Survivin Antibody (32.1) [PE]

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Product Details

Summary
Product Discontinued
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    • Catalog Number
      NB500-237PE
    • Availability
      Product Discontinued

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Survivin Antibody (32.1) [PE] Summary

Immunogen
Full length recombinant human Survivin [UniProt# O15392]
Epitope
The epitope recognized is between amino acids 3-19
Localization
Nuclear
Specificity
NB500-237 is specific for the nuclear form of survivin.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
BIRC5
Purity
Protein G purified
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Applications/Dilutions

Application Notes
This Survivin (32.1) antibody is useful for Immunocytochemistry/Immunofluorescence, Immunohistochemistry on paraffin-embedded sections and Western blot. ELISA was reported in scientific literature. By WB, this antibody recognizes a band at ~16.5 kDa representing Survivin. *The investigator should determine the optimal working dilution for a specific application.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
16.5 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human and hamster.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Survivin Antibody (32.1) [PE]

  • API4 survivin variant 3 alpha
  • API4
  • Apoptosis inhibitor 4 baculoviral IAP repeat-containing protein 5
  • Apoptosis inhibitor survivin
  • baculoviral IAP repeat-containing 5
  • BIRC5
  • EPR-1
  • IAP4
  • Survivin

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAQs for Survivin Antibody (NB500-237PE) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Biotin Labeled NB500-237B
DyLight 350 Labeled NB500-237UV
DyLight 405 Labeled NB500-237V
DyLight 488 Labeled NB500-237G
DyLight 550 Labeled NB500-237R
DyLight 650 Labeled NB500-237C
DyLight 680 Labeled NB500-237FR
DyLight 755 Labeled NB500-237IR
HRP Labeled NB500-237H

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Blogs on Survivin. Showing 1-10 of 14 blog posts - Show all blog posts.

Survivin - an inhibitor of apoptosis that drives tumorigenesis and metastasis
Untitled DocumentApoptosis is the tightly regulated process of programmed cell death. It plays an important role in normal physiologic development but has also been implicated in a number of diseases. Apoptosis is constantly downreg...  Read full blog post.

Survivin - an inhibitor of apoptosis protein
Survivin is an anti-apoptotic protein which is the smallest protein within a large family of proteins including X-linked IAP, c-IAP1 and 2, IAP-like protein-2, melanoma IAP, NAIP, and Livin. Survivin is responsible for a wide range of basic cellula...  Read full blog post.

Cytochrome C - a mediator of apoptosis
Cytochrome C is a small heme protein within the inner mitochondrial membrane responsible for carrying electrons within the respiratory transport chain.  Additionally, cytochrome c has also been identified as a player in programmed cell death (apop...  Read full blog post.

PCNA (Proliferating cell nuclear antigen, polymerase delta auxiliary protein)
PCNA is a nuclear protein essential for DNA replication as well as DNA excision and mismatch repair pathways. It coordinates the recruitment and association of needed components during both of these processes, both of which are essential for cell cycl...  Read full blog post.

Survivin is thrivin'
The survivin anti-apoptotic protein is the smallest member of a large family of proteins such as X-linked IAP, c-IAP1 and 2, IAP-like protein-2, melanoma IAP, Livin, and NAIP. Survivin regulates basic physiological events such as the cell cycle, tumor...  Read full blog post.

Livin: On a Prayer
Livin is a member of the inhibitor of apoptosis proteins (IAP) family that regulates programmed cell death. The Livin protein contains a single baculovirus IAP repeat (BIR) essential for function, along with a COOH-terminal RING-type zinc finger domai...  Read full blog post.

Survivin: As long as I know how to live I know I will
Survivin is an anti-apoptotic protein from a large family with related members such as X-linked IAP, cIAP1 and cIAP2, IAP-like protein-2, melanoma IAP, Livin, and NAIP. Survivin regulates fundamental physiological events including the cell cycle, feta...  Read full blog post.

Survivin: Infographic
Survivin is involved in promoting cell proliferation and is an inhibitor of apoptosis. Survivin has a critical role in cancer proliferation and neural development. It may have an impact on neural cell proliferative responses following brain injury.L...  Read full blog post.

TrkB: Bridging Ontogenesis and Oncogenesis
Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. Interaction of brain-derived neurotrophic factor (BDNF) with its...  Read full blog post.

Caspase 7: The Cell's Suicide Switch
Caspase 7 (also known as CASP7, Mch3, ICE-LAP3, CMH-1) is a member of caspase family of cysteine proteases. It is an apoptosis-related cystein peptidase encoded by the CASP7 gene in humans. CASP7 homologous sequences have been identified in nearly all...  Read full blog post.

Showing 1-10 of 14 blog posts - Show all blog posts.

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Bioinformatics

Gene Symbol BIRC5
Entrez