Total MMP-2 Quantikine ELISA Kit

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Product Details

Summary
Reactivity Hu, Mu, Rt, Po, CaSpecies Glossary
Applications ELISA
Conjugate
HRP

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Catalog# & Conjugate Size Price

Total MMP-2 Quantikine ELISA Kit Summary

Background
The Quantikine Total MMP-2 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure MMP-2 in cell culture supernates, serum, and plasma. It contains NS0-expressed recombinant mouse/rat pro-MMP-2 and has been shown to accurately quantitate the recombinant factor. Results obtained using natural MMP-2 showed linear curves that were parallel to the standard curves obtained using the Quant...ikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring MMP-2.
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Additional Information
For human, mouse, rat, porcine, and canine samples.
Specificity
Recombinant MMP-2 and natural human, mouse, rat, porcine, and canine active, pro-, and TIMP complexed MMP-2.
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
MMP2

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using
MMP200 in the following applications:

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Total MMP-2 Quantikine ELISA Kit

  • 72 kDa gelatinase
  • CLG4
  • CLG4A72 kDa type IV collagenase
  • collagenase type IV-A
  • EC 3.4.24
  • EC 3.4.24.24
  • Gelatinase A
  • matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IVcollagenase)
  • matrix metalloproteinase 2 (gelatinase A, 72kD gelatinase, 72kD type IVcollagenase)
  • Matrix metalloproteinase-2
  • matrix metalloproteinase-II
  • MMP2
  • MMP-2
  • MMP-II
  • MONA
  • neutrophil gelatinase
  • TBE-1matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IVcollagenase)

Background

The matrix metalloproteinases (MMPs) consist of 24 known human zinc proteases with essential roles in breaking down components of the extracellular matrix (ECM). Additional MMP substrates include cytokines, chemokines, growth factors and binding proteins, cell/cell adhesion molecules, and other proteinases. With a few exceptions, MMPs share common structural motifs including a pro-peptide domain, a catalytic domain, a hinge region, and a hemopexin-like domain. Synthesized as pro-enzymes, most MMPs are secreted before conversion to their active form. MMP activities are modulated on several levels including transcription, pro-enzyme activation, or by their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). A subset of MMPs are associated with membranes and designated as membrane-type metalloproteinases (MT-MMP).

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for MMP-2 (MMP200)(80)

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Rat Plasma.

We have publications tested in 1 application: ELISA Capture.


Filter By Application
ELISA Capture
(2)
All Applications
Filter By Species
Human
(57)
Mouse
(13)
Rat
(9)
Rat Plasma
(1)
All Species
Showing Publications 1 - 10 of 80. Show All 80 Publications.
Publications using MMP200 Applications Species
MM Ali, I Mirza, D Naquiallah, C Hassan, M Masrur, FM Bianco, AM Mahmoud CD147 Levels in Blood and Adipose Tissues Correlate with Vascular Dysfunction in Obese Diabetic Adults Journal of cardiovascular development and disease, 2021;9(1):. 2021 [PMID: 35050217] (Human) Human
MK Nisiewicz, A Gajda, A Kowalczyk, A Cupriak, A Kasprzak, M Bamburowic, IP Grudzinski, AM Nowicka Novel electrogravimetric biosensors for the ultrasensitive detection of plasma matrix metalloproteinase-2 considered a potential tumor biomarker Analytica chimica acta, 2022;1191(0):339290. 2022 [PMID: 35033237] (Rat Plasma) Rat Plasma
S Ancona, E Orpianesi, C Bernardell, E Chiaramont, R Chiaramont, S Terraneo, F Di Marco, E Lesma Differential Modulation of Matrix Metalloproteinases-2 and -7 in LAM/TSC Cells Biomedicines, 2021;9(12):. 2021 [PMID: 34944575] (Human) Human
D Bakkalci, A Jay, A Rezaei, CA Howard, HJ Haugen, J Pape, S Kishida, M Kishida, G Jell, TR Arnett, S Fedele, U Cheema Bioengineering the ameloblastoma tumour to study its effect on bone nodule formation Scientific Reports, 2021;11(1):24088. 2021 [PMID: 34916549] (Human) Human
EGJ Ripmeester, MMJ Caron, GGH van den Ak, J Steijns, DAM Surtel, A Cremers, LCW Peeters, LW van Rhijn, TJM Welting BMP7 reduces the fibrocartilage chondrocyte phenotype Scientific Reports, 2021;11(1):19663. 2021 [PMID: 34608249] (Human) Human
X Yue, Y Qian, L Zhu, B Gim, M Bao, J Jia, S Jing, Y Wang, C Tan, F Bottanelli, P Ziltener, S Choi, P Hao, I Lee ACBD3 modulates KDEL receptor interaction with PKA for its trafficking via tubulovesicular carrier Bmc Biology, 2021;19(1):194. 2021 [PMID: 34493279] (Human) Human
M Banaszkiew, A Olejnik, A Krzywonos-, K Ha?ucha, I Bil-Lula Expression of atrial?fetal light chains in cultured human cardiomyocytes after chemical ischemia?reperfusion injury Molecular Medicine Reports, 2021;24(5):. 2021 [PMID: 34490485] (Human) Human
K Wadowska, P B?asiak, A Rzechonek, I Bil-Lula, M ?liwi?ska- New Insights on Old Biomarkers Involved in Tumor Microenvironment Changes and Their Diagnostic Relevance in Non-Small Cell Lung Carcinoma Biomolecules, 2021;11(8):. 2021 [PMID: 34439874] (Human) Human
SE Huang, E Sulistyowa, YY Chao, BN Wu, ZK Dai, JH Hsu, JL Yeh In Vitro Evaluation of the Anti-Inflammatory Effect of KMUP-1 and In Vivo Analysis of Its Therapeutic Potential in Osteoarthritis Biomedicines, 2021;9(6):. 2021 [PMID: 34071594] (Mouse) Mouse
M Jamka, P Bogda?ski, P Krzy?anows, A Mi?kiewicz, J Karolkiewi, M Du?-?uchow, R M?dry, A Lisowska, A Gotz-Wi?ck, S Iskakova, J Walkowiak, E M?dry Endurance Training Depletes Antioxidant System but Does Not Affect Endothelial Functions in Women with Abdominal Obesity: A Randomized Trial with a Comparison to Endurance-Strength Training Journal of Clinical Medicine, 2021;10(8):. 2021 [PMID: 33921520] (Human) Human
Show All 80 Publications.

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Bioinformatics Tool for MMP-2 (MMP200)

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Blogs on MMP-2.

MMP-2: More Than a Cancer Marker
Matrix metalloproteinases (MMP) are a family of endopeptidases involved in the breakdown of extracellular matrix (ECM) during both normal physiological and disease processes. MMP-2 is a zinc-dependent family member that selectively cleaves collagen...  Read full blog post.

CD63: is it pro-metastatic or anti-metastatic?
CD63 is a type II membrane protein belonging to tetraspanin superfamily and it play key roles in the activation of several cellular signaling cascades along with acting as TIMP1 receptor. It is expressed by activated platelets, monocytes,...  Read full blog post.

Integrin alpha v beta 3 - a target for inhibiting tumor angiogenesis
Integrins are a family of transmembrane proteins involved in diverse processes including cell adhesion, signal transduction, cell migration, and differentiation. They exist as heterodimers consisting of noncovalently linked alpha and beta subunits....  Read full blog post.

Cytokeratin 18 - A Intermediate Filament Cyotskeletal Component
Keratins, also called cytokeratins, are a family of filamentous structural proteins that form the intermediate filaments within epithelial cells. Keratins are differentially expressed depending on both the epithelial cell origin and degree of differen...  Read full blog post.

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Bioinformatics

Gene Symbol MMP2