CCR5 Antibody (45531) (MAB182)

Images

 
CCR5 was detected in immersion fixed human dendritic cells using Human CCR5 Monoclonal Antibody (Catalog # MAB182) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ ...read more
Recombinant Human CCL3/MIP‑1 alpha (Catalog # 270-LD) chemoattracts the BaF3 mouse pro‑B cell line transfected with human CCR5 in a dose-dependent manner (orange line). The amount of cells that ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, CyTOF-ready, ICC, Neut
Clone
45531
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

CCR5 Antibody (45531) Summary

Immunogen
NS0 mouse myeloma cell line transfected with human CCR5
Met1-Leu352
Accession # P51681
Specificity
Detects human CCR5.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
CCR5
Purity
Protein A or G purified from ascites
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 2.5 ug/10^6 cells
  • CyTOF-ready
  • Immunocytochemistry 8-25 ug/mL
  • Neutralization 5-20 ug/mL
Publications
Read Publications using
MAB182 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein A or G purified from ascites
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CCR5 Antibody (45531)

  • C-C CKR-5
  • C-C motif chemokine receptor 5 A159A
  • CCCKR5
  • CC-CKR-5FLJ78003
  • CCR5
  • CCR-5
  • CD195 antigen
  • CD195
  • chemokine (C-C motif) receptor 5
  • chemokine receptor CCR5
  • CHEMR13
  • CKR5
  • CKR-5
  • HIV-1 fusion coreceptor
  • IDDM22CMKBR5C-C chemokine receptor type 5

Background

CCR5 is a G protein-linked seven transmembrane domain chemokine receptor. CCR5 serves as a receptor for several chemokines including MIP-1 alpha, MIP-1 beta, MCP-2, and RANTES. It also functions as a coreceptor for macrophage tropic HIV-1 infection.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CCR5 Antibody (MAB182-100)(20)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 6 applications: Bioassay, Flow, ICC, IHC - paraffin, IHC Fresh, Neut.


Filter By Application
Bioassay
(1)
Flow
(10)
ICC
(1)
IHC - paraffin
(1)
IHC Fresh
(1)
Neut
(6)
All Applications
Filter By Species
Human
(20)
All Species
Showing Publications 1 - 10 of 20. Show All 20 Publications.
Publications using MAB182 Applications Species
Ward, S T, Li, K K, Hepburn, E, Weston, C J, Curbishley, S M, Reynolds, G M, Hejmadi, R K, Bicknell, R, Eksteen, B, Ismail, T, Rot, A, Adams, D H The effects of CCR5 inhibition on regulatory T-cell recruitment to colorectal cancer. Br J Cancer, 2015;112(2):319-28. 2015 [PMID: 25405854] (IHC - paraffin,, Human) IHC - paraffin Human
Hartmann N, Giese N, Giese T, Poschke I, Offringa R, Werner J, Ryschich E Prevailing role of contact guidance in intrastromal T-cell trapping in human pancreatic cancer. Clin Cancer Res, 2014;20(13):3422-33. 2014 [PMID: 24763614] (Flow,, Human) Flow Human
Nakano Y, Monde K, Terasawa H, Yuan Y, Yusa K, Harada S, Maeda Y Preferential recognition of monomeric CCR5 expressed in cultured cells by the HIV-1 envelope glycoprotein gp120 for the entry of R5 HIV-1. Virology, 0;452(0):117-24. 0 [PMID: 24606688] (Flow,, Human) Flow Human
Flegler A, Cianci G, Hope T CCR5 conformations are dynamic and modulated by localization, trafficking and G protein association. PLoS ONE, 2014;9(2):e89056. 2014 [PMID: 24586501] (IHC Fresh,, Human) IHC Fresh Human
Alonzo, Francis, Kozhaya, Lina, Rawlings, Stephen, Reyes-Robles, Tamara, DuMont, Ashley L, Myszka, David G, Landau, Nathanie, Unutmaz, Derya, Torres, Victor J CCR5 is a receptor for Staphylococcus aureus leukotoxin ED. Nature, 2013;493(7430):51-5. 2013 [PMID: 23235831] (Bioassay,, Human) Bioassay Human
Duluc, D, Gannevat, J, Anguiano, E, Zurawski, S, Carley, M, Boreham, M, Stecher, J, Dullaers, M, Banchereau, J, Oh, S Functional diversity of human vaginal APC subsets in directing T-cell responses. Mucosal Immunol, 2013;6(3):626-38. 2013 [PMID: 23131784] (Flow,, Human) Flow Human
Jung DW, Che ZM, Kim J, Kim K, Kim KY, Williams D, Kim J Tumor-stromal crosstalk in invasion of oral squamous cell carcinoma: a pivotal role of CCL7. Int. J. Cancer, 2010;127(2):332-44. 2010 [PMID: 19937793] (Neut,, Human) Neut Human
Franciszkiewicz K, Le Floc'h A, Jalil A, Vigant F, Robert T, Vergnon I, Mackiewicz A, Benihoud K, Validire P, Chouaib S, Combadiere C, Mami-Chouaib F Intratumoral induction of CD103 triggers tumor-specific CTL function and CCR5-dependent T-cell retention. Cancer Res., 2009;69(15):6249-55. 2009 [PMID: 19638592] (Flow,, Human) Flow Human
Hartl D, Krauss-Etschmann S, Koller B, Hordijk PL, Kuijpers TW, Hoffmann F, Hector A, Eber E, Marcos V, Bittmann I, Eickelberg O, Griese M, Roos D Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases. J. Immunol., 2008;181(11):8053-67. 2008 [PMID: 19017998] (Flow,, Human) Flow Human
Aldinucci D, Lorenzon D, Cattaruzza L, Pinto A, Gloghini A, Carbone A, Colombatti A Expression of CCR5 receptors on Reed-Sternberg cells and Hodgkin lymphoma cell lines: involvement of CCL5/Rantes in tumor cell growth and microenvironmental interactions. Int. J. Cancer, 2008;122(4):769-76. 2008 [PMID: 17935139] (Flow,, Human) Flow Human
Show All 20 Publications.

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Bioinformatics

Gene Symbol CCR5
Entrez
Uniprot

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