CtIP Antibody

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Immunoprecipitation: CtIP Antibody [NB100-79809] - Samples: Whole cell lysate (1 mg for IP; 1/4 of IP loaded) from MCF7 cells. Antibodies: Affinity purified rabbit anti-CtIP antibody BL1913 (NB100-79809) used at 3 ug/mg ...read more

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications ICC/IF, IP, ChIP
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

CtIP Antibody Summary

Immunogen
The immunogen recognized by this antibody maps to a region between residues 525 and 575 of human CtBP Interacting Protein (Retinoblastoma Binding Protein 8) using the numbering given in entry NP_002885.1 (GeneID 5932).
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
RBBP8
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence
  • Immunoprecipitation 2-5 ug/mg lysate
  • Chromatin Immunoprecipitation (ChIP)
Application Notes
Use in chromatin immunoprecipitation reported in scientific literature (PMID 29244158). Use in ICC/IF reported in secitific publication PMID: 32401820
Publications
Read Publications using
NB100-79809 in the following applications:

Reactivity Notes

Use in Mouse reported in secitific publication PMID: 32401820

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Tris-Citrate/Phosphate (pH 7.0 - 8.0)
Preservative
0.09% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for CtIP Antibody

  • CtBP-interacting protein
  • CtIP
  • DNA endonuclease RBBP8
  • EC 3.1
  • RBBP-8
  • retinoblastoma binding protein 8
  • Retinoblastoma-binding protein 8
  • Retinoblastoma-interacting protein and myosin-like
  • RIMSAE2
  • Sporulation in the absence of SPO11 protein 2 homolog

Background

The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CtIP Antibody (NB100-79809)(4)

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

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Other Available Formats

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Array NB100-79809

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Bioinformatics

Gene Symbol RBBP8
Entrez
Uniprot