Nbs1 Products

Antibodies
Nbs1 Antibody
Nbs1 Antibody
Species: Hu, Mu, Ha, Ma, Pm
Applications: WB, ChIP, ELISA, Flow, IB, ICC/IF, IHC, IHC-P, IP, ISH, PAGE, KO
Host: Rabbit Polyclonal
Nbs1 Antibody (1D7)
Nbs1 Antibody (1D7)
NB100-221
Species: Hu, Mu, Rt
Applications: WB, Simple Western, ICC/IF, IHC, IP, KD
Host: Mouse Monoclonal
Nbs1 Antibody (7E4A2)
Nbs1 Antibody (7E4A2)
NBP2-26297
Species: Hu
Applications: WB, Simple Western, ELISA, Flow, ICC/IF, IHC, IHC-P, KO
Host: Mouse Monoclonal
Formulation Catalog # Availability Price  
Lysates
Nbs1 Overexpression Lysate
Nbs1 Overexpression Lysate
NBL1-13497
Species: Hu
Applications: WB
Proteins
Nbs1 Blocking Peptide
Nbs1 Blocking Peptide
NBP1-06705PEP
Species: Hu
Applications: AC
Nbs1 Blocking Peptide
Nbs1 Blocking Peptide
NBP1-06609PEP
Species: Hu
Recombinant Human Nbs1 Protei ...
Recombinant Human Nbs1 Protein
H00004683-Q01
Species: Hu
Applications: WB, ELISA, PA, PAGE, AP

Description

NBS1 (Nijmegen breakage syndrome protein 1, Nibrin) is the eukaryotic component of MRN complex (Mre11-Rad50-Nbs1) involved in homologous recombination repair for DNA double-strand breaks (DSBs) and DNA damage-induced checkpoint activation. NBS1, a nuclear protein with a theoretical molecular weight of 65-85 kDa, is composed of 2 functional regions: the forkhead associated (FHA) N-terminal domain (24-83 amino acids) and the breast cancer C-terminus (BRCT) domain (105-181 amino acids). Mutations in the NBN gene are associated with Nijmegen breakage syndrome, characterized by microcephaly, growth retardation, immunodeficiency, and an increased susceptibility to prostate cancer, lung cancer, liver cancer and intrahepatic cholangiocarcinoma (IHC) (1).

In DNA double strand break repair, the FHA/BRCT domains bind DNA damage sensor proteins including gamma H2AX (phospho Ser139), phosphorylated MDC1 and CtIP (CtBP-interacting protein). NBS1 then recruits the other members of the MRN complex, Mre11 and Rad50, to the proximity of DNA DSBs. The MRN complex has also been shown to interact with ATM or ATR kinases in the presence of DSBs or replication fork stalling, respectively. Phosphorylation of NBS1 at Ser 278 and Ser343 in response to ionizing radiation (IR) is dependent on ATM and is important for activation of the S phase checkpoint. The activation of ATM in response to DNA damage is also facilitated by MRN and may lead to induction of apoptosis (2, 3).

References

1. Bian L, Meng Y, Zhang M, Li D. (2019) MRE11-RAD50-NBS1 complex alterations and DNA damage response: implications for cancer treatment. Mol Cancer. 26;18(1):169. PMID: 31767017

2. Zhang Y, Zhou J, Lim CU. (2006) The role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint control. Cell Res. 16(1):45-54. PMID: 16467875

3. Komatsu K. NBS1 and multiple regulations of DNA damage response. (2016) J Radiat Res. 57 Suppl 1:i11-i17. PMID: 27068998

Bioinformatics

Uniprot Human
Human
Human
Human
Mouse
Product By Gene ID 4683
Alternate Names
  • Nijmegen breakage syndrome protein 1
  • NBS
  • p95
  • p95 protein of the MRE11/RAD50 complex
  • Nijmegen breakage syndrome 1 (nibrin)
  • ATV
  • MGC87362
  • AT-V2
  • FLJ10155
  • AT-V1
  • NBS1P95
  • Cell cycle regulatory protein p95
  • nibrin

Bioinformatics Tool for Nbs1

Discover related pathways, diseases and genes to Nbs1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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Related Nbs1 Blog Posts

Check out the latest blog posts on Nbs1.
The MRE11 Complex and DNA Damage Response
The maintenance of genome stability depends on the DNA damage response (DDR) which is a complex signaling network including cell cycle checkpoints, DNA repair and damage tolerance pathways. The DDR complex has the ability to sense DNA damage and tra...    Read more.
NBS1: The DNA Repair Trigger
NBS1 (Nijmegen breakage syndrome protein 1) is a component of the MRN complex (Mre11-Rad50-Nbs1) that plays important role in detecting DNA double strand breaks (DSBs) and triggering the downstream cascade. DSBs can be caused by ionizing radiation, ch...    Read more.
NBS1: DNA Repair Trigger
NBS1 (Nijmegen breakage syndrome protein 1) is a component of the MRN complex (Mre11-Rad50-Nbs1) that plays important role in detecting DNA double strand breaks (DSBs) and triggering the downstream cascade. DSBs can be caused by ionizing radiation, ch...    Read more.
Read more Nbs1 related blogs.