Integrin alpha V beta 3 Antibody (23C6)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, Func, IHC, IP, CyTOF-ready
Clone
23C6
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Integrin alpha V beta 3 Antibody (23C6) Summary

Immunogen
A cell suspension containing osteoclasts from osteoclastomas.
Localization
Cell Membrane
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
ITGAV
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10 - 1:1000
  • Functional
  • Immunohistochemistry 1:10 - 1:500
  • Immunoprecipitation 1:10 - 1:500
  • CyTOF-ready
Application Notes
125/124 kDa (reduced), 150kDa (non-reduced)
Publications
Read Publication using
NB100-2677 in the following applications:

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein A or G purified

Notes

Positive control(s): Tonsil.

Alternate Names for Integrin alpha V beta 3 Antibody (23C6)

  • antigen identified by monoclonal L230
  • CD51 antigen
  • CD51
  • Integrin alpha V beta 3
  • integrin alpha-V
  • integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
  • MSK8
  • Vitronectin receptor subunit alpha
  • VNRADKFZp686A08142

Background

Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha V beta 3 is the predominant integrin of osteoclasts (bone resorbing cells) and is upregulated in malignant melanoma. Integrin alpha V beta 3 binds to a range of ECM proteins (e.g. vitronectin, fibrinogen, fibronectin) via an Arg-Gly-Asp (RGD) motif.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Integrin alpha V beta 3 Antibody (NB100-2677)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: FLOW.


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FLOW
(1)
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Product General Protocols

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FAQs for Integrin alpha V beta 3 Antibody (NB100-2677) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NB100-2677AF405
Alexa Fluor 488 Labeled NB100-2677AF488
Alexa Fluor 647 Labeled NB100-2677AF647
Alexa Fluor 700 Labeled NB100-2677AF700
Allophycocyanin Labeled NB100-2677APC
DyLight 350 Labeled NB100-2677UV
DyLight 405 Labeled NB100-2677V
DyLight 488 Labeled NB100-2677G
DyLight 680 Labeled NB100-2677FR
DyLight 755 Labeled NB100-2677IR
PE Labeled NB100-2677PE
PerCP Labeled NB100-2677PCP

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Blogs on Integrin alpha V beta 3.

Integrin alpha v beta 3 - a target for inhibiting tumor angiogenesis
Integrins are a family of transmembrane proteins involved in diverse processes including cell adhesion, signal transduction, cell migration, and differentiation. They exist as heterodimers consisting of noncovalently linked alpha and beta subunits....  Read full blog post.

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Bioinformatics

Gene Symbol ITGAV
Entrez