Nbs1 Antibody [DyLight 650]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 650

Nbs1 Antibody [DyLight 650] Summary

Immunogen
Synthetic peptide made to an internal portion of the mouse NBS1 protein (within residues 350-400). [Swiss-Prot# Q9R207]
Localization
Nucleus. Telomere. Note= Localizes to discrete nuclear foci after treatment with genotoxic agents.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
NBN
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
This NBS1 antibody is useful for Immunohistochemistry on paraffin embedded sections and Western blot, where a band is seen at ~97 kDa.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Nbs1 Antibody [DyLight 650]

  • ATV
  • AT-V1
  • AT-V2
  • Cell cycle regulatory protein p95
  • FLJ10155
  • MGC87362
  • NBN
  • Nbs1
  • NBS1P95
  • NBSNijmegen breakage syndrome protein 1
  • Nibrin
  • Nijmegen breakage syndrome 1 (nibrin)
  • p95 protein of the MRE11/RAD50 complex
  • p95

Background

The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50 double-strand break complex. This protein complex has been implicated in Nijmegen breakage syndrome, an autosomal recessive disorder marked by increased cancer incidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity, thus revealing a direct molecular link between double-strand break repair and cell cycle checkpoint functions.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP1-06609AF350
Alexa Fluor 405 NBP1-06609AF405
Alexa Fluor 488 NBP1-06609AF488
Alexa Fluor 532 NBP1-06609AF532
Alexa Fluor 594 NBP1-06609AF594
Alexa Fluor 647 NBP1-06609AF647
Alexa Fluor 700 NBP1-06609AF700
Alexa Fluor 750 NBP1-06609AF750
Biotin NBP1-06609B
DyLight 350 NBP1-06609UV
DyLight 405 NBP1-06609V
DyLight 488 NBP1-06609G
DyLight 550 NBP1-06609R
DyLight 594 NBP1-06609DL594
DyLight 650 NBP1-06609C
DyLight 680 NBP1-06609FR
DyLight 755 NBP1-06609IR
FITC NBP1-06609F
HRP NBP1-06609H
Janelia Fluor 549 NBP1-06609JF549
Janelia Fluor 646 NBP1-06609JF646

Additional Nbs1 Products

Bioinformatics Tool for Nbs1 Antibody (NBP1-06609C)

Discover related pathways, diseases and genes to Nbs1 Antibody (NBP1-06609C). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for Nbs1 Antibody (NBP1-06609C)

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Pathways for Nbs1 Antibody (NBP1-06609C)

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PTMs for Nbs1 Antibody (NBP1-06609C)

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Research Areas for Nbs1 Antibody (NBP1-06609C)

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Blogs on Nbs1.

The MRE11 Complex and DNA Damage Response
The maintenance of genome stability depends on the DNA damage response (DDR) which is a complex signaling network including cell cycle checkpoints, DNA repair and damage tolerance pathways. The DDR complex has the ability to sense DNA damage and tra...  Read full blog post.

NBS1: The DNA Repair Trigger
NBS1 (Nijmegen breakage syndrome protein 1) is a component of the MRN complex (Mre11-Rad50-Nbs1) that plays important role in detecting DNA double strand breaks (DSBs) and triggering the downstream cascade. DSBs can be caused by ionizing radiation, ch...  Read full blog post.

NBS1: DNA Repair Trigger
NBS1 (Nijmegen breakage syndrome protein 1) is a component of the MRN complex (Mre11-Rad50-Nbs1) that plays important role in detecting DNA double strand breaks (DSBs) and triggering the downstream cascade. DSBs can be caused by ionizing radiation, ch...  Read full blog post.

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Bioinformatics

Gene Symbol NBN