Mre11 Products

Antibodies
Mre11 Antibody
Mre11 Antibody
Species: Hu, Mu, Rt, Ch, Ha, Bt, Bv, Ca, Pm, Eq, Fe, Pm
Applications: WB, Simple Western, ChIP, ELISA, Flow, IB, ICC/IF, IHC, IHC-Fr, IHC-P, IP, PLA, KD, KO
Host: Rabbit Polyclonal
Mre11 Antibody (12D7)
Mre11 Antibody (12D7)
Species: Hu, Mu, Rt
Applications: WB, ELISA, Func, ICC/IF, IHC, IHC-P, IP, PLA, KD
Host: Mouse Monoclonal
Lysates
Mre11 Overexpression Lysate
Mre11 Overexpression Lysate
NBL1-13219
Species: Hu
Applications: WB
Proteins
Recombinant Human Mre11 GST ( ...
Recombinant Human Mre11 GST (N-Ter...
H00004361-P01
Species: Hu
Applications: WB, ELISA, Func, PA, PAGE, AP

Description

Mre11 (double-strand break repair protein MRE11A) is an important component of MRN/X complex (Mre11, Rad50, and Nbs1/Xrs2), playing a central role in double-strand break (DSB) repair, DNA recombination, telomere integrity maintenance, meiotic cell division, and viral infection. Mre11 and Rad50 comprise the catalytic component of the MRN complex with Rad50 involved in ATP hydrolysis and Mre11 functioning as a nuclease having both single-strand endonuclease and double-strand-specific 3'-5' exonuclease activity (1). The MRN complex is also involved in DNA damage signaling via activation of ATM kinase and in telomeres, where it may modulate t-loop formation (2). In addition, Mre11 is a component of the BASC complex (BRCA1, MSH2, MSH6, MLH1, ATM, BLM, RAD50, MRE11A and NBN) and interacts with DCLRE1C/Artemis as well as DCLRE1B/Apollo (3).

The MRN assembles as a hetero-hexamer consisting of 2 RAD50 subunits, 2 MRE11 nucleases, and 2 NBS1 subunits, specific to eukaryotes. Mre11 is highly conserved with the N-terminal region of the human protein sharing approximately 50% amino acid sequence identity with the yeast ortholog. Human Mre11 has 3 known isoforms with the predominant isoform having a theoretical molecular weight of 80.6kDa. This nuclear localized protein has high expression in proliferating tissues. Defects in Mre11 can lead to genomic instability, telomere shortening, aberrant meiosis, hypersensitivity to DNA damage, and ataxia telangiectasia-like disorder (ATLD). MRN expression has been associated with the prognosis of cancer and MRN mutants have been linked to cancer susceptibility in ovarian cancer and glioma (4, 5).

References

1. Paull TT. (2018) 20 Years of Mre11 Biology: No End in Sight. Mol Cell. 71(3):419-427. PMID: 30057197

2. Syed A, Tainer JA. (2018) The MRE11-RAD50-NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair. Annu Rev Biochem. 87:263-294. PMID: 29709199

3. Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J. (2000) BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev. 14(8):927-39. PMID: 10783165

4. Kim JH, Grosbart M, Anand R, Wyman C, Cejka P, Petrini JHJ. (2017) The Mre11-Nbs1 Interface Is Essential for Viability and Tumor Suppression. Cell Rep. 18(2):496-507. PMID: 28076792

5. Bian L, Meng Y, Zhang M, Li D. (2019) MRE11-RAD50-NBS1 complex alterations and DNA damage response: implications for cancer treatment. Mol Cancer. 18(1):169. PMID: 31767017



Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Product By Gene ID 4361
Alternate Names
  • MRE11B
  • endo/exonuclease Mre11
  • MRE11 homolog 1
  • double-strand break repair protein MRE11A
  • HNGS1
  • DNA recombination and repair protein
  • Meiotic recombination 11 homolog A
  • AT-like disease
  • Meiotic recombination 11 homolog 1
  • ATLDmeiotic recombination (S. cerevisiae) 11 homolog A
  • MRE11 homolog A
  • MRE11 meiotic recombination 11 homolog A (S. cerevisiae)

Research Areas for Mre11

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
Checkpoint signaling
Chromatin Research
DNA Double Strand Break Repair
DNA Repair
Homologous Recombination
Non-homologous end-joining
Protein Phosphatase

Bioinformatics Tool for Mre11

Discover related pathways, diseases and genes to Mre11. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related Mre11 Blog Posts

Check out the latest blog posts on Mre11.
The MRE11 Complex and DNA Damage Response
The maintenance of genome stability depends on the DNA damage response (DDR) which is a complex signaling network including cell cycle checkpoints, DNA repair and damage tolerance pathways. The DDR complex has the ability to sense DNA damage and tra...    Read more.
Read more Mre11 related blogs.