Integrin alpha V beta 3 Products

Description

Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha V beta 3 is the predominant integrin of osteoclasts (bone resorbing cells) and is upregulated in malignant melanoma. Integrin alpha V beta 3 binds to a range of ECM proteins (e.g. vitronectin, fibrinogen, fibronectin) via an Arg-Gly-Asp (RGD) motif.

Bioinformatics

Entrez	3685 Human
Product By Gene ID	3685
Alternate Names	antigen identified by monoclonal L230 CD51 antigen CD51 integrin alpha-V integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) MSK8 Vitronectin receptor subunit alpha VNRADKFZp686A08142

Research Areas for Integrin alpha V beta 3

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Cytoskeleton Markers
Extracellular Matrix
Signal Transduction

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Integrin alpha v beta 3 - a target for inhibiting tumor angiogenesis Integrins are a family of transmembrane proteins involved in diverse processes including cell adhesion, signal transduction, cell migration, and differentiation. They exist as heterodimers consisting of noncovalently linked alpha and beta subunits....    Read more.

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