Markiewicz-Potoczny M, Lobanova A, Loeb AM et al. TRF2-mediated telomere protection is dispensable in pluripotent stem cells Pathogens Nov 23 2020 [PMID: 33239785] |
|
|
Mars JC, Tremblay MG, Valere M et al. The chemotherapeutic agent CX-5461 irreversibly blocks RNA polymerase I initiation and promoter release to cause nucleolar disruption, DNA damage and cell inviability NAR Cancer Dec 1 2020 [PMID: 33196044] (ICC/IF, Mouse, Human)
Details: NIH/3T3 cells and HEK292T cells (both treated with CX-5461 and untreated) underwent immunofluorescence microscopy |
ICC/IF |
Mouse, Human |
Rother MB, Pellegrino S, Smith R et al. CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks Mol Cell Nov 13 2020 [PMID: 33188175] (ICC/IF, Human) |
ICC/IF |
Human |
Pinzaru AM, Kareh M, Lamm N et al. Replication stress conferred by POT1 dysfunction promotes telomere relocalization to the nuclear pore Genes Dev Oct 29 2020 [PMID: 33122293] (ISH, Human) |
ISH |
Human |
Gilbreath C, Ma S, Yu L et al. Dynamic differences between DNA damage repair responses in primary tumors and cell lines Transl Oncol Oct 20 2020 [PMID: 33096336] (IHC-P, Human) |
IHC-P |
Human |
SAnchez-MorAn I, RodrIguez C, Lapresa R et al. Nuclear WRAP53 promotes neuronal survival and functional recovery after stroke Sci Adv Oct 1 2020 [PMID: 33028529] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Ostedgaard LS, Price MP, Whitworth KM et al. TDP-43 dysfunction results in R-loop accumulation and DNA replication defects Elife Oct 30 2020 [PMID: 33026343] (ICC/IF, Human) |
ICC/IF |
Human |
Vinchure OS, Whittemore K, Kushwah D et al. miR-490 suppresses telomere maintenance program and associated hallmarks in glioblastoma Cell. Mol. Life Sci. Sep 24 2020 [PMID: 32970185] |
|
|
Kim JJ, Lee SY, Choi JH et al. PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells Mol. Cell Sep 20 2020 [PMID: 32966758] |
|
|
Perez M, GarcIa-Heredia JM, Felipe-Abrio B et al. Sarcoma stratification by combined pH2AX and MAP17 (PDZK1IP1) levels for a better outcome on doxorubicin plus olaparib treatment Signal Transduct Target Ther Sep 23 2020 [PMID: 32963243] (ICC/IF) |
ICC/IF |
|
Britton S, Chanut P, Delteil C et al. ATM antagonizes NHEJ proteins assembly and DNA-ends synapsis at single-ended DNA double strand breaks Nucleic acids research Sep 25 2020 [PMID: 32890395] (Human) |
|
Human |
Rainey MD, Bennett D, O'Dea R et al. ATR Restrains DNA Synthesis and Mitotic Catastrophe in Response to CDC7 Inhibition Cell Rep Sep 1 2020 [PMID: 32877678] (ICC/IF, Human) |
ICC/IF |
Human |
Francica P, Mutlu M, Blomen VA et al. Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining Cell Rep Aug 25 2020 [PMID: 32846126] (WB, KD, Mouse) |
WB, KD |
Mouse |
Ding W, Lim D, Wang Z et al. 2-hexyl-4-pentynoic acid, a potential therapeutic for breast carcinoma by influencing RPA2 hyperphosphorylation-mediated DNA repair DNA Repair Jul 1 2020 [PMID: 32795962] (WB, ICC/IF, Human) |
WB, ICC/IF |
Human |
Tang M, Feng X, Pei G et al. FOXK1 Participates in DNA Damage Response by Controlling 53BP1 Function Cell Rep Aug 11 2020 [PMID: 32783940] |
|
|
Oldrini B, Vaquero-Siguero N, Mu Q et al. MGMT genomic rearrangements contribute to chemotherapy resistance in gliomas Nat Commun Aug 4 2020 [PMID: 32753598] (ICC/IF, Human) |
ICC/IF |
Human |
Balan E, De Groote E, Bouillon M et al. No effect of the endurance training status on senescence despite reduced inflammation in skeletal muscle of older individuals Am. J. Physiol. Endocrinol. Metab. Jul 21 2020 [PMID: 32691630] (Human) |
|
Human |
Li T, Lin S, Li C et al. MiR-185 targets POT1 to induce telomere dysfunction and cellular senescence Aging (Albany NY) Jul 18 2020 [PMID: 32687062] (ICC/IF, Human) |
ICC/IF |
Human |
Zhang C, Chen L, Peng D et al. METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation Mol. Cell Jun 26 2020 [PMID: 32615088] (ICC/IF, Human) |
ICC/IF |
Human |
Saha C, Mohanraju P, Stubbs A et al. Guide-free Cas9 from pathogenic Campylobacter jejuni bacteria causes severe damage to DNA Sci Adv Jun 1 2020 [PMID: 32596446] (WB, ICC/IF, Human) |
WB, ICC/IF |
Human |
Ngo B, Kim E, Osorio-Vasquez V et al. Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition Cancer Discov Jun 22 2020 [PMID: 32571778] (ICC/IF) |
ICC/IF |
|
Qin B, Yu J, Nowsheen S et al. STK38 promotes ATM activation by acting as a reader of histone H4 ufmylation Sci Adv Jun 1 2020 [PMID: 32537488] (Human) |
|
Human |
Wu J, Crowe DL Telomere DNA damage signaling regulates prostate cancer tumorigenesis Mol. Cancer Res. May 28 2020 [PMID: 32467172] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Bellelli R, Youds J, Borel V et al. Synthetic Lethality between DNA Polymerase Epsilon and RTEL1 in Metazoan DNA Replication Cell Rep May 26 2020 [PMID: 32460026] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Dan X, Babbar M, Moore A et al. DNA damage invokes mitophagy through a pathway involving Spata18 Nucleic Acids Res. May 26 2020 [PMID: 32453416] (ICC/IF, Human) |
ICC/IF |
Human |
Kelliher JL, West KL, Gong Q, Leung JWC Histone H2A variants alpha1-extension helix directs RNF168-mediated ubiquitination Nat Commun May 18 2020 [PMID: 32424115] (ICC/IF, Human) |
ICC/IF |
Human |
Hu Z, Mi S, Zhao T et al. BGL3 lncRNA mediates retention of the BRCA1/BARD1 complex at DNA damage sites EMBO J. Apr 29 2020 [PMID: 32347575] (WB) |
WB |
|
Wakita M, Takahashi A et al. A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells. Nat Commun Apr 22 2020 [PMID: 32321921] (IP, WB, Human) |
IP, WB |
Human |
Schochter F, Werner K, KOstler C et al. 53BP1 Accumulation in Circulating Tumor Cells Identifies Chemotherapy-Responsive Metastatic Breast Cancer Patients Cancers (Basel) Apr 9 2020 [PMID: 32283863] (WB, ICC/IF, Human) |
WB, ICC/IF |
Human |
Gzil A, Jaworski D, Antosik P et al. The impact of TP53BP1 and MLH1 on metastatic capability in cases of locally advanced prostate cancer and their usefulness in clinical practice Urol. Oncol. Apr 10 2020 [PMID: 32280038] (IHC-P, Human) |
IHC-P |
Human |
Ramadan R, Vromans E, Anang DC et al. Connexin43 Hemichannel Targeting With TAT-Gap19 Alleviates Radiation-Induced Endothelial Cell Damage Front Pharmacol Mar 5 2020 [PMID: 32210810] (ICC/IF, Human) |
ICC/IF |
Human |
Ferrara-Romeo I, Martinez P, Saraswati S et Al. The mTOR pathway is necessary for survival of mice with short telomeres Nat Commun Mar 3 2020 [PMID: 32127537] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Salvador-Barbero B, Alvarez-FernAndez M, Zapatero-Solana E et al. CDK4/6 Inhibitors Impair Recovery from Cytotoxic Chemotherapy in Pancreatic Adenocarcinoma Cancer Cell Mar 16 2020 [PMID: 32109375] |
|
|
Gauthier T, Duarte-Hospital C, Vignard J et al. Versicolorin A, a precursor in aflatoxins biosynthesis, is a food contaminant toxic for human intestinal cells Environ Int Feb 24 2020 [PMID: 32106047] (ICC/IF, Human) |
ICC/IF |
Human |
Chojnowski A, Ong PF, Foo MXR et al. Heterochromatin loss as a determinant of progerin-induced DNA damage in Hutchinson-Gilford Progeria Aging Cell Feb 22 2020 [PMID: 32087607] (ICC/IF, Human) |
ICC/IF |
Human |
Struve N, Binder ZA, Stead LF et al. EGFRvIII upregulates DNA mismatch repair resulting in increased temozolomide sensitivity of MGMT promoter methylated glioblastoma Oncogene Feb 17 2020 [PMID: 32066879] (ICC/IF, Human) |
ICC/IF |
Human |
Popp HD, Kohl V, Naumann N et al. DNA Damage and DNA Damage Response in Chronic Myeloid Leukemia Int J Mol Sci Feb 11 2020 [PMID: 32053969] (ICC/IF, Human) |
ICC/IF |
Human |
Belmans N, Gilles L, Vermeesen R et al. Quantification of DNA Double Strand Breaks and Oxidation Response in Children and Adults Undergoing Dental CBCT Scan Sci Rep Feb 7 2020 [PMID: 32034200] (ICC/IF, Human) |
ICC/IF |
Human |
Jakl L, Markova E et al. Biodosimetry of Low Dose Ionizing Radiation Using DNA Repair Foci in Human Lymphocytes. Genes (Basel) Apr 1 2020 [PMID: 31947954] (ICC/IF, Human) |
ICC/IF |
Human |
Zelensky AN, Schoonakker M, Brandsma I et al. Low dose ionizing radiation strongly stimulates insertional mutagenesis in a gamma H2AX dependent manner PLoS Genet. Jan 1 2020 [PMID: 31945059] (IB, KO, Mouse) |
IB, KO |
Mouse |
Riancho J, Castanedo-Vazquez D, Gil-Bea F et al. ALS-derived fibroblasts exhibit reduced proliferation rate, cytoplasmic TDP-43 aggregation and a higher susceptibility to DNA damage J. Neurol. Jan 14 2020 [PMID: 31938860] |
|
|
Current K, Meyer C, Magyar CE et al. Investigating PSMA-targeted radioligand therapy efficacy as a function of cellular PSMA levels and intra-tumoral PSMA heterogeneity Clin. Cancer Res. Jan 13 2020 [PMID: 31932492] (IHC-P, Mouse) |
IHC-P |
Mouse |
KOse-Vogel N, Stengel S, Gardey E, et al. Transcriptional Suppression of the NLRP3 Inflammasome and Cytokine Release in Primary Macrophages by Low-Dose Anthracyclines Cells Dec 28 2019 [PMID: 31905600] (ICC/IF, Human) |
ICC/IF |
Human |
Crochemore C, FernAndez-Molina C, Montagne B, et al. CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence Nat Commun Dec 6 2019 [PMID: 31811121] (ICC/IF, Human) |
ICC/IF |
Human |
Santos-Barriopedro I, Li Y, Bahl S, Seto E HDAC8 affects MGMT levels in glioblastoma cell lines via interaction with the proteasome receptor ADRM1 Genes Cancer Dec 5 2019 [PMID: 31798765] (ICC/IF, Human) |
ICC/IF |
Human |
Janoshazi AK, Horton JK, Zhao ML et al. Shining Light on the Response to Repair Intermediates in DNA of Living Cells DNA Repair (Amst.) Nov 12 2019 [PMID: 31790865] (ICC/IF) |
ICC/IF |
|
El-Daher MT, Lemale J, Bruneau J et al. Chronic Intestinal Pseudo-Obstruction and Lymphoproliferative Syndrome as a Novel Phenotype Associated With Tetratricopeptide Repeat Domain 7A Deficiency Front Immunol Nov 7 2019 [PMID: 31787977] (IB, ICC/IF, Mouse, Human) |
IB, ICC/IF |
Mouse, Human |
Henry E, Souissi-Sahraoui I, Deynoux M et al. Human hematopoietic stem/progenitor cells display ROS-dependent long-term hematopoietic defects after exposure to low dose of ionizing radiations Haematologica Nov 28 2019 [PMID: 31780635] (ICC/IF, Human) |
ICC/IF |
Human |
Scherthan H, Lee JH, Maus E et al. Nanostructure of Clustered DNA Damage in Leukocytes after In-Solution Irradiation with the Alpha Emitter Ra-223 Cancers (Basel) Nov 26 2019 [PMID: 31779276] (ICC/IF, Human) |
ICC/IF |
Human |
Aguado J, Sola-Carvajal A, Cancila V et al. Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson-Gilford Progeria Syndrome Nat Commun Nov 18 2019 [PMID: 31740672] (ICC/IF, Human) |
ICC/IF |
Human |
Whittemore K, MartInez-Nevado E, Blasco MA Slower rates of accumulation of DNA damage in leukocytes correlate with longer lifespans across several species of birds and mammals Aging (Albany NY) Nov 15 2019 [PMID: 31730540] (IHC-P, Reptile, Avian) |
IHC-P |
Reptile, Avian |
Munoz-Lorente MA, Cano-Martin AC, Blasco MA Mice with hyper-long telomeres show less metabolic aging and longer lifespans Nat Commun Oct 17 2019 [PMID: 31624261] (IHC-P, Mouse) |
IHC-P |
Mouse |
Yang G, Komaki Y, Yoshida I, Ibuki Y Formaldehyde inhibits UV-induced phosphorylation of histone H2AX Toxicol In Vitro 2019 Oct 12 [PMID: 31614172] (ICC/IF, Human) |
ICC/IF |
Human |
Lu X, Tang M, Zhu Q et al. GLP-catalyzed H4K16me1 promotes 53BP1 recruitment to permit DNA damage repair and cell survival Nucleic Acids Res. 2019 Oct 15 [PMID: 31612207] (IP, KD, Human) |
IP, KD |
Human |
Lee K J, Piett C G et al. Defective base excision repair in the response to DNA damaging agents in triple negative breast cancer. PLoS One Oct 10 2019 [PMID: 31596905] (ICC/IF, Human) |
ICC/IF |
Human |
Bishop DK Non-enzymatic roles of human RAD51 at stalled replication forks. Mason JM, Chan YL, Weichselbaum RW et al. Nat Commun. [PMID: 31562309] (ICC/IF, Human) |
ICC/IF |
Human |
Sambeat A, Ratajczak J, Joffraud M et al. Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage Nat Commun Sep 20 2019 [PMID: 31541116] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Zatreanu D, Han Z, Mitter R et al. Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability Mol. Cell Aug 23 2019 [PMID: 31519522] (ICC/IF, Human) |
ICC/IF |
Human |
Parvin S, Ramirez-Labrada A, Aumann S et al. LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL Cancer Cell Aug 12 2019 [PMID: 31447348] (IP, Human) |
IP |
Human |
Cameron BD, Traver G, Roland JT et al. Bcl2-Expressing Quiescent Type B Neural Stem Cells in the Ventricular-Subventricular Zone Are Resistant to Concurrent Temozolomide/X-Irradiation Stem Cells Dec 1 2019 [PMID: 31430423] (IHC-P, Mouse) |
IHC-P |
Mouse |
Sundaravinayagam Devakumar, Rahjouei Ali, Andreani Matteo et al. 53BP1 Supports Immunoglobulin Class Switch Recombination Independently of Its DNA Double-Strand Break End Protection Function. Cell Reports 2019 August 06 [PMID: 31390554] (WB, Mouse) |
WB |
Mouse |
Hill RJ, Crossan GP DNA cross-link repair safeguards genomic stability during premeiotic germ cell development Nat. Genet. Aug 1 2019 [PMID: 31367016] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Brandsma I, Sato K, van Rossum-Fikkert SE et al. HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis Cell Rep 2019 Jun 25 [PMID: 31242413] (IF, Mouse, Human) |
IF |
Mouse, Human |
Xia Y, Pfeifer CR, Zhu K et al. Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle J. Cell Biol. Jun 25 2019 [PMID: 31239284] |
|
|
Peng J, Tang L, Cai M et al. RECQL5 plays an essential role in maintaining genome stability and viability of triple-negative breast cancer cells Cancer Med Jun 23 2019 [PMID: 31231988] (ICC/IF, Human) |
ICC/IF |
Human |
Grill S, Bisht K, Tesmer VM et al. Two Separation-of-Function Isoforms of Human TPP1 Dictate Telomerase Regulation in Somatic and Germ Cells bioRxiv Jun 18 2019 [PMID: 31216472] (IP, Human) |
IP |
Human |
Liu Y, Efimova EV, Ramamurthy AKron SJ Repair-independent functions of DNA-PKcs protect irradiated cells from mitotic slippage and accelerated senescence J. Cell. Sci. 2019 Jul 01 [PMID: 31189537] |
|
|
Smith LR, Irianto J, Xia Y et al. Constricted migration modulates stem cell differentiation Mol. Biol. Cell Jul 22 2019 [PMID: 31188712] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Pladevall-Morera D, Munk S, Ingham A et al. Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability Nucleic Acids Res. 2019 Jun 10 [PMID: 31180492] (IF, Human) |
IF |
Human |
Wen HJ, Gao S, Wang Y et al. Myeloid cell-derived HB-EGF Drives Tissue Recovery After Pancreatitis Cell Mol Gastroenterol Hepatol May 21 2019 [PMID: 31125624] (IF, Mouse) |
IF |
Mouse |
Ge Y, Wu S, Zhang Z et al. Inhibition of p53 and/or AKT as a new therapeutic approach specifically targeting ALT cancers Protein Cell May 21 2019 [PMID: 31115790] (ICC/IF, Human) |
ICC/IF |
Human |
Cho S, Vashisth M, Abbas A et al. Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest Dev. Cell May 8 2019 [PMID: 31105008] (ICC/IF, Human) |
ICC/IF |
Human |
Campillo-Marcos I, Lazo PA Olaparib and ionizing radiation trigger a cooperative DNA-damage repair response that is impaired by depletion of the VRK1 chromatin kinase J. Exp. Clin. Cancer Res. May 17 2019 [PMID: 31101118] (ICC/IF, Human) |
ICC/IF |
Human |
The autophagy Protein Atg5 Plays a Crucial Role in the Maintenance and Reconstitution Ability of Hematopoietic Stem Cells Jung HE, Shim YR, Oh JE Immune Netw. [PMID: 31089439] (Flow, Mouse) |
Flow |
Mouse |
Huang J, Zhang J, Bellani MA et al. Remodeling of Interstrand Crosslink Proximal Replisomes Is Dependent on ATR, FANCM, and FANCD2 Cell Rep May 7 2019 [PMID: 31067464] |
|
|
Caron P, Pankotai T, Wiegant WW et al. WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks Genes Dev. May 2 2019 [PMID: 31048545] (ICC/IF, KD) |
ICC/IF, KD |
|
Lagunas AM, Francis M, Maniar NB et al. Paracrine Interaction of Cancer Stem Cell Populations Is Regulated by the Senescence-Associated Secretory Phenotype (SASP) Mol. Cancer Res. May 1 2019 [PMID: 31043491] (IHC-P, Mouse) |
IHC-P |
Mouse |
Prieto, I;Zambrano, A;Laso, J;Aranda, A;Samper, E;Monsalve, M; Early induction of senescence and immortalization in PGC-1 alpha-deficient mouse embryonic fibroblasts Free Radic. Biol. Med. Apr 25 2019 [PMID: 31029787] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Nadeau, S;Cheng, A;Colmegna, I;Rodier, F; Quantifying Senescence-Associated Phenotypes in Primary Multipotent Mesenchymal Stromal Cell Cultures Methods Mol. Biol. Apr 25 2019 [PMID: 31020633] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Galindo-Campos, MA;Bedora-Faure, M;Farres, J;Lescale, C;Moreno-Lama, L;Martinez, C;Martin-Caballero, J;Ampurdanes, C;Aparicio, P;Dantzer, F;Cerutti, A;Deriano, L;Yelamos, J; Coordinated signals from the DNA repair enzymes PARP-1 and PARP-2 promotes B-cell development and function Cell Death Differ. Apr 17 2019 [PMID: 30996287] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Gupta, R;Li, W;Yan, XJ;Barrientos, J;Kolitz, JE;Allen, SL;Rai, K;Chiorazzi, N;Mongini, PKA; Mechanism for IL-15-Driven B Cell Chronic Lymphocytic Leukemia Cycling: Roles for AKT and STAT5 in Modulating Cyclin D2 and DNA Damage Response Proteins J. Immunol. Apr 15 2019 [PMID: 30988120] (WB, Flow, Human) |
WB, Flow |
Human |
West, KL;Kelliher, JL;Xu, Z;An, L;Reed, MR;Eoff, RL;Wang, J;Huen, MSY;Leung, JWC; LC8/DYNLL1 is a 53BP1 effector and regulates checkpoint activation Nucleic Acids Res. Apr 15 2019 [PMID: 30982887] (WB, Human) |
WB |
Human |
Zhang, M;Wang, B;Li, T;Liu, R;Xiao, Y;Geng, X;Li, G;Liu, Q;Price, CM;Liu, Y;Wang, F; Mammalian CST averts replication failure by preventing G-quadruplex accumulation Nucleic Acids Res. Apr 12 2019 [PMID: 30976812] (ICC/IF, Human) |
ICC/IF |
Human |
Michelini, F;Rossiello, F;d'Adda di Fagagna, F;Francia, S; RNase A treatment and reconstitution with DNA damage response RNA in living cells as a tool to study the role of non-coding RNA in the formation of DNA damage response foci Nat Protoc May 1 2019 [PMID: 30962605] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Jung HE, Shim YR, Oh JE. The autophagy Protein Atg5 Plays a Crucial Role in the Maintenance and Reconstitution Ability of Hematopoietic Stem Cells Cell Rep. [PMID: 30943404] (Flow, Mouse) |
Flow |
Mouse |
Sekhar, KR;Wang, J;Freeman, ML;Kirschner, AN; Radiosensitization by enzalutamide for human prostate cancer is mediated through the DNA damage repair pathway PLoS ONE Apr 1 2019 [PMID: 30933998] (ICC/IF, Human) |
ICC/IF |
Human |
Gourzones, C;Bellanger, C;Lamure, S;Gadacha, OK;De Paco, EG;Vincent, L;Cartron, G;Klein, B;Moreaux, J; Antioxidant Defenses Confer Resistance to High Dose Melphalan in Multiple Myeloma Cells Cancers (Basel) Mar 28 2019 [PMID: 30925767] (ICC/IF, Human) |
ICC/IF |
Human |
Li S, Su W, Zhang C. Linear Double-stranded DNAs as Innovative Biological Parts to Implement Genetic Circuits in Mammalian Cells FEBS J. Mar 26 2019 [PMID: 30913358] (ICC/IF, Human) |
ICC/IF |
Human |
Belmans N, Gilles L, Virag P et al. Method validation to assess in vivo cellular and subcellular changes in buccal mucosa cells and saliva following CBCT examinations Dentomaxillofac Radiol Mar 26 2019 [PMID: 30912976] (ICC/IF, Human) |
ICC/IF |
Human |
Schiroli G, Conti A, Ferrari S et al. Precise Gene Editing Preserves Hematopoietic Stem Cell Function following Transient p53-Mediated DNA Damage Response Cell Stem Cell Mar 14 2019 [PMID: 30905619] (ICC/IF, Human) |
ICC/IF |
Human |
Qin B, Yu J, Nowsheen S et al. UFL1 promotes histone H4 ufmylation and ATM activation Nat Commun Mar 18 2019 [PMID: 30886146] (ICC/IF, Human) |
ICC/IF |
Human |
Efimova EV, Appelbe OK, Ricco N et al. O-GlcNAcylation enhances double strand break repair, promotes cancer cell proliferation and prevents therapy-induced senescence in irradiated tumors Mol. Cancer Res. Mar 18 2019 [PMID: 30885991] (ICC/IF, Human) |
ICC/IF |
Human |
Selis D, Pande Y, Smoczer C et al. Cytotoxicity and Genotoxicity of a New Intracanal Medicament, 2-hydroxyisocaproic Acid-An InVitro Study J Endod Mar 14 2019 [PMID: 30879773] (ICC/IF, Human) |
ICC/IF |
Human |
Peng Y, Liao Q, Tan W et al. The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors Nat Commun Mar 15 2019 [PMID: 30874560] (ICC/IF, Human) |
ICC/IF |
Human |
Linder B, Wehle A, Hehlgans S et al. Arsenic Trioxide and (-)-Gossypol Synergistically Target Glioma Stem-Like Cells via Inhibition of Hedgehog and Notch Signaling Cancers (Basel) Mar 12 2019 [PMID: 30871073] (ICC/IF, Human) |
ICC/IF |
Human |
Ly P, Brunner SF, Shoshani O et al. Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements Nat. Genet. Apr 1 2019 [PMID: 30833795] (ICC/IF, Human) |
ICC/IF |
Human |
Wang Y, Yang J, Wild AT et al. G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma Nat Commun. 2019 Feb 25 [PMID: 30808951] (ICC/IF, Human) |
ICC/IF |
Human |
Bodo S, Campagne C, Thin TH et al. Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury J. Clin. Invest. Nov 27 2018 [PMID: 30480549] (IHC-P, Human) |
IHC-P |
Human |
Roewenstrunk JM. RNF169 and RNF168 novel substrates of DYRK1A: connecting DYRK1A to DNA-damage repair Thesis 2018 (ICC/IF) |
ICC/IF |
|
Sen P, Lan Y, Li CY et al. Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence Mol. Cell Feb 21 2019 [PMID: 30773298] (ICC/IF, Human) |
ICC/IF |
Human |
Fichtman B, Zagairy F, Biran N et al. Combined loss of LAP1B and LAP1C results in an early onset multisystemic nuclear envelopathy Nat Commun Feb 5 2019 [PMID: 30723199] (ICC/IF, Human) |
ICC/IF |
Human |
Turner R. Relationships between nuclear lamins and telomere biology in progeroid laminopathies and cancer. Thesis. 2015 (WB, ICC/IF, Human) |
WB, ICC/IF |
Human |
Surface L. Functional analysis of the histone variant H2A.Z during lineage commitment. Thesis. 2014 May 30 |
|
|
Ogrodnik M, Zhu Y, Langhi LGP et al. Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis. Cell Metab. Jan 3 2019 [PMID: 30612898] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Coluzzi E, Leone S, Sgura A. Oxidative Stress Induces Telomere Dysfunction and Senescence by Replication Fork Arrest. Cells Jan 3 2019 [PMID: 30609792] (ICC/IF, Human) |
ICC/IF |
Human |
Ovadya Y, Landsberger T, Leins H et al. Impaired immune surveillance accelerates accumulation of senescent cells and aging Nat Commun Dec 21 2018 [PMID: 30575733] (IHC-P, Mouse) |
IHC-P |
Mouse |
Guijarro T, Magro-Lopez E, Manso J et al. Detrimental pro-senescence effects of vitamin D on lung fibrosis Mol. Med. Dec 19 2018 [PMID: 30567504] (ICC/IF, Human) |
ICC/IF |
Human |
Becker JR, Cuella-Martin R, Barazas M et al. The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity Nat Commun Dec 17 2018 [PMID: 30559443] (WB, Human) |
WB |
Human |
Tumini E, Herrera-Moyano E, San Martin-Alonso M et al. The antitumor drugs trabectedin and lurbinectedin induce transcription-dependent replication stress and genome instability Mol. Cancer Res. Dec 14 2018 [PMID: 30552231] (ICC/IF, Human) |
ICC/IF |
Human |
Lafarga V, Sung HM, Haneke K et al. TIAR marks nuclear G2/M transition granules and restricts CDK1 activity under replication stress EMBO Rep. Dec 11 2018 [PMID: 30538118] (ICC/IF, Human) |
ICC/IF |
Human |
Fernandez-Vidal A, Arnaud LC, Maumus M et al. Exposure to the fungicide captan induces DNA base alterations and replicative stress in mammalian cells. Environ. Mol. Mutagen. Nov 24 2018 [PMID: 30471166] (Human) |
|
Human |
Majerska J, Feretzaki M, Glousker G, Lingner J. Transformation-induced stress at telomeres is counteracted through changes in the telomeric proteome including SAMHD1. Life Sci. Alliance Aug 1 2018 [PMID: 30456372] (ICC/IF, Human) |
ICC/IF |
Human |
El-Daher MT, Cagnard N, Gil M et al. Tetratricopeptide repeat domain 7A is a nuclear factor that modulates transcription and chromatin structure. Cell Discov. Nov 13 2018 [PMID: 30455981] (ICC/IF, Human) |
ICC/IF |
Human |
Wu J, Crowe DL. Molecular and cellular basis of mammary gland fibrosis and cancer risk. Int. J. Cancer. Nov 19 2018 [PMID: 30450584] (Human) |
|
Human |
Sung P, Yin T, Wallace C et al. Extracorporeal Shock Wave-Supported Adipose-Derived Fresh Stromal Vascular Fraction Preserved Left Ventricular (LV) Function and Inhibited LV Remodeling in Acute Myocardial Infarction in Rat Neurochem. Int. Sep 29 2018 [PMID: 30416645] (IHC, ICC/IF, Rat) |
IHC, ICC/IF |
Rat |
Sargolzaeiaval F, Zhang J, Schleit J et al. CTC1 mutations in a Brazilian family with progeroid features and recurrent bone fractures. Neurobiol. Dis. Nov 22 2018 [PMID: 30393977] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Bhatia V, Valdes-Sanchez L, Rodriguez-Martinez D et al. Formation of 53BP1 foci and ATM activation under oxidative stress is facilitated by RNA:DNA hybrids and loss of ATM-53BP1 expression promotes photoreceptor cell survival in mice F1000Res Aug 10 2018 [PMID: 30345028] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Razdan N, Vasilopoulos T, Herbig U. Telomere dysfunction promotes transdifferentiation of human fibroblasts into myofibroblasts. Aging Cell Sep 22 2018 [PMID: 30244523] (Human) |
|
Human |
Feng W, Jasin M. 53BP1 nuclear body-marked replication stress in a human mammary cell model of BRCA2 deficiency. J. Agric. Food Chem. Nov 27 2018 (ICC/IF, Human) |
ICC/IF |
Human |
Piquet S, Le Parc F, Bai SK et al. The Histone Chaperone FACT Coordinates H2A.X-Dependent Signaling and Repair of DNA Damage Mol. Cell Dec 6 2018 [PMID: 30344095] (WB, ICC/IF, Human) |
WB, ICC/IF |
Human |
Chakraborty P, Huang JTJ, Hiom K. DHX9 helicase promotes R-loop formation in cells with impaired RNA splicing Nat Commun Oct 19 2018 [PMID: 30341290] (IP, Human) |
IP |
Human |
Munoz-Galvan S, Lucena-Cacace A, Perez M et al. Tumor cell-secreted PLD increases tumor stemness by senescence-mediated communication with microenvironment. Oncogene. Oct 10 2018 [PMID: 30305726] (ICC/IF, Human) |
ICC/IF |
Human |
Tete A, Gallais I, Imran M et al. Mechanisms involved in the death of steatotic WIF-B9 hepatocytes co-exposed to benzo[a]pyrene and ethanol: a possible key role for xenobiotic metabolism and nitric oxide. Free Radic. Biol. Med. Sep 27 2018 [PMID: 30268890] (ICC/IF, Human) |
ICC/IF |
Human |
Albers E, Sbroggio M, Pladevall-Morera D et al. Loss of PICH Results in Chromosomal Instability, p53 Activation, and Embryonic Lethality. Cell Rep Sep 18 2018 [PMID: 30232008] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Johnson TI, Costa ASH, Ferguson AN, Frezza C. Fumarate hydratase loss promotes mitotic entry in the presence of DNA damage after ionising radiation. Cell Death Dis Sep 6 2018 [PMID: 30190474] (ICC/IF, Human) |
ICC/IF |
Human |
Chow TT, Shi X, Wei JH et al. Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection. Nat Commun Sep 4 2018 [PMID: 30181605] (ICC/IF, Human) |
ICC/IF |
Human |
Xia Y, Ivanovska IL, Zhu K et al. Nuclear rupture at sites of high curvature compromises retention of DNA repair factors. J. Cell Biol. Aug 31 2018 [PMID: 30171044] (ICC/IF, Human) |
ICC/IF |
Human |
Petroni M, Sardina F, Infante P et al. MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors. Cell Death Dis Aug 30 2018 [PMID: 30166519] (ICC/IF, IHC-P, Human) |
ICC/IF, IHC-P |
Human |
Hehlgans S, Booms P, Gullulu O et al. Radiation Sensitization of Basal Cell and Head and Neck Squamous Cell Carcinoma by the Hedgehog Pathway Inhibitor Vismodegib Int J Mol Sci Aug 23 2018 [PMID: 30142876] (ICC/IF, Human) |
ICC/IF |
Human |
Qi Y, Toyooka T, Kashiwagi H et al. 2,4-Dimethylaniline generates phosphorylated histone H2AX in human urothelial and hepatic cells through reactive oxygen species produced by cytochrome P450 2E1 Arch. Toxicol. Aug 21 2018 [PMID: 30132044] (ICC/IF, Human) |
ICC/IF |
Human |
Muoio D, Berardinelli F, Leone S et al. Naphthalene diimide-derivatives G-quadruplex ligands induce cell proliferation inhibition, mild telomeric dysfunction and cell cycle perturbation in U251MG glioma cells FEBS J. Aug 10 2018 [PMID: 30095224] (ICC/IF, Human) |
ICC/IF |
Human |
de Carcer G, Venkateswaran SV, Salgueiro L et al. Plk1 overexpression induces chromosomal instability and suppresses tumor development Nat Commun Aug 1 2018 [PMID: 30069007] (Mouse) |
|
Mouse |
Evangelista FM, Maglott-Roth A, Stierle M et al. Transcription and mRNA export machineries SAGA and TREX-2 maintain monoubiquitinated H2B balance required for DNA repair J. Cell Biol. Jul 27 2018 [PMID: 30054449] (ICC/IF, Human) |
ICC/IF |
Human |
Timm S, Lorat Y, Jakob B et al. Clustered DNA damage concentrated in particle trajectories causes persistent large-scale rearrangements in chromatin architecture. Radiother Oncol Jul 23 2018 [PMID: 30049456] (ICC/IF, Human) |
ICC/IF |
Human |
Ghezraoui H, Oliveira C, Becker JR et al. 53BP1 cooperation with the REV7-shieldin complex underpins DNA structure-specific NHEJ Nature Aug 1 2018 [PMID: 30046110] (WB, Mouse) |
WB |
Mouse |
Mirman Z, Lottersberger F, Takai H et al. 53BP1-RIF1-shieldin counteracts DSB resection through CST-and Pola-dependent fill-in. Nature. Jul 18 2018 [PMID: 30022158] (WB, Mouse) |
WB |
Mouse |
Georgilis A, Klotz S et al. PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells. Cancer Cell Sep 7 2018 [PMID: 29990503] (ICC/IF, Human) |
ICC/IF |
Human |
Genard G, Wera AC, Huart C et al. Proton irradiation orchestrates macrophage reprogramming through NFkB signaling Cell Death Dis Jun 27 2018 [PMID: 29950610] (ICC/IF, Human) |
ICC/IF |
Human |
Su W, Hong L, Xu X et al. miR-30 disrupts senescence and promotes cancer by targeting both p16INK4A and DNA damage pathways Oncogene Oct 1 2018 [PMID: 29907771] (ICC/IF, Human) |
ICC/IF |
Human |
Pecqueux C, Arslan A, Heller M et al. FGF-2 is a driving force for chromosomal instability and a stromal factor associated with adverse clinico-pathological features in prostate cancer Urol. Oncol. Jun 7 2018 [PMID: 29887238] (Human) |
|
Human |
Vallabhaneni H, Lynch PJ, Chen G et al. High Basal Levels of GH2AX in Human Induced Pluripotent Stem Cells are Linked to Replication-Associated DNA Damage and Repair Stem Cells Jun 6 2018 [PMID: 29873142] (Human) |
|
Human |
Canovas B, Igea A, Sartori AA et al. Targeting p38a Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells Cancer Cell May 14 2018 [PMID: 29805078] (Human) |
|
Human |
Bellelli R, Borel V et al. Pol epislon Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis. Mol Cell May 17 2018 [PMID: 29754823] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Le O, Palacio L, Bernier G et al. INK4a/ARF Expression Impairs Neurogenesis in the Brain of Irradiated Mice. Stem Cell Reports Apr 1 2018 [PMID: 29706499] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Biechonski S, Olender L, Zipin-Roitman A et al. Attenuated DNA damage responses and increased apoptosis characterize human hematopoietic stem cells exposed to irradiation. Sci Rep Apr 17 2018 [PMID: 29666389] (ICC/IF, Human) |
ICC/IF |
Human |
La Torre M, Merigliano C, Burla R et al. Mice with reduced expression of the telomere-associated protein Ft1 develop p53-sensitive progeroid traits. Aging Cell Apr 10 2018 [PMID: 29635765] (Mouse) |
|
Mouse |
Mitxelena J, Apraiz A, Vallejo-Rodriguez J et al. An E2F7-dependent transcriptional program modulates DNA damage repair and genomic stability. Nucleic Acids Res. Mar 24 2018 [PMID: 29590434] (ICC/IF) |
ICC/IF |
|
Bossuet-Greif N, Vignard J, Taieb F et al. The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells. MBio. Mar 20 2018 [PMID: 29559578] (ICC/IF, Human) |
ICC/IF |
Human |
Richter K, Paakkola T, Mennerich D et al. USP28 Deficiency Promotes Breast and Liver Carcinogenesis as well as Tumor Angiogenesis in a HIF-independent Manner. Mol Cancer Res 2018 Jun [PMID: 29545478] |
|
|
Massonneau J, Ouellet C, Lucien F et al. Suboptimal extracellular pH values alter DNA damage response to induced double-strand breaks. FEBS Open Bio. Mar 1 2018 [PMID: 29511618] (ICC/IF, Human) |
ICC/IF |
Human |
Castiglione MP, Ramos RL, Leheste JR, Torres G. Central and Peripheral Expression of DNA Double-Strand Breaks in Human and Mouse Tissues. Anat Rec (Hoboken). 2018 Feb 21 [PMID: 29466834] (Human) |
|
Human |
Her J, Ray C, Altshuler J et al. 53BP1 Mediates ATR-Chk1 Signaling and Protects Replication Forks under Conditions of Replication Stress. Mol Cell Biol 2018 Apr 15 [PMID: 29378830] |
|
|
Yuan J, Liu Y, Wang J et al. Long-term Persistent Organic Pollutants Exposure Induced Telomere Dysfunction and Senescence-Associated Secretary Phenotype. J. Gerontol. A Biol. Sci. Med. Sci. Jul 9 2018 [PMID: 29360938] (ICC/IF, Human) |
ICC/IF |
Human |
Gavish-Izakson M, Velpula BB, Elkon R et al. Nuclear poly(A)-binding protein 1 is an ATM target and essential for DNA double-strand break repair. Nucleic Acids Res. 2017 Dec 14 [PMID: 29253183] (Human) |
|
Human |
Chitale, SRichly, H, DICER- and MMSET-catalyzed H4K20me2 recruits the nucleotide excision repair factor XPA to DNA damage sites. J. Cell Biol. [PMID: 29233865] (WB, Human) |
WB |
Human |
Bill M A, Srivastava K et al. Dual effects of radiation bystander signaling in urothelial cancer: purinergic-activation of apoptosis attenuates survival of urothelial cancer and normal urothelial cells. Oncotarget Nov 14 2017 [PMID: 29228614] (ICC/IF, Human) |
ICC/IF |
Human |
Fujita K, Mao Y, Uchida S et al. Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1. Nat Commun 2017 Nov 30 [PMID: 29192206] (WB, Mouse) |
WB |
Mouse |
Michelini F, Pitchiaya S, Vitelli V et al. Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks Nat. Cell Biol. 2017 Dec 01 [PMID: 29180822] (ICC/IF) |
ICC/IF |
|
Jongen JMJ, van der Waals LM, Trumpi K et al. Downregulation of DNA repair proteins and increased DNA damage in hypoxic colon cancer cells is a therapeutically exploitable vulnerability Oncotarget. 2017 Oct 17 [PMID: 29156796] (WB, Human) |
WB |
Human |
Bejarano L, Schuhmacher AJ, Mendez M et al. Inhibition of TRF1 Telomere Protein Impairs Tumor Initiation and Progression in Glioblastoma Mouse Models and Patient-Derived Xenografts Cancer Cell. 2017 Nov 13 [PMID: 29136505] (Mouse) |
|
Mouse |
Lagunas A M, Wu J et al. Telomere DNA damage signaling regulates cancer stem cell evolution, epithelial mesenchymal transition, and metastasis. Oncotarget Jun 10 2017 [PMID: 29113290] (IHC, Mouse) |
IHC |
Mouse |
Vohhodina J, Barros EM, Savage AL et al. The RNA processing factors THRAP3 and BCLAF1 promote the DNA damage response through selective mRNA splicing and nuclear export Nucleic Acids Res. 2017 Nov 03 [PMID: 29112714] (WB, Human) |
WB |
Human |
Jones SE, Fleuren EDG, Frankum J et al. ATR is a therapeutic target in synovial sarcoma. Cancer Res. 2017 Oct 16 [PMID: 29038346] (ICC/IF, Human) |
ICC/IF |
Human |
Hosokawa K, MacArthur BD, Ikushima YM et al. The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age. Nat Commun. 2017 Oct 06 [PMID: 28986560] (Flow, Mouse) |
Flow |
Mouse |
Schuhwerk H, Bruhn C, Siniuk K et al. Kinetics of poly (ADP-ribosyl) ation, but not PARP1 itself, determines the cell fate in response to DNA damage in vitro and in vivo Nucleic Acids Research 2017 Aug 18 [PMID: 28977496] (Mouse) |
|
Mouse |
Kim H, Li F, He Q et al. Systematic analysis of human telomeric dysfunction using inducible telosome/shelterin CRISPR/Cas9 knockout cells Cell Discov. 2017 Sep 25 [PMID: 28955502] (ICC/IF, Human) |
ICC/IF |
Human |
Patel DS, Misenko SM, Her J, Bunting SF. BLM helicase regulates DNA repair by counteracting RAD51 loading at DNA double-strand break sites J. Cell Biol. 2017 Sep 14 [PMID: 28912125] (Human) |
|
Human |
Traver G, Mont S, Gius D et al. Loss of Nrf2 promotes alveolar type 2 cell loss in irradiated, fibrotic lung Free Radic. Biol. Med. 2017 Nov 01 [PMID: 28870520] (WB, Mouse) |
WB |
Mouse |
Perkhofer L, Schmitt A, Romero Carrasco MC et al. ATM deficiency generating genomic instability sensitizes pancreatic ductal adenocarcinoma cells to therapy-induced DNA damage Cancer Res. 2017 Aug 08 [PMID: 28790064] (Human) |
|
Human |
Lai X, Broderick R, Bergoglio V et al. MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells Nat Commun 2017 Jul 17 [PMID: 28714477] (ICC/IF, Human) |
ICC/IF |
Human |
Mikula-Pietrasik J, Uruski P, Pakula M et al. Oxidative stress contributes to hepatocyte growth factor-dependent pro-senescence activity of ovarian cancer cells. Free Radic. Biol. Med. 2017 Jun 23 [PMID: 28652056] |
|
|
Liu R, King A, Hoch NC et al. ASCIZ/ATMIN is dispensable for ATM signaling in response to replication stress. DNA Repair (Amst.). 2017 Jun 17 [PMID: 28648892] (WB, ICC/IF, Mouse) |
WB, ICC/IF |
Mouse |
Zhang T, Zhang Z, Li F et al. Looping-out mechanism for resolution of replicative stress at telomeres. EMBO Rep. Aug 1 2017 [PMID: 28615293] (ICC/IF, Human) |
ICC/IF |
Human |
Ogrodnik M, Miwa S et al. Cellular senescence drives age-dependent hepatic steatosis. Nat Commun Jun 13 2017 [PMID: 28608850] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Yosef R, Pilpel N, Papismadov N et al. p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling. EMBO J. 2017 Jun 12 [PMID: 28607003] (ICC/IF, Human) |
ICC/IF |
Human |
Jaiswal H, Benada J, Mullers E et al. ATM/Wip1 activities at chromatin control Plk1 re-activation to determine G2 checkpoint duration. EMBO J. Jul 14 2017 [PMID: 28607002] (ICC/IF, Human) |
ICC/IF |
Human |
Garzon J, Rodriguez R, Kong Z et al. Shortage of dNTPs underlies altered replication dynamics and DNA breakage in the absence of the APC/C cofactor Cdh1. Oncogene. 2017 Jun 12 [PMID: 28604743] (Mouse) |
|
Mouse |
Ha K, Ma C, Lin H et al. The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites. Nat Commun. 2017 Jun 12 [PMID: 28604711] (ICC/IF, Human) |
ICC/IF |
Human |
Di Marco S, Hasanova Z et al. RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis. Mol Cell Jan 6 2017 [PMID: 28575661] (ICC/IF, Human) |
ICC/IF |
Human |
Hilmi K, Jangal M, Marques M et al. CTCF facilitates DNA double-strand break repair by enhancing homologous recombination repair. Sci Adv May 1 2017 [PMID: 28560323] (WB, Human) |
WB |
Human |
Contrepois K, Coudereau C, Benayoun BA et al. Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression Nat Commun. 2017 May 09 [PMID: 28489069] (IHC-P, Human) |
IHC-P |
Human |
Liu G, Wang H et al. The Effect of VPA on Increasing Radiosensitivity in Osteosarcoma Cells and Primary-Culture Cells from Chemical Carcinogen-Induced Breast Cancer in Rats. Int J Mol Sci Oct 5 2017 [PMID: 28489060] (ICC/IF, Human) |
ICC/IF |
Human |
Becker J, Bonnet C, Clifford G et al. BARD1 links histone H2A Lysine-15 ubiquitination to initiation of BRCA1-dependent homologous recombination bioRxiv Jun 2 2020 (WB, Human) |
WB |
Human |
Tamayo-Orrego L, Gallo D, Racicot F et al. Sonic hedgehog accelerates DNA replication to cause replication stress promoting cancer initiation in medulloblastoma Nat Cancer Jul 20 2020 |
|
|
Yu Z, Mersaoui S, Guitton-Sert L et al. DDX5 resolves R-loops at DNA double-strand breaks to promote DNA repair and avoid chromosomal deletions NAR Cancer Sep 1 2020 (ICC/IF, KD, Human) |
ICC/IF, KD |
Human |
Baselet Bjorn, Belmans Niels, Coninx Emma et al. Functional Gene Analysis Reveals Cell Cycle Changes and Inflammation in Endothelial Cells Irradiated with a Single X-ray Dose. Front Pharmacol 2017 [PMID: 28487652] (ICC/IF, Human) |
ICC/IF |
Human |
Farg M A, Konopka A et al. The DNA damage response (DDR) is induced by the C9orf72 repeat expansion in amyotrophic lateral sclerosis. Hum Mol Genet Jan 8 2017 [PMID: 28481984] (WB, Human) |
WB |
Human |
Meloche J, Lampron M C et al. Implication of Inflammation and Epigenetic Readers in Coronary Artery Remodeling in Patients With Pulmonary Arterial Hypertension. Arterioscler Thromb Vasc Biol Jan 8 2017 [PMID: 28473439] (IHC, Human) |
IHC |
Human |
Latella L, Dall'Agnese A, Sesillo FB et al. DNA damage signaling mediates the functional antagonism between replicative senescence and terminal muscle differentiation. Genes Dev. Apr 1 2017 [PMID: 28446595] |
|
|
Huang D, Lu W, Zou S et al. Rho GDP-dissociation inhibitor alpha is a potential prognostic biomarker and controls telomere regulation in colorectal cancer Cancer Sci. 2017 Jul 01 [PMID: 28417530] (IHC-P, Human) |
IHC-P |
Human |
Cottineau J, Kottemann MC, Lach FP et al. Inherited GINS1 deficiency underlies growth retardation along with neutropenia and NK cell deficiency. J. Clin. Invest. May 1 2017 [PMID: 28414293] (ICC/IF, Human) |
ICC/IF |
Human |
Vancevska A, Douglass KM, Pfeiffer V et al. The telomeric DNA damage response occurs in the absence of chromatin decompaction. Genes Dev 2017 Mar 15 [PMID: 28381410] (WB, Human) |
WB |
Human |
Dixon CR, Platani M, Makarov AA, Schirmer EC. Microinjection of Antibodies Targeting the Lamin A/C Histone-Binding Site Blocks Mitotic Entry and Reveals Separate Chromatin Interactions with HP1, CenpB and PML. Cells. Mar 25 2017 [PMID: 28346356] (ICC/IF, Human) |
ICC/IF |
Human |
Yang TB, Chen Q, Deng JT et al. Mutual reinforcement between telomere capping and canonical Wnt signalling in the intestinal stem cell niche. Nat Commun. Mar 17 2017 [PMID: 28303901] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Ji S, Zhu L, Gao Y et al. Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening. Cell Res. Mar 17 2017 [PMID: 28303890] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Nonnekens J, Chatalic KL, Molkenboer-Kuenen JD et al. (213)Bi-Labeled Prostate-Specific Membrane Antigen-Targeting Agents Induce DNA Double-Strand Breaks in Prostate Cancer Xenografts. Cancer Biother. Radiopharm. Mar 1 2017 [PMID: 28301262] |
|
|
Leung JW, Makharashvili N, Agarwal P et al. ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair Genes Dev. 2017 Feb 01 [PMID: 28242625] (Human) |
|
Human |
Rossiello F, Aguado J, Sepe S et al. DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs. Nat Commun. Feb 27 2017 [PMID: 28239143] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Liu Y, Cussiol JR, Dibitetto D et al. TOPBP1(Dpb11) plays a conserved role in homologous recombination DNA repair through the coordinated recruitment of 53BP1(Rad9). J. Cell Biol. 2017 Feb 22 [PMID: 28228534] |
|
|
Tan R, Nakajima S, Wang Q et al. Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1. Mol. Cell. 2017 Feb 08 [PMID: 28216227] |
|
|
Cheng LC, Tan VM, Ganesan S, Drake JM. Integrating phosphoproteomics into the clinical management of prostate cancer. Clin Transl Med 2017 Dec 01 [PMID: 28197968] (WB, ICC/IF) |
WB, ICC/IF |
|
Reynolds JJ, Bicknell LS, Carroll P et al. Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism. Nat. Genet. 2017 Feb 13 [PMID: 28191891] |
|
|
Viziteu E, Klein B, Basbous J et al. RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma. Leukemia 2017 Mar 10 [PMID: 28186131] |
|
|
Kalimutho M, Bain AL, Mukherjee B et al. Enhanced dependency of KRAS mutant colorectal cancer cells on RAD51-dependent homologous recombination repair identified from genetic interactions in Saccharomyces cerevisiae. Mol Oncol. 2017 Feb 07 [PMID: 28173629] |
|
|
Taniguchi J B, Kondo K et al. RpA1 ameliorates symptoms of mutant ataxin-1 knock-in mice and enhances DNA damage repair. Hum Mol Genet Oct 15 2016 [PMID: 28173122] (IHC, WB, Mouse) |
IHC, WB |
Mouse |
Feldman S, Wuerffel R, Achour I et al. 53BP1 Contributes to Igh Locus Chromatin Topology during Class Switch Recombination. J. Immunol. 2017 Feb 03 [PMID: 28159901] (ChIP, Mouse) |
ChIP |
Mouse |
Liu X, Liu F, Gao S et al. A single non-synonymous NCOA5 variation in type 2 diabetic patients with hepatocellular carcinoma impairs the function of NCOA5. Cancer Letters 2017 Jan 27 [PMID: 28137631] (ICC/IF, Human) |
ICC/IF |
Human |
Mytych J, Wos I, Solek P, Koziorowski M. Protective role of klotho protein on epithelial cells upon co-culture with activated or senescent monocytes. Exp Cell Res 2017 Jan 15 [PMID: 28011195] (Human) |
|
Human |
Tumini E, Barroso S, Aguilera A. Roles of human POLD1 and POLD3 in genome stability. Sci Rep. Dec 15 2016 [PMID: 27974823] (ICC/IF, Human) |
ICC/IF |
Human |
Wiedemann EM Peycheva M Pavri R. DNA Replication Origins in Immunoglobulin Switch Regions Regulate Class Switch Recombination in an R-Loop-Dependent Manner. Cell Rep. Dec 13 2016 [PMID: 27974207] (ChIP) |
ChIP |
|
Smirin-Yosef P, Zuckerman-Levin N, Tzur S et al. A biallelic mutation in the homologous recombination repair gene SPIDR is associated with human gonadal dysgenesis. J. Clin. Endocrinol. Metab. Dec 14 2016 [PMID: 27967308] (Human) |
|
Human |
Luo K, Li L, Li Y et al. A phosphorylation-deubiquitination cascade regulates the BRCA2-RAD51 axis in homologous recombination. Genes Dev. Dec 1 2016 [PMID: 27941124] (ICC/IF, Human) |
ICC/IF |
Human |
Jia P, Chastain M, Zou Y et al. Human MLH1 suppresses the insertion of telomeric sequences at intra-chromosomal sites in telomerase-expressing cells. Nucleic Acids Res. Nov 29 2016 [PMID: 27903905] (Human) |
|
Human |
Hess J, Unger K, Orth M et al. Genomic amplification of Fanconi anemia complementation group A (FancA) in head and neck squamous cell carcinoma (HNSCC): Cellular mechanisms of radioresistance and clinical relevance. Cancer Lett. Nov 17 2016 [PMID: 27867017] (Human) |
|
Human |
Hansen RK, Mund A, Poulsen SL et al. SCAI promotes DNA double-strand break repair in distinct chromosomal contexts. Nat. Cell Biol. Dec 1 2016 [PMID: 27820601] (Mouse) |
|
Mouse |
Li M, Yu X, Chen Q. Chemopreventive effects of ROS targeting in a murine model of BRCA1-deficient breast cancer. Cancer Res. Nov 4 2016 [PMID: 27815389] (Human) |
|
Human |
Telomere shortening and metabolic compromise underlie dystrophic cardiomyopathy. Chang AC, Ong SG, LaGory EL et al. Proc. Natl. Acad. Sci. U.S.A. [PMID: 27799523] (Flow, Mouse) |
Flow |
Mouse |
Bezine E, Malaise Y, Loeuillet A et al. Cell resistance to the Cytolethal Distending Toxin involves an association of DNA repair mechanisms. Sci Rep 2016 Oct 24 [PMID: 27775089] |
|
|
Piechota M, Sunderland P, Wysocka A et al. Is senescence-associated beta-galactosidase a marker of neuronal senescence? Oncotarget. 2016 Dec 05 [PMID: 27768595] (ICC/IF, Rat) |
ICC/IF |
Rat |
Toonen LJ, Schmidt I, Luijsterburg MS et al. Antisense oligonucleotide-mediated exon skipping as a strategy to reduce proteolytic cleavage of ataxin-3. Sci Rep Oct 12 2016 [PMID: 27731380] |
|
|
Sobiepanek A, Milner-Krawczyk M, Bobecka-Wesolowska K, Kobiela T The effect of delphinidin on the mechanical properties of keratinocytes exposed to UVB radiation. J. Photochem. Photobiol. B, Biol. Nov 1 2016 [PMID: 27716574] (Human) |
|
Human |
Coucoravas Christos, Dhanjal Soniya, Henriksson Sofia et al. Phosphorylation of the Cajal body protein WRAP53 beta by ATM promotes its involvement in the DNA damage response. Rna Biology 2017 Jun 3 [PMID: 27715493] (ICC/IF, Human) |
ICC/IF |
Human |
Przybylska Dorota, Janiszewska Dorota, Gozdzik Aleksandra et al. NOX4 downregulation leads to senescence of human vascular smooth muscle cells. Oncotarget 2016 [PMID: 27655718] (ICC/IF, Human) |
ICC/IF |
Human |
Imamura T, Fujita K, Tagawa K et al. Identification of hepta-histidine as a candidate drug for Huntington's disease by in silico-in vitro- in vivo-integrated screens of chemical libraries Sci Rep Sep 22 2016 [PMID: 27653664] (IHC, Mouse) |
IHC |
Mouse |
Jakl L, Lobachevsky P, Vokalova L et al. Validation of JCountPro software for efficient assessment of ionizing radiation-induced foci in human lymphocytes. Int J Radiat Biol 2016 Dec [PMID: 27648492] (Human) |
|
Human |
Lescale C, Lenden Hasse H, Blackford A et al. Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination. Cell Rep Sep 13 2016 [PMID: 27601299] (ICC/IF, Human) |
ICC/IF |
Human |
Bhatt N, Ghosh R, Roy S et al. Robust reprogramming of Ataxia-Telangiectasia patient and carrier erythroid cells to induced pluripotent stem cells. Stem Cell Res. Aug 12 2016 [PMID: 27596957] (ICC/IF) |
ICC/IF |
|
Croco E, Marchionni S, Bocchini M et al. DNA Damage Detection by 53BP1: Relationship to Species Longevity. J. Gerontol. A Biol. Sci. Med. Sci. 2016 Aug 29 [PMID: 27573809] |
|
|
Nonnekens J, van Kranenburg M, Beerens CE et al. Potentiation of Peptide Receptor Radionuclide Therapy by the PARP Inhibitor Olaparib. Theranostics. Aug 29 2016 [PMID: 27570553] (ICC/IF, Human) |
ICC/IF |
Human |
Henry A, Nokin Mj, Leroi N et al. New role of osteopontin in DNA repair and impact on Human glioblastoma radiosensitivity. Oncotarget Aug 22 2016 [PMID: 27563812] |
|
|
Graciotti M, Fang Z, Johnsson K, Gonczy P. Chemical genetic screen identifies natural products modulating centriole number. Chembiochem. Aug 25 2016 [PMID: 27558802] (Human) |
|
Human |
Montero JJ, Lopez de Silanes I, Grana O, Blasco MA. Telomeric RNAs are essential to maintain telomeres. Nat Commun. Aug 17 2016 [PMID: 27531349] (ICC/IF) |
ICC/IF |
|
Schmidt JC, Zaug AJ, Cech TR et al. Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres Cell. 2016 Aug 10 [PMID: 27523609] (ICC/IF, Human) |
ICC/IF |
Human |
Taniguchi JB, Kondo K, Fujita K et al. RpA1 ameliorates symptoms of mutant ataxin-1 knock-in mice and enhances DNA damage repair. Hum. Mol. Genet. Aug 11 2016 [PMID: 27516390] (IHC, Mouse) |
IHC |
Mouse |
Patel PL, Suram A, Mirani N et al. Derepression of hTERT gene expression promotes escape from oncogene-induced cellular senescence. Proc. Natl. Acad. Sci. U.S.A. Aug 23 2016 [PMID: 27503890] (ICC/IF, Human) |
ICC/IF |
Human |
Chua S, Lee FY, Chiang HJ et al. The cardioprotective effect of melatonin and exendin-4 treatment in a rat model of cardiorenal syndrome. J. Pineal Res. Jul 28 2016 [PMID: 27465663] (IHC, ICC/IF, Rat) |
IHC, ICC/IF |
Rat |
Butterworth KT, Nicol JR, Ghita M et al. Preclinical evaluation of gold-DTDTPA nanoparticles as theranostic agents in prostate cancer radiotherapy. Nanomedicine (Lond). Aug 1 2016 [PMID: 27463088] (ICC/IF, Human) |
ICC/IF |
Human |
Lambrus BG, Daggubati V, Uetake Y et al. A USP28-53BP1-p53-p21 signaling axis arrests growth after centrosome loss or prolonged mitosis J. Cell Biol. 2016 Jul 18 [PMID: 27432896] (WB, ICC/IF) |
WB, ICC/IF |
|
Mao P, Liu J, Zhang Z et al. Homologous recombination-dependent repair of telomeric DSBs in proliferating human cells Nat Commun 2016 Jul 11 [PMID: 27396625] (ICC/IF) |
ICC/IF |
|
Fong CS, Mazo G, Das T et al. 53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosis Elife 2016 Jul 16 [PMID: 27371829] |
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|
Picco V, Coste I, Giraud-Panis MJ et al. ERK1/2/MAPK pathway-dependent regulation of the telomeric factor TRF2 Oncotarget Jul 19 2016 [PMID: 27366950] (ICC/IF) |
ICC/IF |
|
Parekh PR, Choudhuri R, Weyemi U et al. Evaluation of surrogate tissues as indicators of drug activity in a melanoma skin model. Cancer Med Jun 23 2016 [PMID: 27339860] (IHC) |
IHC |
|
Jullien D, Vignard J, Fedor Y et al. Chromatibody, a novel non-invasive molecular tool to explore and manipulate chromatin in living cells. J. Cell. Sci. May 20 2016 [PMID: 27206857] (ICC/IF, Human) |
ICC/IF |
Human |
Stankovic-Valentin N, Drzewicka K, Konig C et al. Redox regulation of SUMO enzymes is required for ATM activity and survival in oxidative stress. EMBO J. May 12 2016 [PMID: 27174643] |
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|
Ho TLF, Guilbaud G, Blow JJ et al. The KRAB Zinc Finger Protein Roma/Zfp157 Is a Critical Regulator of Cell-Cycle Progression and Genomic Stability. Cell Reports. 2016 Apr 14 [PMID: 27149840] (IHC-P, Mouse) |
IHC-P |
Mouse |
Kreienkamp R, Croke M, Neumann MA et al. Vitamin D receptor signaling improves Hutchinson-Gilford progeria syndrome cellular phenotypes. Oncotarget. Apr 27 2016 [PMID: 27145372] (WB, Human) |
WB |
Human |
Pauty J, Cote MF, Rodrigue A et al. Investigation of the DNA damage response to SFOM-0046, a new small-molecule drug inducing DNA double-strand breaks Sci Rep Mar 22 2016 [PMID: 27001483] (ICC/IF, Human) |
ICC/IF |
Human |
O'Hagan-Wong K, Nadeau S, Carrier-Leclerc A et al. Increased IL-6 secretion by aged human mesenchymal stromal cells disrupts hematopoietic stem and progenitor cells' homeostasis. Oncotarget 2016 Mar 22 [PMID: 26934440] (ICC/IF) |
ICC/IF |
|
Francia S, Cabrini M, Matti V et al. DICER, DROSHA and DNA damage-response RNAs are necessary for the secondary recruitment of DNA damage response factors J. Cell. Sci. Feb 16 2016 [PMID: 26906421] (ICC/IF, Human) |
ICC/IF |
Human |
Cekan P, Hasegawa K, Pan Y et al. RCC1-dependent activation of Ran accelerates cell cycle and DNA repair, inhibiting DNA damage-induced cell senescence. Mol Biol Cell 2016 Apr 15 [PMID: 26864624] (WB) |
WB |
|
Nagy Z, Kalousi A, Furst A et al. Tankyrases Promote Homologous Recombination and Check Point Activation in Response to DSBs. PLoS Genet 2016 Feb [PMID: 26845027] (WB) |
WB |
|
Lescale C, Abramowski V, Bedora-Faure M et al. RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair. Nat Commun. 2016 Feb 02 [PMID: 26833222] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Martinez I, Garcia-Carpizo V, Guijarro T et al. Induction of DNA double-strand breaks and cellular senescence by human respiratory syncytial virus Virulence May 18 2016 [PMID: 26809688] (ICC/IF, Human) |
ICC/IF |
Human |
Zhang H, Liu H, Chen Y et al. A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choice. Nat Commun. 2016 Jan 05 [PMID: 26727879] (WB, ICC/IF, Human) |
WB, ICC/IF |
Human |
Chatalic KLS, Konijnenberg M, Nonnekens J. In Vivo Stabilization of a Gastrin-Releasing Peptide Re-ceptor Antagonist Enhances PET Imaging and Radionu-clide Therapy of Prostate Cancer in Preclinical Studies. Theranostics. 2016 Jan 01 [PMID: 26722377] (IHC-P, Mouse) |
IHC-P |
Mouse |
Obermeier K, Sachsenweger J, Friedl TW et al. Heterozygous PALB2 c.1592delT mutation channels DNA double-strand break repair into error-prone pathways in breast cancer patients. Oncogene. 2015 Dec 07 [PMID: 26640152] (WB, ICC/IF, Human) |
WB, ICC/IF |
Human |
Rall M, Kraft D, Volcic M et al. Impact of Charged Particle Exposure on Homologous DNA Double-Strand Break Repair in Human Blood-Derived Cells. Front Oncol 2015 [PMID: 26618143] (ICC/IF, Human) |
ICC/IF |
Human |
Han X, Liu Z, Jo MC et al. CRISPR-Cas9 delivery to hard-to-transfect cells via membrane deformation. Sci Adv 2015 Aug [PMID: 26601238] (ICC/IF) |
ICC/IF |
|
Li M, Huang R, Jiang X et al. CRISPR/Cas9 Promotes Functional Study of Testis Specific X-Linked Gene In Vivo. PLoS ONE. 2015 Nov 25 [PMID: 26599493] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Werner E, Wang H, Doetsch PW. Role of Pro-inflammatory Cytokines in Radiation-Induced Genomic Instability in Human Bronchial Epithelial Cells. Radiat. Res. 2015 Nov 18 [PMID: 26579942] (ICC/IF, Human)
Details: 53BP1 antibody along with gamma-H2AX was used for the detection of DNA repair foci in irradiated Human Bronchial Epithelial Cells (HBEC3-KT) fixed with 4% paraformaldehyde and permeabilized with 0.2% Triton™ X-100. |
ICC/IF |
Human |
Dalm SU, Nonnekens J, Doeswijk GN et al. Comparison of the Therapeutic Response to Treatment with a 177Lu-Labeled Somatostatin Receptor Agonist and Antagonist in Preclinical Models. J Nucl Med 2016 Feb [PMID: 26514177] |
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|
Hehlgans S, Oppermann J, Reichert S et al. The SMAC mimetic BV6 sensitizes colorectal cancer cells to ionizing radiation by interfering with DNA repair processes and enhancing apoptosis. Radiat Oncol 2015 Sep 19 [PMID: 26383618] (ICC/IF, Human) |
ICC/IF |
Human |
Annunziato S Precision modeling of breast cancer in the CRISPR era Thesis Jan 1 2020 |
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|
Chaudhary P, Marshall TI, Currell FJ et al. Variations in the Processing of DNA Double-Strand Breaks Along 60-MeV Therapeutic Proton Beams. Int J Radiat Oncol Biol Phys 2015 Jul 29 [PMID: 26452569] |
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|
Weaver AN, Cooper TS, Rodriguez M et al. DNA double strand break repair defect and sensitivity to poly ADP-ribose polymerase (PARP) inhibition in human papillomavirus 16-positive head and neck squamous cell carcinoma. Oncotarget 2015 Sep 29 [PMID: 26336991] (ICC/IF) |
ICC/IF |
|
Smith S Persistent telomere cohesion protects aged cells from premature senescence bioRxiv Jan 1 2020 (ICC/IF, Human) |
ICC/IF |
Human |
Storch K, Cordes N. The impact of CDK9 on radiosensitivity, DNA damage repair and cell cycling of HNSCC cancer cells. Int. J. Oncol. 2015 Nov 13 [PMID: 26573875] |
|
|
Djuzenova CS, Zimmermann M, Katzer A et al. A prospective study on histone Y-H2AX and 53BP1 foci expression in rectal carcinoma patients: correlation with radiation therapy-induced outcome. BMC Cancer. 2015 Nov 06 [PMID: 26541290] (ICC/IF, Human) |
ICC/IF |
Human |
Markova E, Somsedikova A, Vasilyev S et al. DNA repair foci and late apoptosis/necrosis in peripheral blood lymphocytes of breast cancer patients undergoing radiotherapy. Int. J. Radiat. Biol. 2015 Nov 04 [PMID: 26537244] (ICC/IF, Human) |
ICC/IF |
Human |
Perez M, Munoz-Galvan S, Jimenez-Garcia MP et al. Efficacy of CDK4 inhibition against sarcomas depends on their levels of CDK4 and p16ink4 mRNA. Oncotarget 2015 Dec 1 [PMID: 26528855] (WB) |
WB |
|
Kubben N, Brimacombe KR, Donegan M et al. A high-content imaging-based screening pipeline for the systematic identification of anti-progeroid compounds. Methods 2015 Sep 01 [PMID: 26341717] (ICC/IF, Human) |
ICC/IF |
Human |
Vandromme M, Gaillard S, Charasson V, Ribeyre C KDM5 histone-demethylases contribute to replication stress response and tolerance. bioRxiv Dec 16 2019 (Human) |
|
Human |
Chojnowski A, Ong PF, Wong ES et al. Progerin reduces LAP2alpha-telomere association in Hutchinson-Gilford progeria. Elife 2015 [PMID: 26312502] |
|
|
Lin H, Ha K, Lu G et al. Cdc14A and Cdc14B Redundantly Regulate DNA Double-Strand Break Repair. Mol Cell Biol 2015 Nov [PMID: 26283732] (Mouse) |
|
Mouse |
Durdik M, Kosik P, Gursky J et al. Imaging flow cytometry as a sensitive tool to detect low-dose-induced DNA damage by analyzing 53BP1 and gammaH2AX foci in human lymphocytes. Cytometry A. 2015 Aug 04 [PMID: 26243567] (Flow, ICC/IF, Human) |
Flow, ICC/IF |
Human |
Ortega-Martinez S. Dexamethasone acts as a radiosensitizer in three astrocytoma cell lines via oxidative stress. Redox Biol 2015 Aug [PMID: 26160768] (ICC/IF) |
ICC/IF |
|
Petroni M, Sardina F, Heil C et al. The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress. Cell Death Differ 2016 Feb [PMID: 26068589] (WB) |
WB |
|
Fukuda Takayo, Wu Wenwen, Okada Maiko et al. Class I histone deacetylase inhibitors inhibit the retention of BRCA1 and 53BP1 at the site of DNA damage. Cancer Science 2015 [PMID: 26053117] (WB, Human) |
WB |
Human |
Beyreuther E, Karsch L, Laschinsky L. Radiobiological response to ultra-short pulsed megavoltage electron beams of ultra-high pulse dose rate. Int. J. Radiat. Biol. 2015 May 13 [PMID: 25968557] (ICC/IF, Human)
Details: 53BP1 antibody was used for ICC-IF staining of cytospun cells of two human squamous cell carcinoma cell lines of different radiosensitivity -FaDu/undifferentiated HNSCC of moderate radiosensitivity and SKX/moderately well differentiated HNSCC of higher radiosensitivity than FaDu. Immunostaining was performed 24 h after irradiation and primary antibody was used at 1:3000 dilution with detection via AF488 conjugated secondary antibody. |
ICC/IF |
Human |
Markiewicz E, Barnard S, Haines J et al. Nonlinear ionizing radiation-induced changes in eye lens cell proliferation, cyclin D1 expression and lens shape. Open Biol. 2015 Apr 01 [PMID: 25924630] (ICC/IF, WB, Human)
Details: 53BP1 antibody was used for WB and ICC-IF applications on human lens epithgelial cell line FHL124 exposed or not to low-dose IR up to 2.28 Gy. See full text for protocol details and the data images (Figure 2 and 5). |
ICC/IF, WB |
Human |
Yu Q, Katlinskaya YV, Carbone CJ et al. DNA-Damage-Induced Type I Interferon Promotes Senescence and Inhibits Stem Cell Function Cell Rep 2015 Apr 21 [PMID: 25921537] (ICC/IF, Human) |
ICC/IF |
Human |
Boucher D, Vu T, Bain AL et al. Ssb2/Nabp1 is dispensable for thymic maturation, male fertility, and DNA repair in mice. FASEB J. 2015 Apr 27 [PMID: 25917330] (ICC/IF, Mouse)
Details: Vimentin antibody used for IHC on mouse cryosections from wounds that were untreated and treated with an in vitro-engineered adipose dressing (Fig 1A and 1E). |
ICC/IF |
Mouse |
Zong D, Callen E, Pegoraro G et al. Ectopic expression of RNF168 and 53BP1 increases mutagenic but not physiological non-homologous end joining. Nucleic Acids Res. 2015 May 26 [PMID: 25916843] (WB, ICC/IF, Mouse) |
WB, ICC/IF |
Mouse |
Vermezovic J, Adamowicz M, Santarpia L et al. Notch is a direct negative regulator of the DNA-damage response Nat. Struct. Mol. Biol. 2015 Apr 20 [PMID: 25895060] (ICC/IF, Human) |
ICC/IF |
Human |
Meir M, Galanty Y, Kashani L et al. The COP9 signalosome is vital for timely repair of DNA double-strand breaks Nucleic Acids Res. 2015 Apr 08 [PMID: 25855810] (WB, Human) |
WB |
Human |
Bol GM, Vesuna F, Xie M et al. Targeting DDX3 with a small molecule inhibitor for lung cancer therapy. EMBO Mol Med. 2015 Mar 27 [PMID: 25820276] (ICC/IF, Human) |
ICC/IF |
Human |
Xu G, Chapman JR, Brandsma I et al. REV7 counteracts DNA double-strand break resection and affects PARP inhibition. Nature. 2015 Mar 23 [PMID: 25799992] (WB, Mouse) |
WB |
Mouse |
Augello MA, Berman-Booty LD, Carr R et al. Consequence of the tumor-associated conversion to cyclin D1b. EMBO Mol Med. 2015 Mar 18 [PMID: 25787974] (ICC/IF, Human) |
ICC/IF |
Human |
Papp SJ, Huber AL, Jordan SD et al. DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization. Elife. 2015 Mar 11 [PMID: 25756610] (WB, ICC/IF, IP, Human, Mouse) |
WB, ICC/IF, IP |
Human, Mouse |
Mar FA, Debnath J, Stohr BA. Autophagy-Independent Senescence and Genome Instability Driven by Targeted Telomere Dysfunction Autophagy 2015 Mar 09 [PMID: 25751002] (ICC/IF, Human) |
ICC/IF |
Human |
Nakagawa Y, Sedukhina AS, Okamoto N et al. NF-kappaB signaling mediates acquired resistance after PARP inhibition. Oncotarget 2015 Feb 28 [PMID: 25686825] |
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|
Boccardi V, Razdan N, Kaplunov J et al. Stn1 is critical for telomere maintenance and long-term viability of somatic human cells Aging Cell. 2015 Feb 14 [PMID: 25684230] (ICC/IF, Human) |
ICC/IF |
Human |
Vancevska A, Pfeiffer V, Feretzaki M, Ahmed W SMCHD1 Promotes ATM-dependent DNA Damage Signaling and Repair of Uncapped Telomeres bioRxiv (ICC/IF, Human) |
ICC/IF |
Human |
Lewinska A, Jarosz P, Czech J, Rzeszutek I. Capsaicin-induced genotoxic stress does not promote apoptosis in A549 human lung and DU145 prostate cancer cells Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 2015 Feb 01 [PMID: 25813723] (ICC/IF, Human)
Details: 53BP1 antibody used in ICC-IF staining application for the detection of 53BP1 foci on human lung A549 and DU145 prostate cancer cells which were treated or not with 5-250uM concentrations of Capsaicin for 24 hours (Fig. 5C). The immunoassay was performed on interphase nuclei and implicated - 20 minutes fixation of cells with 3.7% formaldehyde containing 0.1% Triton X-100 in PBS, blocking with 1%BSA-0.25% Triton X-100-PBS at RT for 30 minutes, incubation of cells with primary antibody at 1:200 dilution in blocking buffer for ON at 4C, detection with FITC-conjugated secondary antibody and Hoechst 33,342, analysis of data with reference to number of 53BP foci. |
ICC/IF |
Human |
Luitel K, Bozeman R, Kaisani A et al. Proton radiation-induced cancer progression Life Sciences in Space Research Aug 1 2018 (IHC-Fr, Mouse) |
IHC-Fr |
Mouse |
Calvo L, Cheng S, Skulimowski M et al. Cellular senescence is a central response to cytotoxic chemotherapy in high-grade serous ovarian cancer. bioRxiv Sep 25 2018 (ICC/IF, Human) |
ICC/IF |
Human |
Aarts M, Bajrami I, Herrera-Abreu MT et al. Functional genetic screen identifies increased sensitivity to WEE1 inhibition in cells with defects in Fanconi Anaemia and HR pathways Mol. Cancer Ther. 2015 Feb 11 [PMID: 25673822] (ICC/IF, Human) |
ICC/IF |
Human |
Grabowska W, Kucharewicz K, Wnuk M et al. Curcumin induces senescence of primary human cells building the vasculature in a DNA damage and ATM-independent manner Age (Dordr). 2015 Feb 01 [PMID: 25649709] (ICC/IF)
Details: 53BP1 antibody used in ICC-IF application for the detection of DNA damage/DNA double-strand breaks during curcumin-induced senescence of human vascular smooth muscle cell /VSMCs and endothelial cells/Ecs. The assay involved - fixation of cells in 70 % ethanol, 1:500 dilution of primary antibody, detection of 53BP1 foci using Alexa 488 conjugated secondary antibody and DAPI (Fig 4). |
ICC/IF |
|
Gibbs-Seymour I, Markiewicz E, Bekker-Jensen S et al. Lamin A/C-dependent interaction with 53BP1 promotes cellular responses to DNA damage Aging Cell. 2015 Jan 23 [PMID: 25645366] (IP, Human) |
IP |
Human |
Lewinska A, Wnuk M, Grabowska W et al. Curcumin induces oxidation-dependent cell cycle arrest mediated by SIRT7 inhibition of rDNA transcription in human aortic smooth muscle cells Toxicol. Lett. 2015 Mar 18 [PMID: 25644192] (ICC/IF, Human) |
ICC/IF |
Human |
Torres G, Leheste JR, Ramos RL. Immunocytochemical localization of dna double-strand breaks in human and rat brain Neuroscience. 2015 Jan 27 [PMID: 25637486] (ICC/IF, Rat) |
ICC/IF |
Rat |
Badie S, Carlos AR, Folio C et al. BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres EMBO J. 2015 Jan 12 [PMID: 25582120] (WB, ICC/IF, Mouse) |
WB, ICC/IF |
Mouse |
Diotti R, Kalan S, Matveyenko A, Loayza D. DNA-directed Polymerase Subunits Play a Vital Role in Human Telomeric Overhang Processing. Mol. Cancer Res. 2014 Dec 17 [PMID: 25519149] (ICC/IF, Human) |
ICC/IF |
Human |
Mender I, Gryaznov S, Dikmen ZG et al. Induction of Telomere Dysfunction Mediated by the Telomerase Substrate Precursor 6-Thio-2'-Deoxyguanosine. Cancer Discov. 2014 Dec 16 [PMID: 25516420] (FISH) |
FISH |
|
Ito H, Fujita K, Tagawa K et al. HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knock-in mice. EMBO Mol Med. 2015 Jan 06 [PMID: 25510912] (IHC-P, Mouse) |
IHC-P |
Mouse |
Herrera-Moyano Emilia, Moriel-Carretero Maria, Montelone Beth A, Aguilera A. The rem mutations in the ATP-binding groove of the Rad3/XPD helicase lead to Xeroderma pigmentosum-Cockayne syndrome-like phenotypes. PLoS Genet. 2014 Dec 11 [PMID: 25500814] (ICC/IF) |
ICC/IF |
|
Baranski OA, Kalinichenko VV, Adami GR. Increased FOXM1 expression can stimulate DNA repair in normal hepatocytes in vivo but also increases nuclear foci associated with senescence. Cell Prolif. 2014 Dec 05 [PMID: 25477198] (IHC-Fr, Mouse)
Details: 53BP1 antibody used at 1-1000 dilution for IHC-Fr application on 2% PFA fixed liver sections of C57BL/6 and Tg(TTR-FOXM1)1Rhc mice that were exposed to Diethylnitrosamine/DEN carcinogen (Figure 3 and 4). |
IHC-Fr |
Mouse |
Uringa EJ, Baldeyron C, Odijk H et al. A mRad51-GFP antimorphic allele affects homologous recombination and DNA damage sensitivity. DNA Repair (Amst) 2015 Jan [PMID: 25463395] |
|
|
Baltanas FC, Valero J, Alonso JR et al. Nuclear Signs of Pre-neurodegeneration. Methods Mol. Biol. 2014 Nov 28 [PMID: 25431056] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Grill S, Bisht KK, Tesmer VM, Sifuentes CJ Two separation-of-function isoforms of human TPP1 and a novel intragenic noncoding RNA dictate telomerase regulation in somatic and germ cells. bioRxiv May 3 2019 (ICC/IF, Human) |
ICC/IF |
Human |
Sykora P, Misiak M, Wang Y et al. DNA polymerase b deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes. Nucleic Acids Res 2014 Dec 30 [PMID: 25552414] (IHC-P, Mouse)
Details: Using the DyLight 550 conjugated version of NB100-304, catalog number NB100-304R. |
IHC-P |
Mouse |
Neumayer G, Nguyen Md. TPX2 Impacts Acetylation of Histone H4 at Lysine 16: Implications for DnA Damage Response PLoS OnE et al. 2014 Nov 04 [PMID: 25365214] (WB, ICC/IF, Human)
Details: 53BP antibody used for WB and ICC-IF on HeLa cells subjected to miRnA-mediated depletion of TPX2. |
WB, ICC/IF |
Human |
Weipert F. Studies on the interaction of the inhibitor of apoptosis protein Survivin with DNA-dependent protein kinase to modulate DNA double-strand break repair. Book. 2018 (WB, Human) |
WB |
Human |
Zimmermann M, Kibe T, Kabir S, De Lange T. TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling. Genes Dev. 2014 Oct 24 [PMID: 25344324] (WB, ICC/IF, Mouse) |
WB, ICC/IF |
Mouse |
Fumagalli M, Rossiello F, Mondello C, D'Adda Di Fagagna F. Stable Cellular Senescence Is Associated with Persistent DDR Activation. PLoS OnE. 2014 Oct 24 [PMID: 25340529] (ICC/IF, Human) |
ICC/IF |
Human |
Li Z, Wang H, Wang Y et al. Effect of Radiation Quality on Mutagenic Joining of Enzymatically-Induced DnA Double-Strand Breaks in Previously Irradiated Human Cells. Radiat. Res. 2014 Oct 20 [PMID: 25329962] |
|
|
Gazzaniga FS, Blackburn EH An antiapoptotic role for telomerase RNA in human immune cells independent of telomere integrity or telomerase enzymatic activity Blood. 2014 Dec 10 [PMID: 25320237] (ICC/IF, KD, Human) |
ICC/IF, KD |
Human |
Burdak-Rothkamm S, Rothkamm K, Mcclelland K et al. BRCA1, FAnCD2 and Chk1 are potential molecular targets for the modulation of a radiation-induced DnA damage response in bystander cells. Cancer Lett. 2014 Oct 07 [PMID: 25304378] (ICC/IF, Human) |
ICC/IF |
Human |
Tang M, Li Y, Zhang X et al. Structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) promotes non-homologous end joining and inhibits homologous recombination repair upon DnA damage. J. Biol. Chem. 2014 Oct 07 [PMID: 25294876] (WB, ICC/IF, Human) |
WB, ICC/IF |
Human |
Werner E, Wang H, Doetsch PW. Opposite Roles for p38MAPK-Driven Responses and Reactive Oxygen Species in the Persistence and Resolution of Radiation-Induced Genomic Instability. PLoS ONE. 2014 Oct 02 [PMID: 25271419] (ICC/IF, Human)
Details: 53BP1 antibody used for ICC-IF of radiation exposed HBEC-3KT cells - fixed in 4% paraformaldehyde, permeabilized with PBS-0.2% TritonX-100 (Figure 2). |
ICC/IF |
Human |
Roukos V, Burgess RC, Misteli T. Generation of cell-based systems to visualize chromosome damage and translocations in living cells. Nat Protoc. 2014 Oct 01 [PMID: 25255091] |
|
|
Houlihan SL, Feng Y. The scaffold protein Nde1 safeguards the brain genome during S phase of early neural progenitor differentiation. Elife. 2014 Sep 23 [PMID: 25245017] (IHC-P, Mouse) |
IHC-P |
Mouse |
Taggart LE, McMahon SJ, Currell FJ et al. The role of mitochondrial function in gold nanoparticle mediated radiosensitisation. Cancer Nanotechnol. 2014 Sep 22 [PMID: 25243023] (ICC/IF, Human) |
ICC/IF |
Human |
Pefani DE, Latusek R, Pires I et al. RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2. Nat. Cell Biol. 2014 Sep 14 [PMID: 25218637] |
|
|
Canonical Non-Homologous End Joining in Mitosis Induces Genome Instability and Is Suppressed by M-phase-Specific Phosphorylation of XRCC4. Terasawa M, Shinohara A, Shinohara M. PLoS Genet. [PMID: 25166505] (Flow, ICC/IF, Human) |
Flow, ICC/IF |
Human |
Santos J, Gil J. TRIM28/KAP1 regulates senescence. Immunol. Lett. 2014 Aug 23 [PMID: 25160591] (WB, ICC/IF, Human) |
WB, ICC/IF |
Human |
Gole B, Baumann C, Mian E et al. Endonuclease G initiates DNA rearrangements at the MLL breakpoint cluster upon replication stress. Oncogene. 2014 Aug 18 [PMID: 25132265] |
|
|
Vassilopoulos A, Tominaga Y, Kim HS et al. WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesis. Oncogene. 2014 Aug 04 [PMID: 25088202] (IHC-P, Mouse) |
IHC-P |
Mouse |
Frescas David, de Lange Titia. Binding of TPP1 protein to TIN2 protein is required for POT1a,b protein-mediated telomere protection. J Biol Chem. 2014 Aug 29 [PMID: 25056954] (Mouse) |
|
Mouse |
Carlessi L, Poli EF, Bechi G et al. Functional and molecular defects of hiPSC-derived neurons from patients with ATM deficiency. Cell Death Dis 2014 Jul 18 [PMID: 25032865] (ICC/IF, Human)
Details: 53BP1 antibody used for ICC-IF on neurons derived from hiPSC /human-induced pluripotent stem cells generated from reprogrammed fibroblasts from ATM-null A-T patients and normal controls to pluripotency. Cells washed with 0.9% NaCl, air dried and fixed in 3%PFA, permeabilized in 0.5% Triton X100/PBS -5 min/4C and blocked with 5% BSA before primary labelling for staininng the nuclear foci. Figure 6e shows the IR-induced nuclear foci/53BP1 immunostaining. |
ICC/IF |
Human |
Chene G, Ouellet V, Rahimi K et al. DNA Damage Signaling and Apoptosis in Preinvasive Tubal Lesions of Ovarian Carcinoma. Int. J. Gynecol. Cancer 2014 Jul 01 [PMID: 24987917] (IHC-P, Human)
Details: 53BP1 antibody used at 1:10,000 dilution for IHC-P on a TMA containing benign fallopian tubes, serous tubal intraepithelial carcinoma (STIC), high-grade serous ovarian cancer (HGSC) from patients with STICs (associated ovarian cancer /AOC) from the same patient and HGSCs without STICs/non-AOC (FIGURE 1). |
IHC-P |
Human |
Peng M, Xie J, Ucher A et al. Crosstalk between BRCA-Fanconi anemia and mismatch repair pathways prevents MSH2-dependent aberrant DNA damage responses. EMBO J. 2014 Jun 25 [PMID: 24966277] (WB, ICC/IF, Human, Mouse)
Details: Figure 1G - WB of 53BP1 or FANCJ in U2OS cells stably expressing shRNA vectors to either control or 53BP1 (a or b) that were also transfected with siRNAs to Con or FANCJ. Figure 7 E immunofluorescence of cells with 53BP1 foci in untreated MEFs |
WB, ICC/IF |
Human, Mouse |
Naipal KA, Verkaik NS, Ameziane N et al. Functional ex vivo assay to select Homologous Recombination deficient breast tumors for PARP inhibitor treatment. Clin. Cancer Res. 2014 Jun 24 [PMID: 24963051] (IHC-P, Human)
Details: For evaluating formation of ionizing radiation induced foci (IRIF), breast tumor tissue obtained from patients undergoing wide local excision or amputation for breast cancer were processed for IHC-P using anti-53BP1 (NB100-304) at 1/500 dilution. Figure S3 shows gamma-H2AX and 53BP1 nuclear foci indicate the induction of DSBs in tissue slices. |
IHC-P |
Human |
Broering TJ, Alavattam KG, Sadreyev RI et al. BRCA1 establishes DNA damage signaling and pericentric heterochromatin of the X chromosome in male meiosis. J. Cell Biol. 2014 Jun 09 [PMID: 24914237] (ICC/IF, Mouse)
Details: Immunostaining of meiotic chromosome spreads (Figure 1D) and mid-pachytene spermatocytes with 53BP1 signal on XY chromatin (Figure 1E) |
ICC/IF |
Mouse |
Tubbs AT, Dorsett Y, Chan E et al. kAP-1 Promotes Resection of Broken DNA Ends Not Protected by Gamma-H2AX and 53BP1 in G1-Phase Lymphocytes. Mol. Cell. Biol. 2014 May 19 [PMID: 24842905] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Polato F, Callen E, Wong N et al. CtIP-mediated resection is essential for viability and can operate independently of BRCA1. J. Exp. Med. 2014 May 19 [PMID: 24842372] (WB, ICC/IF, Mouse) |
WB, ICC/IF |
Mouse |
Coker H, Brockdorff N. SMCHD1 accumulates at DNA damage sites and facilitates the repair of DNA double-strand breaks. J. Cell. Sci. 2014 May 01 [PMID: 24790221] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Bazzi H, Anderson KV. Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo. Proc. Natl. Acad. Sci. U.S.A. 2014 Apr 15 [PMID: 24706806] (IHC-Fr, Mouse) |
IHC-Fr |
Mouse |
Popuri V, Hsu J, Khadka P et al. Human RECQL1 participates in telomere maintenance. Nucleic Acids Res. 3/12/2014 [PMID: 24623817] (ICC/IF, Human) |
ICC/IF |
Human |
Leung JW, Agarwal P, Canny MD et al. Nucleosome Acidic Patch Promotes RNF168- and RING1B/BMI1-Dependent H2AX and H2A Ubiquitination and DNA Damage Signaling. PLoS Genet. 3/1/2014 [PMID: 24603765] (ICC/IF, Human) |
ICC/IF |
Human |
Zahn A, Eranki AK, Patenaude AM et al. Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination. Proc. Natl. Acad. Sci. U.S.A. 3/3/2014 [PMID: 24591601] (ChIP, Mouse) |
ChIP |
Mouse |
Porro A, Feuerhahn S et al. TERRA-reinforced association of LSD1 with MRE11 promotes processing of uncapped telomeres. Cell Rep Feb 27 2014 [PMID: 24529708] (ICC/IF, Human) |
ICC/IF |
Human |
Lamkowski Andreas, Forcheron Fabien, Agay Diane et al. DNA damage focus analysis in blood samples of minipigs reveals acute partial body irradiation. PLoS One. 2014 Feb 03 [PMID: 24498326] |
|
|
Frescas D, de Lange T. et al. TRF2-tethered TIN2 can mediate telomere protection by TPP1/POT1. Mol. Cell. Biol. 2014 Jan 28 [PMID: 24469404] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Frescas D, de Lange T. et al. A TIN2 dyskeratosis congenita mutation causes telomerase-independent telomere shortening in mice. Genes Dev. 2014 Jan 22 [PMID: 24449270] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Chen B, Gilbert LA, Cimini BA et al. Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system. Cell 2013 Dec 19 [PMID: 24360272] (Human) |
|
Human |
Mariotti LG, Pirovano G, Savage KI et al. Use of the gamma-H2AX Assay to Investigate DNA Repair Dynamics Following Multiple Radiation Exposures. PLoS One 2013 Nov 29 [PMID: 24312182] (ICC/IF, Human) |
ICC/IF |
Human |
Bielak-Zmijewska A, Wnuk M, Przybylska D et al. A comparison of replicative senescence and doxorubicin-induced premature senescence of vascular smooth muscle cells isolated from human aorta. Biogerontology. 2013 Nov 16 [PMID: 24243065] (ICC/IF, Human) |
ICC/IF |
Human |
Mouron S, Rodriguez-Acebes S, Martinez-Jimenez MI et al. Repriming of DNA synthesis at stalled replication forks by human PrimPol. Nat Struct Mol Biol. 2013 Dec [PMID: 24240614] (ICC/IF, Human) |
ICC/IF |
Human |
Chan EA, Teng G, Corbett E et al. Peripheral subnuclear positioning suppresses Tcrb recombination and segregates Tcrb alleles from RAG2. Proc Natl Acad Sci U S A. 2013 Nov 26 [PMID: 24218622] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Bekes M, Okamoto K, Crist SB et al. DUB-Resistant Ubiquitin to Survey Ubiquitination Switches in Mammalian Cells. Cell Rep. 2013 Nov 14 [PMID: 24210823] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Caganova M, Carrisi C, Varano G et al. Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis. J Clin Invest. 2013 Dec 2 [PMID: 24200695] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Chitnis MM, Lodhia KA, Aleksic T et al. IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous end-joining and homologous recombination. Oncogene. 2013 Nov 4 [PMID: 24186206] (ICC/IF, Human) |
ICC/IF |
Human |
Shee C, Cox BD, Gu F et al. Engineered proteins detect spontaneous DNA breakage in Human and bacterial cells. Elife. 2013 Oct 29 [PMID: 24171103] (ICC/IF, Human) |
ICC/IF |
Human |
Cortizas EM, Zahn A, Hajjar ME et al. Alternative End-Joining and Classical Nonhomologous End-Joining Pathways Repair Different Types of Double-Strand Breaks during Class-Switch Recombination. J Immunol. 2013 Dec 1 [PMID: 24146042] (WB, Mouse) |
WB |
Mouse |
Oommen D, Prise KM. Down-regulation of PERK enhances resistance to ionizing radiation. Biochem Biophys Res Commun. 2013 Nov 8 [PMID: 24103755] (ICC/IF, Human) |
ICC/IF |
Human |
Nakashima M, Nandakumar J, Sullivan KD et al. Inhibition of telomerase recruitment and cancer cell death. J Biol Chem. 2013 Nov 15 [PMID: 24097987] (ICC/IF, Human) |
ICC/IF |
Human |
Croke M, Neumann MA, Grotsky DA et al. Differences in 53BP1 and BRCA1 regulation between cycling and non-cycling cells. Cell Cycle 2013 Dec 1 [PMID: 24091731] (ICC/IF, Human) |
ICC/IF |
Human |
Despars G, Carbonneau CL, Bardeau P et al. Loss of the Osteogenic Differentiation Potential during Senescence Is Limited to Bone Progenitor Cells and Is Dependent on p53. PLoS One. 2013 Aug 29 [PMID: 24009740] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Scheers I, Lombard C, Paganelli M et al. Human Umbilical Cord Matrix Stem Cells Maintain Multilineage Differentiation Abilities and Do Not Transform during Long-Term Culture. PLoS One. 2013 Aug 9 [PMID: 23951150] (ICC/IF, Human) |
ICC/IF |
Human |
Kocher S, Spies-Naumann A, Kriegs M. ATM is required for the repair of Topotecan-induced replication-associated double-strand breaks. Radiother Oncol. 2013 Aug 5 [PMID: 23928469] (ICC/IF, Human) |
ICC/IF |
Human |
Dibitetto D, Sims J, AscenCAo C et al. Intrinsic ATR signaling shapes DNA end resection and suppresses toxic DNA-PKcs signaling NAR Cancer Jun 1 2020 |
|
|
Yang J, Griffin P, Vera D et al. Erosion of the Epigenetic Landscape and Loss of Cellular Identity as a Cause of Aging in Mammals SSRN Journal 2019 Oct 03 (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Lee K, Mann E, da Silva L et al. DNA damage measurements within tissue samples with Repair Assisted Damage Detection (RADD) Current Research in Biotechnology Nov 1 2019 (IHC-P, Human) |
IHC-P |
Human |
Reduction of Nipbl impairs cohesin loading locally and affects transcription but not cohesion-dependent functions in a mouse model of Cornelia de Lange Syndrome. Remeseiro S, Cuadrado A, Kawauchi S et al. Biochim Biophys Acta. [PMID: 23920377] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Britton S, Coates J, Jackson SP. A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair. J Cell Biol. 2013 Aug 5 [PMID: 23897892] (ICC/IF, Human) |
ICC/IF |
Human |
Han X, Liu D, Zhang Y et al. Akt regulates TPP1 homodimerization and telomere protection. Aging Cell 2013 Jul 17 [PMID: 23862686] (ICC/IF, Human) |
ICC/IF |
Human |
Feng X, Luo Z, Jiang S et al. The telomere-associated homeobox-containing protein TAH1 participates in telomere maintenance in ALT Cells. J Cell Sci 2013 Jun 26 [PMID: 23813958] (ICC/IF, Human) |
ICC/IF |
Human |
Gascoigne KE, Cheeseman IM. Induced dicentric chromosome formation promotes genomic rearrangements and tumorigenesis. Chromosome Res 2013 Jul [PMID: 23793898] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Martinez P, Gomez-Lopez G, Garcia F et al. RAP1 Protects from Obesity through Its Extratelomeric Role Regulating Gene Expression. Cell Rep 2013 Jun 27 [PMID: 23791526] (IHC-P, ICC/IF, Mouse) |
IHC-P, ICC/IF |
Mouse |
Yeung F, Ramirez CM, Mateos-Gomez PA et al. Nontelomeric Role for Rap1 in Regulating Metabolism and Protecting against Obesity. Cell Rep 2013 Jun 27 [PMID: 23791522] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Wei D, Parsels LA, Karnak D et al. Inhibition of Protein Phosphatase 2A Radiosensitizes Pancreatic Cancers by Modulating CDC25C/CDK1 and Homologous Recombination Repair. Clin Cancer Res 2013 Aug 15 [PMID: 23780887] (ICC/IF, Human) |
ICC/IF |
Human |
Elsen S, Collin-Faure V, Gidrol X, Lemercier C. The opportunistic pathogen Pseudomonas aeruginosa activates the DNA double-strand break signaling and repair pathway in infected cells. Cell Mol Life Sci 2013 Jun 13 [PMID: 23760206] (ICC/IF, WB, Human) |
ICC/IF, WB |
Human |
Streppel MM, Pai S, Campbell NR et al. microRNA 223 Is Upregulated in the Multistep Progression of Barrett's Esophagus and Modulates Sensitivity to Chemotherapy by Targeting PARP1. Clin Cancer Res. 2013 Aug 1 [PMID: 23757351] (ICC/IF, Human) |
ICC/IF |
Human |
Kalan S, Matveyenko A, Loayza D. LIM Protein Ajuba Participates in the Repression of the ATR-Mediated DNA Damage Response. Front Genet 2013 May 28 [PMID: 23755068] (ICC/IF, Human) |
ICC/IF |
Human |
Floyd SR, Pacold ME, Huang Q et al. The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. Nature 2013 Jun 13 [PMID: 23728299] (ICC/IF, WB, Human) |
ICC/IF, WB |
Human |
Zhou ZW, Tapias A, Bruhn C et al. DNA damage response in microcephaly development of MCPH1 Mouse model. DNA Repair (Amst) 2013 May 14 [PMID: 23683352] (ICC/IF, IHC, Mouse) |
ICC/IF, IHC |
Mouse |
Djuzenova CS, Elsner I, Katzer A et al. Radiosensitivity in breast cancer assessed by the histone gamma-H2AX and 53BP1 foci. Radiat Oncol 2013 Apr 24 [PMID: 23617930] (ICC/IF, Human) |
ICC/IF |
Human |
Taylor BJ, Nik-Zainal S, Wu YL et al. DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis. Elife 2013 Apr 16 [PMID: 23599896] (ICC/IF, Human) |
ICC/IF |
Human |
Ausborn NL, Wang T, Wentz SC et al. 53BP1 expression is a modifier of the prognostic value of lymph node ratio and CA 19--9 in pancreatic adenocarcinoma BMC Cancer 2013 Mar 26 [PMID: 23530749] (IHC-P, Human) |
IHC-P |
Human |
Suberbielle E, Sanchez PE, Kravitz AV et al. Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-beta Nat Neurosci 2013 Mar 24 [PMID: 23525040] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Zhang Y, Chen LY, Han X et al. Phosphorylation of TPP1 regulates cell cycle-dependent telomerase recruitment Proc Natl Acad Sci U S A 2013 Apr 2 [PMID: 23509301] (ICC/IF, Human) |
ICC/IF |
Human |
Ramsay AJ, Quesada V, Foronda M et al. POT1 mutations cause telomere dysfunction in chronic lymphocytic leukemia Nat Genet 2013 Mar 17 [PMID: 23502782] (ICC/IF, Human) |
ICC/IF |
Human |
Grosso S, Doyen J, Parks SK et al. MiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines Cell Death Dis 2013 Mar 14 [PMID: 23492775] (ICC/IF, Human) |
ICC/IF |
Human |
Korwek Z, Bielak-Zmijewska A, Mosieniak G et al. DNA damage-independent apoptosis induced by curcumin in normal resting human T cells and leukaemic Jurkat cells. Mutagenesis 2013 Mar 13 [PMID: 23486648] (ICC/IF, Human) |
ICC/IF |
Human |
Jeyapalan JC, Sedivy JM. How to measure RNA expression in rare senescent cells expressing any specific protein such as p16Ink4a. Aging (Albany NY) 2013 Feb [PMID: 23454889] (ICC/IF, Human) |
ICC/IF |
Human |
Dreesen O, Chojnowski A, Ong PF et al. Lamin B1 fluctuations have differential effects on cellular proliferation and senescence. J Cell Biol 2013 Mar 4 [PMID: 23439683] (ICC/IF, Human) |
ICC/IF |
Human |
Bohringer M, Obermeier K, Griner N et al. siRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/- with susceptibility versus C57BL/6-Trp53+/- mice with resistance to mammary tumors. Oncogene 2013 Feb 25 [PMID: 23435420] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Berti M, Chaudhuri AR, Thangavel S et al. Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition. Nat Struct Mol Biol 2013 Feb 10 [PMID: 23396353] (ICC/IF, Human) |
ICC/IF |
Human |
Okamoto K, Bartocci C, Ouzounov I et al. A two-step mechanism for TRF2-mediated chromosome-end protection. Nature 2013 Feb 6 [PMID: 23389450] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Grotsky DA, Gonzalez-Suarez I, Novell A et al. BRCA1 loss activates cathepsin L-mediated degradation of 53BP1 in breast cancer cells. J Cell Biol 2013 Jan 21 [PMID: 23337117] (WB, ICC/IF, IHC-P, Human) |
WB, ICC/IF, IHC-P |
Human |
Zimmermann M, Lottersberger F, Buonomo SB et al. 53BP1 regulates DSB repair using Rif1 to control 5' end resection. Science 2013 Feb 8 [PMID: 23306437] (Mouse) |
|
Mouse |
Stout GJ, Blasco MA. Telomere length and telomerase activity impact the UV sensitivity syndrome xeroderma pigmentosum Cancer Res 2013 Jan 3 [PMID: 23288511] (Mouse) |
|
Mouse |
Sotiropoulou PA, Karambelas AE, Debaugnies M et al. BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny Genes Dev 2012 Dec 27 [PMID: 23271346] (IHC, ICC/IF, Mouse) |
IHC, ICC/IF |
Mouse |
Caretti V, Hiddingh L, Lagerweij T et al. WEE1 Kinase Inhibition Enhances the Radiation Response of Diffuse Intrinsic Pontine Gliomas. Mol Cancer Ther 2013 Feb [PMID: 23270927] (ICC/IF, Human) |
ICC/IF |
Human |
Courilleau C, Chailleux C, Jauneau A et al. The chromatin remodeler p400 ATPase facilitates Rad51-mediated repair of DNA double-strand breaks J Cell Biol 2012 Dec 24 [PMID: 23266955] (ICC/IF, Human) |
ICC/IF |
Human |
Pei H, Wu X, Liu T et al. The Histone Methyltransferase MMSET Regulates Class Switch Recombination J Immunol 2012 Dec 14 [PMID: 23241889] (WB, Mouse) |
WB |
Mouse |
Hartlerode AJ, Guan Y, Rajendran A et al. Impact of Histone H4 Lysine 20 Methylation on 53BP1 Responses to Chromosomal Double Strand Breaks PLoS One 2012 [PMID: 23209566] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Ziebarth AJ, Nowsheen S, Steg AD et al. Endoglin (CD105) Contributes to Platinum Resistance and Is A Target for Tumor-Specific Therapy in Epithelial Ovarian Cancer Clin Cancer Res 2013 Jan 1 [PMID: 23147994] (IHC, ICC/IF, Mouse) |
IHC, ICC/IF |
Mouse |
Mokrani-Benhelli H, Gaillard L, Biasutto P et al. Primary Microcephaly, Impaired DNA Replication, and Genomic Instability Caused by Compound Heterozygous ATR Mutations Hum Mutat 2012 Oct 30 [PMID: 23111928] (ICC/IF, Human) |
ICC/IF |
Human |
Rodrigue A, Coulombe Y, Jacquet K et al. The RAD51 paralogs ensure cellular protection against mitotic defects and aneuploidy. J Cell Sci. 2013 Jan 1 [PMID: 23108668] (ICC/IF, Human) |
ICC/IF |
Human |
Nandakumar J, Bell CF, Weidenfeld I et al. The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity Nature 2012 Oct 24 [PMID: 23103865] (ICC/IF, Human) |
ICC/IF |
Human |
Popuri V, Croteau DL, Brosh RM Jr, Bohr VA. RECQ1 is required for cellular resistance to replication stress and catalyzes strand exchange on stalled replication fork structures Cell Cycle 2012 Nov 15 [PMID: 23095637] (ICC/IF, Human) |
ICC/IF |
Human |
Mirza S, Katafiasz BJ, Kumar R et al. Alteration/deficiency in activation-3 (Ada3) plays a critical role in maintaining genomic stability Cell Cycle 2012 Nov 15 [PMID: 23095635] (WB, Mouse) |
WB |
Mouse |
Korwek Z, Sewastianik T, Bielak-Zmijewska A et al Inhibition of ATM blocks the EPE-induced DNA damage response and apoptosis of resting human T cells DNA Repair (Amst). 2012 Nov 1 [PMID: 23058634] (ICC/IF, Human) |
ICC/IF |
Human |
Mund A, Schubert T, Staege H et al. SPOC1 modulates DNA repair by regulating key determinants of chromatin compaction and DNA damage response Nucleic Acids Res 2012 Oct 2 [PMID: 23034801] (ICC/IF, Human) |
ICC/IF |
Human |
Popova T, Manie E, Rieunier G et al. Ploidy and Large-Scale Genomic Instability Consistently Identify Basal-like Breast Carcinomas with BRCA1/2 Inactivation Cancer Res 2012 Oct 22 [PMID: 22933060] (ICC/IF, Human) |
ICC/IF |
Human |
Squatrito M, Vanoli F, Schultz N et al. 53BP1 Is a Haploinsufficient Tumor Suppressor and Protects Cells from Radiation Response in Glioma Cancer Res 2012 Oct 15 [PMID: 22915756] (IHC, Mouse) |
IHC |
Mouse |
Trainor C, Butterworth KT, McGarry CK et al. DNA Damage Responses following Exposure to Modulated Radiation Fields PLoS One 2012 [PMID: 22912853] (ICC/IF, Human) |
ICC/IF |
Human |
Eke I, Storch K, Kastner I et al. Three-dimensional Invasion of Human Glioblastoma Cells Remains Unchanged by X-ray and Carbon Ion Irradiation In Vitro Int J Radiat Oncol Biol Phys 2012 Aug 14 [PMID: 22901381] (ICC/IF, Human) |
ICC/IF |
Human |
Lovejoy CA, Li W, Reisenweber S et al. Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway PLoS Genet 2012 Jul [PMID: 22829774] (ICC/IF, Human) |
ICC/IF |
Human |
Bosco N, de Lange T. A TRF1-controlled common fragile site containing interstitial telomeric sequences Chromosoma 2012 Jul 13 [PMID: 22790221] (ICC/IF, Human) |
ICC/IF |
Human |
Eke I, Dickreuter E, Cordes N. Enhanced radiosensitivity of head and neck squamous cell carcinoma cells by ?1 integrin inhibition Radiother Oncol 2012 Jun 28 [PMID: 22748391] (ICC/IF, Human) |
ICC/IF |
Human |
Laschinsky L, Baumann M, Beyreuther E et al. Radiobiological effectiveness of laser accelerated electrons in comparison to electron beams from a conventional linear accelerator J Radiat Res 2012 Jun 1 [PMID: 22739009] (ICC/IF, Human) |
ICC/IF |
Human |
Francia S, Michelini F, Saxena A, Tang D, de Hoon M, Anelli V, Mione M, Carninci P, d’Adda di Fagagna F. Site-specific DICER and DROSHA RNA products control the DNA-damage response. Nature doi:101038/nature11179. 2012 May 23. [PMID: 22722852] (ICC/IF, Human, Mouse) |
ICC/IF |
Human, Mouse |
Bolderson E, Savage KI, Mahen R et al. Kruppel-associated Box (KRAB)-associated Co-repressor (KAP-1) Ser-473 Phosphorylation Regulates Heterochromatin Protein 1Beta (HP1-Beta) Mobilization and DNA Repair in Heterochromatin J Biol Chem 2012 Aug 10 [PMID: 22715096] (ICC/IF, Human) |
ICC/IF |
Human |
Pires IM, Olcina MM, Anbalagan S et al. Targeting radiation-resistant hypoxic tumour cells through ATR inhibition Br J Cancer 2012 Jun 19 [PMID: 22713662] (ICC/IF, Human) |
ICC/IF |
Human |
Davoli T, de Lange T. Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells Cancer Cell 2012 Jun 12 [PMID: 22698402] (ICC/IF, Human) |
ICC/IF |
Human |
Nishimaki N, Tsukimoto M, Kitami A, Kojima S. Autocrine regulation of ?-irradiation-induced DNA damage response via extracellular nucleotides-mediated activation of P2Y6 and P2Y12 receptors DNA Repair 2012 Jun 8 [PMID: 22682873] (ICC/IF, Human) |
ICC/IF |
Human |
Sato Y, Yamagata A, Goto-Ito S et al. Molecular Basis of Lys-63-linked Polyubiquitination Inhibition by the Interaction between Human Deubiquitinating Enzyme OTUB1 and Ubiquitin-conjugating Enzyme UBC13 J Biol Chem 2012 Jun 7 [PMID: 22679021] (ICC/IF, Human) |
ICC/IF |
Human |
Pont AR, Sadri N, Hsiao SJ, Smith S, Schneider RJ. mRNA Decay Factor AUF1 Maintains Normal Aging, Telomere Maintenance, and Suppression of Senescence by Activation of Telomerase Transcription. Mol Cell. 2012 May 23. [PMID: 22633954] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Wong V, Armknecht S, Zhitkovich A. Metabolism of Cr(VI) by ascorbate but not glutathione is a low oxidant-generating process. J Trace Elem Med Biol. 2012 May 7. [PMID: 22572042] (ICC/IF, Human) |
ICC/IF |
Human |
Suram A, Kaplunov J, Patel PL, Ruan H, Cerutti A, Boccardi V, Fumagalli M, Di Micco R, Mirani N, Lal Gurung R, Prakash Hande M, d'Adda di Fagagna F, Herbig U. Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions. EMBO J. 2012 May 8. [PMID: 22569128] (IHC, ICC/IF, Human) |
IHC, ICC/IF |
Human |
Luijsterburg MS, Acs K, Ackermann L, Wiegant WW, Bekker-Jensen S, Larsen DH, Khanna KK, van Attikum H, MailN, Dantuma NP. A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure. EMBO J. 2012 Apr 24. [PMID: 22531782] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Grenier L, Robaire B, Hales BF. The activation of DNA damage detection and repair responses in cleavage-stage rat embryos by a damaged paternal genome. Toxicol Sci;127(2):555-66. 2012 Jun. [PMID: 22454429] (ICC/IF, Rat) |
ICC/IF |
Rat |
Wilsker D, Chung JH, Bunz F. Chk1 suppresses bypass of mitosis and tetraploidization in p53-deficient cancer cells Cell Cycle 2012 Apr 15 [PMID: 22433954] (WB, ICC/IF, Human) |
WB, ICC/IF |
Human |
Fumagalli M, Rossiello F, Clerici M et al. Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation Nat Cell Biol 2012 Mar 18 [PMID: 22426077] (ICC/IF, Human) |
ICC/IF |
Human |
Mallette FA, Mattiroli F, Cui G, Young LC, Hendzel MJ, Mer G, Sixma TK, Richard S. RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites. EMBO J doi: 101038/emboj47. 2012 Feb 28. [PMID: 22373579] |
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|
Polo S, Blackford A, Chapman R et al. Regulation of DNA-end resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair. Mol Cell 2012 Feb 24 [PMID: 22365830] (ICC/IF, Human) |
ICC/IF |
Human |
Meng Y, Efimova EV, Hamzeh KW, Darga TE, Mauceri HJ, Fu YX, Kron SJ, Weichselbaum RR. Radiation-inducible Immunotherapy for Cancer: Senescent Tumor Cells as a Cancer Vaccine. Mol Ther. doi: 10.1038/mt.2012.19. 2012 Feb 14. [PMID: 22334019] |
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|
Kibe R, Zhang S, Guo D, Marrero L, Tsien F, Rodriguez P, Khan S, Zieske A, Huang J, Li W, Durum SK, Iwakuma T, Cui Y. IL-7R? deficiency in p53(null) mice exacerbates thymocyte telomere erosion and lymphomagenesis. Cell Death Differ. 2012 Jan 27. [PMID: 22281704] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Dominguez-Sanchez MS, Barroso S, Gomez-Gonzalez B et al. Genome instability and transcription elongation impairment in human cells depleted of THO/TREX. PLoS Genet 2011 Dec [PMID: 22144908] (WB) |
WB |
|
Gomes J, Magalhaes A, Michel V, Amado IF, Aranha P, Ovesen RG, Hansen HC, Gartner F, Reis CA, Touati E. Pteridium aquilinum and Its Ptaquiloside Toxin Induce DNA Damage Response in Gastric Epithelial Cells, a Link With Gastric Carcinogenesis. Toxicol Sci;126(1):60-71. 2012 Mar. [PMID: 22143989] |
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Kizil C, Brand M. Cerebroventricular microinjection (CVMI) into adult zebrafish brain is an efficient misexpression method for forebrain ventricular cells. PLoS One 2011 [PMID: 22076157] (ICC/IF) |
ICC/IF |
|
Le VT, Trilling M, Hengel H. The cytomegaloviral protein pUL138 acts as potentiator of tumor necrosis factor (TNF) receptor 1 surface density to enhance ULb'-encoded modulation of TNF-alpha signaling. J Virol 2011 Dec [PMID: 21976655] (WB) |
WB |
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Beura LK, Dinh PX, Osorio FA, Pattnaik AK. Cellular poly(c) binding proteins 1 and 2 interact with porcine reproductive and respiratory syndrome virus nonstructural protein 1beta and support viral replication. J Virol 2011 Dec [PMID: 21976648] (ICC/IF) |
ICC/IF |
|
Fink LS, Roell M, Caiazza E et al. 53BP1 contributes to a robust genomic stability in human fibroblasts Aging 2011 Sep [PMID: 21931182] |
|
|
Zhang W, Peng G, Lin S-Y, Zhang P. DNA damage response is suppressed by high CDK1 activity in mitotic mammalian cells. J Biol Chem. 2011 Aug 30. [PMID: 21878640] |
|
|
Fernandez-L A, Squatrito M, Northcott P et al. Oncogenic YAP promotes radioresistance and genomic instability in medulloblastoma through IGF2-mediated Akt activation. Oncogene. 2011 Aug 29. [PMID: 21874045] |
|
|
Hara MR, Kovacs JJ, Whalen EJ et al. A stress response pathway regulates DNA damage through [beta](2)-adrenoreceptors and [beta]-arrestin-1. Nature. 2011 Aug 21. [PMID: 21857681] |
|
|
Reichert S, Rodel C, Mirsch J, Harter PN, Tomicic MT, Mittelbronn M, Kaina B, Rodel F. Survivin inhibition and DNA double-strand break repair: a molecular mechanism to overcome radioresistance in glioblastoma. Radiother Oncol;101(1):51-8. 2011 Oct. [PMID: 21852011] (WB, ICC/IF, Human) |
WB, ICC/IF |
Human |
Pediatric-inspired intensified therapy of adult T-ALL reveals the favorable outcome of NOTCH1/FBXW7 mutations, but not of low ERG/BAALC expression: a GRAALL study. Ben Abdelali R, Asnafi V, Leguay T et al. Blood [PMID: 21835957] (Flow, Human) |
Flow |
Human |
Gonzalez-Suarez I, Redwood AB, Grotsky DA et al. A new pathway that regulates 53BP1 stability implicates cathepsin L and vitamin D in DNA repair. EMBO J 2011 Jul 12 [PMID: 21750527] (ICC/IF, WB, Mouse) |
ICC/IF, WB |
Mouse |
Redwood AB, Perkins SM, Vanderwaal RP et al. A dual role for A-type lamins in DNA double-strand break repair. Cell Cycle 2011 Aug 1 [PMID: 21701264] (ICC/IF) |
ICC/IF |
|
Viana-Pereira M, Lee A, Popov S et al. Microsatellite instability in pediatric high grade glioma is associated with genomic profile and differential target gene inactivation PLoS One 2011 [PMID: 21637783] (ICC/IF, Human) |
ICC/IF |
Human |
Singh M, Kindelberger D, Nagymanyoki Z et al. Matrix metalloproteinases and their inhibitors and inducer in gestational trophoblastic diseases and normal placenta. Gynecol Oncol. Jul. 2011 [PMID: 21514631] (IHC-P, Human) |
IHC-P |
Human |
Baldeyron C, Soria G, Roche D et al. HP1alpha recruitment to DNA damage by p150CAF-1 promotes homologous recombination repair. J Cell Biol 2011 Apr 4 [PMID: 21464229] (WB, ICC/IF, Human) |
WB, ICC/IF |
Human |
Harrigan JA, Belotserkovskaya R, Coates J et al. Replication stress induces 53BP1-containing OPT domains in G1 cells. J Cell Biol;193(1):97-108. 2011 Apr 4. [PMID: 21444690] |
|
|
Mortensen M, Soilleux EJ, Djordjevic G et al. The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance. J Exp Med;208(3):455-67. 2011 Mar 14. [PMID: 21339326] |
|
|
Galron R, Gruber R, Lifshitz V et al. Astrocyte dysfunction associated with cerebellar attrition in a Nijmegen breakage syndrome animal model J Mol Neurosci 2011 Oct [PMID: 21279473] (IHC, ICC/IF, Mouse) |
IHC, ICC/IF |
Mouse |
Squatrito M, Brennan CW, Helmy K et al. Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas. Cancer Cell 2010 Dec 14 [PMID: 21156285] (IHC) |
IHC |
|
Westin ER, Aykin-Burns N, Buckingham EM, Spitz DR, Goldman FD, Klingelhutz AJ. The p53/p21(WAF/CIP) pathway mediates oxidative stress and senescence in dyskeratosis congenita cells with telomerase insufficiency. Antioxid Redox Signal;14(6):985-97. 2011 Mar 15. [PMID: 21087144] (ICC/IF, Human) |
ICC/IF |
Human |
Gong Y, de Lange T. A Shld1-controlled POT1a provides support for repression of ATR signaling at telomeres through RPA exclusion. Mol Cell 2010 Nov 12 [PMID: 21070964] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Herranz D, Munoz-Martin M, Canamero M et al. Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer. Nat Commun 2010 [PMID: 20975665] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Chayot R, Danckaert A, Montagne B, Ricchetti M. Lack of DNA polymerase mu affects the kinetics of DNA double-strand break repair and impacts on cellular senescence. DNA Repair (Amst) 2010 Nov 10 [PMID: 20947452] (Mouse) |
|
Mouse |
Xie A, Odate S, Chandramouly G, Scully R. H2AX post-translational modifications in the ionizing radiation response and homologous recombination. Cell Cycle 2010 Sep 1 [PMID: 20703100] (Mouse) |
|
Mouse |
Samantha A Sheppard Diego Loayza. LIM-domain proteins TRIP6 and LPP associate with shelterin to mediate telomere protection. Aging (Albany NY); 2(7): 432-444. 2010 July. [PMID: 20634563] |
|
|
Bouwman P, Aly A, Escandell JM et al. 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers. Nat Struct Mol Biol 2010 Jun [PMID: 20453858] (WB) |
WB |
|
Le ON, Rodier F, Fontaine F, Coppe JP, Campisi J, DeGregori J, Laverdiere C, Kokta V, Haddad E, Beausejour CM. Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status. Aging Cell;9(3):398-409. 2010 Jun. [PMID: 20331441] |
|
|
B Orsburn, B Escudero, M Prakash et al. Differential Requirement for H2AX and 53BP1 in Organismal Development and Genome Maintenance in the Absence of Poly(ADP)ribosyl Polymerase 1. Mol. Cell. Biol. 30 (10): 2341-2352. 2010 [PMID: 20231360] |
|
|
Selective targeting of radiation-resistant tumor-initiating cells. Zhang M, Atkinson RL, Rosen JM. Proc Natl Acad Sci U S A. [PMID: 20133717] (Flow, ICC/IF, Mouse) |
Flow, ICC/IF |
Mouse |
S-H Moon, L Lin, X Zhang et al. Wild-type p53-induced Phosphatase 1 Dephosphorylates Histone Variant {gamma}-H2AX and Suppresses DNA Double Strand Break Repair. J. Biol. Chem. 285 (17): 12935-12947. 2010 [PMID: 20118229] |
|
|
Kibe T, Osawa GA, Keegan CE et al. Telomere protection by TPP1 is mediated by POT1a and POT1b. Mol Cell Biol. 2009 Dec 7. [PMID: 19995905] |
|
|
Kim GJ, Georg I, Scherthan H et al. Dicer is required for Sertoli cell function and survival. Int J Dev Biol 2010 [PMID: 19876815] (IHC, Mouse) |
IHC |
Mouse |
Brouwer AK, Schimmel J, Wiegant JC et al. Telomeric DNA mediates de novo PML body formation. Mol Biol Cell;20(22):4804-15. 2009 Nov. [PMID: 19793919] |
|
|
Dimitrova N, de Lange T. Cell Cycle-Dependent Role of MRN at Dysfunctional Telomeres: ATM Signaling-Dependent Induction of Nonhomologous End Joining (NHEJ) in G1 and Resection-Mediated Inhibition of NHEJ in G2. Mol Cell Biol;29(20):5552-5563. 2009 [PMID: 19667071] |
|
|
Watrin E, Peters JM et al. The cohesin complex is required for the DNA damage-induced G2/M checkpoint in mammalian cells. EMBO J 2009 Sep 2 [PMID: 19629043] (ICC/IF, Human) |
ICC/IF |
Human |
Higuchi Y, Shoji JY, Arioka M, Kitamoto K. Endocytosis is crucial for cell polarity and apical membrane recycling in the filamentous fungus Aspergillus oryzae. Eukaryot Cell 2009 Jan [PMID: 19028995] (ICC/IF) |
ICC/IF |
|
Fedorovich NE, Oudshoorn MH, van Geemen D et al. The effect of photopolymerization on stem cells embedded in hydrogels. Biomaterials 2009 Jan [PMID: 18930540] (ICC/IF, Goat) |
ICC/IF |
Goat |
Ruiz L, Traskine M, Ferrer I et al. Characterization of the p53 response to oncogene-induced senescence. PLoS One 2008 [PMID: 18800172] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Konishi A, de Lange T. Cell cycle control of telomere protection NHEJ revealed by a ts mutation in the DNA-binding domain of TRF2. Genes Dev;22(9):1221-30. 1-May-08. [PMID: 18451109] |
|
|
Hokey DA, Johnson FB, Smith J et al. Activation drives PD-1 expression during vaccine-specific proliferation and following lentiviral infection in macaques. Eur J Immunol 2008 May [PMID: 18389475] (Primate) |
|
Primate |
Denchi EL, de Lange T. Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature;448(7157):1001-2. 2007 Aug 30. [PMID: 17687332] |
|
|
Callen E, Jankovic M et al. ATM prevents the persistence and propagation of chromosome breaks in lymphocytes. Cell Jul 13 2007 [PMID: 17599403] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
Valero J, Berciano MT, Weruaga E et al. Pre-neurodegeneration of mitral cells in the pcd mutant mouse is associated with DNA damage, transcriptional repression, and reorganization of nuclear speckles and Cajal bodies. Mol Cell Neurosci 2006 Nov [PMID: 16978877] |
|
|
Hockemeyer, D, Daniels, J, Takai, H, de Lange, T. Recent Expansion of the Telomeric Complex in Rodents: Two Distinct POT1 Proteins Protect Mouse Telomeres. Cell. Vol 126, 63-77.1. 14-Jul-06. [PMID: 16839877] |
|
|
Patton KM, McGuire TC, Hines MT et al. Rhodococcus equi-specific cytotoxic T lymphocytes in immune horses and development in asymptomatic foals. Infect Immun 2005 Apr [PMID: 15784549] (IP) |
IP |
|
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