Survivin Products

Antibodies
Antibody Packs
Survivin Antibody Pack
Survivin Antibody Pack
NB100-911
Species: Hu, Mu, Rt, Ca, Fe
Applications: WB, ICC/IF, IHC, IHC-P, IP
Host: Mouse
Antibody Pairs
Survivin Antibody Pair
Survivin Antibody Pair
H00000332-AP11
Species: Hu
Applications: S-ELISA
ELISA Kits
Lysates
Survivin Overexpression Lysat ...
Survivin Overexpression Lysate (De...
H00000332-T01
Species: Hu
Applications: WB
Survivin Overexpression Lysat ...
Survivin Overexpression Lysate (Na...
NBL1-07987
Applications: WB
Proteins
Survivin Recombinant Protein
Survivin Recombinant Protein
H00000332-P01
Species: Hu
Applications: WB, ELISA, IP, PA
Survivin Peptide
Survivin Peptide
NB110-92717PEP
Species: Hu
Survivin Partial Recombinant ...
Survivin Partial Recombinant Protein
H00000332-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
Survivin RNAi
Survivin RNAi
H00000332-R01V
Species: Hu
Applications: WB, RNAi SP
Survivin RNAi
Survivin RNAi
H00000332-R01
Species: Hu
Survivin RNAi
Survivin RNAi
H00000332-R02
Species: Hu

Description

Survivin is an anti-apoptotic protein expressed in the G2/M cell cycle phase. At the onset of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptotic function and increased caspase 3 activity. Survivin encodes a structurally unique inhibitor of apoptosis (IAP). Survivin expression is turned off during fetal development and is not found in non-neoplastic adult human tissues. Survivin becomes abundantly re-expressed in transformed cells and in all of the most common cancers of lung, colon, pancreas, breast and prostate in vivo. Survivin, also known as BIRC5, is also abundantly expressed in brain tissues (astrocytes and some neurons) of adult rats following traumatic brain injury. Survivin has been found co-expressed with NeuN (mature neuronal marker) and PCNA (a cell cycle protein. Survivin might affect regulation of neural cell proliferative responses after brain injury. Survivin is also an inhibitor of apoptosis (IAP), or programmed cell death, that is selectively overexpressed in common human cancers.

Bioinformatics

Entrez Human
Mouse
Rat
Canine
Feline
Uniprot Human
Human
Human
Human
Human
Human
Human
Rat
Product By Gene ID 332
Alternate Names
  • BIRC5
  • IAP4
  • EPR-1
  • baculoviral IAP repeat-containing 5
  • Apoptosis inhibitor survivin
  • Apoptosis inhibitor 4 baculoviral IAP repeat-containing protein 5
  • API4 survivin variant 3 alpha

Bioinformatics Tool for Survivin

Discover related pathways, diseases and genes to Survivin. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related Survivin Blog Posts

Check out the latest blog posts on Survivin.
Survivin - an inhibitor of apoptosis that drives tumorigenesis and metastasis
Untitled DocumentApoptosis is the tightly regulated process of programmed cell death. It plays an important role in normal physiologic development but has also been implicated in a number of diseases. Apoptosis is constantly downreg...    Read more.
Survivin - an inhibitor of apoptosis protein
Survivin is an anti-apoptotic protein which is the smallest protein within a large family of proteins including X-linked IAP, c-IAP1 and 2, IAP-like protein-2, melanoma IAP, NAIP, and Livin. Survivin is responsible for a wide range of basic cellula...    Read more.
Cytochrome C - a mediator of apoptosis
Cytochrome C is a small heme protein within the inner mitochondrial membrane responsible for carrying electrons within the respiratory transport chain.  Additionally, cytochrome c has also been identified as a player in programmed cell death (apop...    Read more.
PCNA (Proliferating cell nuclear antigen, polymerase delta auxiliary protein)
PCNA is a nuclear protein essential for DNA replication as well as DNA excision and mismatch repair pathways. It coordinates the recruitment and association of needed components during both of these processes, both of which are essential for cell cycl...    Read more.
Survivin is thrivin'
The survivin anti-apoptotic protein is the smallest member of a large family of proteins such as X-linked IAP, c-IAP1 and 2, IAP-like protein-2, melanoma IAP, Livin, and NAIP. Survivin regulates basic physiological events such as the cell cycle, tumor...    Read more.
Livin: On a Prayer
Livin is a member of the inhibitor of apoptosis proteins (IAP) family that regulates programmed cell death. The Livin protein contains a single baculovirus IAP repeat (BIR) essential for function, along with a COOH-terminal RING-type zinc finger domai...    Read more.
Survivin: As long as I know how to live I know I will
Survivin is an anti-apoptotic protein from a large family with related members such as X-linked IAP, cIAP1 and cIAP2, IAP-like protein-2, melanoma IAP, Livin, and NAIP. Survivin regulates fundamental physiological events including the cell cycle, feta...    Read more.
Survivin: Infographic
Survivin is involved in promoting cell proliferation and is an inhibitor of apoptosis. Survivin has a critical role in cancer proliferation and neural development. It may have an impact on neural cell proliferative responses following brain injury.L...    Read more.
TrkB: Bridging Ontogenesis and Oncogenesis
Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. Interaction of brain-derived neurotrophic factor (BDNF) with its...    Read more.
Caspase 7: The Cell's Suicide Switch
Caspase 7 (also known as CASP7, Mch3, ICE-LAP3, CMH-1) is a member of caspase family of cysteine proteases. It is an apoptosis-related cystein peptidase encoded by the CASP7 gene in humans. CASP7 homologous sequences have been identified in nearly all...    Read more.
PCNA Antibodies: Marking Cell Proliferation & DNA Replication
Proliferating Cell Nuclear Antigen (PCNA), also known as the polymerase delta auxiliary protein, is a nuclear protein essential for DNA replication as well as DNA excision and mismatch repair pathways. It has a large role in cell cycle regulation and...    Read more.
TrkB: Docking for Neurotrophins and Beyond.
Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. TrK's are activated by several neurotrophins, which are small pro...    Read more.
Survivin Sandwich ELISA: There's a Kit for That
The Survivin antibody is widely used in apoptosis studies, and as a cellular marker. Today, biochemists have a wide range of Survivin antibody products to choose from, suitable for use in Western Blot, Chromatin Immunoprecipitation (ChIP), Immunofluor...    Read more.
Survivin Acetylation: Affecting Apoptosis and Cancer
Survivin (BRIC5) is an inhibitor of apoptosis that also promotes cellular adaptation under stressful conditions and helps to regulate cell division. Recently, an antibody study by Dr. H Wang et al. at Brown University [PMID: 20826784] found that Survi...    Read more.
Read more Survivin related blogs.