Mre11 Products

Antibodies
Mre11 Antibody
Mre11 Antibody
NB100-142
Species: Hu, Mu, Rt, Ch, Ha
Applications: WB, Simple Western, ChIP, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP
Host: Rabbit Polyclonal
Mre11 Antibody
Mre11 Antibody
NB100-56339
Species: Hu
Applications: WB, IHC-P
Host: Rabbit Polyclonal
Mre11 Antibody
Mre11 Antibody
AF2284
Species: Hu
Applications: WB
Host: Chicken Polyclonal
Lysates
Mre11 Overexpression Lysate ( ...
Mre11 Overexpression Lysate (Native)
NBL1-13219
Applications: WB
Proteins
Mre11 Recombinant Protein
Mre11 Recombinant Protein
H00004361-P01
Species: Hu
Applications: WB, ELISA, PA
RNAi
Mre11 RNAi
Mre11 RNAi
H00004361-R02
Species: Hu
Mre11 RNAi
Mre11 RNAi
H00004361-R01
Species: Hu

Description

The hMre11-hRad50-NBS1 protein plays a central role in the human cellular DNA-Damage response, with recent studies indicating that these proteins help link DNA-damage detection to DNA-repair and cell cycle-checkpoint functions. This protein complex has been implicated in the activation of cell cycle-regulatory pathways, due to the fact that the NBS1 gene mutates in the chromosomal-instability syndrome, Nijmegen breakdown syndrome (NBS), which is characterized by increased cancer incidence, cell cycle checkpoint defects, and ionizing radiation sensitivity. HMre11-hRad50 foci form in response to DNA double-strand breaks and rely upon a DNA damage-induced signaling pathway. However, hMre11 migrates to sites of damage while hRad51 does not localize at these sites. These findings are consistent with the distinct role of these proteins in DNA repair.

MRE11 antibodies are useful tools for DNA repair research, cell cycle research, and for certian cancer studies.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Product By Gene ID 4361
Alternate Names
  • endo/exonuclease Mre11
  • MRE11 homolog 1
  • double-strand break repair protein MRE11A
  • HNGS1
  • DNA recombination and repair protein
  • Meiotic recombination 11 homolog A
  • AT-like disease
  • Meiotic recombination 11 homolog 1
  • MRE11MRE11B
  • ATLDmeiotic recombination (S. cerevisiae) 11 homolog A
  • MRE11 homolog A
  • MRE11 meiotic recombination 11 homolog A (S. cerevisiae)

Research Areas for Mre11

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
Checkpoint signaling
Chromatin Research
DNA Double Strand Break Repair
DNA Repair
Homologous Recombination
Non-homologous end-joining
Protein Phosphatase

Bioinformatics Tool for Mre11

Discover related pathways, diseases and genes to Mre11. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related Mre11 Blog Posts

Check out the latest blog posts on Mre11.
The MRE11 Complex and DNA Damage Response
The maintenance of genome stability depends on the DNA damage response (DDR) which is a complex signaling network including cell cycle checkpoints, DNA repair and damage tolerance pathways. The DDR complex has the ability to sense DNA damage and tra...    Read more.
Read more Mre11 related blogs.