Total MMP-2 Quantikine ELISA Kit



Product Details

Reactivity Hu, Mu, Rt, Po, CaSpecies Glossary
Applications ELISA

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Total MMP-2 Quantikine ELISA Kit Summary

The Quantikine Total MMP-2 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure MMP-2 in cell culture supernates, serum, and plasma. It contains NS0-expressed recombinant mouse/rat pro-MMP-2 and has been shown to accurately quantitate the recombinant factor. Results obtained using natural MMP-2 showed linear curves that were parallel to the standard curves obtained using the Quant...ikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring MMP-2.
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Additional Information
For human, mouse, rat, porcine, and canine samples.
Recombinant MMP-2 and natural human, mouse, rat, porcine, and canine active, pro-, and TIMP complexed MMP-2.
Assay Type
Solid Phase Sandwich ELISA
See PDF Datasheet for details
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details


Application Notes
No significant interference observed with available related molecules.
Read Publications using
MMP200 in the following applications:

Packaging, Storage & Formulations

Store the unopened product at 2 - 8 °C. Do not use past expiration date.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Total MMP-2 Quantikine ELISA Kit

  • 72 kDa gelatinase
  • CLG4
  • CLG4A72 kDa type IV collagenase
  • collagenase type IV-A
  • EC 3.4.24
  • EC
  • Gelatinase A
  • matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IVcollagenase)
  • matrix metalloproteinase 2 (gelatinase A, 72kD gelatinase, 72kD type IVcollagenase)
  • Matrix metalloproteinase-2
  • matrix metalloproteinase-II
  • MMP2
  • MMP-2
  • MMP-II
  • MONA
  • neutrophil gelatinase
  • TBE-1matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IVcollagenase)


The matrix metalloproteinases (MMPs) consist of 24 known human zinc proteases with essential roles in breaking down components of the extracellular matrix (ECM). Additional MMP substrates include cytokines, chemokines, growth factors and binding proteins, cell/cell adhesion molecules, and other proteinases. With a few exceptions, MMPs share common structural motifs including a pro-peptide domain, a catalytic domain, a hinge region, and a hemopexin-like domain. Synthesized as pro-enzymes, most MMPs are secreted before conversion to their active form. MMP activities are modulated on several levels including transcription, pro-enzyme activation, or by their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). A subset of MMPs are associated with membranes and designated as membrane-type metalloproteinases (MT-MMP).

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to

Publications for MMP-2 (MMP200)(95)

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 1 application: ELISA Capture.

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Showing Publications 1 - 10 of 95. Show All 95 Publications.
Publications using MMP200 Applications Species
H Oue, Y Yamazaki, W Qiao, C Yuanxin, Y Ren, A Kurti, F Shue, TM Parsons, RB Perkerson, K Kawatani, N Wang, SC Starling, B Roy, IE Mosneag, T Aikawa, ML Holm, CC Liu, Y Inoue, PM Sullivan, YW Asmann, BY Kim, G Bu, T Kanekiyo LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4 JCI Insight, 2023-04-10;8(7):. 2023-04-10 [PMID: 37036005] (Mouse) Mouse
J Kudelski, A Tokarzewic, M Gudowska-S, B Mroczko, P Ch?osta, M Bruczko-Go, P Mitura, G M?ynarczyk The Significance of Matrix Metalloproteinase 9 (MMP-9) and Metalloproteinase 2 (MMP-2) in Urinary Bladder Cancer Biomedicines, 2023-03-20;11(3):. 2023-03-20 [PMID: 36979935] (Human) Human
L Ostrowska, J Smarkusz-Z, A Gornowicz, K Lendzion, B Zy?k, D Pogodzi?sk Analysis of Selected Salivary Adipokines and Cytokines in Patients with Obesity-A Pilot Study International Journal of Molecular Sciences, 2023-02-18;24(4):. 2023-02-18 [PMID: 36835557] (Human) Human
B Zy?k, L Ostrowska, J Smarkusz-Z, K Witczak-Sa, A Gornowicz, A Bielawska Pro-Inflammatory Adipokine and Cytokine Profiles in the Saliva of Obese Patients with Non-Alcoholic Fatty Liver Disease (NAFLD)-A Pilot Study International Journal of Molecular Sciences, 2023-02-02;24(3):. 2023-02-02 [PMID: 36769216] (Human) Human
A Radajewska, J Szyller, J Niewiadoms, A Noszczyk-N, I Bil-Lula Punica granatum L. Polyphenolic Extract as an Antioxidant to Prevent Kidney Injury in Metabolic Syndrome Rats Oxidative Medicine and Cellular Longevity, 2023-01-05;2023(0):6144967. 2023-01-05 [PMID: 36644578] (Rat) Rat
LY Wang, CS Tan, MKP Lai, S Hilal Factors Associated with RANTES, EMMPIRIN, MMP2 and MMP9, and the Association of These Biomarkers with Cardiovascular Disease in a Multi-Ethnic Population Journal of Clinical Medicine, 2022-12-08;11(24):. 2022-12-08 [PMID: 36555898] (Human) Human
A Olejnik, A Krzywonos-, M Banaszkiew, I Bil-Lula Klotho Protein Decreases MMP-Mediated Degradation of Contractile Proteins during Ischaemia/Reperfusion Injury to the Cardiomyocytes International Journal of Molecular Sciences, 2022-12-07;23(24):. 2022-12-07 [PMID: 36555091] (Human) Human
I Tsomidis, G Notas, C Xidakis, A Voumvourak, DN Samonakis, M Koulentaki, E Kouroumali Enzymes of Fibrosis in Chronic Liver Disease Biomedicines, 2022-12-08;10(12):. 2022-12-08 [PMID: 36551935] (Human) Human
A Bahabayi, N Yang, T Xu, Y Xue, L Ma, X Gu, Y Wang, K Jia Expression of Matrix Metalloproteinase-2,-7,-9 in Serum during Pregnancy in Patients with Pre-Eclampsia: A Prospective Study International Journal of Environmental Research and Public Health, 2022-11-04;19(21):. 2022-11-04 [PMID: 36361378] (Human) Human
TE Peterson, C Landon, SA Haberlen, F Bhondoekha, MW Plankey, FJ Palella, DA Piggott, JB Margolick, TT Brown, WS Post, KC Wu Circulating biomarker correlates of left atrial size and myocardial extracellular volume fraction among persons living with and without HIV BMC cardiovascular disorders, 2022-09-03;22(1):393. 2022-09-03 [PMID: 36057773] (Human) Human
Show All 95 Publications.

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MMP-2: More Than a Cancer Marker
Matrix metalloproteinases (MMP) are a family of endopeptidases involved in the breakdown of extracellular matrix (ECM) during both normal physiological and disease processes. MMP-2 is a zinc-dependent family member that selectively cleaves collagen...  Read full blog post.

CD63: is it pro-metastatic or anti-metastatic?
CD63 is a type II membrane protein belonging to tetraspanin superfamily and it play key roles in the activation of several cellular signaling cascades along with acting as TIMP1 receptor. It is expressed by activated platelets, monocytes,...  Read full blog post.

Integrin alpha v beta 3 - a target for inhibiting tumor angiogenesis
Integrins are a family of transmembrane proteins involved in diverse processes including cell adhesion, signal transduction, cell migration, and differentiation. They exist as heterodimers consisting of noncovalently linked alpha and beta subunits....  Read full blog post.

Cytokeratin 18 - A Intermediate Filament Cyotskeletal Component
Keratins, also called cytokeratins, are a family of filamentous structural proteins that form the intermediate filaments within epithelial cells. Keratins are differentially expressed depending on both the epithelial cell origin and degree of differen...  Read full blog post.

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Gene Symbol MMP2