CD4 Products

Antibodies
Antibody Pairs
CD4 Antibody Pair [HRP]
CD4 Antibody Pair [HRP]
NBP2-79613
Species: Ma
Applications: ELISA, S-ELISA
Host: Mouse Monoclonal
Conjugate Catalog # Availability Size Price
ELISA Kits
Mouse CD4 ELISA Kit (Colorime ...
Mouse CD4 ELISA Kit (Colorimetric)
NBP2-75148
Species: Mu
Applications: ELISA
Human CD4 ELISA Kit (Colorime ...
Human CD4 ELISA Kit (Colorimetric)
NBP2-75145
Species: Hu
Applications: ELISA
Rat CD4 ELISA Kit (Colorimetr ...
Rat CD4 ELISA Kit (Colorimetric)
NBP2-75149
Species: Rt
Applications: ELISA
Lysates
CD4 Overexpression Lysate
CD4 Overexpression Lysate
NBP2-04168
Species: Hu
Applications: WB
Proteins
Recombinant Human CD4 Protein ...
Recombinant Human CD4 Protein
NBP2-50553
Species: Hu
Applications: PAGE
Recombinant Human sCD4 Protei ...
Recombinant Human sCD4 Protein
514-CD
Species: Hu
Applications: Bioactivity
Formulation Catalog # Availability Price  
Recombinant Human CD4 Protein ...
Recombinant Human CD4 Protein, CF
10327-CD
Species: Hu
Applications: Bioactivity
Formulation Catalog # Availability Price  

Description

CD4 (cluster of differentiation 4), also known as L3T4 or T4, is a 55 kDa single chain type I transmembrane glycoprotein belonging to the immunoglobin (Ig) superfamily. CD4 is predominantly expressed on most thymocytes, a subset of mature T lymphocytes, and weakly on monocytes, tissue macrophages, dendritic cells, and granulocytes. It is also expressed on neurons and glial cells in the brain (1). CD4 is expressed along with CD8 on double positive T cells during their development in the thymus. Either CD4 or CD8 expression is then lost giving rise to single positive (SP) CD4+ or CD8+ mature T cells. CD4+ SP cells (T helper cells) further differentiate into multiple subsets of CD4+ cells including Th1, Th2, Th17, Tfh, and Treg cells which regulate humoral and cellular immunity (2). The extracellular region of CD4 consists of 372 amino acids (aa) with four immunoglobin-like domains (D1-D4). The structures of D1 and D3 resemble variable (IgV) domains while D2 and D4 resemble constant (IgC) domains (3).

Given its critical role in T cell development, CD4 also has diverse immunology-related functions. CD4 acts as a coreceptor with the T-cell receptor (TCR) during T cell activation and thymic differentiation by binding directly to major histocompatibility complex (MHC) class II antigens and associating with the protein tyrosine kinase, Lck (4). This interaction contributes to the formation of the immunological synapse (5). Defects in antigen presentation cause dysfunction of CD4+ T cells and the almost complete loss of MHC II expression on B cells in peripheral blood, as observed in severe combined immunodeficiency (SCID) (6). CD4 also functions as a receptor for the human immunodeficiency virus (HIV) by binding to gp120, the envelope glycoprotein of HIV-1. It has been shown that the V-like domains are critical for binding to gp120 (7). In immune mediated and infectious diseases of the central nervous system, CD4 functions as an indirect mediator of neuronal damage (8).

References

1. Omri, B., Crisanti, P., Alliot, F., Marty, M., Rutin, J., Levallois, C.,... Pessac, B. (1994). CD4 expression in neurons of the central nervous system. International Immunology, 6(3), 377-385. doi:10.1093/intimm/6.3.377

2. Wan, Y. Y., & Flavell, R. A. (2009). How diverse-CD4 effector T cells and their functions. Journal of Molecular Cell Biology, 1(1), 20-36. doi:10.1093/jmcb/mjp001

3. Wu, H., Myszka, D. G., Tendian, S. W., Brouillette, C. G., Sweet, R. W., Chaiken, I. M., & Hendrickson, W. A. (1996). Kinetic and structural analysis of mutant CD4 receptors that are defective in HIV gp120 binding. Proceedings of the National Academy of Sciences, 93(26), 15030-15035. doi:10.1073/pnas.93.26.15030

4. Doyle, C., & Strominger, J. L. (1987). Interaction between CD4 and class II MHC molecules mediates cell adhesion. Nature, 330, 256-259. doi:10.1038/330256a0

5. Vignali, D. A. (2010). CD4 on the road to coreceptor status. The Journal of Immunology, 184(11), 5933-5934. doi:10.4049/jimmunol.1090037

6. Tasher, D., & Dalal, I. (2012). The genetic basis of severe combined immunodeficiency and its variants. The Application of Clinical Genetics, 5, 67-80. doi:10.2147/tacg.s18693

7. Arthos, J., Deen, K. C., Chaikin, M. A., Fornwald, J. A., Sathe, G., Sattentau, Q. J.,... Sweet, R. W. (1989). Identification of the residues in human CD4 critical for the binding of HIV. Cell, 57(3), 469-481. doi:10.1016/0092-8674(89)90922-7

8. Buttini, M., Westland, C. E., Masliah, E., Yafeh, A. M., Wyss-Coray, T., Mucke, L. (1998). Novel role of human cd4 molecule identified in neurodegeneration. Nature Medicine, 4(4), 441-446. doi:10.1038/nm0498-441

Bioinformatics

Entrez Human
Mouse
Rat
Monkey
Uniprot Human
Human
Product By Gene ID 920
Alternate Names
  • CD_antigen: CD4
  • CD4
  • CD4mut
  • CD4 antigen
  • T-cell surface antigen T4/Leu-3
  • T-cell surface glycoprotein CD4
  • CD4 antigen (p55)
  • CD4 receptor
  • CD4 molecule

Research Areas for CD4

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
CD Markers
Cell Biology
Cellular Markers
Cytokine Research
Immunology
Stem Cell Markers

Bioinformatics Tool for CD4

Discover related pathways, diseases and genes to CD4. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

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CD20 (Cluster of differentiation 20, Membrane-spanning 4-domains subfamily A member 1 (MS4A1), CVID5, B-lymphocyte surface antigen B1)
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CD8 alpha - Marker for cytotoxic T lymphocytes
The T-cell co-receptor CD8 is a cell-surface glycoprotein that bridges the lipid bilayer by interacting externally with ligands, such as major histocompatibility complex (MHC) class I, as well as internally with signaling molecules such as tyrosine ki...    Read more.
Lymphocyte activation gene 3 (LAG3): No lag time in immune response
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CD4 - An Important Co-receptor Assisting TCRs
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CD4, HIV and T Cell Signaling
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FOXP3: Master Regulatory Transcriptional Factor
FOXP3, a forkhead family transcription factor specially expressed in regulatory T (Treg) cells, controls the expression of many key immune-regulatory genes. Treg cells are a population of T lymphocytes that have critical roles in the immune system hom...    Read more.
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