consists of exon 1 and 2 and the acquisition of a new in-frame spot codon, predicting a truncated 74 amino acid protein. Users are encouraged to refer to the NCBI AceView (http://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/) and BLAST (http://www.ncbi.nlm.nih.gov/BLAST/) data bases for more information about survivin and splice variants.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
Mehra R, Yang D, Handorf E et al. Analysis of a protein expression biomarkers in HPV negative SCCHN. Cancer Research: Abstract from AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. 2014 (IHC-P, Human)
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Product General Protocols
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Cytochrome C - a mediator of apoptosis Cytochrome C is a small heme protein within the inner mitochondrial membrane responsible for carrying electrons within the respiratory transport chain. Additionally, cytochrome c has also been identified as a player in programmed cell death (apop... Read full blog post.
Survivin is thrivin' The survivin anti-apoptotic protein is the smallest member of a large family of proteins such as X-linked IAP, c-IAP1 and 2, IAP-like protein-2, melanoma IAP, Livin, and NAIP. Survivin regulates basic physiological events such as the cell cycle, tumor... Read full blog post.
Livin: On a Prayer Livin is a member of the inhibitor of apoptosis proteins (IAP) family that regulates programmed cell death. The Livin protein contains a single baculovirus IAP repeat (BIR) essential for function, along with a COOH-terminal RING-type zinc finger domai... Read full blog post.
Survivin: Infographic Survivin is involved in promoting cell proliferation and is an inhibitor of apoptosis. Survivin has a critical role in cancer proliferation and neural development. It may have an impact on neural cell proliferative responses following brain injury.L... Read full blog post.
TrkB: Bridging Ontogenesis and Oncogenesis Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. Interaction of brain-derived neurotrophic factor (BDNF) with its... Read full blog post.
Caspase 7: The Cell's Suicide Switch Caspase 7 (also known as CASP7, Mch3, ICE-LAP3, CMH-1) is a member of caspase family of cysteine proteases. It is an apoptosis-related cystein peptidase encoded by the CASP7 gene in humans. CASP7 homologous sequences have been identified in nearly all... Read full blog post.
TrkB: Docking for Neurotrophins and Beyond. Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. TrK's are activated by several neurotrophins, which are small pro... Read full blog post.