Total MMP-2 Quantikine ELISA Kit

• Reactivity: Hu, Mu, Rt, Po, Ca
• Applications: ELISA
• Conjugate: HRP

Total MMP-2 Quantikine ELISA Kit Summary

• Background: The Quantikine Total MMP-2 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure MMP-2 in cell culture supernates, serum, and plasma. It contains NS0-expressed recombinant mouse/rat pro-MMP-2 and has been shown to accurately quantitate the recombinant factor. Results obtained using natural MMP-2 showed linear curves that were parallel to the standard curves obtained using the Quant...ikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring MMP-2.
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• Additional Information: For human, mouse, rat, porcine, and canine samples.
• Specificity: Recombinant MMP-2 and natural human, mouse, rat, porcine, and canine active, pro-, and TIMP complexed MMP-2.
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: MMP2

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Total MMP-2 Quantikine ELISA Kit

• 72 kDa gelatinase
• CLG4
• CLG4A72 kDa type IV collagenase
• collagenase type IV-A
• EC 3.4.24
• EC 3.4.24.24
• Gelatinase A
• matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IVcollagenase)
• matrix metalloproteinase 2 (gelatinase A, 72kD gelatinase, 72kD type IVcollagenase)
• Matrix metalloproteinase-2
• matrix metalloproteinase-II
• MMP2
• MMP-2
• MMP-II
• MONA
• neutrophil gelatinase
• TBE-1matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IVcollagenase)

Background

The matrix metalloproteinases (MMPs) consist of 24 known human zinc proteases with essential roles in breaking down components of the extracellular matrix (ECM). Additional MMP substrates include cytokines, chemokines, growth factors and binding proteins, cell/cell adhesion molecules, and other proteinases. With a few exceptions, MMPs share common structural motifs including a pro-peptide domain, a catalytic domain, a hinge region, and a hemopexin-like domain. Synthesized as pro-enzymes, most MMPs are secreted before conversion to their active form. MMP activities are modulated on several levels including transcription, pro-enzyme activation, or by their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). A subset of MMPs are associated with membranes and designated as membrane-type metalloproteinases (MT-MMP).

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for MMP-2 (MMP200)(95)

Publications using MMP200

• H Oue, Y Yamazaki, W Qiao, C Yuanxin, Y Ren, A Kurti, F Shue, TM Parsons, RB Perkerson, K Kawatani, N Wang, SC Starling, B Roy, IE Mosneag, T Aikawa, ML Holm, CC Liu, Y Inoue, PM Sullivan, YW Asmann, BY Kim, G Bu, T Kanekiyo LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4 JCI Insight, 2023-04-10;8(7):. 2023-04-10 [PMID: 37036005] (Mouse)
• J Kudelski, A Tokarzewic, M Gudowska-S, B Mroczko, P Ch?osta, M Bruczko-Go, P Mitura, G M?ynarczyk The Significance of Matrix Metalloproteinase 9 (MMP-9) and Metalloproteinase 2 (MMP-2) in Urinary Bladder Cancer Biomedicines, 2023-03-20;11(3):. 2023-03-20 [PMID: 36979935] (Human)
• L Ostrowska, J Smarkusz-Z, A Gornowicz, K Lendzion, B Zy?k, D Pogodzi?sk Analysis of Selected Salivary Adipokines and Cytokines in Patients with Obesity-A Pilot Study International Journal of Molecular Sciences, 2023-02-18;24(4):. 2023-02-18 [PMID: 36835557] (Human)
• B Zy?k, L Ostrowska, J Smarkusz-Z, K Witczak-Sa, A Gornowicz, A Bielawska Pro-Inflammatory Adipokine and Cytokine Profiles in the Saliva of Obese Patients with Non-Alcoholic Fatty Liver Disease (NAFLD)-A Pilot Study International Journal of Molecular Sciences, 2023-02-02;24(3):. 2023-02-02 [PMID: 36769216] (Human)
• A Radajewska, J Szyller, J Niewiadoms, A Noszczyk-N, I Bil-Lula Punica granatum L. Polyphenolic Extract as an Antioxidant to Prevent Kidney Injury in Metabolic Syndrome Rats Oxidative Medicine and Cellular Longevity, 2023-01-05;2023(0):6144967. 2023-01-05 [PMID: 36644578] (Rat)
• LY Wang, CS Tan, MKP Lai, S Hilal Factors Associated with RANTES, EMMPIRIN, MMP2 and MMP9, and the Association of These Biomarkers with Cardiovascular Disease in a Multi-Ethnic Population Journal of Clinical Medicine, 2022-12-08;11(24):. 2022-12-08 [PMID: 36555898] (Human)
• A Olejnik, A Krzywonos-, M Banaszkiew, I Bil-Lula Klotho Protein Decreases MMP-Mediated Degradation of Contractile Proteins during Ischaemia/Reperfusion Injury to the Cardiomyocytes International Journal of Molecular Sciences, 2022-12-07;23(24):. 2022-12-07 [PMID: 36555091] (Human)
• I Tsomidis, G Notas, C Xidakis, A Voumvourak, DN Samonakis, M Koulentaki, E Kouroumali Enzymes of Fibrosis in Chronic Liver Disease Biomedicines, 2022-12-08;10(12):. 2022-12-08 [PMID: 36551935] (Human)
• A Bahabayi, N Yang, T Xu, Y Xue, L Ma, X Gu, Y Wang, K Jia Expression of Matrix Metalloproteinase-2,-7,-9 in Serum during Pregnancy in Patients with Pre-Eclampsia: A Prospective Study International Journal of Environmental Research and Public Health, 2022-11-04;19(21):. 2022-11-04 [PMID: 36361378] (Human)
• TE Peterson, C Landon, SA Haberlen, F Bhondoekha, MW Plankey, FJ Palella, DA Piggott, JB Margolick, TT Brown, WS Post, KC Wu Circulating biomarker correlates of left atrial size and myocardial extracellular volume fraction among persons living with and without HIV BMC cardiovascular disorders, 2022-09-03;22(1):393. 2022-09-03 [PMID: 36057773] (Human)
• D Weng, T Han, J Dong, M Zhang, Y Mi, Y He, X Li, X Zhu Angiogenin and MMP-2 as potential biomarkers in the differential diagnosis of gestational trophoblastic diseases Medicine, 2022-02-04;101(5):e28768. 2022-02-04 [PMID: 35119039] (Human)
• EE Abd El-Fat, S Saber, ME Youssef, H Eissa, E El-Ahwany, NA Amin, M Alqarni, GE Batiha, AJ Obaidullah, MMY Kaddah, AG Ahmed Gaaf, AAE Mourad, G Mostafa-He, AM Abdelhamid AKT-AMPKalpha-mTOR-dependent HIF-1alpha Activation is a New Therapeutic Target for Cancer Treatment: A Novel Approach to Repositioning the Antidiabetic Drug Sitagliptin for the Management of Hepatocellular Carcinoma Frontiers in Pharmacology, 2022-01-12;12(0):720173. 2022-01-12 [PMID: 35095479] (Mouse)
• MM Ali, I Mirza, D Naquiallah, C Hassan, M Masrur, FM Bianco, AM Mahmoud CD147 Levels in Blood and Adipose Tissues Correlate with Vascular Dysfunction in Obese Diabetic Adults Journal of cardiovascular development and disease, 2021-12-28;9(1):. 2021-12-28 [PMID: 35050217] (Human)
• MK Nisiewicz, A Gajda, A Kowalczyk, A Cupriak, A Kasprzak, M Bamburowic, IP Grudzinski, AM Nowicka Novel electrogravimetric biosensors for the ultrasensitive detection of plasma matrix metalloproteinase-2 considered a potential tumor biomarker Analytica chimica acta, 2021-11-19;1191(0):339290. 2021-11-19 [PMID: 35033237] (Rat)
• C Jiguet-Jig, S Boissonnea, E Denicolai, V Hein, R Lasseur, J Garcia, S Romain, R Appay, T Graillon, W Mason, AF Carpentier, AA Brandes, L' Ouafik, W Wick, A Baaziz, JP Gigan, RJ Argüello, D Figarella-, O Chinot, E Tabouret Plasmatic MMP9 released from tumor-infiltrating neutrophils is predictive for bevacizumab efficacy in glioblastoma patients: an AVAglio ancillary study Acta neuropathologica communications, 2022-01-03;10(1):1. 2022-01-03 [PMID: 34980260] (Human)
• S Ancona, E Orpianesi, C Bernardell, E Chiaramont, R Chiaramont, S Terraneo, F Di Marco, E Lesma Differential Modulation of Matrix Metalloproteinases-2 and -7 in LAM/TSC Cells Biomedicines, 2021-11-24;9(12):. 2021-11-24 [PMID: 34944575] (Human)
• D Bakkalci, A Jay, A Rezaei, CA Howard, HJ Haugen, J Pape, S Kishida, M Kishida, G Jell, TR Arnett, S Fedele, U Cheema Bioengineering the ameloblastoma tumour to study its effect on bone nodule formation Scientific Reports, 2021-12-16;11(1):24088. 2021-12-16 [PMID: 34916549] (Human, Rat)
• EGJ Ripmeester, MMJ Caron, GGH van den Ak, J Steijns, DAM Surtel, A Cremers, LCW Peeters, LW van Rhijn, TJM Welting BMP7 reduces the fibrocartilage chondrocyte phenotype Scientific Reports, 2021-10-04;11(1):19663. 2021-10-04 [PMID: 34608249] (Human)
• X Yue, Y Qian, L Zhu, B Gim, M Bao, J Jia, S Jing, Y Wang, C Tan, F Bottanelli, P Ziltener, S Choi, P Hao, I Lee ACBD3 modulates KDEL receptor interaction with PKA for its trafficking via tubulovesicular carrier Bmc Biology, 2021-09-07;19(1):194. 2021-09-07 [PMID: 34493279] (Human)
• M Banaszkiew, A Olejnik, A Krzywonos-, K Ha?ucha, I Bil-Lula Expression of atrial?fetal light chains in cultured human cardiomyocytes after chemical ischemia?reperfusion injury Molecular Medicine Reports, 2021-09-07;24(5):. 2021-09-07 [PMID: 34490485] (Human)
• K Wadowska, P B?asiak, A Rzechonek, I Bil-Lula, M ?liwi?ska- New Insights on Old Biomarkers Involved in Tumor Microenvironment Changes and Their Diagnostic Relevance in Non-Small Cell Lung Carcinoma Biomolecules, 2021-08-13;11(8):. 2021-08-13 [PMID: 34439874] (Human)
• SE Huang, E Sulistyowa, YY Chao, BN Wu, ZK Dai, JH Hsu, JL Yeh In Vitro Evaluation of the Anti-Inflammatory Effect of KMUP-1 and In Vivo Analysis of Its Therapeutic Potential in Osteoarthritis Biomedicines, 2021-05-28;9(6):. 2021-05-28 [PMID: 34071594] (Mouse)
• M Jamka, P Bogda?ski, P Krzy?anows, A Mi?kiewicz, J Karolkiewi, M Du?-?uchow, R M?dry, A Lisowska, A Gotz-Wi?ck, S Iskakova, J Walkowiak, E M?dry Endurance Training Depletes Antioxidant System but Does Not Affect Endothelial Functions in Women with Abdominal Obesity: A Randomized Trial with a Comparison to Endurance-Strength Training Journal of Clinical Medicine, 2021-04-12;10(8):. 2021-04-12 [PMID: 33921520] (Human)
• Y Yuan, H Naito, K Kitamori, S Hashimoto, T Asano, T Nakajima The antihypertensive agent hydralazine reduced extracellular matrix synthesis and liver fibrosis in nonalcoholic steatohepatitis exacerbated by hypertension PLoS ONE, 2020-12-14;15(12):e0243846. 2020-12-14 [PMID: 33315911] (Rat)
• Q Liang, Q Lin, Y Li, W Luo, X Huang, Y Jiang, C Qin, J Nong, X Chen, SR Sooranna, L Pinhu Effect of SIS3 on Extracellular Matrix Remodeling and Repair in a Lipopolysaccharide-Induced ARDS Rat Model Journal of Immunology Research, 2020-11-25;2020(0):6644687. 2020-11-25 [PMID: 33294466] (Rat)
• A Waszczykow, M Podgórski, M Waszczykow, Z Gerlicz-Ko, P Jurowski Matrix Metalloproteinases MMP-2 and MMP-9, Their Inhibitors TIMP-1 and TIMP-2, Vascular Endothelial Growth Factor and sVEGFR-2 as Predictive Markers of Ischemic Retinopathy in Patients with Systemic Sclerosis-Case Series Report Int J Mol Sci, 2020-11-18;21(22):. 2020-11-18 [PMID: 33218057] (Human)
• MMS Balla, S Patwardhan, PK Melwani, P Purwar, A Kumar, CS Pramesh, S Laskar, BN Pandey Prognosis of metastasis based on age and serum analytes after follow-up of non-metastatic lung cancer patients Transl Oncol, 2020-11-11;14(1):100933. 2020-11-11 [PMID: 33188981] (Human)
• M Banaszkiew, A Krzywonos-, A Olejnik, I Bil-Lula Tissue Expression of Atrial and Ventricular Myosin Light Chains in the Mechanism of Adaptation to Oxidative Stress Int J Mol Sci, 2020-11-09;21(21):. 2020-11-09 [PMID: 33182231] (Rat)
• T Phillips, L Huitema, R Cepeda, DL Cobos, RIM Perez, MS Garza, F Ringpfeil, B Dasgeb, J Uitto, JC Salas-Alan, V Alexeev, O Igoucheva Aberrant recruitment of leukocytes defines poor wound healing in patients with recessive dystrophic epidermolysis bullosa J Dermatol Sci, 2020-10-17;0(0):. 2020-10-17 [PMID: 33143962] (Human)
• JJ Noh, MS Kim, YJ Cho, SY Jeong, YY Lee, JY Ryu, JJ Choi, I Bae, Z Wu, BG Kim, JR Hwang, JW Lee Anti-Cancer Activity of As4O6 and its Efficacy in a Series of Patient-Derived Xenografts for Human Cervical Cancer Pharmaceutics, 2020-10-19;12(10):. 2020-10-19 [PMID: 33086573] (Human)
• E Saba, SH Kim, YY Lee, HK Kim, SS Roh, YS Kwak, CK Park, SD Kim, MH Rhee Anti-Melanogenic Effects of Korean Red Ginseng Oil in an Ultraviolet B-Induced Hairless Mouse Model Molecules, 2020-10-16;25(20):. 2020-10-16 [PMID: 33081281] (Mouse)
• G Morad, CC Daisy, HH Otu, TA Libermann, ST Dillon, MA Moses Cdc42-Dependent Transfer of mir301 from Breast Cancer-Derived Extracellular Vesicles Regulates the Matrix Modulating Ability of Astrocytes at the Blood-Brain Barrier Int J Mol Sci, 2020-05-28;21(11):. 2020-05-28 [PMID: 32481745] (Mouse)
• T Nii, K Makino, Y Tabata A cancer invasion model of cancer-associated fibroblasts aggregates combined with TGF-&beta1 release system Regen Ther, 2020-03-04;14(0):196-204. 2020-03-04 [PMID: 32154334] (Human)
• YY Liu, SY Wang, YN Li, WJ Bian, LQ Zhang, YH Li, L Long, X Liu, XW Zhang, ZG Li Activity of fibroblast-like synoviocytes in rheumatoid arthritis was impaired by dickkopf-1 targeting siRNA Chin. Med. J., 2020-03-20;0(6):679-686. 2020-03-20 [PMID: 32068606] (Human)
• A Schröder, S Kriesen, G Hildebrand, K Manda First Insights into the Effect of Low-Dose X-Ray Irradiation in Adipose-Derived Stem Cells Int J Mol Sci, 2019-12-02;20(23):. 2019-12-02 [PMID: 31810198] (Human)
• YL Chuang, HW Fang, A Ajitsaria, KH Chen, CY Su, GS Liu, CL Tseng Development of Kaempferol-Loaded Gelatin Nanoparticles for the Treatment of Corneal Neovascularization in Mice Pharmaceutics, 2019-11-28;11(12):. 2019-11-28 [PMID: 31795237] (Mouse)
• A Kobus, J Bagi?ska, J ?api?ska-A, S ?awicki, A Kierklo Levels of Selected Matrix Metalloproteinases, Their Inhibitors in Saliva, and Oral Status in Juvenile Idiopathic Arthritis Patients vs. Healthy Controls Biomed Res Int, 2019-10-28;2019(0):7420345. 2019-10-28 [PMID: 31781639] (Human)
• S Simón Serr, A Grönberg, L Longato, K Rombouts, J Kuo, M Gregory, S Moss, E Elmér, G Mazza, P Gallay, M Pinzani, MJ Hansson, R Massoumi Evaluation of NV556, a Novel Cyclophilin Inhibitor, as a Potential Antifibrotic Compound for Liver Fibrosis Cells, 2019-11-08;8(11):. 2019-11-08 [PMID: 31717385] (Human)
• Y Sun, Y Xiao, H Sun, Z Zhao, J Zhu, L Zhang, J Dong, T Han, Q Jing, J Zhou, Z Jing miR-27a regulates vascular remodeling by targeting endothelial cells' apoptosis and interaction with vascular smooth muscle cells in aortic dissection Theranostics, 2019-10-18;9(25):7961-7975. 2019-10-18 [PMID: 31695809] (Human)
• M Aoki, K Koga, M Miyazaki, M Hamasaki, N Koshikawa, M Oyama, H Kozuka-Hat, M Seiki, BP Toole, K Nabeshima CD73 complexes with emmprin to regulate MMP-2 production from co-cultured sarcoma cells and fibroblasts BMC Cancer, 2019-09-12;19(1):912. 2019-09-12 [PMID: 31510956] (Human)
• DP Zhang, YF Peng, HL Zhang, JG Ma, M Zhao, S Yin, TT Wei Basilar Artery Tortuosity Is Associated With White Matter Hyperintensities by TIMP-1 Front Neurosci, 2019-08-14;13(0):836. 2019-08-14 [PMID: 31474817] (Human)
• B Singh, N Ghosh, D Saha, S Sarkar, P Bhattachar, K Chaudhury Effect of doxycyline in chronic obstructive pulmonary disease - An exploratory study Pulm Pharmacol Ther, 2019-07-24;0(0):101831. 2019-07-24 [PMID: 31349003] (Human)
• N Hao, TT Chiou, CH Wu, YY Lei, PL Liang, MC Chao, H Yang, JB Chen Longitudinal Changes of PAI-1, MMP-2, and VEGF in Peritoneal Effluents and Their Associations with Peritoneal Small-Solute Transfer Rate in New Peritoneal Dialysis Patients Biomed Res Int, 2019-05-05;2019(0):2152584. 2019-05-05 [PMID: 31192253] (Human)
• M Kunin, V Carmon, P Beckerman, D Dinour Effect of Peritoneal Dialysis on Serum Fibrosis Biomarkers in Patients with Refractory Congestive Heart Failure Int J Mol Sci, 2019-05-28;20(11):. 2019-05-28 [PMID: 31141909] (Human)
• Y Xie, Y Wang, H Ding, M Guo, X Wang, Q Dong, M Cui Highly glycosylated CD147 promotes hemorrhagic transformation after rt-PA treatment in diabetes: a novel therapeutic target? J Neuroinflammation, 2019-04-05;16(1):72. 2019-04-05 [PMID: 30953513] (Mouse)
• J Yuan, S Wu, Y Wang, S Pan, P Wang, L Cheng Inflammatory cytokines in highly myopic eyes Sci Rep, 2019-03-05;9(1):3517. 2019-03-05 [PMID: 30837544] (Human)
• AE Bulboac?, AS Porfire, LR Tefas, PM Boarescu, SD Bolboac?, IC St?nescu, AC Bulboac?, G Dogaru Liposomal Curcumin is Better than Curcumin to Alleviate Complications in Experimental Diabetic Mellitus Molecules, 2019-02-27;24(5):. 2019-02-27 [PMID: 30818888] (Rat)
• R Schmitt, A Tscheuschl, P Laschinski, X Uffelmann, P Discher, J Fuchs, M Kreibich, R Peyronnet, FA Kari A potential key mechanism in ascending aortic aneurysm development: Detection of a linear relationship between MMP-14/TIMP-2 ratio and active MMP-2 PLoS ONE, 2019-02-22;14(2):e0212859. 2019-02-22 [PMID: 30794673] (Human)
• A Krzywonos-, A Franczak, A Olejnik, M Radomski, JF Gilmer, G Sawicki, M Wo?niak, I Bil-Lula Cardioprotective effect of MMP-2-inhibitor-NO-donor hybrid against ischaemia/reperfusion injury J. Cell. Mol. Med., 2019-02-07;0(0):. 2019-02-07 [PMID: 30729745] (Rat)
• H Yogasundar, A Nikhanj, BN Putko, M Boutin, S Jain-Ghai, A Khan, C Auray-Blai, ML West, GY Oudit Elevated Inflammatory Plasma Biomarkers in Patients With Fabry Disease: A Critical Link to Heart Failure With Preserved Ejection Fraction J Am Heart Assoc, 2018-11-06;7(21):e009098. 2018-11-06 [PMID: 30571380] (Human)
• DC Woodworth, A Dagher, A Curatolo, M Sachdev, C Ashe-McNal, BD Naliboff, JS Labus, JR Landis, JJ Kutch, EA Mayer, RS Lee, MA Moses, BM Ellingson Changes in brain white matter structure are associated with urine proteins in urologic chronic pelvic pain syndrome (UCPPS): A MAPP Network study PLoS ONE, 2018-12-05;13(12):e0206807. 2018-12-05 [PMID: 30517112] (Human)
• CK Wu, MM Su, YF Wu, JJ Hwang, LY Lin Combination of Plasma Biomarkers and Clinical Data for the Detection of Myocardial Fibrosis or Aggravation of Heart Failure Symptoms in Heart Failure with Preserved Ejection Fraction Patients J Clin Med, 2018-11-08;7(11):. 2018-11-08 [PMID: 30413105] (Human)
• S Zeng, B Zhu, J Zeng, W Wu, C Jiang Zeylenone represses the progress of human prostate cancer by downregulating the Wnt/??catenin pathway Mol Med Rep, 2018-10-17;0(0):. 2018-10-17 [PMID: 30365080] (Human)
• K Sugimoto, T Nakamura, T Tokunaga, Y Uehara, T Okada, T Taniwaki, T Fujimoto, H Mizuta Matrix metalloproteinase promotes elastic fiber degradation in ligamentum flavum degeneration PLoS ONE, 2018-08-01;13(8):e0200872. 2018-08-01 [PMID: 30067795] (Mouse)
• XF Huang, SZ Zhang, YY You, N Zhang, H Lu, A Daugherty, XJ Xie Ginkgo biloba extracts prevent aortic rupture in angiotensin II-infused hypercholesterolemic mice Acta Pharmacol. Sin., 2018-05-18;0(0):. 2018-05-18 [PMID: 29777203] (Mouse)
• O Dörr, C Walther, C Liebetrau, T Keller, H Tabert, N Boeder, M Bayer, P Bauer, H Möllmann, L Gaede, C Troidl, S Voss, T Bauer, CW Hamm, H Nef Specific biomarkers of myocardial inflammation and remodeling processes as predictors of mortality in high-risk patients undergoing percutaneous mitral valve repair (MitraClip) Clin Cardiol, 2018-04-17;0(0):. 2018-04-17 [PMID: 29663512] (Human)
• RG Rempe, AMS Hartz, ELB Soldner, BS Sokola, SR Alluri, EL Abner, RJ Kryscio, A Pekcec, J Schlichtig, B Bauer Matrix Metalloproteinase-Mediated Blood-Brain Barrier Dysfunction in Epilepsy J. Neurosci., 2018-04-09;0(0):. 2018-04-09 [PMID: 29632167] (Rat)
• F Mayyas, R Jaradat, KH Alzoubi Cardiac effects of fish oil in a rat model of streptozotocin-induced diabetes Nutr Metab Cardiovasc Dis, 2018-02-25;0(0):. 2018-02-25 [PMID: 29615288] (Rat)
• S Shanmugana, VN Sumantran, N Angayarkan Epigallocatechin gallate & curcumin prevent transforming growth factor beta 1-induced epithelial to mesenchymal transition in ARPE-19 cells Indian J. Med. Res., 2017-11-01;146(0):S85-S96. 2017-11-01 [PMID: 29578200] (Human)
• C Robinson, L Tsang, A Solomon, AJ Woodiwiss, S Gunter, M Mer, HC Hsu, M Gomes, GR Norton, AME Millen, PH Dessein Nesfatin-1 and visfatin expression is associated with reduced atherosclerotic disease risk in patients with rheumatoid arthritis Peptides, 2018-02-21;102(0):31-37. 2018-02-21 [PMID: 29475075] (Human)
• J Ma, D Li, FF Kong, D Yang, H Yang, XX Ma miR-302a-5p/367-3p-HMGA2 axis regulates malignant processes during endometrial cancer development J. Exp. Clin. Cancer Res., 2018-02-01;37(1):19. 2018-02-01 [PMID: 29391048] (Human)
• W Szcz?sny, M Kuligowska, S D?browieck, J Szmytkowsk, A Re?li?ski, M S?upski Activity of metalloproteinases and adiponectin in obese patients-a possible factor of incisional hernias after bariatric procedures J Zhejiang Univ Sci B, 2018-01-01;19(1):65-70. 2018-01-01 [PMID: 29308609] (ELISA Capture, Human)
• Y Tie, C Zhai, Y Zhang, X Qin, F Yu, H Li, M Shan, C Zhang CCAAT/enhancer-binding protein ? overexpression alleviates myocardial remodelling by regulating angiotensin-converting enzyme-2 expression in diabetes J. Cell. Mol. Med., 2017-12-21;0(0):. 2017-12-21 [PMID: 29266779] (Mouse)
• A Bao, KF Che, S Bozinovski, J Ji, JA Gregory, S Kumlien Ge, M Adner, LO Cardell, A Lindén Recombinant human IL-26 facilitates the innate immune response to endotoxin in the bronchoalveolar space of mice in vivo PLoS ONE, 2017-12-05;12(12):e0188909. 2017-12-05 [PMID: 29206862] (Mouse)
• W Zhang, P Zhou, A Meng, R Zhang, Y Zhou Down-regulating Myoferlin inhibits the vasculogenic mimicry of�melanoma via decreasing MMP-2 and inducing mesenchymal-to-epithelial transition J. Cell. Mol. Med., 2017-11-22;0(0):. 2017-11-22 [PMID: 29164766] (Human)
• CN Ajaero, CR Chong, NEK Procter, S Liu, YY Chirkov, T Heresztyn, WPA Chan, MA Arstall, AD McGavigan, MP Frenneaux, JD Horowitz Does cardiac resynchronization therapy restore peripheral circulatory homeostasis? ESC Heart Fail, 2017-10-13;5(1):129-138. 2017-10-13 [PMID: 29030923] (ELISA Capture, Human)
• IS Song, YJ Jeong, JH Park, S Shim, SW Jang Chebulinic acid inhibits smooth muscle cell migration by suppressing PDGF-R? phosphorylation and inhibiting matrix metalloproteinase-2 expression Sci Rep, 2017-09-18;7(1):11797. 2017-09-18 [PMID: 28924208] (Human)
• SH Kim, HJ Choi, WK Yang, JE Lee, JH Cho, IJ Park, S Park, BK Park, M Jin Suppressive Effect of the n-Hexane Extract of Litsea japonica Fruit Flesh on Monosodium-Iodoacetate-Induced Osteoarthritis in Rats Evid Based Complement Alternat Med, 2017-08-22;2017(0):1791403. 2017-08-22 [PMID: 28904551] (Rat)
• J Ibarrola, E Martínez-M, JR Sádaba, V Arrieta, A García-Peñ, V Álvarez, A Fernández-, A Gainza, P Rossignol, V Cachofeiro, N López-Andr Beneficial Effects of Galectin-3 Blockade in Vascular and Aortic Valve Alterations in an Experimental Pressure Overload Model Int J Mol Sci, 2017-07-31;18(8):. 2017-07-31 [PMID: 28758988] (Rat)
• M Skerenova, V Mikulova, O Capoun, T Zima, P Tesarova Circulating tumor cells and serum levels of MMP-2, MMP-9 and VEGF as markers of the metastatic process in patients with high risk of metastatic progression Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 2017-05-16;0(0):. 2017-05-16 [PMID: 28529342] (Human)
• X Wang, Y Zhang, L Zhou, R Wei, L Dong Comparison of fibrin glue and Vicryl sutures in conjunctival autografting for pterygium surgery Mol. Vis., 2017-04-19;23(0):275-285. 2017-04-19 [PMID: 28465659] (Human)
• ME Niño, SE Serrano, DC Niño, DM McCosham, ME Cardenas, VP Villareal, M Lopez, A Pazin-Filh, FA Jaimes, F Cunha, R Schulz, D Torres-Due TIMP1 and MMP9 are predictors of mortality in septic patients in the emergency department and intensive care unit unlike MMP9/TIMP1 ratio: Multivariate model PLoS ONE, 2017-02-13;12(2):e0171191. 2017-02-13 [PMID: 28192449] (Human)
• R Melchionna, P Iapicca, F Di Modugno, P Trono, I Sperduti, M Fassan, I Cataldo, BC Rusev, RT Lawlor, MG Diodoro, M Milella, GL Grazi, MJ Bissell, A Scarpa, P Nisticò The pattern of hMENA isoforms is regulated by TGF-?1 in pancreatic cancer and may predict patient outcome Oncoimmunology, 2016-08-12;5(12):e1221556. 2016-08-12 [PMID: 28123868] (Human)
• A Mobley, S Zhang, J Bondaruk, Y Wang, T Majewski, NP Caraway, L Huang, E Shoshan, G Velazquez-, G Nitti, S Lee, JG Lee, E Fuentes-Ma, D Willis, L Zhang, CC Guo, H Yao, K Baggerly, Y Lotan, SP Lerner, C Dinney, D McConkey, M Bar-Eli, B Czerniak Aurora Kinase A is a Biomarker for Bladder Cancer Detection and Contributes to its Aggressive Behavior Sci Rep, 2017-01-19;7(0):40714. 2017-01-19 [PMID: 28102366] (Human)
• Ilias P Doulamis A sirtuin 1/MMP2 prognostic index for myocardial infarction in patients with advanced coronary artery disease Int. J. Cardiol, 2016-12-23;0(0):. 2016-12-23 [PMID: 28043667] (Human)
• Concomitant elevations of MMP-9, NGAL, proMMP-9/NGAL and neutrophil elastase in serum of smokers with chronic obstructive pulmonary disease J. Cell. Mol. Med, 2016-12-22;0(0):. 2016-12-22 [PMID: 28004483] (Human)
• Differential diagnosis of lung cancer, its metastasis and chronic obstructive pulmonary disease based on serum Vegf, Il-8 and MMP-9 Sci Rep, 2016-11-04;6(0):36065. 2016-11-04 [PMID: 27811960] (Human)
• MMP-2 Isoforms in Aortic Tissue and Serum of Patients with Ascending Aortic Aneurysms and Aortic Root Aneurysms PLoS ONE, 2016-11-01;11(11):e0164308. 2016-11-01 [PMID: 27802285] (Human)
• CP-25, a novel compound, protects against autoimmune arthritis by modulating immune mediators of inflammation and bone damage Sci Rep, 2016-05-17;6(0):26239. 2016-05-17 [PMID: 27184722] (Rat)
• W Qin, Y Tsukasaki, S Dasgupta, N Mukhopadhy, M Ikebe, ER Sauter Exosomes in Human Breast Milk Promote EMT Clin Cancer Res, 2016-04-08;0(0):. 2016-04-08 [PMID: 27060153] (Human)
• H Kang, DH Ahn, JH Pak, KH Seo, NI Baek, SW Jang Magnobovatol inhibits smooth muscle cell migration by suppressing PDGF-R? phosphorylation and inhibiting matrix metalloproteinase-2 expression Int J Mol Med, 2016-04-04;37(5):1239-46. 2016-04-04 [PMID: 27049716] (Human)
• Kmiecik A, Pula B, Suchanski J, Olbromski M, Gomulkiewicz A, Owczarek T, Kruczak A, Ambicka A, Rys J, Ugorski M, Podhorska-Okolow M, Dziegiel P Metallothionein-3 Increases Triple-Negative Breast Cancer Cell Invasiveness via Induction of Metalloproteinase Expression. PLoS ONE, 2015-05-01;10(5):e0124865. 2015-05-01 [PMID: 25933064] (Human)
• Sivasankar S, Lavanya R, Brindha P, Angayarkanni N Aqueous and alcoholic extracts of Triphala and their active compounds chebulagic acid and chebulinic acid prevented epithelial to mesenchymal transition in retinal pigment epithelial cells, by inhibiting SMAD-3 phosphorylation. PLoS ONE, 2015-03-20;10(3):e0120512. 2015-03-20 [PMID: 25793924] (Human)
• Ekstrom E, Bergenfelz C, von Bulow V, Serifler F, Carlemalm E, Jonsson G, Andersson T, Leandersson K WNT5A induces release of exosomes containing pro-angiogenic and immunosuppressive factors from malignant melanoma cells. Mol Cancer, 2014-04-26;13(0):88. 2014-04-26 [PMID: 24766647] (Human)
• Naik , Pooja, Fofaria , Neel, Prasad , Shikha, Sajja , Ravi K, Weksler , Babette, Couraud , Pierre-O, Romero , Ignacio, Cucullo , Luca Oxidative and pro-inflammatory impact of regular and denicotinized cigarettes on blood brain barrier endothelial cells: is smoking reduced or nicotine-free products really safe? BMC Neurosci, 2014-04-23;15(0):51. 2014-04-23 [PMID: 24755281] (Human)
• Huang Z, Tan N, Guo W, Wang L, Li H, Zhang T, Liu X, Xu Q, Li J, Guo Z Overexpression of EMMPRIN isoform 2 is associated with head and neck cancer metastasis. PLoS ONE, 2014-04-04;9(4):e91596. 2014-04-04 [PMID: 24705283] (Human)
• Gomez I, Benyahia C, Louedec L, Leseche G, Jacob M, Longrois D, Norel X Decreased PGE(2) content reduces MMP-1 activity and consequently increases collagen density in human varicose vein. PLoS ONE, 2014-02-05;9(2):e88021. 2014-02-05 [PMID: 24505358]
• Braicu E, Gasimli K, Richter R, Nassir M, Kummel S, Blohmer J, Yalcinkaya I, Chekerov R, Ignat I, Ionescu A, Mentze M, Fotopoulou C, Pop C, Lichtenegger W, Sehouli J Role of serum VEGFA, TIMP2, MMP2 and MMP9 in monitoring response to adjuvant radiochemotherapy in patients with primary cervical cancer--results of a companion protocol of the randomized NOGGO-AGO phase III clinical trial. Anticancer Res, 2014-01-01;34(1):385-91. 2014-01-01 [PMID: 24403492] (Human)
• Choi , Jong Ho, Jung , Jieun, Na , Kyu-Hwan, Cho , Kyung Ji, Yoon , Tae Ki, Kim , Gi Jin Effect of mesenchymal stem cells and extracts derived from the placenta on trophoblast invasion and immune responses. Stem Cells Dev, 2013-10-19;23(2):132-45. 2013-10-19 [PMID: 24138604] (Human)
• D'Arcy , Colleen, Feeney , Sandra J, McLean , Catriona, Gehrig , Stefan M, Lynch , Gordon S, Smith , Jaclyn E, Cowling , Belinda, Mitchell , Christin, McGrath , Meagan J Identification of FHL1 as a therapeutic target for Duchenne muscular dystrophy. Hum Mol Genet, 2013-09-18;23(3):618-36. 2013-09-18 [PMID: 24087791] (Human)
• Raghuwanshi S, Smith N, Rivers E, Thomas A, Sutton N, Hu Y, Mukhopadhyay S, Chen X, Leung T, Richardson R G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis. J Immunol, 2013-04-15;190(10):5329-36. 2013-04-15 [PMID: 23589623] (Mouse)
• Bakalova R, Zhelev Z, Aoki I, Saga T Tissue redox activity as a hallmark of carcinogenesis: from early to terminal stages of cancer. Clin Cancer Res, 2013-03-26;19(9):2503-17. 2013-03-26 [PMID: 23532887] (Mouse)
• Braicu E, Fotopoulou C, Chekerov R, Richter R, Blohmer J, Kummel S, Stamatian F, Yalcinkaya I, Mentze M, Lichtenegger W, Sehouli J Role of serum concentration of VEGFR1 and TIMP2 on clinical outcome in primary cervical cancer: results of a companion protocol of the randomized, NOGGO-AGO phase III adjuvant trial of simultaneous cisplatin-based radiochemotherapy vs. carboplatin and paclitaxel containing sequential radiotherapy. Cytokine, 2013-02-14;61(3):755-8. 2013-02-14 [PMID: 23415672] (Human)
• Awla D, Abdulla A, Syk I, Jeppsson B, Regner S, Thorlacius H Neutrophil-derived matrix metalloproteinase-9 is a potent activator of trypsinogen in acinar cells in acute pancreatitis. J. Leukoc. Biol., 2011-11-18;91(5):711-9. 2011-11-18 [PMID: 22100390] (Mouse)
• Kim DY, Park JW, Jeoung D, Ro JY Celastrol suppresses allergen-induced airway inflammation in a mouse allergic asthma model. Eur. J. Pharmacol., 2009-04-05;612(1):98-105. 2009-04-05 [PMID: 19356734] (Mouse)

Bioinformatics

• Gene Symbol: MMP2