Hu, Mu, Rt, Ch, Po, Bv, Eq, Fi, Gp, Pm, Sh, Xp, ZeApplications:
WB, ICC/IF, IHC, IHC-PHost:
Hu, Mu, Pm, RMApplications:
WB, Flow, Flow-IC, ICC/IF, CyTOF-readyHost:
WB, Simple Western, CyTOF-ready, Flow, ICC/IFHost:
Hu, Mu, Rt, Bv, Xp, Ye, ZeApplications:
ELISA, Flow, Func-Inh, IHC, In vitro, In vivo, B/N
WB, ELISA, IP, PA, AP
Myeloid differentiation Marker 88 (MyD88) is a universal adaptor molecule for the Toll/IL1R and is involved in the inflammatory response induced by IL1, IL18 and LPS. MyD88 associates with and recruits IRAK to IL1 receptor complex in response to IL1. This pathway further leads to activation of NFkB. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL1 and IL18, and MyD88 deficient mice lack responses to bacterial product LPS that employs Toll like receptors 2 and 4 as the signaling receptors.
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|MYD88: Fanning Inflammation and Immune Responses
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|TLR7 and Immune Response Regulation
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|MYD88 Expression and Tumorigenesis
MyD88, also called myeloid differentiation primary response gene 88, encodes a cytosolic adapter protein that plays an essential role in innate and adaptive immune responses. The innate immune system recognizes the presence of bacterial pathogens thro... Read more.
|Toll-like receptors in the intestinal epithelial cells
By Jamshed Arslan, Pharm. D., PhD. Toll-like receptors (TLRs) are microbe-sensing proteins that act as first responders to danger signals. TLRs help the intestinal epithelial cells (IECs) recognize commensal bacteria ... Read more.