Recombinant Human IL-2 Protein

Recombinant Human IL-2 (Catalog # 202-IL) stimulates cell proliferation of the CTLL‑2 mouse cytotoxic T cell line. The ED50 for this effect is 0.0500-0.250 ng/mL.

1 μg/lane of Recombinant Human IL-2 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 13 kDa.

As an alternative, please consider our next generation Recombinant Human IL-2 (BT-002). It has equivalent bioactivity to Recombinant Human IL-2 (Catalog # 202-IL). It combines R&D Systems quality with scalability that allows for a solid supply chain. Both Recombinant Human IL-2 proteins are measured in a cell proliferation assay using CTLL 2 mouse cytotoxic T cells.

Equivalent bioactivity of GMP (202-GMP), Animal-Free (AFL202) and RUO (Catalog # 202-IL) grades of Recombinant Human IL-2 as measured in a cell proliferation assay CTLL 2 mouse cytotoxic T cells (orange, green, red, respectively).

• Reactivity: Hu
• Applications: Bioactivity

Recombinant Human IL-2 Protein Summary

• Details of Functionality: Measured in a cell proliferation assay using CTLL‑2 mouse cytotoxic T cells. Gearing, A.J.H. and C.B. Bird (1987) in Lymphokines and Interferons, A Practical Approach. Clemens, M.J. et al. (eds): IRL Press. 295. The ED₅₀ for this effect is 0.0500-0.250 ng/mL.
• Source: E. coli-derived human IL-2 protein
  Ala21-Thr153, with an N-terminal Met
• Accession #: P60568
• N-terminal Sequence: Met
• Protein/Peptide Type: Recombinant Proteins
• Gene: IL2
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Endotoxin Note: <0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 15 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• SDS-PAGE: 13 kDa, under reducing conditions.

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution Instructions: Reconstitute at 100 μg/mL in sterile 100 mM Acetic Acid containing at least 0.1% human or bovine serum albumin. Alternatively, reconstitute at 100 μg/mL in sterile deionized water and use within 24 hours, store at 2 to 8 °C.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human IL-2 Protein

• Aldesleukin
• IL2
• IL-2
• IL-2lymphokine
• interleukin 2
• interleukin-2
• involved in regulation of T-cell clonal expansion
• Proleukin
• T cell growth factor
• T-cell growth factor
• TCGF

Background

Recombinant Interleukin-2 (IL-2) is expressed in E. coli and has been engineered to contain the serine for cysteine substitution found in Proleukin^® (aldesleukin). Recombinant IL-2 is widely used in cell culture for the expansion of T cells. IL-2 is expressed by CD4+ and CD8+ T cells, gamma δ T cells, B cells, dendritic cells, and eosinophils (1-3). Mature human IL-2 shares 56% and 66% amino acid (aa) sequence identity with mouse and rat IL-2, respectively. Human and mouse IL-2 exhibit cross-species activity (4). The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes (5-7). The 55 kDa IL-2 R alpha is specific for IL-2 and binds with low affinity. The 75 kDa IL-2 R beta , which is also a component of the IL-15 receptor, binds IL-2 with intermediate affinity. The 64 kDa common gamma chain gamma c/IL-2 R gamma , which is shared with the receptors for IL-4, -7, -9, -15, and -21, does not independently interact with IL-2. Upon ligand binding, signal transduction is performed by both IL-2 R beta and gamma c.

IL-2 is best known for its autocrine and paracrine activity on T cells. It drives resting T cells to proliferate and induces IL-2 and IL-2 R alpha synthesis (1, 2). It contributes to T cell homeostasis by promoting the Fas-induced death of naïve CD4+ T cells but not activated CD4+ memory lymphocytes (8). IL-2 plays a central role in the expansion and maintenance of regulatory T cells, although it inhibits the development of Th17 polarized cells (9-11). Thus, IL-2 may be a key cytokine in the natural suppression of autoimmunity (12, 13).

IL-2 expression and concentration can have either immunostimulatory effects at high doses or immunosuppressive effects at low doses due to its preferential binding to different receptor subunits expressed by various immune cell types. This has led to the generation of recombinant IL-2 variants aimed at modifying IL-2 receptor binding for increased antitumor efficacy (14, 15). These variants are typically used in combination with immune checkpoint inhibitors instead of as a monotherapy (14). IL-2 can be genetically engineered to express in NK cells for CAR T cell therapies, and in combination with other cytokines like IL-15, can increase cell viability and proliferation (16). In addition to adoptive cell transfer and checkpoint blockade inhibitors, cancer vaccines that boost immune responses have been combined with IL-2 treatment with promising results in recent studies (15).

In cell culture, IL-2 is a frequently used cytokine for the proliferation, differentiation, and increased antibody secretion of B cells as they transform into plasma cells in vitro (17). IL-2 is also a classically used cytokine for the expansion of NK cells, early differentiated T cells and effector memory Treg cells for adoptive cell transfer cancer immunotherapy (16, 18). GMP IL-2 is a commonly used supplement for the expansion of these cell types for cellular therapies.

1. Ma, A. et al. (2006) Annu. Rev. Immunol. 24:657.
2. Gaffen, S.L. and K.D. Liu (2004) Cytokine 28:109.
3. Taniguchi, T. et al. (1983) Nature 302:305.
4. Mosmann, T.R. et al. (1987) J. Immunol. 138:1813.
5. Liparoto, S.F. et al. (2002) Biochemistry 41:2543.
6. Wang, X. et al. (2005) Science 310:1159.
7. Bodnar, A. et al. (2008) Immunol. Lett. 116:117.
8. Jaleco, S. et al. (2003) J. Immunol. 171:61.
9. Malek, T.R. (2003) J. Leukoc. Biol. 74:961.
10. Laurence, A. et al. (2007) Immunity 26:371.
11. Kryczek, I. et al. (2007) J. Immunol. 178:6730.
12. Afzali, B. et al. (2007) Clin. Exp. Immunol. 148:32.
13. Fehervari, Z.et al. (2006) Trends Immunol. 27:109.
14. Xue, D. et al. (2021) Antibody Therapeutics. 4(2): 123-133.
15. Wolfarth, A.A. et al. (2022) Immune Netw. 22(1): e5.
16. Koehl, U. et al. (2015) Oncoimmunology. 5(4).
17. Marsman, C. et al. (2022) Front. In Immunol. 13(815449).
18. Chamucero-Millares, J.A. et al. (2021) Cellular Immunology. 360(104257).

Publications for IL-2 (202-IL)(352)

Publications using 202-IL

• G Silva, AF Rodrigues, S Ferreira, C Matos, RP Eleutério, G Marques, K Kucheryava, AR Lemos, PMF Sousa, R Castro, A Barbas, D Simão, PM Alves Novel scFv against Notch Ligand JAG1 Suitable for Development of Cell Therapies toward JAG1-Positive Tumors Biomolecules, 2023;13(3):. 2023-01-01 [PMID: 36979394] (Bioassay, Human)
• R Boytz, S Seitz, E Gaudiano, JJ Patten, PT Keiser, JH Connor, AH Sharpe, RA Davey Inactivation of Ebola Virus and SARS-CoV-2 in Cell Culture Supernatants and Cell Pellets by Gamma Irradiation Viruses, 2022;15(1):. 2022-01-01 [PMID: 36680083] (Bioassay, Complex Species Category)
• ACH Szeto, ACF Ferreira, J Mannion, PA Clark, M Sivasubram, MWD Heycock, A Crisp, HE Jolin, P Kozik, MD Knolle, ANJ McKenzie An alphavbeta3 integrin checkpoint is critical for efficient TH2 cell cytokine polarization and potentiation of antigen-specific immunity Nature Immunology, 2023;24(1):123-135. 2023-01-01 [PMID: 36550322] (Bioassay, Human)
• MJ Lee, MW Leong, A Rustagi, A Beck, L Zeng, S Holmes, LS Qi, CA Blish SARS-CoV-2 escapes direct NK cell killing through Nsp1-mediated downregulation of ligands for NKG2D Cell Reports, 2022;41(13):111892. 2022-01-01 [PMID: 36543165] (Cell Culture, Human)
• E Cruz-Loren, NP Ramirez, J Lee, S Pandhe, L Wang, J Hernandez-, AM Spivak, V Planelles, T Petersen, MK Jain, ED Martinez, I D'Orso Host Cell Redox Alterations Promote Latent HIV-1 Reactivation through Atypical Transcription Factor Cooperativity Viruses, 2022;14(10):. 2022-01-01 [PMID: 36298843] (Bioassay, Human)
• WE Jiao, S Xu, YL Qiao, YG Kong, L Sun, YQ Deng, R Yang, ZZ Tao, QQ Hua, SM Chen Notch2-dependent GATA3+ Treg cells alleviate allergic rhinitis by suppressing the Th2 cell response International immunopharmacology, 2022;112(0):109261. 2022-01-01 [PMID: 36155282] (Bioassay, Human)
• B Noailly, M Yaugel-Nov, J Werquin, F Jospin, D Drocourt, T Bourlet, N Rochereau, S Paul Antiviral Activities of HIV-1-Specific Human Broadly Neutralizing Antibodies Are Isotype-Dependent Vaccines, 2022;10(6):. 2022-01-01 [PMID: 35746511] (Bioassay, Human)
• Somasundaram A, Cillo A, Lampenfeld C, Workman C, Kunning S, Oliveri L, Velez M, Joyce S, Calderon M, Dadey R, Rajasundaram D, Normolle D, Watkins S, Herman J, Kirkwood J, Lipson E, Ferris R, Bruno T, Vignali D Systemic Immune Dysfunction in Cancer Patients Driven by IL6 Induction of LAG3 in Peripheral CD8+ T Cells. Cancer Immunol Res, 0;10(7):885-899. [PMID: 35587532] (Bioassay, Human)
• G Rodionov, M Rosenzwaig, MS Tzadok, M Kvint, E Gevir, E Zorde-Khva, A Peled, S Yarkoni, A Ofer Short treatment of peripheral blood cells product with Fas ligand using closed automated cell processing system significantly reduces immune cell reactivity of the graft in vitro and in vivo Bone marrow transplantation, 2022;0(0):. 2022-01-01 [PMID: 35538142] (Bioassay, Human)
• CA Robinson, TD Lyddon, HM Gil, DT Evans, YV Kuzmichev, J Richard, A Finzi, S Welbourn, L Rasmussen, NM Nebane, VV Gupta, S Ananthan, Z Cai, ER Wonderlich, CE Augelli-Sz, R Bostwick, RG Ptak, SM Schader, MC Johnson Novel Compound Inhibitors of HIV-1NL4-3 Vpu Viruses, 2022;14(4):. 2022-01-01 [PMID: 35458546] (Bioassay, Human)
• P Lopez, O Ajibola, A Pagliuzza, R Zayats, WH Koh, A Herschhorn, N Chomont, TT Murooka T cell migration potentiates HIV infection by enhancing viral fusion and integration Cell Reports, 2022;38(8):110406. 2022-01-01 [PMID: 35196491] (Bioassay, Human)
• CH Kang, Y Kim, DY Lee, SU Choi, HK Lee, CH Park c-Met-Specific Chimeric Antigen Receptor T Cells Demonstrate Anti-Tumor Effect in c-Met Positive Gastric Cancer Cancers, 2021;13(22):. 2021-01-01 [PMID: 34830894] (Bioassay, Human)
• SA Saenz, A Local, T Carr, A Shakya, S Koul, H Hu, L Chourb, J Stedman, J Malley, LA D'Agostino, V Shanmugasu, J Malona, CE Schwartz, L Beebe, M Clements, G Rajaraman, J Cho, L Jiang, A Dubrovskiy, M Kreilein, R Shimanovic, LG Hamann, L Escoubet, JM Ellis Small molecule allosteric inhibitors of RORgammat block Th17-dependent inflammation and associated gene expression in vivo PLoS ONE, 2021;16(11):e0248034. 2021-01-01 [PMID: 34752458] (Bioassay, Human)
• P Prakhar, J Alvarez-De, H Keller, A Crossman, X Tai, YK Park, JH Park The small intestine epithelium exempts Foxp3+ Tregs from their IL-2 requirement for homeostasis and effector function JCI Insight, 2021;6(21):. 2021-01-01 [PMID: 34747370] (Bioassay, Mouse)
• MN Theodoraki, S Laban, EK Jackson, R Lotfi, PJ Schuler, C Brunner, TK Hoffmann, TL Whiteside, L Hofmann Changes in circulating exosome molecular profiles following surgery/(chemo)radiotherapy: early detection of response in head and neck cancer patients British Journal of Cancer, 2021;0(0):. 2021-01-01 [PMID: 34642463] (Bioassay, Human)
• S Yu, C Di, S Chen, M Guo, J Yan, Z Zhu, L Liu, R Feng, Y Xie, R Zhang, J Chen, M Wang, D Wei, H Fang, T Yin, J Huang, S Chen, H Lu, J Zhu, J Qu Distinct immune signatures discriminate between asymptomatic and presymptomatic SARS-CoV-2pos subjects Cell Research, 2021;0(0):. 2021-01-01 [PMID: 34561618] (Bioassay, Human)
• L Dai, Q Wang, X Lv, F Gao, Z Chen, Y Shen Elevated beta-secretase 1 expression mediates CD4+ T cell dysfunction via PGE2 signalling in Alzheimer&#039;s disease Brain, Behavior, and Immunity, 2021;98(0):337-348. 2021-01-01 [PMID: 34500034] (Bioassay, Mouse)
• S Deng, X Hu, L Luo, W Tang, Y Jiang, F Yin, C Hu, J Feng, X Li Anaphylatoxins orchestrate Th17 response via interactions between CD16+ monocytes and pleural mesothelial cells in tuberculous pleural effusion PloS Neglected Tropical Diseases, 2021;15(7):e0009508. 2021-01-01 [PMID: 34237073] (Bioassay, Human)
• HL Penny, JL Sieow, SY Gun, MC Lau, B Lee, J Tan, C Phua, F Toh, Y Nga, WH Yeap, B Janela, D Kumar, H Chen, J Yeong, JA Kenkel, A Pang, D Lim, HC Toh, TLK Hon, CI Johnson, HJ Khameneh, A Mortellaro, EG Engleman, O Rotzschke, F Ginhoux, JP Abastado, J Chen, SC Wong Targeting Glycolysis in Macrophages Confers Protection Against Pancreatic Ductal Adenocarcinoma International Journal of Molecular Sciences, 2021;22(12):. 2021-01-01 [PMID: 34198548] (Bioassay, Mouse)
• ED Rossignol, AS Dugast, H Compere, CA Cottrell, J Copps, S Lin, D Cizmeci, MS Seaman, ME Ackerman, AB Ward, G Alter, B Julg Mining HIV controllers for broad and functional antibodies to recognize and eliminate HIV-infected cells Cell Reports, 2021;35(8):109167. 2021-01-01 [PMID: 34038720] (Bioassay, Human)
• KO Jang, YW Lee, H Kim, DK Chung Complement Inactivation Strategy of Staphylococcus aureus Using Decay-Accelerating Factor and the Response of Infected HaCaT Cells International Journal of Molecular Sciences, 2021;22(8):. 2021-01-01 [PMID: 33924622] (Cell Culture, Human)
• AM Farhat, AC Weiner, C Posner, ZS Kim, B Orcutt-Jah, SM Carlson, AS Meyer Modeling cell-specific dynamics and regulation of the common gamma chain cytokines Cell Reports, 2021;35(4):109044. 2021-01-01 [PMID: 33910015] (Bioassay, Human)
• AT Tan, M Linster, CW Tan, N Le Bert, WN Chia, K Kunasegara, Y Zhuang, CYL Tham, A Chia, GJD Smith, B Young, S Kalimuddin, JGH Low, D Lye, LF Wang, A Bertoletti Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients Cell Reports, 2021;34(6):108728. 2021-01-01 [PMID: 33516277] (Bioassay, Human)
• JH Ruth, M Gurrea-Rub, KS Athukorala, SM Rasmussen, D Weber, PM Randon, RJ Gedert, ME Lind, MA Amin, PL Campbell, PS Tsou, Y Mao-Draaye, Q Wu, TM Lanigan, VG Keshamouni, NG Singer, F Lin, DA Fox CD6 is a target for cancer immunotherapy JCI Insight, 2021;0(0):. 2021-01-01 [PMID: 33497367] (Bioassay, Human)
• Z Zi, H Zhao, H Wang, X Ma, F Wei B7-H3 Chimeric Antigen Receptor Redirected T Cells Target Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma Cancers, 2020;12(12):. 2020-01-01 [PMID: 33348781] (Cell Culture, Human)
• O Bartok, A Pataskar, R Nagel, M Laos, E Goldfarb, D Hayoun, R Levy, PR Körner, IZM Kreuger, J Champagne, EA Zaal, OB Bleijervel, X Huang, J Kenski, J Wargo, A Brandis, Y Levin, O Mizrahi, M Alon, S Lebon, W Yang, MM Nielsen, N Stern-Gino, M Altelaar, CR Berkers, T Geiger, DS Peeper, J Olweus, Y Samuels, R Agami Anti-tumour immunity induces aberrant peptide presentation in melanoma Nature, 2020;0(0):. 2020-01-01 [PMID: 33328638] (Cell Culture, Human)
• S Campinoti, A Gjinovci, R Ragazzini, L Zanieri, L Ariza-McNa, M Catucci, S Boeing, JE Park, JC Hutchinson, M Muñoz-Ruiz, PG Manti, G Vozza, CE Villa, DE Phylactopo, C Maurer, G Testa, HJ Stauss, SA Teichmann, NJ Sebire, AC Hayday, D Bonnet, P Bonfanti Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds Nature Communications, 2020;11(1):6372. 2020-01-01 [PMID: 33311516] (Cell Culture, Human)
• Z Li, C Hajian, WC Greene Identification of unrecognized host factors promoting HIV-1 latency PloS Pathogens, 2020;16(12):e1009055. 2020-01-01 [PMID: 33270809] (Cell Culture, Human)
• Roudko V, Bozkus C, Orfanelli T, McClain C, Carr C, O'Donnell T, Chakraborty L, Samstein R, Huang K, Blank S, Greenbaum B, Bhardwaj N Shared Immunogenic Poly-Epitope Frameshift Mutations in Microsatellite Unstable Tumors. Cell, 0;183(6):1634-1649.e17. [PMID: 33259803] (Bioassay, Human)
• KK Naidoo, ZB Shangase, T Rashid, A Ngubane, N Ismail, T Ndung'u, CF Thobakgale The DARC-null trait is associated with moderate modulation of NK cell profiles and unaltered cytolytic T cell profiles in black South Africans PLoS ONE, 2020;15(11):e0242448. 2020-01-01 [PMID: 33211774] (Bioassay, Human)
• MW Grunst, AG Grandea, SK Janaka, I Hammad, P Grimes, JA Karl, R Wiseman, DH O'Connor, DT Evans Functional Interactions of Common Allotypes of Rhesus Macaque Fc&amp;gammaR2A and Fc&amp;gammaR3A with Human and Macaque IgG Subclasses J Immunol, 2020;0(0):. 2020-01-01 [PMID: 33208458] (Cell Culture, Human)
• BMF Winkel, LR Pelgrom, R van Schuij, E Baalbergen, MS Ganesh, H Gerritsma, CM de Korne, N Duszenko, MCC Langenberg, SC Chevalley-, HH Smits, EC de Jong, B Everts, B Franke-Fay, M Roestenber Plasmodium sporozoites induce regulatory macrophages PLoS Pathog., 2020;16(9):e1008799. 2020-01-01 [PMID: 32898164] (Cell Culture, Human)
• M Bachsais, S Salti, K Zaoui, GS Hassan, F Aoudjit, W Mourad CD154 inhibits death of T cells via a Cis interaction with the alpha5beta1 integrin PLoS ONE, 2020;15(8):e0235753. 2020-01-01 [PMID: 32745080] (Cell Culture, Human)
• IJ Beccard, L Hofmann, JC Schroeder, S Ludwig, S Laban, C Brunner, R Lotfi, TK Hoffmann, EK Jackson, PJ Schuler, MN Theodoraki Immune Suppressive Effects of Plasma-Derived Exosome Populations in Head and Neck Cancer Cancers (Basel), 2020;12(7):. 2020-01-01 [PMID: 32708274] (Cell Culture, Human)
• W Gao, S Xu, M Zhang, S Liu, SP Siu, H Peng, JC Ng, GS Tsao, AW Chan, VL Chow, JY Chan, TS Wong NADPH oxidase 5&amp;alpha promotes the formation of CD271 tumor-initiating cells in oral cancer Am J Cancer Res, 2020;10(6):1710-1727. 2020-01-01 [PMID: 32642285] (Cell Culture, Human)
• J Yan, SP Pandey, BJ Barnes, JR Turner, C Abraham T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation Cell Rep, 2020;31(13):107820. 2020-01-01 [PMID: 32610123] (Bioassay, Human)
• SL Bevington, STH Ng, GJ Britton, P Keane, DC Wraith, PN Cockerill Chromatin Priming Renders T Cell Tolerance-Associated Genes Sensitive to Activation below the�Signaling Threshold for Immune Response Genes Cell Rep, 2020;31(10):107748. 2020-01-01 [PMID: 32521273] (Bioassay, Mouse)
• A Dharan, N Bachmann, S Talley, V Zwikelmaie, EM Campbell Nuclear pore blockade reveals that HIV-1 completes reverse transcription and uncoating in the nucleus Nat Microbiol, 2020;0(0):. 2020-01-01 [PMID: 32483230] (Bioassay, Human)
• Y Wan, C Zhang, Y Xu, M Wang, Q Rao, H Xing, Z Tian, K Tang, Y Mi, Y Wang, J Wang Hyperfunction of CD4 CD25 regulatory T cells in de novo acute myeloid leukemia BMC Cancer, 2020;20(1):472. 2020-01-01 [PMID: 32456622] (Cell Culture, Human)
• Y Gong, K Zhi, PKB Nagesh, N Sinha, P Chowdhury, H Chen, S Gorantla, MM Yallapu, S Kumar An Elvitegravir Nanoformulation Crosses the Blood-Brain Barrier and Suppresses HIV-1 Replication in Microglia Viruses, 2020;12(5):. 2020-01-01 [PMID: 32443728] (Bioassay, Human)
• K Froning, J Maguire, A Sereno, F Huang, S Chang, K Weichert, AJ Frommelt, J Dong, X Wu, H Austin, EM Conner, JR Fitchett, AR Heng, D Balasubram, MT Hilgers, B Kuhlman, SJ Demarest Computational stabilization of T cell receptors allows pairing with antibodies to form bispecifics Nat Commun, 2020;11(1):2330. 2020-01-01 [PMID: 32393818] (Bioassay, Human)
• Y Hu, H Liu, C Fang, C Li, F Xhyliu, H Dysert, J Bodo, G Habermehl, BE Russell, W Li, M Chappell, X Jiang, SL Ondrejka, ED Hsi, JP Maciejewsk, Q Yi, KC Anderson, NC Munshi, G Ao, JN Valent, J Lin, J Zhao Targeting of CD38 by the tumor suppressor miR-26a serves as a novel potential therapeutic agent in multiple myeloma Cancer Res., 2020;0(0):. 2020-01-01 [PMID: 32193289] (Cell Culture, Human)
• T Chirkova, B Ha, BH Rimawi, AGP Oomens, TV Hartert, LJ Anderson In vitro model for the assessment of human immune responses to subunit RSV vaccines PLoS ONE, 2020;15(3):e0229660. 2020-01-01 [PMID: 32191728] (Cell Culture, Human)
• AE Morelli, TL Sumpter, DM Rojas-Cana, M Bandyopadh, Z Chen, O Tkacheva, WJ Shufesky, CT Wallace, SC Watkins, A Berger, CJ Paige, LD Falo, AT Larregina Neurokinin-1 Receptor Signaling Is Required for Efficient Ca2+ Flux in T-Cell-Receptor-Activated T Cells Cell Rep, 2020;30(10):3448-3465.e8. 2020-01-01 [PMID: 32160549] (Bioassay, Mouse)
• S Zicari, AL Sharma, G Sahu, L Dubrovsky, L Sun, H Yue, T Jada, A Ochem, G Simon, M Bukrinsky, M Tyagi DNA dependent protein kinase (DNA-PK) enhances HIV transcription by promoting RNA polymerase II activity and recruitment of transcription machinery at HIV LTR Oncotarget, 2020;11(7):699-726. 2020-01-01 [PMID: 32133046] (Cell Culture, Human)
• Y Gong, P Chowdhury, PKB Nagesh, MA Rahman, K Zhi, MM Yallapu, S Kumar Novel elvitegravir nanoformulation for drug delivery across the blood-brain barrier to achieve HIV-1 suppression in the CNS macrophages Sci Rep, 2020;10(1):3835. 2020-01-01 [PMID: 32123217] (Cell Culture, Human)
• J Lubow, MC Virgilio, M Merlino, DR Collins, M Mashiba, BG Peterson, Z Lukic, MM Painter, F Gomez-Rive, V Terry, G Zimmerman, KL Collins Mannose receptor is an HIV restriction factor counteracted by Vpr in macrophages Elife, 2020;9(0):. 2020-01-01 [PMID: 32119644] (Bioassay, Human)
• T Petrova, J Pesic, K Pardali, M Gaestel, JSC Arthur p38 MAPK signalling regulates cytokine production in IL-33 stimulated Type 2 Innate Lymphoid cells Sci Rep, 2020;10(1):3479. 2020-01-01 [PMID: 32103032] (Cell Culture, Human)
• R Fonseca, LK Beura, CF Quarnstrom, HE Ghoneim, Y Fan, CC Zebley, MC Scott, NJ Fares-Fred, S Wijeyesing, EA Thompson, H Borges da, V Vezys, B Youngblood, D Masopust Developmental plasticity allows outside-in immune responses by resident memory T cells Nat. Immunol., 2020;0(0):. 2020-01-01 [PMID: 32066954] (Cell Culture, Human)
• PJ Metz, KA Ching, T Xie, P Delgado Cu, S Niessen, JH Tatlock, K Jensen-Per, BW Murray Symmetric Arginine Dimethylation Is Selectively Required for mRNA Splicing and the Initiation of Type I and Type III Interferon Signaling Cell Rep, 2020;30(6):1935-1950.e8. 2020-01-01 [PMID: 32049022] (Bioassay, Human)
• SV Radhakrish, T Luetkens, SD Scherer, P Davis, ER Vander Mau, ML Olson, S Yousef, J Panse, Y Abdiche, KD Li, RR Miles, W Matsui, AL Welm, D Atanackovi CD229 CAR T cells eliminate multiple myeloma and tumor propagating cells without fratricide Nat Commun, 2020;11(1):798. 2020-01-01 [PMID: 32034142] (Cell Culture, Human)
• A Mauriello, C Manolio, B Cavalluzzo, A Avallone, M Borrelli, A Morabito, E Iovine, A Chambery, R Russo, ML Tornesello, FM Buonaguro, M Tagliamont, L Buonaguro Immunological effects of adjuvants in subsets of antigen presenting cells of cancer patients undergoing chemotherapy J Transl Med, 2020;18(1):34. 2020-01-01 [PMID: 31973714] (Cell Culture, Human)
• JB McBrien, M Mavigner, L Franchitti, SA Smith, E White, GK Tharp, H Walum, K Busman-Suh, CR Aguilera-S, WO Thayer, RA Spagnuolo, M Kovarova, A Wahl, B Cervasi, DM Margolis, TH Vanderford, DG Carnathan, M Paiardini, JD Lifson, JH Lee, JT Safrit, SE Bosinger, JD Estes, CA Derdeyn, JV Garcia, DA Kulpa, A Chahroudi, G Silvestri Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells Nature, 2020;0(0):. 2020-01-01 [PMID: 31969705] (Cell Culture, Mouse)
• J Brzostek, N Gautam, X Zhao, EW Chen, M Mehta, DWH Tung, YL Chua, J Yap, SH Cho, S Sankaran, V Rybakin, G Fu, NRJ Gascoigne T cell receptor and cytokine signal integration in CD8+ T cells is mediated by the protein Themis Nat. Immunol., 2020;0(0):. 2020-01-01 [PMID: 31932808] (Cell Culture, Mouse)
• D Gate, N Saligrama, O Leventhal, AC Yang, MS Unger, J Middeldorp, K Chen, B Lehallier, D Channappa, MB De Los San, A McBride, J Pluvinage, F Elahi, GK Tam, Y Kim, M Greicius, AD Wagner, L Aigner, DR Galasko, MM Davis, T Wyss-Coray Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer&#039;s disease Nature, 2020;577(7790):399-404. 2020-01-01 [PMID: 31915375] (Cell Culture, Human)
• JJ Montoya, MA Turnidge, DH Wai, AR Patel, DW Lee, V Gokhale, LH Hurley, RJ Arceci, C Wetmore, DO Azorsa In vitro activity of a G-quadruplex-stabilizing small molecule that synergizes with Navitoclax to induce cytotoxicity in acute myeloid leukemia cells BMC Cancer, 2019;19(1):1251. 2019-01-01 [PMID: 31881855] (Bioassay, Human)
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• N Ilic, A Gruden-Mov, J Cvetkovic, S Tomic, DB Vucevic, C Aranzamend, M Colic, E Pinelli, L Sofronic-M Trichinella spiralis Excretory-Secretory Products Induce Tolerogenic Properties in Human Dendritic CellsviaToll-Like Receptors 2 and 4 Front Immunol, 2018;9(0):11. 2018-01-01 [PMID: 29416536] (Bioassay, Human)
• D Wang, XF Huang, B Hong, XT Song, L Hu, M Jiang, B Zhang, H Ning, Y Li, C Xu, X Lou, B Li, Z Yu, J Hu, J Chen, F Yang, H Gao, G Ding, L Liao, L Rollins, L Jones, SY Chen, H Chen Efficacy of intracellular immune checkpoint-silenced DC vaccine JCI Insight, 2018;3(3):. 2018-01-01 [PMID: 29415891] (Bioassay, Human)
• M Najar, M Fayyad-Kaz, N Meuleman, D Bron, H Fayyad-Kaz, L Lagneaux Mesenchymal stromal cells of the bone marrow and natural killer cells: cell interactions and cross modulation J Cell Commun Signal, 2018;0(0):. 2018-01-01 [PMID: 29350342] (Bioassay, Human)
• A Misra, E Gleeson, W Wang, C Ye, P Zhou, JT Kimata Glycosyl-phosphatidylinositol-Anchored Anti-HIV Env Single Chain Variable Fragments Interfere with HIV-1 Env Processing and Viral Infectivity J. Virol., 2018;0(0):. 2018-01-01 [PMID: 29321330] (Bioassay, Human)
• A Camelo, G Rosignoli, Y Ohne, RA Stewart, C Overed-Say, MA Sleeman, RD May IL-33, IL-25, and TSLP induce a distinct phenotypic and activation profile in human type 2 innate lymphoid cells Blood Adv, 2017;1(10):577-589. 2017-01-01 [PMID: 29296700] (Human)
• E Netchiporo, J Gantchev, M Tsang, P Thibault, AK Watters, JM Hughes, FM Ghazawi, A Woetmann, N Ødum, D Sasseville, IV Litvinov Analysis of CTCL cell lines reveals important differences between mycosis fungoides/S�zary syndrome vs. HTLV-1+ leukemic cell lines Oncotarget, 2017;8(56):95981-95998. 2017-01-01 [PMID: 29221181] (Bioassay, Human)
• S Galland, J Vuille, P Martin, I Letovanec, A Caignard, G Fregni, I Stamenkovi Tumor-Derived Mesenchymal Stem Cells Use Distinct Mechanisms to Block the Activity of Natural Killer Cell Subsets Cell Rep, 2017;20(12):2891-2905. 2017-01-01 [PMID: 28930684] (Bioassay, Human)
• L Sarmiento, J De Rosa, A Machicote, LA Billordo, P Baz, PM Fernández, I Kaimen Mac, A Blanco, EI Arana Characterization of tonsillar IL10 secreting B cells and their role in the pathophysiology of tonsillar hypertrophy Sci Rep, 2017;7(1):11077. 2017-01-01 [PMID: 28894116] (Bioassay, Human)
• Y Nakayama, J Kosek, L Capone, EM Hur, PH Schafer, GE Ringheim Aiolos Overexpression in Systemic Lupus Erythematosus B Cell Subtypes and BAFF-Induced Memory B Cell Differentiation Are Reduced by CC-220 Modulation of Cereblon Activity J. Immunol., 2017;199(7):2388-2407. 2017-01-01 [PMID: 28848067] (Bioassay, Human)
• VA Gall, AV Philips, N Qiao, K Clise-Dwye, AA Perakis, M Zhang, GT Clifton, P Sukhumalch, Q Ma, SM Reddy, D Yu, JJ Molldrem, GE Peoples, G Alatrash, EA Mittendorf Trastuzumab Increases HER2 Uptake and Cross-Presentation by Dendritic Cells Cancer Res., 2017;0(0):. 2017-01-01 [PMID: 28819024] (Bioassay, Human)
• Z Lu, N Xu, X Zhou, G Gao, L Li, J Huang, Y Li, Q Lu, B He, C Pan, X Liu Therapeutic immune monitoring of CD4(+)CD25(+) T cells in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors Oncol Lett, 2017;14(2):1363-1372. 2017-01-01 [PMID: 28808483] (Bioassay, Human)
• A Tovar-Sala, A Weinberg Cytomegalovirus infection in HIV-infected and uninfected individuals is characterized by circulating regulatory T cells of unconstrained antigenic specificity PLoS ONE, 2017;12(7):e0180691. 2017-01-01 [PMID: 28683106] (Bioassay, Human)
• U Bughani, A Saha, A Kuriakose, R Nair, RB Sadashivar, R Venkataram, S Patel, AT Deshchougu, SK S, E Montero, HV Pai, DV Palanivelu, R Melarkode, P Nair T cell activation and differentiation is modulated by a CD6 domain 1 antibody Itolizumab PLoS ONE, 2017;12(7):e0180088. 2017-01-01 [PMID: 28672038] (Bioassay, Human)
• DL Bolton, K McGinnis, G Finak, P Chattopadh, R Gottardo, M Roederer Combined single-cell quantitation of host and SIV genes and proteins ex vivo reveals host-pathogen interactions in individual cells PLoS Pathog., 2017;13(6):e1006445. 2017-01-01 [PMID: 28654687] (Bioassay, Primate - Macaca mulatta (Rhesus Macaque))
• M Jourdan, N Robert, M Cren, C Thibaut, C Duperray, A Kassambara, M Cogné, K Tarte, B Klein, J Moreaux Characterization of human FCRL4-positive B cells PLoS ONE, 2017;12(6):e0179793. 2017-01-01 [PMID: 28636654] (Bioassay, Human)
• A Pavesi, AT Tan, S Koh, A Chia, M Colombo, E Antonecchi, C Miccolis, E Ceccarello, G Adriani, MT Raimondi, RD Kamm, A Bertoletti A 3D microfluidic model for preclinical evaluation of TCR-engineered T cells against solid tumors JCI Insight, 2017;2(12):. 2017-01-01 [PMID: 28614795] (Bioassay, Human)
• M Mediavilla, J Castro, A Chiappori, D Noyes, DC Hernandez, J Stagg, SJ Antonia A Novel Antagonist of the Immune Checkpoint Protein Adenosine A2a Receptor Restores Tumor-Infiltrating Lymphocyte Activity in the Context of the Tumor Microenvironment Neoplasia, 2017;19(7):530-536. 2017-01-01 [PMID: 28582704] (Bioassay, Human)
• AP Vicari, AM Schoepfer, B Meresse, L Goffin, O Léger, S Josserand, N Guégan, S Yousefi, A Straumann, N Cerf-Bensu, HU Simon, Y Chvatchko Discovery and characterization of a novel humanized anti-IL-15 antibody and its relevance for the treatment of refractory celiac disease and eosinophilic esophagitis MAbs, 2017;0(0):0. 2017-01-01 [PMID: 28581883] (Surface Plasmon Resonance, Human)
• Y Barsheshet, G Wildbaum, E Levy, A Vitenshtei, C Akinseye, J Griggs, SA Lira, N Karin CCR8(+)FOXp3(+) Treg cells as master drivers of immune regulation Proc. Natl. Acad. Sci. U.S.A., 2017;0(0):. 2017-01-01 [PMID: 28533380] (Bioassay, Human)
• HG Hilton, CP McMurtrey, AS Han, Z Djaoud, LA Guethlein, JH Blokhuis, JL Pugh, A Goyos, A Horowitz, R Buchli, KW Jackson, W Bardet, DA Bushnell, PJ Robinson, JL Mendoza, ME Birnbaum, M Nielsen, KC Garcia, WH Hildebrand, P Parham The Intergenic Recombinant HLA-B?46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands Cell Rep, 2017;19(7):1394-1405. 2017-01-01 [PMID: 28514659] (Bioassay, Human)
• A Leiber, J Schwarz, N Köstlin, B Spring, B Fehrenbach, N Katava, CF Poets, C Gille Neonatal myeloid derived suppressor cells show reduced apoptosis and immunosuppressive activity upon infection with Escherichia coli Eur. J. Immunol., 2017;0(0):. 2017-01-01 [PMID: 28493377] (Bioassay, Human)
• F Kawamura, M Inaki, A Katafuchi, Y Abe, N Tsuyama, Y Kurosu, A Yanagi, M Higuchi, S Muto, T Yamaura, H Suzuki, H Noji, S Suzuki, MA Yoshida, M Sasatani, K Kamiya, M Onodera, A Sakai Establishment of induced pluripotent stem cells from normal B cells and inducing AID expression in their differentiation into hematopoietic progenitor cells Sci Rep, 2017;7(1):1659. 2017-01-01 [PMID: 28490810] (Bioassay, Human)
• JL Platt, I Silva, SJ Balin, AR Lefferts, E Farkash, TM Ross, MC Carroll, M Cascalho C3d regulates immune checkpoint blockade and enhances antitumor immunity JCI Insight, 2017;2(9):. 2017-01-01 [PMID: 28469081] (Bioassay, Mouse)
• N Köstlin, M Vogelmann, B Spring, J Schwarz, J Feucht, C Härtel, TW Orlikowsky, CF Poets, C Gille Granulocytic myeloid derived suppressor cells from human cord blood modulate T-helper-cell response towards an anti-inflammatory phenotype Immunology, 2017;0(0):. 2017-01-01 [PMID: 28464218] (Bioassay, Human)
• M Schoenhals, M Jourdan, A Bruyer, A Kassambara, B Klein, J Moreaux Hypoxia favors the generation of human plasma cells Cell Cycle, 2017;0(0):1-14. 2017-01-01 [PMID: 28463531] (Bioassay, Human)
• J Ding, ML Fishel, AM Reed, E McAdams, M Czader, AA Cardoso, MR Kelley Ref-1/APE1 as Transcriptional Regulator and Novel Therapeutic Target in Pediatric T-cell Leukemia Mol. Cancer Ther., 2017;0(0):. 2017-01-01 [PMID: 28446640] (Bioassay, Human)
• A Pichugin, OV Iarovaia, A Gavrilov, I Sklyar, N Barinova, A Barinov, E Ivashkin, G Caron, S Aoufouchi, SV Razin, T Fest, M Lipinski, YS Vassetzky The IGH locus relocalizes to a recombination compartment in the perinucleolar region of differentiating B-lymphocytes Oncotarget, 2017;0(0):. 2017-01-01 [PMID: 28445143] (Bioassay, Human)
• PA Frischmeye, M Masilamani, W Gu, E Brittain, R Wood, J Kim, K Nadeau, KM Jarvinen, A Grishin, R Lindblad, HA Sampson Mechanistic Correlates of Clinical Responses to Omalizumab in the Setting of Oral Immunotherapy for Milk Allergy J. Allergy Clin. Immunol., 2017;0(0):. 2017-01-01 [PMID: 28414061] (Bioassay, Human)
• A Van Hout, T D'huys, M Oeyen, D Schols, T Van Loy Comparison of cell-based assays for the identification and evaluation of competitive CXCR4 inhibitors PLoS ONE, 2017;12(4):e0176057. 2017-01-01 [PMID: 28410420] (Bioassay, Human)
• Y Xia, Q Zhang, Q Zhen, Y Zhao, N Liu, T Li, Y Hao, Y Zhang, C Luo, X Wu Negative regulation of tumor-infiltrating NK cell in clear cell renal cell carcinoma patients through the exosomal pathway Oncotarget, 2017;8(23):37783-37795. 2017-01-01 [PMID: 28384121] (Bioassay, Human)
• LA Novotny, JD Clements, SD Goodman, LO Bakaletz Transcutaneous immunization with a bandaid prevents experimental otitis media in a polymicrobial model Clin. Vaccine Immunol., 2017;0(0):. 2017-01-01 [PMID: 28381402] (Bioassay, Chinchilla)
• DY Hu, RC Wirasinha, CC Goodnow, SR Daley IL-2 prevents deletion of developing T-regulatory cells in the thymus Cell Death Differ., 2017;0(0):. 2017-01-01 [PMID: 28362433] (Bioassay, Mouse)
• S Bagheri, M Yousefi, E Safaie Qam, F Riazi-Rad, M Abolhassan, V Younesi, R Dorostkar, AA Movassaghp, Z Sharifzade Selection of single chain antibody fragments binding to the extracellular domain of 4-1BB receptor by phage display technology Tumour Biol, 2017;39(3):1010428317695. 2017-01-01 [PMID: 28347235] (Bioassay, Human)
• H Takada, KI Imadome, H Shibayama, M Yoshimori, L Wang, Y Saitoh, S Uota, S Yamaoka, T Koyama, N Shimizu, K Yamamoto, S Fujiwara, O Miura, A Arai EBV induces persistent NF-?B activation and contributes to survival of EBV-positive neoplastic T- or NK-cells PLoS ONE, 2017;12(3):e0174136. 2017-01-01 [PMID: 28346502] (Bioassay, Human)
• R Havunen, M Siurala, S Sorsa, S Grönberg-V, M Behr, S Tähtinen, JM Santos, P Karell, J Rusanen, DM Nettelbeck, A Ehrhardt, A Kanerva, A Hemminki Oncolytic Adenoviruses Armed with Tumor Necrosis Factor Alpha and Interleukin-2 Enable Successful Adoptive Cell Therapy Mol Ther Oncolytics, 2017;4(0):77-86. 2017-01-01 [PMID: 28345026] (Bioassay, Mouse)
• S Tousa, M Semitekolo, I Morianos, A Banos, AI Trochoutso, TM Brodie, N Poulos, K Samitas, M Kapasa, D Konstantop, G Paraskevop, M Gaga, CM Hawrylowic, F Sallusto, G Xanthou Activin-A co-opts IRF4 and AhR signaling to induce human regulatory T cells that restrain asthmatic responses Proc. Natl. Acad. Sci. U.S.A, 2017;0(0):. 2017-01-01 [PMID: 28320933] (Bioassay, Human)
• X Li, P Lu, B Li, W Zhang, R Yang, Y Chu, K Luo Interleukin 2 and interleukin 10 function synergistically to promote CD8(+) T cell cytotoxicity, which is suppressed by regulatory T cells in breast cancer Int. J. Biochem. Cell Biol, 2017;0(0):. 2017-01-01 [PMID: 28274688] (Bioassay, Human)
• C Tao, H Shao, W Zhang, H Bo, F Wu, H Shen, S Huang ??TCR immunoglobulin constant region domain exchange in human ??TCRs improves TCR pairing without altering TCR gene-modified T cell function Mol Med Rep, 2017;0(0):. 2017-01-01 [PMID: 28259946] (Bioassay, Human)
• MM Shikhagaie, ÅK Björklund, J Mjösberg, JS Erjefält, AS Cornelisse, XR Ros, SM Bal, JJ Koning, RE Mebius, M Mori, M Bruchard, B Blom, H Spits Neuropilin-1 Is Expressed on Lymphoid Tissue Residing LTi-like Group 3 Innate Lymphoid Cells and Associated with Ectopic Lymphoid Aggregates Cell Rep, 2017;18(7):1761-1773. 2017-01-01 [PMID: 28199847] (Bioassay, Human)
• JE Hammonds, N Beeman, L Ding, S Takushi, AC Francis, JJ Wang, GB Melikyan, P Spearman Siglec-1 initiates formation of the virus-containing compartment and enhances macrophage-to-T cell transmission of HIV-1 PLoS Pathog, 2017;13(1):e1006181. 2017-01-01 [PMID: 28129379] (Bioassay, Human)
• A Lanna, DC Gomes, B Muller-Dur, T McDonnell, D Escors, DW Gilroy, JH Lee, M Karin, AN Akbar A sestrin-dependent Erk-Jnk-p38 MAPK activation complex inhibits immunity during aging Nat. Immunol, 2017;0(0):. 2017-01-01 [PMID: 28114291] (Bioassay, Human)
• GJ Britton, R Ambler, DJ Clark, EV Hill, HM Tunbridge, KE McNally, BR Burton, P Butterweck, C Sabatos-Pe, LA Hampton-O', P Verkade, C Wlfing, DC Wraith PKC? links proximal T cell and Notch signaling through localized regulation of the actin cytoskeleton Elife, 2017;6(0):. 2017-01-01 [PMID: 28112644] (Bioassay, Mouse)
• DA Donahue, F Porrot, N Couespel, O Schwartz SUN2 silencing impairs CD4 T cell proliferation and alters sensitivity to HIV-1 infection independently of Cyclophilin A J. Virol, 2017;0(0):. 2017-01-01 [PMID: 28077629] (Bioassay, Human)
• Elias S, Schmidt A, Kannan V, Andersson J, Tegner J TGF-beta Affects the Differentiation of Human GM-CSF+ CD4+ T Cells in an Activation- and Sodium-Dependent Manner. Front Immunol, 0;7(0):603. [PMID: 28066414] (Bioassay, Human)
• L J Spicer G protein-coupled receptor 34 in ovarian granulosa cells of cattle: changes during follicular development and potential functional implications Domest. Anim. Endocrinol, 2016;59(0):90-99. 2016-01-01 [PMID: 28040605] (Bioassay, Bovine)
• Ivan Carcamo-Or Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity Cell Stem Cell, 2016;0(0):. 2016-01-01 [PMID: 28017796] (Bioassay, Human)
• Unlocking bat immunology: establishment of Pteropus alecto bone marrow-derived dendritic cells and macrophages Sci Rep, 2016;6(0):38597. 2016-01-01 [PMID: 27934903] (Bioassay, Bat - Pteropus alecto)
• Preclinical validation: LV/IL-12 transduction of patient leukemia cells for immunotherapy of AML Mol Ther Methods Clin Dev, 2016;3(0):16074. 2016-01-01 [PMID: 27933304] (Bioassay, Human)
• Genetic, immunological, and clinical features of patients with bacterial and fungal infections due to inherited IL-17RA deficiency Proc. Natl. Acad. Sci. U.S.A, 2016;0(0):. 2016-01-01 [PMID: 27930337] (Bioassay, Human)
• Fabrizio Antonangel Natural killer cell recognition of in vivo drug-induced senescent multiple myeloma cells Oncoimmunology, 2016;5(10):e1218105. 2016-01-01 [PMID: 27853638] (Bioassay, Mouse)
• Yadollah Omidi Development of screen-printed tryptophan-kynurenine immunosensor for in vitro assay of kynurenine-mediated immunosuppression effect of cancer cells on activated T-cells Biosens Bioelectron, 2016;0(0):. 2016-01-01 [PMID: 27840038] (Bioassay, Human)
• L Liu, W Wang, J Matz, C Ye, L Bracq, J Delon, JT Kimata, Z Chen, S Benichou, P Zhou The Glycosylphosphatidylinositol-Anchored Variable Region of Llama Heavy Chain-Only Antibody JM4 Efficiently Blocks both Cell-Free and T Cell-T Cell Transmission of Human Immunodeficiency Virus Type 1 J. Virol., 2016;90(23):10642-10659. 2016-01-01 [PMID: 27654286] (Bioassay, Human)
• Native cellulose nanofibrills induce immune tolerance in vitro by acting on dendritic cells Sci Rep, 2016;6(0):31618. 2016-01-01 [PMID: 27558765] (Bioassay, Human)
• Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status Circ Res, 2016;0(0):. 2016-01-01 [PMID: 27418629] (Bioassay, Human)
• M Ke, H Wang, Y Zhou, J Li, Y Liu, M Zhang, J Dou, T Xi, B Shen, C Zhou SEP enhanced the antitumor activity of 5-fluorouracil by up-regulating NKG2D/MICA and reversed immune suppression via inhibiting ROS and caspase-3 in mice Oncotarget, 2016;7(31):49509-49526. 2016-01-01 [PMID: 27385218] (Bioassay, Human)
• Jun Li Long noncoding RNA NRON contributes to HIV-1 latency by specifically inducing tat protein degradation Nat Commun, 2016;7(0):11730. 2016-01-01 [PMID: 27291871] (Bioassay, Human)
• Effects of Cigarette Smoke Condensate on Oxidative Stress, Apoptotic Cell Death, and HIV Replication in Human Monocytic Cells PLoS ONE, 2016;11(5):e0155791. 2016-01-01 [PMID: 27203850] (Bioassay, Human)
• The extracellular interactome of the human adenovirus family reveals diverse strategies for immunomodulation Nat Commun, 2016;7(0):11473. 2016-01-01 [PMID: 27145901] (Bioassay, Human)
• Functional differences in hepatitis C virus nonstructural (NS) 3/4A- and 5A-specific T cell responses Sci Rep, 2016;6(0):24991. 2016-01-01 [PMID: 27141891] (Bioassay, Human)
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• RB Jones, S Mueller, R O'Connor, K Rimpel, DD Sloan, D Karel, HC Wong, EK Jeng, AS Thomas, JB Whitney, SY Lim, C Kovacs, E Benko, S Karandish, SH Huang, MJ Buzon, M Lichterfel, A Irrinki, JP Murry, A Tsai, H Yu, R Geleziunas, A Trocha, MA Ostrowski, Irvi A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes PLoS Pathog, 2016;12(4):e1005545. 2016-01-01 [PMID: 27082643] (Bioassay, Human)
• Schmidt A, Zhang X, Joshi R, Iqbal S, Wahlund C, Gabrielsson S, Harris R, Tegner J Human macrophages induce CD4(+)Foxp3(+) regulatory T cells via binding and re-release of TGF-beta. Immunol Cell Biol, 0;94(8):747-62. [PMID: 27075967] (Bioassay, Human)
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• TM Garcia-Bat, E Kim, F Concha-Ben, S Trivedi, RB Mailliard, A Gambotto, RL Ferris Enhanced Cytotoxic CD8 T Cell Priming Using Dendritic Cell-Expressing Human Papillomavirus-16 E6/E7-p16INK4 Fusion Protein with Sequenced Anti-Programmed Death-1 J. Immunol, 2016;196(6):2870-8. 2016-01-01 [PMID: 26851223] (Bioassay, Human)
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• Supper V, Schiller H, Paster W, Forster F, Boulegue C, Mitulovic G, Leksa V, Ohradanova-Repic A, Machacek C, Schatzlmaier P, Zlabinger G, Stockinger H Association of CD147 and Calcium Exporter PMCA4 Uncouples IL-2 Expression from Early TCR Signaling. J Immunol, 2016;196(3):1387-99. 2016-01-01 [PMID: 26729804] (Luminex Development, Human)
• Kostlin N, Hofstadter K, Ostermeir A, Spring B, Leiber A, Haen S, Abele H, Bauer P, Pollheimer J, Hartl D, Poets C, Gille C Granulocytic Myeloid-Derived Suppressor Cells Accumulate in Human Placenta and Polarize toward a Th2 Phenotype. J Immunol, 2016;196(3):1132-45. 2016-01-01 [PMID: 26712947] (Bioassay, Human)
• Chai S, Yap Y, Foo Y, Yap L, Ponniah S, Teo S, Cheong S, Patel V, Lim K Identification of Four-Jointed Box 1 (FJX1)-Specific Peptides for Immunotherapy of Nasopharyngeal Carcinoma. PLoS ONE, 2015;10(11):e0130464. 2015-01-01 [PMID: 26536470] (Bioassay, Human)
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• Sumption N, Goodhead D, Anderson R Alpha-Particle-Induced Complex Chromosome Exchanges Transmitted through Extra-Thymic Lymphopoiesis In Vitro Show Evidence of Emerging Genomic Instability. PLoS ONE, 2015;10(8):e0134046. 2015-01-01 [PMID: 26252014] (Bioassay, Human)
• Capuano C, Romanelli M, Pighi C, Cimino G, Rago A, Molfetta R, Paolini R, Santoni A, Galandrini R Anti-CD20 Therapy Acts via FcgammaRIIIA to Diminish Responsiveness of Human Natural Killer Cells. Cancer Res, 2015;75(19):4097-108. 2015-01-01 [PMID: 26229120] (Bioassay, Human)
• Fujiwara H, Ochi T, Ochi F, Miyazaki Y, Asai H, Narita M, Okamoto S, Mineno J, Kuzushima K, Shiku H, Yasukawa M Antileukemia multifunctionality of CD4(+) T cells genetically engineered by HLA class I-restricted and WT1-specific T-cell receptor gene transfer. Leukemia, 2015;29(12):2393-401. 2015-01-01 [PMID: 26104661] (Bioassay, Human)
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• Odorizzi P, Pauken K, Paley M, Sharpe A, Wherry E Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells. J Exp Med, 2015;212(7):1125-37. 2015-01-01 [PMID: 26034050] (Bioassay, Mouse)
• Cerino A, Bremer C, Glebe D, Mondelli M A Human Monoclonal Antibody against Hepatitis B Surface Antigen with Potent Neutralizing Activity. PLoS ONE, 2015;10(4):e0125704. 2015-01-01 [PMID: 25923526] (Bioassay, Human)
• Ling Y, Cypowyj S, Aytekin C, Galicchio M, Camcioglu Y, Nepesov S, Ikinciogullari A, Dogu F, Belkadi A, Levy R, Migaud M, Boisson B, Bolze A, Itan Y, Goudin N, Cottineau J, Picard C, Abel L, Bustamante J, Casanova J, Puel A Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis. J Exp Med, 2015;212(5):619-31. 2015-01-01 [PMID: 25918342] (Bioassay, Human)
• Li Y, Yan B, Wang H, Li H, Li Q, Zhao D, Chen Y, Zhang Y, Li W, Zhang J, Wang S, Shen J, Li Y, Guindi E, Zhao Y Hair regrowth in alopecia areata patients following Stem Cell Educator therapy. BMC Med, 2015;13(0):87. 2015-01-01 [PMID: 25896390] (Bioassay, Human)
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FAQs for IL-2 (202-IL). (Showing 1 - 1 of 1 FAQs).

1. we bought the rHIL-2 protein ref 202-IL-500 and it says that the reconstitution has to be done in acetic acid, but I need to use the protein in PBS, is that possible to reconstitute it directly in PBS instead? would it be stable?
   • It will not be soluble in PBS alone so 100 mM acetic acid is required for it to go into solution. Then you can dilute into PBS only and that should not affect your experimentation.

Bioinformatics

• Gene Symbol: IL2
• Uniprot:
  • P60568()