ATM Products

Rat ATM ELISA Kit (Colorimetr ...
Rat ATM ELISA Kit (Colorimetric)
Species: Rt
Applications: ELISA
Mouse ATM ELISA Kit (Colorime ...
Mouse ATM ELISA Kit (Colorimetric)
Species: Mu
Applications: ELISA
Human ATM ELISA Kit (Colorime ...
Human ATM ELISA Kit (Colorimetric)
Species: Hu
Applications: ELISA
Recombinant Human ATM Protein ...
Recombinant Human ATM Protein
Species: Hu
Applications: WB, ELISA, PA, AP
Recombinant Human ATM Protein ...
Recombinant Human ATM Protein
Species: Hu
Applications: WB, ELISA, PA, AP
ATM Recombinant Protein Antig ...
ATM Recombinant Protein Antigen
Species: Hu
Applications: AC


The ATM (ataxia telangiectasia mutated) is a member of the PI3/PI4-kinase family. This serine/threonine kinase protein is recruited to the site of DNA double stranded functions in DNA repair to initiate activation of the DNA damage checkpoint. Specifically, ATM phosphorylates the histone variant H2AX on Ser139, which signals recruitment of other proteins to initiate DNA double strand repair.

ATM and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in the ATM gene are associated with ataxia telangiectasia, an autosomal recessive disorder.


Entrez Human
Uniprot Human
Product By Gene ID 472
Alternate Names
  • ATC
  • TEL1, telomere maintenance 1, homolog
  • ataxia telangiectasia mutated (includes complementation groups A, C and D)
  • serine-protein kinase ATM
  • ATA
  • AT mutated
  • AT1
  • MGC74674
  • EC
  • DKFZp781A0353
  • A-T mutated
  • ATE
  • TELO1
  • ATDC
  • TEL1
  • ataxia telangiectasia mutatedATD

Bioinformatics Tool for ATM

Discover related pathways, diseases and genes to ATM. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Vizit™, under license from BioVista Inc.

Related ATM Blog Posts

Check out the latest blog posts on ATM.
Further unraveling the role of gamma H2AX in DNA damage response
Our genome experiences a moderate amount of DNA damage in our cells on a daily basis.  This DNA damage can be in response to external environmental factors, or be a result of our internal metabolic processes going awry.  While normal rates of DNA ...    Read more.
The recent relationship of BRCA1 and 53BP1
The p53-binding protein 1 (53BP1) is a DNA damage response factor, which is recruited to nuclear structures at the site of DNA damage.  DNA double-strand breaks (DSBs) are mutations that are detrimental to cell viability and genome stability, and m...    Read more.
Application Highlight: Recent uses of TERF2 in immunofluorescence (IF)
Telomeres are a region of repeat nucleotide sequences located at the end of chromosomes to protect our DNA from becoming damaged via end-to-end fusion.  TERF2, or telomeric-repeat binding factor 2, is important for telomere integrity and aids in th...    Read more.
ATM - detecting and responding to DNA damage
Ataxia telangiectasia mutated (ATM) is essential for the maintenance of genomic stability. ATM is a 370 kDa serine-threonine kinase that is constitutively expressed in various tissues. Although primarily nuclear, ATM is also found at lower levels...    Read more.
53BP1 - a marker for DNA Double Strand Break
53BP1 (p53 binding protein 1) was originally thought to be an enhancer for p53 transcriptional, but later studies have demonstrated that it is actually a substrate for ataxia telangiectasia mutated (ATM). 53BP1 is a classic late DNA damage response...    Read more.
53BP1 - DNA damage is no fun
The 53BP1 (p53 binding protein 1) was initially believed to be a p53 transcriptional enhancing partner, but it has now been established as an ataxia telangiectasia mutated (ATM) substrate. As a late DNA damage response (DDR) marker, 53BP1 appears duri...    Read more.
ATM and DSB Repair in Cancer
Ataxia Telangiectasia Mutated (ATM) is a serine/threonine protein kinase that is the master regulator of the DNA double-strand break (DSB) repair pathway. ATM is a key part of the cell cycle machinery that activates checkpoint signaling in response to...    Read more.
Read more ATM related blogs.