MyD88 Antibody


Western Blot: MyD88 Antibody [NB100-56698] - Analysis of MyD88 in human spleen cell lysate using 0.5 ug/ml of NB100-56698.
Immunocytochemistry/ Immunofluorescence: MyD88 Antibody [NB100-56698] - MyD88 antibody was tested in Daudi cells at a 1:20 dilution against Dylight 488 (Green). Actin and nuclei were counterstained against Phalloidin more
Immunohistochemistry-Paraffin: MyD88 Antibody [NB100-56698] - IHC analysis of a formalin fixed and paraffin embedded tissue section of human liver using MyD88 Antibody at 1:100 dilution. This antibody generated a very more
Immunohistochemistry-Paraffin: MyD88 Antibody [NB100-56698] - IHC analysis of a formalin fixed and paraffin embedded tissue section of human liver using MyD88 Antibody at 1:100 dilution. This antibody generated a very more

Product Details

Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P
1.0 mg/ml

Order Details

MyD88 Antibody Summary

A synthetic peptide corresponding to human MyD88 (between amino acids 200-270).
Because of high sequence homology, this antibody is expected to detect multiple isoforms of MyD88 protein.
Predicted Species
Porcine (100%), Zebrafish (93%), Xenopus (93%), Primate (100%), Guinea Pig (94%), Sheep (100%), Bovine (100%), Equine (100%), Fish (93%)
Protein G purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.05% Sodium Azide
1.0 mg/ml
Protein G purified


Read Publications using
NB100-56698 in the following applications:

Reactivity Notes

The immunogen sequence shows over 90% homology with several vertebrates and this antibody is expected to cross-react with multiple species among vertebrate animals.

Alternate Names for MyD88 Antibody

  • MYD88D
  • myeloid differentiation primary response gene (88)
  • myeloid differentiation primary response protein MyD88


MyD88, a protein involved in interleukin-1 (IL-1) mediated signalling was originally isolated as myeloid differentiation primary response gene (3,4). MyD88 possesses a N-terminal death domain similar to cytoplasmic segments of TNF receptor 1, Fas, and C-terminal region related to IL-1 and Toll receptors. Overexpression of MyD88 induces activation the c-Jun N-terminal kinase and NF-kB through its death domain (1,2). The C-terminus of MyD88 interacts with the IL-1 receptor and blocks NF-kB activation induced by IL-1, but not by NF-kB.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for MyD88 Antibody (NB100-56698)(10)

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 2 applications: ICC/IF, WB.

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Showing Publications 1 - 10 of 10.
Publications using NB100-56698 Applications Species
Shi M, Zhang Y, Liu L et al. MAP1S regulates the phagocytosis of bacteria and TLR signaling. J. Biol. Chem. 2015 Nov 12 [PMID:26565030] (WB, ICC/IF, Mouse) WB, ICC/IF Mouse
Dumas A, Amiable N, de Rivero Vaccari JP et al. The Inflammasome Pyrin Contributes to Pertussis Toxin-Induced IL-1B Synthesis, Neutrophil Intravascular Crawling and Autoimmune Encephalomyelitis. PLoS Pathog. 2014 May 01 [PMID:24875775] (WB, Mouse) WB Mouse
Li Y, Zhang H, Zhang H et al. Toll-like receptor 4 signaling contributes to paclitaxel-induced peripheral neuropathy. J Pain 2014 Apr 19 [PMID:24755282] (Rat) Rat
Harvey SA, Dangi A, Tandon A et al. The Transcriptomic Response of Rat Hepatic Stellate Cells to Endotoxin: Implications for Hepatic Inflammation and Immune Regulation. PLoS One 2013 Dec 9 [PMID:24349206] (WB, Rat) WB Rat
Pathak SK, Basu S, Basu KK et al. Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages. Nat Immunol. 2007 Jun [PMID:17486091] (WB) WB
Palladino MA, Johnson TA, Gupta R et al. Members of the Toll-like receptor family of innate immunity pattern-recognition receptors are abundant in the male rat reproductive tract. Biol Reprod. 2007 Jun [PMID:17314314] (WB, Rat) WB Rat
Saccani A, Schioppa T, Porta C et al. p50 nuclear factor-kappaB overexpression in tumor-associated macrophages inhibits M1 inflammatory responses and antitumor resistance. Cancer Res. 2006 Dec 1 [PMID:17145890] (WB, Human) WB Human
Macagno A, Molteni M, Rinaldi A et al. A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression. J Exp Med. 2006 Jun 12 [PMID:16717116]
Srivastava MD, Srivastava BI. Expression of mRNA and proteins for toll-like receptors, associated molecules, defensins and LL-37 by SRIK-NKL, a CD8+ NK/T cell line. Leuk Res. 2005 Jul [PMID:15927677]
Jeyaseelan S, Manzer R, Young SK et al. Induction of CXCL5 during inflammation in the rodent lung involves activation of alveolar epithelium. Am J Respir Cell Mol Biol. 2005 Jun [PMID:15778492]

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Blogs on MyD88.

TRIF/TICAM1 and mitochondrial dynamics in the innate immune response
TRIF, also known as toll like receptor adaptor molecule 1 or TICAM1, is known for its role in invading foreign pathogens as part of our innate immune response. TRIF/TICAM1 is a TIR-domain adaptor protein (toll/interleukin-1 receptor) that interacts...  Read full blog post.

The role of TLR4 in breast cancer
Toll like receptors (TLRs) are highly conserved proteins that are first known for their role in pathogen recognition and immune response activation.  In order to elicit the necessary immune response in reaction to a foreign pathogen, TLRs trigger cy...  Read full blog post.

MYD88 Expression and Tumorigenesis
MyD88, also called myeloid differentiation primary response gene 88, encodes a cytosolic adapter protein that plays an essential role in innate and adaptive immune responses. The innate immune system recognizes the presence of bacterial pathogens thro...  Read full blog post.

TLR7 and Immune Response Regulation
Toll-like receptor 7 (TLR7) is a protein encoded by the TLR7 gene in humans and is a member of TLR family. TLRs controls host immune response against pathogens (e.g. viruses, bacteria and fungi) through recognition of pathogen-associated molecular pat...  Read full blog post.

MYD88: Fanning Inflammation and Immune Responses
Myeloid differentiation primary response gene 88 (MYD88) encodes a cytosolic adapter protein that plays an essential role in innate and adaptive immune responses. MYD88 protein functions as an essential signal transducer in the interleukin-1 and in To...  Read full blog post.

MyD88 Antibodies for IL Signaling and Immunity Research
The myeloid differentiation protein MyD88 (myeloid differentiation primary response protein) was originally identified and characterized as a primary upregulated response gene in interleukin-6 mediated myeloid differentiation. Now, MyD88 is known to b...  Read full blog post.

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Product PDFs


Gene Symbol MYD88

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