Recombinant Human FGF basic/FGF2/bFGF (146 aa) Protein

• Reactivity: Hu
• Applications: Bioactivity

Recombinant Human FGF basic/FGF2/bFGF (146 aa) Protein Summary

• Details of Functionality: Measured in a cell proliferation assay using NR6R‑3T3 mouse fibroblast cells. Raines, E.W. et al. (1985) Methods Enzymol. 109:749. The ED₅₀ for this effect is 0.1-0.6 ng/mL.
• Source: E. coli-derived human FGF basic/FGF2/bFGF protein
  Pro143-Ser288, with an N-terminal Ala
• Accession #: P09038
• N-terminal Sequence: Ala-Pro143
• Protein/Peptide Type: Recombinant Proteins
• Gene: FGF2
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Endotoxin Note: <0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 16.5 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• SDS-PAGE: 17 kDa, reducing conditions

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in Tris-HCl and NaCl with BSA as a carrier protein.
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution Instructions: Reconstitute at 100-250 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human FGF basic/FGF2/bFGF (146 aa) Protein

• basic fibroblast growth factor bFGF
• Basic fibroblast growth factor
• bFGF
• FGF basic
• FGF2
• FGF-2
• FGFBprostatropin
• fibroblast growth factor 2 (basic)
• HBGF-2
• heparin-binding growth factor 2
• Prostatropin

Background

FGF basic (also known as FGF-2 and HBGF-2) is a member of the FGF superfamily of mitogenic proteins which show 35-60% amino acid conservation. FGF acidic and basic are unique from other members of the family in that they lack classical secretory signal peptides. However, they are both readily secreted from cells by an alternative secretory pathway involving direct translocation and aided by several chaperones. FGF acidic (FGF-1) and FGF basic (FGF-2) were the first two identified FGFs, and the designations acidic and basic refer to their relative isoelectric points. The full length human FGF basic protein is 288 amino acids, but there are multiple start sites which produce various shorter forms. Further adding to the complexity, a variety of forms of FGF basic are produced as a result of N-terminal extensions. These extensions affect localization of FGF basic in cellular compartments but do not affect biological activity. FGF basic has been isolated from a number of sources, including neural tissue, adrenal cortex, pituitary gland, corpus luteum, and placenta. Binding of FGF to heparin or cell surface heparan sulfate proteoglycans is required for FGF binding with high affinity to FGF receptors. FGF basic stimulates proliferation of all cells of mesodermal origin as well as many cells of neuroectodermal, ectodermal, and endodermal origin. FGF basic also induces neuronal differentiation, survival, and regeneration, and modulates embryonic development and differentiation. These observed in vitro functions suggest FGF basic may play a role in vivo in the modulation of such normal processes as angiogenesis, wound healing and tissue repair, embryonic development and differentiation, and neuronal function and neural degeneration. Additionally, FGF basic may also participate in the development of several pathological conditions resulting from excessive cell proliferation and/or angiogenesis.

1. Coulier, F. et al. (1997) J. Mol. Evol. 44:43.
2. Chen, C.H. et al. (2004) Curr. Vasc. Pharmacol. 2:33.
3. Mohammadi, M. et al. (2005) Curr. Opin. Struct. Biol. 15:506.
4. Fernig, D. et al. (1994) Prog. Growth Factor Res. 5:353.

Publications for FGF basic/FGF2/bFGF (233-FB)(513)

Publications using 233-FB

• Majd, H;Amin, S;Ghazizadeh, Z;Cesiulis, A;Arroyo, E;Lankford, K;Majd, A;Farahvashi, S;Chemel, AK;Okoye, M;Scantlen, MD;Tchieu, J;Calder, EL;Le Rouzic, V;Shibata, B;Arab, A;Goodarzi, H;Pasternak, G;Kocsis, JD;Chen, S;Studer, L;Fattahi, F; Deriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy Cell stem cell 2023-05-04 [PMID: 37146583] (Bioassay, Human)
• Hartmann, J;Henschel, N;Bartmann, K;D�nmez, A;Brockerhoff, G;Koch, K;Fritsche, E; Molecular and Functional Characterization of Different BrainSphere Models for Use in Neurotoxicity Testing on Microelectrode Arrays Cells 2023-04-27 [PMID: 37174670] (Stimulation, Human)
• Matkovic Leko, I;Schneider, RT;Thimraj, TA;Schrode, N;Beitler, D;Liu, HY;Beaumont, K;Chen, YW;Snoeck, HW; A distal lung organoid model to study interstitial lung disease, viral infection and human lung development Nature protocols 2023-05-10 [PMID: 37165073] (Bioassay, Human)
• AA Almad, L Garcia, A Takanohash, A Gagne, W Yang, J Ann McGuir, D French, A Vanderver Generation of three induced Pluripotent Stem Cell lines from individuals with Hypomyelination with Atrophy of Basal Ganglia and Cerebellum caused by a c.745G&gt;A (p.D249N) autosomal dominant mutation in TUBB4A Stem Cell Research, 2023-03-26;69(0):103083. 2023-03-26 [PMID: 37003180] (Bioassay, Human)
• Y Fan, J Hackland, A Baggiolini, LY Hung, H Zhao, P Zumbo, P Oberst, AP Minotti, E Hergenrede, S Najjar, Z Huang, NM Cruz, A Zhong, M Sidharta, T Zhou, E de Stanchi, D Betel, RM White, M Gershon, KG Margolis, L Studer hPSC-derived sacral neural crest enables rescue in a severe model of Hirschsprung&#039;s disease Cell Stem Cell, 2023-03-02;30(3):264-282.e9. 2023-03-02 [PMID: 36868194] (Bioassay, Human)
• Y Fan, J Hackland, A Baggiolini, LY Hung, H Zhao, P Zumbo, P Oberst, AP Minotti, E Hergenrede, S Najjar, Z Huang, NM Cruz, A Zhong, M Sidharta, T Zhou, E de Stanchi, D Betel, RM White, M Gershon, KG Margolis, L Studer hPSC-derived sacral neural crest enables rescue in a severe model of Hirschsprung&#039;s disease Cell Stem Cell, 2023;30(3):264-282.e9. 2023 [PMID: 36868194] (Bioassay, Human)
• NB Campbell, Y Patel, TL Moore, M Medalla, E Zeldich Extracellular Vesicle Treatment Alleviates Neurodevelopmental and Neurodegenerative Pathology in Cortical Spheroid Model of Down Syndrome International Journal of Molecular Sciences, 2023-02-09;24(4):. 2023-02-09 [PMID: 36834891] (Bioassay, Human)
• AR Dicks, GI Maksaev, Z Harissa, A Savadipour, R Tang, N Steward, W Liedtke, CG Nichols, CL Wu, F Guilak Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes Elife, 2023-02-22;12(0):. 2023-02-22 [PMID: 36810131] (Bioassay, Human)
• JM Gonzalez-M, S Ivins, CL Andoniadou, P Le Tissier, P Scambler, JP Martinez-B An expression and function analysis of the CXCR4/SDF-1 signalling axis during pituitary gland development PLoS ONE, 2023-02-17;18(2):e0280001. 2023-02-17 [PMID: 36800350] (Bioassay, Mouse)
• EF Cohn, BLL Clayton, M Madhavan, S Yacoub, Y Federov, K Paul-Fried, TJ Shafer, PJ Tesar Pervasive environmental chemicals impair oligodendrocyte development bioRxiv : the preprint server for biology, 2023-02-12;0(0):. 2023-02-12 [PMID: 36798415] (Bioassay, Human, Mouse)
• L Pang, M Dunterman, W Xuan, A Gonzalez, Y Lin, WH Hsu, F Khan, RS Hagan, WA Muller, AB Heimberger, P Chen Circadian regulator CLOCK promotes tumor angiogenesis in glioblastoma Cell Reports, 2023-02-14;42(2):112127. 2023-02-14 [PMID: 36795563] (Bioassay, Human)
• RC Gimple, G Zhang, S Wang, T Huang, J Lee, S Taori, D Lv, D Dixit, ME Halbert, AR Morton, RL Kidwell, Z Dong, BC Prager, L Kim, Z Qiu, L Zhao, Q Xie, Q Wu, S Agnihotri, JN Rich Sorting-nexin-10 sustains platelet-derived growth factor receptor signaling in glioblastoma stem cells via endosomal protein sorting JCI Insight, 2023-03-22;0(0):. 2023-03-22 [PMID: 36795488] (Bioassay, Human)
• L Feige, T Kozaki, G Dias de Me, V Guillemot, F Larrous, F Ginhoux, H Bourhy Susceptibilities of CNS Cells towards Rabies Virus Infection Is Linked to Cellular Innate Immune Responses Viruses, 2022-12-29;15(1):. 2022-12-29 [PMID: 36680128] (Bioassay, Human)
• B Xu, H Shimauchi-, Y Yoshimoto, T Sadakata, Y Ishizaki Transplanted human iPSC-derived vascular endothelial cells promote functional recovery by recruitment of regulatory T cells to ischemic white matter in the brain Journal of Neuroinflammation, 2023-01-17;20(1):11. 2023-01-17 [PMID: 36650518] (Bioassay, Human)
• N Wang, J He, X Feng, S Liao, Y Zhao, F Tang, K Kee Single-cell profiling of lncRNAs in human germ cells and molecular analysis reveals transcriptional regulation of LNC1845 on LHX8 Elife, 2023-01-05;12(0):. 2023-01-05 [PMID: 36602025] (Bioassay, Human)
• M Chuai, G Serrano Ná, M Serra, L Mahadevan, CJ Weijer Reconstruction of distinct vertebrate gastrulation modes via modulation of key cell behaviors in the chick embryo Science Advances, 2023-01-04;9(1):eabn5429. 2023-01-04 [PMID: 36598979] (Bioassay, Chick)
• SC Lin, YC Liao, PM Chen, YY Yang, YH Wang, SL Tung, CM Chuang, YW Sung, TH Jang, SE Chuang, LH Wang Periostin promotes ovarian cancer metastasis by enhancing M2 macrophages and cancer-associated fibroblasts via integrin-mediated NF-kappaB and TGF-beta2 signaling Journal of Biomedical Science, 2022-12-22;29(1):109. 2022-12-22 [PMID: 36550569] (Cell Culture, Human)
• C Degorre, IC Sutton, SL Lehman, UT Shankavara, K Camphausen, PJ Tofilon Glioblastoma cells have increased capacity to repair radiation-induced DNA damage after migration to the olfactory bulb Cancer Cell International, 2022-12-08;22(1):389. 2022-12-08 [PMID: 36482431] (Cell Culture, Human)
• JE Kaserman, RB Werder, F Wang, T Matte, MI Higgins, M Dodge, J Lindstrom-, P Bawa, A Hinds, E Bullitt, IS Caballero, X Shi, RE Gerszten, N Brunetti-P, M Liesa, C Villacorta, AN Hollenberg, DN Kotton, AA Wilson Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity Cell Reports, 2022-12-06;41(10):111775. 2022-12-06 [PMID: 36476855] (Bioassay, Human)
• AA Widjaja, S Viswanatha, SG Shekeran, E Adami, WW Lim, S Chothani, J Tan, JWT Goh, HM Chen, SY Lim, CM Boustany-K, J Hawkins, E Petretto, N Hübner, S Schafer, TM Coffman, SA Cook Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease Nature Communications, 2022-12-05;13(1):7497. 2022-12-05 [PMID: 36470928] (Bioassay, Human)
• HF Wu, W Yu, K Saito-Diaz, CW Huang, J Carey, F Lefcort, GW Hart, HX Liu, N Zeltner Norepinephrine transporter defects lead to sympathetic hyperactivity in Familial Dysautonomia models Nature Communications, 2022-11-17;13(1):7032. 2022-11-17 [PMID: 36396637] (Bioassay, Human)
• M Fujita, MM Chen, DR Siwak, S Sasagawa, A Oosawa-Tat, K Arihiro, A Ono, R Miura, K Maejima, H Aikata, M Ueno, S Hayami, H Yamaue, K Chayama, JS Lee, Y Lu, GB Mills, H Liang, SS Nishizuka, H Nakagawa Proteo-genomic characterization of virus-associated liver cancers reveals potential subtypes and therapeutic targets Nature Communications, 2022-10-29;13(1):6481. 2022-10-29 [PMID: 36309506] (Bioassay, Human)
• JH Song, J Choi, YJ Hong, H La, TK Hong, K Hong, JT Do Developmental Potency and Metabolic Traits of Extended Pluripotency Are Faithfully Transferred to Somatic Cells via Cell Fusion-Induced Reprogramming Cells, 2022-10-17;11(20):. 2022-10-17 [PMID: 36291134] (Bioassay, Human)
• AN Cho, F Bright, N Morey, C Au, LM Ittner, YD Ke Efficient Gene Expression in Human Stem Cell Derived-Cortical Organoids Using Adeno Associated Virus Cells, 2022-10-11;11(20):. 2022-10-11 [PMID: 36291062] (Bioassay, Human)
• VR Herrera Mi, B Canciani, L Mangiavini, JFS Filipe, L Aidos, M Pallaoro, GM Peretti, P Pocar, SC Modina, A Di Giancam Endostatin in 3D Fibrin Hydrogel Scaffolds Promotes Chondrogenic Differentiation in Swine Neonatal Meniscal Cells Biomedicines, 2022-09-27;10(10):. 2022-09-27 [PMID: 36289678] (Bioassay, Porcine)
• H Wang, B Keepers, Y Qian, Y Xie, M Colon, J Liu, L Qian Cross-lineage potential of Ascl1 uncovered by comparing diverse reprogramming regulatomes Cell Stem Cell, 2022-10-06;29(10):1491-1504.e9. 2022-10-06 [PMID: 36206732] (Bioassay, Mouse)
• P Dong, GE Hoffman, P Apontes, J Bendl, S Rahman, MB Fernando, B Zeng, JM Vicari, W Zhang, K Girdhar, KG Townsley, R Misir, CommonMind, KJ Brennand, V Haroutunia, G Voloudakis, JF Fullard, P Roussos Population-level variation in enhancer expression identifies disease mechanisms in the human brain Nature Genetics, 2022-09-26;54(10):1493-1503. 2022-09-26 [PMID: 36163279] (Bioassay, Human)
• D Yang, J Gomez-Garc, S Funakoshi, T Tran, I Fernandes, GD Bader, MA Laflamme, GM Keller Modeling human multi-lineage heart field development with pluripotent stem cells Cell Stem Cell, 2022-09-01;29(9):1382-1401.e8. 2022-09-01 [PMID: 36055193] (Bioassay, Human)
• Y Tang, DJ Kwiatkowsk, EP Henske Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment Nature Communications, 2022-08-26;13(1):5018. 2022-08-26 [PMID: 36028490] (Bioassay, Mouse)
• S Martin, KC Allan, O Pinkard, T Sweet, PJ Tesar, J Coller Oligodendrocyte differentiation alters tRNA modifications and codon optimality-mediated mRNA decay Nature Communications, 2022-08-25;13(1):5003. 2022-08-25 [PMID: 36008413] (Bioassay, Mouse)
• K Kishimoto, K Iwasawa, A Sorel, C Ferran-Her, L Han, M Morimoto, JM Wells, T Takebe, AM Zorn Directed differentiation of human pluripotent stem cells into diverse organ-specific mesenchyme of the digestive and respiratory systems Nature Protocols, 2022-08-17;0(0):. 2022-08-17 [PMID: 35978039] (Cell Culture, Human)
• D Hao, L Lu, H Song, Y Duan, J Chen, R Carney, JJ Li, P Zhou, J Nolta, KS Lam, JK Leach, DL Farmer, A Panitch, A Wang Engineered extracellular vesicles with high collagen-binding affinity present superior in situ retention and therapeutic efficacy in tissue repair Theranostics, 2022-08-08;12(13):6021-6037. 2022-08-08 [PMID: 35966577] (Cell Culture, Human)
• Q Ma, Y Xiao, W Xu, M Wang, S Li, Z Yang, M Xu, T Zhang, ZN Zhang, R Hu, Q Su, F Yuan, T Xiao, X Wang, Q He, J Zhao, ZJ Chen, Z Sheng, M Chai, H Wang, W Shi, Q Deng, X Cheng, W Li ZnT8 loss-of-function accelerates functional maturation of hESC-derived beta cells and resists metabolic stress in diabetes Nature Communications, 2022-07-16;13(1):4142. 2022-07-16 [PMID: 35842441] (Bioassay, Human)
• CW Lee, YF Chen, AW Hsiao, AY Wang, OY Shen, BY Wang, LWC Ho, WT Lin, CHJ Choi, OK Lee Demystifying the long noncoding RNA landscape of small EVs derived from human mesenchymal stromal cells Journal of advanced research, 2021-11-19;39(0):73-88. 2021-11-19 [PMID: 35777918] (Bioassay, Human)
• MK Eltahir, M Nakamori, S Hattori, T Kimura, H Mochizuki, S Nagano Pharmacotherapy alleviates pathological changes in human direct reprogrammed neuronal cell model of myotonic dystrophy type 1 PLoS ONE, 2022-07-01;17(7):e0269683. 2022-07-01 [PMID: 35776705] (Bioassay, Human)
• Y Tsujisaka, T Hatani, C Okubo, R Ito, A Kimura, M Narita, K Chonabayas, S Funakoshi, A Lucena-Cac, T Toyoda, K Osafune, T Kimura, H Saito, Y Yoshida Purification of human iPSC-derived cells at large scale using microRNA switch and magnetic-activated cell sorting Stem Cell Reports, 2022-06-09;0(0):. 2022-06-09 [PMID: 35688152] (Bioassay, Human)
• MK Samanta, S Gayen, C Harris, E Maclary, Y Murata-Nak, RM Malcore, RS Porter, PM Garay, CN Vallianato, PB Samollow, S Iwase, S Kalantry Activation of Xist by an evolutionarily conserved function of KDM5C demethylase Nature Communications, 2022-05-11;13(1):2602. 2022-05-11 [PMID: 35545632] (Bioassay, Mouse)
• M Cloutier, S Kumar, E Buttigieg, L Keller, B Lee, A Williams, S Mojica-Per, I Erliandri, AMD Rocha, K Cadigan, GD Smith, S Kalantry Preventing erosion of X-chromosome inactivation in human embryonic stem cells Nature Communications, 2022-05-06;13(1):2516. 2022-05-06 [PMID: 35523820] (Bioassay, Mouse)
• C Rodriguez-, N Kale, MJ Carlini, N Shrivastav, AA Rodrigues, B Khalil, JJ Bravo-Cord, M Alexander, J Ji, Y Hong, F Behbod, MS Sosa NR2F1 is a barrier to dissemination of early stage breast cancer cells Cancer Research, 2022-06-15;0(0):. 2022-06-15 [PMID: 35471456] (Cell Culture, Mouse)
• Y Quan, M Wang, C Xu, X Wang, Y Wu, D Qin, Y Lin, X Lu, F Lu, L Li Cnot8 eliminates na�ve regulation networks and is essential for na�ve-to-formative pluripotency transition Nucleic Acids Research, 2022-05-06;0(0):. 2022-05-06 [PMID: 35390160] (Bioassay, Mouse)
• BK Gage, S Merlin, C Olgasi, A Follenzi, GM Keller Therapeutic correction of hemophilia A by transplantation of hPSC-derived liver sinusoidal endothelial cell progenitors Cell Reports, 2022-04-05;39(1):110621. 2022-04-05 [PMID: 35385743] (Bioassay, Human)
• I Kim, A Ghosh, N Bundschuh, L Hinte, E Petrosyan, F von Meyenn, O Bar-Nur Integrative molecular roadmap for direct conversion of fibroblasts into myocytes and myogenic progenitor cells Science Advances, 2022-04-06;8(14):eabj4928. 2022-04-06 [PMID: 35385316] (Cell Culture, Mouse)
• Y Shinmyo, K Saito, T Hamabe-Hor, N Kameya, A Ando, K Kawasaki, TAD Duong, M Sakashita, J Roboon, T Hattori, T Kannon, K Hosomichi, M Slezak, MG Holt, A Tajima, O Hori, H Kawasaki Localized astrogenesis regulates gyrification of the cerebral cortex Science Advances, 2022-03-11;8(10):eabi5209. 2022-03-11 [PMID: 35275722] (Bioassay, Mouse)
• J Chen, K Qiao, C Zhang, X Zhou, Q Du, Y Deng, L Cao VRK2 activates TNFalpha/NF-kappaB signaling by phosphorylating IKKbeta in pancreatic cancer International journal of biological sciences, 2022-01-09;18(3):1288-1302. 2022-01-09 [PMID: 35173553] (Bioassay, Human)
• K Zhao, Y Shi, J Yu, L Yu, A Mael, Y Li, A Kolton, T Joyce, J Odorico, PO Berggren, SN Yang Intracameral Microimaging of Maturation of Human iPSC Derivatives into Islet Endocrine Cells Cell Transplantation, 2022-01-01;31(0):9636897211066. 2022-01-01 [PMID: 35156411] (Bioassay, Human)
• G Iannello, A Patel, D Sirabella, B Corneo, VV Thaker Derivation and characterization of the induced pluripotent stem cell line CUIMCi004-A from a patient with a novel frameshift variant in exon 18a of OCRL Stem Cell Research, 2021-12-23;59(0):102635. 2021-12-23 [PMID: 35074682] (Bioassay, Human)
• Z Pan, R Zhao, B Li, Y Qi, W Qiu, Q Guo, S Zhang, S Zhao, H Xu, M Li, Z Gao, Y Fan, J Xu, H Wang, S Wang, J Qiu, Q Wang, X Guo, L Deng, P Zhang, H Xue, G Li EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3 Molecular Cancer, 2022-01-14;21(1):16. 2022-01-14 [PMID: 35031058] (Bioassay, Human)
• Y Miura, MY Li, O Revah, SJ Yoon, G Narazaki, SP Pa?ca Engineering brain assembloids to interrogate human neural circuits Nature Protocols, 2022-01-06;17(1):15-35. 2022-01-06 [PMID: 34992269] (Bioassay, Human)
• S Rezaei-Lot, F Vujovic, M Simonian, N Hunter, RM Farahani Programmed genomic instability regulates neural transdifferentiation of human brain microvascular pericytes Genome Biology, 2021-12-09;22(1):334. 2021-12-09 [PMID: 34886891] (Bioassay, Human)
• AK Eicher, DO Kechele, N Sundaram, HM Berns, HM Poling, LE Haines, JG Sanchez, K Kishimoto, M Krishnamur, L Han, AM Zorn, MA Helmrath, JM Wells Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells Cell Stem Cell, 2021-12-01;0(0):. 2021-12-01 [PMID: 34856121] (Bioassay, Human)
• AF de Souza, FF Bressan, NCG Pieri, RC Botigelli, T Revay, SK Haddad, DT Covas, ES Ramos, WA King, FV Meirelles Generation of Primordial Germ Cell-like Cells from iPSCs Derived from Turner Syndrome Patients Cells, 2021-11-10;10(11):. 2021-11-10 [PMID: 34831322] (Bioassay, Human)
• MA Fayaz, GDS Rosa, A Honaramooz Neonatal Porcine Germ Cells Dedifferentiate and Display Osteogenic and Pluripotency Properties Cells, 2021-10-20;10(11):. 2021-10-20 [PMID: 34831039] (Bioassay, Porcine)
• RS Kenchappa, Y Liu, MG Argenziano, MA Banu, AC Mladek, R West, A Luu, A Quiñones-H, D Hambardzum, V Justilien, M Leitges, JN Sarkaria, PA Sims, P Canoll, NR Murray, AP Fields, SS Rosenfeld Protein kinase C? and SRC signaling define reciprocally related subgroups of glioblastoma with distinct therapeutic vulnerabilities Cell Reports, 2021-11-23;37(8):110054. 2021-11-23 [PMID: 34818553] (Bioassay, Human)
• Y Gu, Y Chen, L Wei, S Wu, K Shen, C Liu, Y Dong, Y Zhao, Y Zhang, C Zhang, W Zheng, J He, Y Wang, Y Li, X Zhao, H Wang, J Tan, L Wang, Q Zhou, G Xie, H Liang, J Ou ABHD5 inhibits YAP-induced c-Met overexpression and colon cancer cell stemness via suppressing YAP methylation Nature Communications, 2021-11-18;12(1):6711. 2021-11-18 [PMID: 34795238] (Bioassay, Human)
• T Arad, N Fainstein, S Goldfarb, M Lachish, T Ganz, T Ben-Hur CD200 -dependent and -independent immune-modulatory functions of neural stem cells Stem Cell Research, 2021-10-07;56(0):102559. 2021-10-07 [PMID: 34634761] (Cell Culture, Mouse)
• R Linares-Sa, W Kim, NA Bolar, H Zhang, BA Koch-Bojal, S Yoon, PP Shah, A Karnay, DS Park, JM Luppino, SC Nguyen, A Padmanabha, CL Smith, A Poleshko, Q Wang, L Li, D Srivastava, G Vahedi, GH Eom, GA Blobel, EF Joyce, R Jain BRD4 orchestrates genome folding to promote neural crest differentiation Nature Genetics, 2021-10-05;53(10):1480-1492. 2021-10-05 [PMID: 34611363] (Bioassay, Human)
• de Rus Jacquet A, Tancredi J, Lemire A, DeSantis M, Li W, O'Shea E The LRRK2 G2019S mutation alters astrocyte-to-neuron communication via extracellular vesicles and induces neuron atrophy in a human iPSC-derived model of Parkinson&#039;s disease. Elife, 2021-09-30;10(0):. 2021-09-30 [PMID: 34590578] (Bioassay, Human)
• Q Heydt, C Xintaropou, A Clear, M Austin, I Pislariu, F Miraki-Mou, P Cutillas, K Korfi, M Calaminici, W Cawthorn, K Suchacki, A Nagano, JG Gribben, M Smith, JD Cavenagh, H Oakervee, A Castleton, D Taussig, B Peck, A Wilczynska, L McNaughton, D Bonnet, F Mardakheh, B Patel Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence Nature Communications, 2021-09-17;12(1):5507. 2021-09-17 [PMID: 34535653] (Cell Culture, Human)
• F Vujovic, S Rezaei-Lot, N Hunter, RM Farahani The fate of notch-1 transcript is linked to cell cycle dynamics by activity of a natural antisense transcript Nucleic Acids Research, 2021-10-11;0(0):. 2021-10-11 [PMID: 34520549] (Bioassay, Human)
• Y Aghazadeh, F Poon, F Sarangi, FTM Wong, ST Khan, X Sun, R Hatkar, BJ Cox, SS Nunes, MC Nostro Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models Cell Stem Cell, 2021-09-03;0(0):. 2021-09-03 [PMID: 34480863] (Bioassay, Human)
• M Restan Per, R Sharma, NZ Masri, SM Willerth 3D Bioprinting Mesenchymal Stem Cell-Derived Neural Tissues Using a Fibrin-Based Bioink Biomolecules, 2021-08-21;11(8):. 2021-08-21 [PMID: 34439916] (Bioassay, Human)
• T Jia, T Jacquet, F Dalonneau, P Coudert, E Vaganay, C Exbrayat-H, J Vollaire, V Josserand, F Ruggiero, JL Coll, B Eymin FGF-2 promotes angiogenesis through a SRSF1/SRSF3/SRPK1-dependent axis that controls VEGFR1 splicing in endothelial cells Bmc Biology, 2021-08-25;19(1):173. 2021-08-25 [PMID: 34433435] (Bioassay, Human)
• AV Parent, G Faleo, J Chavez, M Saxton, DI Berrios, NR Kerper, Q Tang, M Hebrok Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection Cell Reports, 2021-08-17;36(7):109538. 2021-08-17 [PMID: 34407395] (Bioassay, Human)
• N Shimamura, K Fujii, S Ohkoshi Detection and quantification of human-specific mRNA from hepatocyte-like cells derived from dental pulp using real-time polymerase chain reaction Journal of oral biosciences, 2021-07-24;0(0):. 2021-07-24 [PMID: 34311038] (Bioassay, Human)
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• B You, F Mercier, E Assenat, C Langlois-J, O Glehen, J Soulé, L Payen, V Kepenekian, M Dupuy, F Belouin, E Morency, V Saywell, M Flacelière, P Elies, P Liaud, T Mazard, D Maucort-Bo, W Tan, B Vire, L Villeneuve, M Ychou, M Kohli, D Joubert, A Prieur The oncogenic and druggable hPG80 (Progastrin) is overexpressed in multiple cancers and detected in the blood of patients EBioMedicine, 2019-12-24;51(0):102574. 2019-12-24 [PMID: 31877416] (Bioassay, Human)
• D Chen, N Sun, L Hou, R Kim, J Faith, M Aslanyan, Y Tao, Y Zheng, J Fu, W Liu, M Kellis, A Clark Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors Cell Rep, 2019-12-24;29(13):4568-4582.e5. 2019-12-24 [PMID: 31875561] (Cell Culture, Human)
• A Bonafina, MF Trinchero, AS Ríos, P Bekinschte, AF Schinder, G Paratcha, F Ledda GDNF and GFRalpha1 Are Required for Proper Integration of Adult-Born Hippocampal Neurons Cell Rep, 2019-12-24;29(13):4308-4319.e4. 2019-12-24 [PMID: 31875542] (Cell Culture, Mouse)
• C Fisher, G Obaid, C Niu, W Foltz, A Goldstein, T Hasan, L Lilge Liposomal Lapatinib in Combination with Low-Dose Photodynamic Therapy for the Treatment of Glioma J Clin Med, 2019-12-14;8(12):. 2019-12-14 [PMID: 31847378] (Bioassay, Human)
• C Peng, L Lu, Y Li, J Hu Neurospheres induced from human adipose-derived stem cells as a new source of neural progenitor cells Cell Transplant, 2019-12-08;0(0):9636897198886. 2019-12-08 [PMID: 31813268] (Bioassay, Human)
• M Ali, F Kabir, JJ Thomson, Y Ma, C Qiu, M Delannoy, SY Khan, SA Riazuddin Comparative transcriptome analysis of hESC- and iPSC-derived lentoid bodies Sci Rep, 2019-12-06;9(1):18552. 2019-12-06 [PMID: 31811247] (Bioassay, Human)
• S Weber, SE Koschade, CM Hoffmann, TD Dubash, KM Giessler, SM Dieter, F Herbst, H Glimm, CR Ball The notch target gene HEYL modulates metastasis forming capacity of colorectal cancer patient-derived spheroid cells in vivo BMC Cancer, 2019-12-03;19(1):1181. 2019-12-03 [PMID: 31796022] (Bioassay, Human)
• D Hao, C He, B Ma, L Lankford, L Reynaga, DL Farmer, F Guo, A Wang Hypoxic Preconditioning Enhances Survival and Proangiogenic Capacity of Human First Trimester Chorionic Villus-Derived Mesenchymal Stem Cells for Fetal Tissue Engineering Stem Cells Int, 2019-11-12;2019(0):9695239. 2019-11-12 [PMID: 31781252] (Tissue Culture, Human)
• M Vermeulen, F Del Vento, M Kanbar, S Pyr Dit Ru, D Vertommen, J Poels, C Wyns Generation of Organized Porcine Testicular Organoids in Solubilized Hydrogels from Decellularized Extracellular Matrix Int J Mol Sci, 2019-11-03;20(21):. 2019-11-03 [PMID: 31684200] (Bioassay, Porcine)
• Y Koutmani, IA Gampieraki, A Polissidis, M Ximerakis, PN Koutsoudak, A Polyzos, G Agrogianni, S Karaliota, D Thomaidou, LL Rubin, PK Politis, KP Karalis CRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult Hippocampus Cell Rep, 2019-10-22;29(4):932-945.e7. 2019-10-22 [PMID: 31644914] (Bioassay, Mouse)
• A Tripathi, C Volsko, JP Garcia, E Agirre, KC Allan, PJ Tesar, BD Trapp, G Castelo-Br, FJ Sim, R Dutta Oligodendrocyte Intrinsic miR-27a Controls Myelination and Remyelination Cell Rep, 2019-10-22;29(4):904-919.e9. 2019-10-22 [PMID: 31644912] (Bioassay, Mouse)
• J Chen, B Ananthanar, KS Springer, KJ Wolf, SM Sheyman, VD Tran, S Kumar Suppression of LIM Kinase 1 and LIM Kinase 2 Limits Glioblastoma Invasion Cancer Res., 2019-10-22;0(0):. 2019-10-22 [PMID: 31641031] (Bioassay, Human)
• F Inoue, A Kreimer, T Ashuach, N Ahituv, N Yosef Identification and Massively Parallel Characterization of Regulatory Elements Driving Neural Induction Cell Stem Cell, 2019-10-17;0(0):. 2019-10-17 [PMID: 31631012] (Bioassay, Human)
• T Yung, F Poon, M Liang, S Coquenlorg, EC McGaugh, CC Hui, MD Wilson, MC Nostro, TH Kim Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals Nat Commun, 2019-10-11;10(1):4647. 2019-10-11 [PMID: 31604927] (Bioassay, Human)
• R Liu, X Zhang, Z Fan, Y Wang, G Yao, X Wan, Z Liu, B Yang, L Yu Human amniotic mesenchymal stem cells improve the follicular microenvironment to recover ovarian function in premature ovarian failure mice Stem Cell Res Ther, 2019-10-02;10(1):299. 2019-10-02 [PMID: 31578152] (Bioassay, Human)
• T Tabata, M Petitt, J Fang-Hoove, DC Freed, F Li, Z An, D Wang, TM Fu, L Pereira Neutralizing Monoclonal Antibodies Reduce Human Cytomegalovirus Infection and Spread in Developing Placentas Vaccines (Basel), 2019-09-29;7(4):. 2019-09-29 [PMID: 31569508] (Bioassay, Human)
• Q Mei, A Bansal, MKG Jayakumar, Z Zhang, J Zhang, H Huang, D Yu, CJA Ramachandr, DJ Hausenloy, TW Soong, Y Zhang Manipulating energy migration within single lanthanide activator for switchable upconversion emissions towards bidirectional photoactivation Nat Commun, 2019-09-27;10(1):4416. 2019-09-27 [PMID: 31562321] (Bioassay, Human)
• V Lungova, X Chen, Z Wang, C Kendziorsk, SL Thibeault Human induced pluripotent stem cell-derived vocal fold mucosa mimics development and responses to smoke exposure Nat Commun, 2019-09-24;10(1):4161. 2019-09-24 [PMID: 31551422] (Bioassay, Human)
• CY Lee, TJ Huang, MH Wu, YY Li, KD Lee High Expression of Acid-Sensing Ion Channel 2 (ASIC2) in Bone Cells in Osteoporotic Vertebral Fractures Biomed Res Int, 2019-08-19;2019(0):4714279. 2019-08-19 [PMID: 31531354] (Bioassay, Human)
• Y Yuan, C Zhou, Q Yang, S Ma, X Wang, X Guo, Y Ding, J Tang, Y Zeng, D Li HIV-1 Tat protein inhibits the hematopoietic support function of human bone marrow mesenchymal stem cells Virus Res., 2019-09-12;273(0):197756. 2019-09-12 [PMID: 31521762] (Bioassay, Human)
• J Domingo-Pr, V Abad-Moral, M Riera, R Navarro, B Corcostegu, E Pomares Generation of an induced pluripotent stem cell line (FRIMOi007-A) derived from an incomplete achromatopsia patient carrying a novel homozygous mutation in PDE6C gene Stem Cell Res, 2019-09-04;40(0):101569. 2019-09-04 [PMID: 31520890] (Cell Culture, Human)
• J Domingo-Pr, M Riera, V Abad-Moral, S Ruiz-Nogal, B Corcostegu, E Pomares Generation of Best disease-derived induced pluripotent stem cell line (FRIMOi006-A) carrying a novel dominant mutation in BEST1 gene Stem Cell Res, 2019-09-04;40(0):101570. 2019-09-04 [PMID: 31518904] (Cell Culture, Human)
• KM Walter, K Dach, K Hayakawa, S Giersiefer, H Heuer, PJ Lein, E Fritsche Ontogenetic expression of thyroid hormone signaling genes: An in vitro and in vivo species comparison PLoS ONE, 2019-09-12;14(9):e0221230. 2019-09-12 [PMID: 31513589] (Bioassay, Human, Rat)
• Y Shen, K Pu, K Zheng, X Ma, J Qin, L Jiang, J Li Differentially Expressed microRNAs in MIA PaCa-2 and PANC-1 Pancreas Ductal Adenocarcinoma Cell Lines are Involved in Cancer Stem Cell Regulation Int J Mol Sci, 2019-09-10;20(18):. 2019-09-10 [PMID: 31510100] (Bioassay, Human)
• V Ravi, AB Madhankuma, T Abraham, B Slagle-Web, JR Connor Liposomal delivery of ferritin heavy chain 1 (FTH1) siRNA in patient xenograft derived glioblastoma initiating cells suggests different sensitivities to radiation and distinct survival mechanisms PLoS ONE, 2019-09-06;14(9):e0221952. 2019-09-06 [PMID: 31491006] (Bioassay, Human)
• SP Hong, TE Chan, Y Lombardo, G Corleone, N Rotmensz, S Bravaccini, A Rocca, G Pruneri, KR McEwen, RC Coombes, I Barozzi, L Magnani Single-cell transcriptomics reveals multi-step adaptations to endocrine therapy Nat Commun, 2019-09-02;10(1):3840. 2019-09-02 [PMID: 31477698] (Cell Culture, Human)
• J Tiihonen, M Koskuvi, M Lähteenvuo, PLJ Virtanen, I Ojansuu, O Vaurio, Y Gao, I Hyötyläine, KA Puttonen, E Repo-Tiiho, T Paunio, MR Rautiainen, S Tyni, J Koistinaho, Š Lehtonen Neurobiological roots of psychopathy Mol. Psychiatry, 2019-08-27;0(0):. 2019-08-27 [PMID: 31455857] (Bioassay, Human)
• L Messerschm, S Fischer, P Wiedemann, A Bringmann, M Hollborn Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation Mol. Vis., 2019-06-30;25(0):329-344. 2019-06-30 [PMID: 31341381] (Bioassay, Human)
• SB Yoon, YH Park, SA Choi, HJ Yang, PS Jeong, JJ Cha, S Lee, SH Lee, JH Lee, BW Sim, BS Koo, SJ Park, Y Lee, YH Kim, JJ Hong, JS Kim, YB Jin, JW Huh, SR Lee, BS Song, SU Kim Real-time PCR quantification of spliced X-box binding protein 1 (XBP1) using a universal primer method PLoS ONE, 2019-07-22;14(7):e0219978. 2019-07-22 [PMID: 31329612] (Cell Culture, Bovine, Macaca fascicularis (cynomolgus monkey), Mouse, Porcine)
• S Tongkobpet, R Rungsiwiwu, K Pruksanano, K Suphapeeti, V Shotelersu Generation of two human iPSC lines (MDCUi001-A and MDCUi001-B) from dermal fibroblasts of a Thai patient with X-linked osteogenesis imperfecta using integration-free Sendai virus Stem Cell Res, 2019-06-29;39(0):101493. 2019-06-29 [PMID: 31326747] (Bioassay, Human)
• TC Lin, YY Lin, CC Hsu, YP Yang, CH Yang, DK Hwang, CY Wang, YY Liu, WL Lo, SH Chiou, CH Peng, SJ Chen, YL Chang Nanomedicine-based Curcumin Approach Improved ROS Damage in Best Dystrophy-specific Induced Pluripotent Stem Cells Cell Transplant, 2019-07-17;0(0):9636897198601. 2019-07-17 [PMID: 31313605] (Bioassay, Human)
• S Pecha, K Yorgan, M Röhl, B Geertz, A Hansen, F Weinberger, S Sehner, H Ehmke, H Reichenspu, T Eschenhage, AP Schwoerer Human iPS cell-derived engineered heart tissue does not affect ventricular arrhythmias in a guinea pig cryo-injury model Sci Rep, 2019-07-08;9(1):9831. 2019-07-08 [PMID: 31285568] (Cell Culture, Human)
• SH Yang, M Andrabi, R Biss, S Murtuza Ba, M Iqbal, AD Sharrocks ZIC3 Controls the Transition from Naive to Primed Pluripotency Cell Rep, 2019-06-11;27(11):3215-3227.e6. 2019-06-11 [PMID: 31189106] (Bioassay, Mouse)
• J Domingo-Pr, M Riera, A Burés-Jels, B Corcostegu, E Pomares Establishment of an induced pluripotent stem cell line (FRIMOi005-A) derived from a retinitis pigmentosa patient carrying a dominant mutation in RHO gene Stem Cell Res, 2019-05-22;38(0):101468. 2019-05-22 [PMID: 31146251] (Bioassay, Human)
• M Meijer, K Rehbach, JW Brunner, JA Classen, HCA Lammertse, LA van Linge, D Schut, T Krutenko, M Hebisch, LN Cornelisse, PF Sullivan, M Peitz, RF Toonen, O Brüstle, M Verhage A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons Cell Rep, 2019-05-14;27(7):2199-2211.e6. 2019-05-14 [PMID: 31091456] (Bioassay, Human)
• N Kawai, Y Hirohashi, Y Ebihara, T Saito, A Murai, T Saito, T Shirosaki, T Kubo, M Nakatsugaw, T Kanaseki, T Tsukahara, T Shichinohe, L Li, S Hirano, T Torigoe ABCG2 expression is related to low 5-ALA photodynamic diagnosis (PDD) efficacy and cancer stem cell phenotype, and suppression of ABCG2 improves the efficacy of PDD PLoS ONE, 2019-05-13;14(5):e0216503. 2019-05-13 [PMID: 31083682] (Bioassay, Human)
• ML Shiao, C Yuan, AT Crane, JP Voth, M Juliano, LLH Stone, Z Nan, Y Zhang, N Kuzmin-Nic, PR Sanberg, AW Grande, WC Low Immunomodulation with Human Umbilical Cord Blood Stem Cells Ameliorates Ischemic Brain Injury - A Brain Transcriptome Profiling Analysis Cell Transplant, 2019-05-08;0(0):9636897198367. 2019-05-08 [PMID: 31066288] (Bioassay, Human)
• A Hall, K Choi, W Liu, J Rose, C Zhao, Y Yu, Y Na, Y Cai, RA Coover, Y Lin, E Dombi, M Kim, D Levanon, Y Groner, E Boscolo, D Pan, PP Liu, QR Lu, N Ratner, G Huang, J Wu RUNX represses Pmp22 to drive neurofibromagenesis Sci Adv, 2019-04-24;5(4):eaau8389. 2019-04-24 [PMID: 31032403] (Bioassay, Mouse)
• EE Mulkearns-, LA Torre-Heal, DJ Silver, JT Eurich, D Bayik, E Serbinowsk, M Hitomi, J Zhou, B Przychodze, R Zhang, SA Sprowls, JS Hale, TJ Alban, A Berezovsky, BA Bell, PR Lockman, BK Jha, JD Lathia Development of a Cx46 Targeting Strategy for Cancer Stem Cells Cell Rep, 2019-04-23;27(4):1062-1072.e5. 2019-04-23 [PMID: 31018124] (Bioassay, Xenograft)
• L Sun, F Wang, H Chen, D Liu, T Qu, X Li, D Xu, F Liu, Z Yin, Y Chen Co-Transplantation of Human Umbilical Cord Mesenchymal Stem Cells and Human Neural Stem Cells Improves the Outcome in Rats with Spinal Cord Injury Cell Transplant, 2019-04-23;0(0):9636897198445. 2019-04-23 [PMID: 31012325] (Bioassay, Human)
• M Urbischek, H Rannikmae, T Foets, K Ravn, M Hyvönen, M de la Roch Organoid culture media formulated with growth factors of defined cellular activity Sci Rep, 2019-04-17;9(1):6193. 2019-04-17 [PMID: 30996238] (Bioassay, Human)
• G MacLeod, DA Bozek, N Rajakulend, V Monteiro, M Ahmadi, Z Steinhart, MM Kushida, H Yu, FJ Coutinho, FMG Cavalli, I Restall, X Hao, T Hart, HA Luchman, S Weiss, PB Dirks, S Angers Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells Cell Rep, 2019-04-16;27(3):971-986.e9. 2019-04-16 [PMID: 30995489] (Bioassay, Human)
• B Mair, J Tomic, SN Masud, P Tonge, A Weiss, M Usaj, AHY Tong, JJ Kwan, KR Brown, E Titus, M Atkins, KSK Chan, L Munsie, A Habsid, H Han, M Kennedy, B Cohen, G Keller, J Moffat Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies Cell Rep, 2019-04-09;27(2):599-615.e12. 2019-04-09 [PMID: 30970261] (Differentiation, Differentiation, Human)
• T Ryynänen, A Pelkonen, K Grigoras, OME Ylivaara, T Hyvärinen, J Ahopelto, M Prunnila, S Narkilahti, J Lekkala Microelectrode Array With Transparent ALD TiN Electrodes Front Neurosci, 2019-03-22;13(0):226. 2019-03-22 [PMID: 30967754] (Bioassay, Human)
• SFB Fadhlullah, NBA Halim, JYT Yeo, RLY Ho, P Um, BT Ang, C Tang, WH Ng, DM Virshup, IAW Ho Pathogenic mutations in neurofibromin identifies a leucine-rich domain regulating glioma cell invasiveness Oncogene, 2019-04-09;38(27):5367-5380. 2019-04-09 [PMID: 30967630] (Bioassay, Human)
• S Varum, A Baggiolini, L Zurkirchen, ZK Atak, C Cantù, E Marzorati, R Bossart, J Wouters, J Häusel, E Tuncer, D Zingg, D Veen, N John, M Balz, MP Levesque, K Basler, S Aerts, N Zamboni, R Dummer, L Sommer Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation Cell Stem Cell, 2019-04-04;24(4):637-653.e9. 2019-04-04 [PMID: 30951662] (Bioassay, Mouse)
• M Matsushita, Y Mori, K Uchiumi, T Ogata, M Nakamura, H Yoda, H Soda, N Takiguchi, Y Nabeya, O Shimozato, T Ozaki PTPRK suppresses progression and chemo-resistance of colon cancer cells via direct inhibition of pro-oncogenic CD133 FEBS Open Bio, 2019-04-18;0(0):. 2019-04-18 [PMID: 30947381] (Bioassay, Human)
• M Rutgers, F Bach, L Vonk, M van Rijen, V Akrum, A van Boxtel, W Dhert, L Creemers PTH decreases in vitro human cartilage regeneration without affecting hypertrophic differentiation PLoS ONE, 2019-04-04;14(4):e0213483. 2019-04-04 [PMID: 30947269] (Bioassay, Human)
• HL Zhang, P Wang, MZ Lu, SD Zhang, L Zheng c-Myc maintains the self-renewal and chemoresistance properties of colon cancer stem cells Oncol Lett, 2019-02-28;17(5):4487-4493. 2019-02-28 [PMID: 30944638] (Bioassay, Human)
• K Itoh, S Masumori, D Mukai, H Sakakibara, M Yasuda, K Shimoi Dosage time affects alkylating agents induced micronuclei in mouse peripheral blood reticulocytes through the function of erythropoietin J Toxicol Sci, 2019-01-01;44(4):273-282. 2019-01-01 [PMID: 30944280] (In Vivo, Mouse)
• Z Shen, C Zhang, L Qu, C Lu, M Xiao, R Ni, J Liu MKP-4 suppresses hepatocarcinogenesis by targeting ERK1/2 pathway Cancer Cell Int., 2019-03-18;19(0):61. 2019-03-18 [PMID: 30923463] (Bioassay, Human)
• K Barber, L Studer, F Fattahi Derivation of enteric neuron lineages from human pluripotent stem cells Nat Protoc, 2019-03-25;14(4):1261-1279. 2019-03-25 [PMID: 30911172] (Bioassay, Human)
• Z Wang, L Kang, H Zhang, Y Huang, L Fang, M Li, PJ Brown, CH Arrowsmith, J Li, J Wong AKT drives SOX2 overexpression and cancer cell stemness in esophageal cancer by protecting SOX2 from UBR5-mediated degradation Oncogene, 2019-03-20;0(0):. 2019-03-20 [PMID: 30894683] (Bioassay, Human)
• MA Ajmone-Cat, A Onori, C Toselli, E Stronati, M Morlando, I Bozzoni, E Monni, Z Kokaia, G Lupo, L Minghetti, S Biagioni, E Cacci Increased FUS levels in astrocytes leads to astrocyte and microglia activation and neuronal death Sci Rep, 2019-03-14;9(1):4572. 2019-03-14 [PMID: 30872738] (Bioassay, Human)
• N Funk, M Munz, T Ott, K Brockmann, A Wenninger-, R Kühn, D Vogt-Weise, F Giesert, W Wurst, T Gasser, S Biskup The Parkinson&#039;s disease-linked Leucine-rich repeat kinase 2 (LRRK2) is required for insulin-stimulated translocation of GLUT4 Sci Rep, 2019-03-14;9(1):4515. 2019-03-14 [PMID: 30872638] (Bioassay, Mouse)
• H Xu, B Wang, M Ono, A Kagita, K Fujii, N Sasakawa, T Ueda, P Gee, M Nishikawa, M Nomura, F Kitaoka, T Takahashi, K Okita, Y Yoshida, S Kaneko, A Hotta Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility Cell Stem Cell, 2019-03-07;0(0):. 2019-03-07 [PMID: 30853558] (Bioassay, Human)
• N Naldaiz-Ga, M Goicoechea, IM Aragón, V Pérez-Lópe, S Fuertes-Al, B Herrera-Im, A López de M, R de Luna-Di, PM Baptista, MA Fernández, MF Lara, A Izeta Isolation and characterization of myogenic precursor cells from human cremaster muscle Sci Rep, 2019-03-05;9(1):3454. 2019-03-05 [PMID: 30837559] (Bioassay, Human)
• YP Xu, Y Qiu, B Zhang, G Chen, Q Chen, M Wang, F Mo, J Xu, J Wu, RR Zhang, ML Cheng, NN Zhang, B Lyu, WL Zhu, MH Wu, Q Ye, D Zhang, JH Man, XF Li, J Cui, Z Xu, B Hu, X Zhou, CF Qin Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids Cell Res., 2019-02-27;0(0):. 2019-02-27 [PMID: 30814679] (Bioassay, Human)
• J Ooi, SR Langley, X Xu, KH Utami, B Sim, Y Huang, NP Harmston, YL Tay, A Ziaei, R Zeng, D Low, F Aminkeng, RM Sobota, F Ginhoux, E Petretto, MA Pouladi Unbiased Profiling of Isogenic Huntington Disease hPSC-Derived CNS and Peripheral Cells Reveals Strong Cell-Type Specificity of CAG Length Effects Cell Rep, 2019-02-26;26(9):2494-2508.e7. 2019-02-26 [PMID: 30811996]
• M Riera, A Patel, A Burés-Jels, B Corcostegu, S Chang, E Pomares, B Corneo, JR Sparrow Generation of two iPS cell lines (FRIMOi003-A and FRIMOi004-A) derived from Stargardt patients carrying ABCA4 compound heterozygous mutations Stem Cell Res, 2019-02-13;36(0):101389. 2019-02-13 [PMID: 30798147] (Bioassay, Human)
• N Muraoka, K Nara, F Tamura, H Kojima, H Yamakawa, T Sadahiro, K Miyamoto, M Isomi, S Haginiwa, H Tani, S Kurotsu, R Osakabe, S Torii, S Shimizu, H Okano, Y Sugimoto, K Fukuda, M Ieda Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming Nat Commun, 2019-02-20;10(1):674. 2019-02-20 [PMID: 30787297] (Bioassay, Mouse)
• M Kunova Bos, A Nita, T Gregor, M Varecha, I Gudernova, B Fafilek, T Barta, N Basheer, SP Abraham, L Balek, M Tomanova, J Fialova Ku, J Bosak, D Potesil, J Zieba, J Song, P Konik, S Park, I Duran, Z Zdrahal, D Smajs, G Jansen, Z Fu, HW Ko, A Hampl, L Trantirek, D Krakow, P Krejci Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase Proc. Natl. Acad. Sci. U.S.A., 2019-02-19;0(0):. 2019-02-19 [PMID: 30782830] (Bioassay, Human)
• TS Winston, K Suddhapas, C Wang, R Ramos, P Soman, Z Ma Serum-Free Manufacturing of Mesenchymal Stem Cell Tissue Rings Using Human-Induced Pluripotent Stem Cells Stem Cells Int, 2019-01-15;2019(0):5654324. 2019-01-15 [PMID: 30766604] (Bioassay, Human)
• E Ito, S Miyagawa, M Takeda, A Kawamura, A Harada, H Iseoka, S Yajima, N Sougawa, N Mochizuki-, S Yasuda, Y Sato, Y Sawa Tumorigenicity assay essential for facilitating safety studies of hiPSC-derived cardiomyocytes for clinical application Sci Rep, 2019-02-13;9(1):1881. 2019-02-13 [PMID: 30760836] (Bioassay, Human)
• JH Wang, ST Huang, L Zhang, ZG Liu, RX Liang, SW Jiang, YN Jiang, XJ Yu, YC Jiang, XZ Li, PF Zhang, ZS Wen, M Zheng Combined prognostic value of the cancer stem cell markers CD47 and CD133 in esophageal squamous cell carcinoma Cancer Med, 2019-02-11;0(0):. 2019-02-11 [PMID: 30741466] (Bioassay, Human)
• S Bunda, P Heir, J Metcalf, ASC Li, S Agnihotri, S Pusch, M Yasin, M Li, K Burrell, S Mansouri, O Singh, M Wilson, A Alamsahebp, R Nejad, B Choi, D Kim, A von Deimli, G Zadeh, K Aldape CIC protein instability contributes to tumorigenesis in glioblastoma Nat Commun, 2019-02-08;10(1):661. 2019-02-08 [PMID: 30737375] (Bioassay, Human)
• S Ashraf, S Bell, C O'Leary, P Canning, I Micu, JA Fernandez, M O'Hare, P Barabas, H McCauley, DP Brazil, AW Stitt, JG McGeown, TM Curtis CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularisation JCI Insight, 2019-03-21;0(0):. 2019-03-21 [PMID: 30721154] (Bioassay, Human)
• JH Jo, SB Park, S Park, HS Lee, C Kim, DE Jung, SY Song Novel Gastric Cancer Stem Cell-Related Marker LINGO2 Is Associated with Cancer Cell Phenotype and Patient Outcome Int J Mol Sci, 2019-01-28;20(3):. 2019-01-28 [PMID: 30696080] (Bioassay, Human)
• M Riera, A Patel, B Corcostegu, S Chang, B Corneo, JR Sparrow, E Pomares Generation of an induced pluripotent stem cell line (FRIMOi002-A) from a retinitis pigmentosa patient carrying compound heterozygous mutations in USH2A gene Stem Cell Res, 2019-01-17;35(0):101386. 2019-01-17 [PMID: 30685615] (Bioassay, Human)
• M Riera, A Patel, B Corcostegu, S Chang, JR Sparrow, E Pomares, B Corneo Establishment and characterization of an iPSC line (FRIMOi001-A) derived from a retinitis pigmentosa patient carrying PDE6A mutations Stem Cell Res, 2019-01-17;35(0):101385. 2019-01-17 [PMID: 30685614] (Bioassay, Human)
• A Montel-Hag, CS Seet, S Li, B Chick, Y Zhu, P Chang, S Tsai, V Sun, S Lopez, HC Chen, C He, CJ Chin, D Casero, GM Crooks Organoid-Induced Differentiation of Conventional T Cells from Human Pluripotent Stem Cells Cell Stem Cell, 2019-01-17;0(0):. 2019-01-17 [PMID: 30661959] (Bioassay)
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• Darby S, Murphy T, Thomas H, Robson CN, Leung HY, Mathers ME, Gnanapragasam VJ Similar expression to FGF (Sef) inhibits fibroblast growth factor-induced tumourigenic behaviour in prostate cancer cells and is downregulated in aggressive clinical disease. Br. J. Cancer, 2009-11-03;101(11):1891-9. 2009-11-03 [PMID: 19888221] (Bioassay, Human)
• Cattaruzza L, Gloghini A, Olivo K, Di Francia R, Lorenzon D, De Filippi R, Carbone A, Colombatti A, Pinto A, Aldinucci D Functional coexpression of Interleukin (IL)-7 and its receptor (IL-7R) on Hodgkin and Reed-Sternberg cells: Involvement of IL-7 in tumor cell growth and microenvironmental interactions of Hodgkin&#039;s lymphoma. Int. J. Cancer, 2009-09-01;125(5):1092-101. 2009-09-01 [PMID: 19391137] (Bioassay, Human)
• Fischer AJ, Scott MA, Ritchey ER, Sherwood P Mitogen-activated protein kinase-signaling regulates the ability of Muller glia to proliferate and protect retinal neurons against excitotoxicity. Glia, 2009-11-01;57(14):1538-52. 2009-11-01 [PMID: 19306360] (In Vivo, Chicken)
• Riekstina U, Muceniece R, Cakstina I, Muiznieks I, Ancans J Characterization of human skin-derived mesenchymal stem cell proliferation rate in different growth conditions. Cytotechnology, 2009-02-14;58(3):153-62. 2009-02-14 [PMID: 19219561] (Bioassay, Human)
• Shi S, Mercer S, Eckert GJ, Trippel SB Growth factor regulation of growth factors in articular chondrocytes. J. Biol. Chem., 2009-01-09;284(11):6697-704. 2009-01-09 [PMID: 19136669] (Bioassay, Human)
• Ma LH, Webb SE, Chan CM, Zhang J, Miller AL Establishment of a transitory dorsal-biased window of localized Ca2+ signaling in the superficial epithelium following the mid-blastula transition in zebrafish embryos. Dev. Biol., 2008-12-24;327(1):143-57. 2008-12-24 [PMID: 19133253] (Bioassay, Zebrafish)
• Bernardo AS, Cho CH, Mason S, Docherty HM, Pedersen RA, Vallier L, Docherty K Biphasic induction of Pdx1 in mouse and human embryonic stem cells can mimic development of pancreatic beta-cells. Stem Cells, 2009-02-01;27(2):341-51. 2009-02-01 [PMID: 19056911] (Bioassay, Mouse)
• Chojnacki A, Kelly JJ, Hader W, Weiss S Distinctions between fetal and adult human platelet-derived growth factor-responsive neural precursors. Ann. Neurol., 2008-08-01;64(2):127-42. 2008-08-01 [PMID: 18756507] (Bioassay, Human)
• Nedeau AE, Bauer RJ, Gallagher K, Chen H, Liu ZJ, Velazquez OC A CXCL5- and bFGF-dependent effect of PDGF-B-activated fibroblasts in promoting trafficking and differentiation of bone marrow-derived mesenchymal stem cells. Exp. Cell Res., 2008-04-25;314(11):2176-86. 2008-04-25 [PMID: 18570917] (Bioassay, Mouse)
• Desbordes SC, Placantonakis DG, Ciro A, Socci ND, Lee G, Djaballah H, Studer L High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell Stem Cell, 2008-06-05;2(6):602-12. 2008-06-05 [PMID: 18522853] (Bioassay, Human)
• Yang L, Soonpaa MH, Adler ED, Roepke TK, Kattman SJ, Kennedy M, Henckaerts E, Bonham K, Abbott GW, Linden RM, Field LJ, Keller GM Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. Nature, 2008-04-23;453(7194):524-8. 2008-04-23 [PMID: 18432194] (Bioassay, Human)
• Ladewig J, Koch P, Endl E, Meiners B, Opitz T, Couillard-Despres S, Aigner L, Brustle O Lineage selection of functional and cryopreservable human embryonic stem cell-derived neurons. Stem Cells, 2008-04-17;26(7):1705-12. 2008-04-17 [PMID: 18420830] (Bioassay, Human)
• Rao RC, Boyd J, Padmanabhan R, Chenoweth JG, McKay RD Efficient Serum-Free Derivation of Oligodendrocyte Precursors from Neural Stem Cell-Enriched Cultures. Stem Cells, 2009-01-01;0(0):. 2009-01-01 [PMID: 18403757] (Bioassay, Mouse)
• Kiprilov EN, Awan A, Desprat R, Velho M, Clement CA, Byskov AG, Andersen CY, Satir P, Bouhassira EE, Christensen ST, Hirsch RE Human embryonic stem cells in culture possess primary cilia with hedgehog signaling machinery. J. Cell Biol., 2008-03-10;180(5):897-904. 2008-03-10 [PMID: 18332216] (Bioassay, Human)
• Keshet GI, Goldstein I, Itzhaki O, Cesarkas K, Shenhav L, Yakirevitch A, Treves AJ, Schachter J, Amariglio N, Rechavi G MDR1 expression identifies human melanoma stem cells. Biochem. Biophys. Res. Commun., 2008-02-13;368(4):930-6. 2008-02-13 [PMID: 18279661] (Bioassay, Human)
• Patel VN, Likar KM, Zisman-Rozen S, Cowherd SN, Lassiter KS, Sher I, Yates EA, Turnbull JE, Ron D, Hoffman MP Specific heparan sulfate structures modulate FGF10-mediated submandibular gland epithelial morphogenesis and differentiation. J. Biol. Chem., 2008-01-28;283(14):9308-17. 2008-01-28 [PMID: 18230614] (Bioassay, Mouse)
• Elkabetz Y, Panagiotakos G, Al Shamy G, Socci ND, Tabar V, Studer L Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage. Genes Dev., 2008-01-15;22(2):152-65. 2008-01-15 [PMID: 18198334] (Bioassay, Human)
• Schulz TC, Swistowska AM, Liu Y A large-scale proteomic analysis of human embryonic stem cells. BMC Genomics, 2007-12-27;8(0):478. 2007-12-27 [PMID: 18162134] (Bioassay, Human)
• Dobson NR, Zhou YX, Flint NC, Armstrong RC Musashi1 RNA-binding protein regulates oligodendrocyte lineage cell differentiation and survival. Glia, 2008-02-01;56(3):318-30. 2008-02-01 [PMID: 18098125] (Bioassay, Rat)
• Shojaei F, Wu X, Zhong C, Yu L, Liang XH, Yao J, Blanchard D, Bais C, Peale FV, van Bruggen N, Ho C, Ross J, Tan M, Carano RA, Meng YG, Ferrara N Bv8 regulates myeloid-cell-dependent tumour angiogenesis. Nature, 2007-12-06;450(7171):825-31. 2007-12-06 [PMID: 18064003] (Bioassay, Mouse)
• Zhang P, Li J, Tan Z, Wang C, Liu T, Chen L, Yong J, Jiang W, Sun X, DU L, Ding M, Deng H Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells. Blood, 2007-11-27;111(4):1933-41. 2007-11-27 [PMID: 18042803] (Bioassay, Human)
• You JJ, Yang CH, Huang JS, Chen MS, Yang CM Fractalkine, a CX3C chemokine, as a mediator of ocular angiogenesis. Invest. Ophthalmol. Vis. Sci., 2007-11-01;48(11):5290-8. 2007-11-01 [PMID: 17962485] (Bioassay, Bovine, Human)
• Lu J, Jiang W, Yang JH, Chang PY, Walterscheid JP, Chen HH, Marcelli M, Tang D, Lee YT, Liao WS, Yang CY, Chen CH Electronegative LDL impairs vascular endothelial cell integrity in diabetes by disrupting fibroblast growth factor 2 (FGF2) autoregulation. Diabetes, 2007-10-24;57(1):158-66. 2007-10-24 [PMID: 17959932] (Bioassay, Bovine)
• Patel VN, Knox SM, Likar KM, Lathrop CA, Hossain R, Eftekhari S, Whitelock JM, Elkin M, Vlodavsky I, Hoffman MP Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis. Development, 2007-10-24;134(23):4177-86. 2007-10-24 [PMID: 17959718] (Bioassay, Mouse)
• Wang L, Schulz TC, Sherrer ES, Dauphin DS, Shin S, Nelson AM, Ware CB, Zhan M, Song CZ, Chen X, Brimble SN, McLean A, Galeano MJ, Uhl EW, D'Amour KA, Chesnut JD, Rao MS, Blau CA, Robins AJ Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling. Blood, 2007-08-29;110(12):4111-9. 2007-08-29 [PMID: 17761519] (Bioassay, Human)
• Watanabe K, Bianco C, Strizzi L, Hamada S, Mancino M, Bailly V, Mo W, Wen D, Miatkowski K, Gonzales M, Sanicola M, Seno M, Salomon DS Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration. J. Biol. Chem., 2007-08-24;282(43):31643-55. 2007-08-24 [PMID: 17720976] (Bioassay, Human)
• Inagaki A, Soeda A, Oka N, Kitajima H, Nakagawa J, Motohashi T, Kunisada T, Iwama T Long-term maintenance of brain tumor stem cell properties under at non-adherent and adherent culture conditions. Biochem. Biophys. Res. Commun., 2007-07-18;361(3):586-92. 2007-07-18 [PMID: 17673180] (Bioassay, Human)
• Tesar PJ, Chenoweth JG, Brook FA, Davies TJ, Evans EP, Mack DL, Gardner RL, McKay RD New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature, 2007-06-27;448(7150):196-9. 2007-06-27 [PMID: 17597760] (Bioassay, Human, Mouse)
• Vallier L, Alexander M, Pedersen R Conditional gene expression in human embryonic stem cells. Stem Cells, 2007-02-22;25(6):1490-7. 2007-02-22 [PMID: 17322103] (Bioassay, Human)
• Salero E, Hatten ME Differentiation of ES cells into cerebellar neurons. Proc. Natl. Acad. Sci. U.S.A., 2007-02-09;104(8):2997-3002. 2007-02-09 [PMID: 17293457] (Bioassay, Mouse)
• Rajesh</LastName><ForeNam D</Initial, Rajesh D, Chinnasamy N, Mitalipov SM, Wolf DP, Slukvin I, Thomson JA, Shaaban AF Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells. Stem Cells, 2007-02-01;25(2):490-9. 2007-02-01 [PMID: 17284653] (Bioassay, Human, Mouse)
• Josephson R, Ording CJ, Liu Y, Shin S, Lakshmipathy U, Toumadje A, Love B, Chesnut JD, Andrews PW, Rao MS, Auerbach JM Qualification of embryonal carcinoma 2102Ep as a reference for human embryonic stem cell research. Stem Cells, 2007-02-01;25(2):437-46. 2007-02-01 [PMID: 17284651] (Bioassay, Human)
• Williamson D, Selfe J, Lu YJ, Pritchard-Jones K, Murai K, Jones P, Workman P, Shipley J Role for amplification and expression of glypican-5 in rhabdomyosarcoma. Cancer Res., 2007-01-01;67(1):57-65. 2007-01-01 [PMID: 17210683] (Bioassay, Human, Xenopus)
• McLean AB, D&amp;apos;Amour KA, Jones KL, Krishnamoorthy M, Kulik MJ, Reynolds DM, Sheppard AM, Liu H, Xu Y, Baetge EE, Dalton S Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed. Stem Cells, 2007-01-01;25(1):29-38. 2007-01-01 [PMID: 17204604] (Bioassay, Human)
• Nakayama T, Mutsuga N, Tosato G FGF2 posttranscriptionally down-regulates expression of SDF1 in bone marrow stromal cells through FGFR1 IIIc. Blood, 2006-10-31;109(4):1363-72. 2006-10-31 [PMID: 17077327] (Bioassay, Mouse)
• Bartunek J, Croissant JD, Wijns W, Gofflot S, de Lavareille A, Vanderheyden M, Kaluzhny Y, Mazouz N, Willemsen P, Penicka M, Mathieu M, Homsy C, De Bruyne B, McEntee K, Lee IW, Heyndrickx GR Pretreatment of adult bone marrow mesenchymal stem cells with cardiomyogenic growth factors and repair of the chronically infarcted myocardium. Am. J. Physiol. Heart Circ. Physiol., 2006-10-20;292(2):H1095-104. 2006-10-20 [PMID: 17056665] (Bioassay, Canine, Human)
• Porat Y, Porozov S, Belkin D, Shimoni D, Fisher Y, Belleli A, Czeiger D, Silverman WF, Belkin M, Battler A, Fulga V, Savion N Isolation of an adult blood-derived progenitor cell population capable of differentiation into angiogenic, myocardial and neural lineages. Br. J. Haematol., 2006-12-01;135(5):703-14. 2006-12-01 [PMID: 17052254] (Bioassay, Human)
• Benzing C, Segschneider M, Leinhaas A, Itskovitz-Eldor J, Brustle O Neural conversion of human embryonic stem cell colonies in the presence of fibroblast growth factor-2. Neuroreport, 2006-11-06;17(16):1675-81. 2006-11-06 [PMID: 17047452] (Bioassay, Human)
• Greber B, Lehrach H, Adjaye J Fibroblast growth factor 2 modulates transforming growth factor beta signaling in mouse embryonic fibroblasts and human ESCs (hESCs) to support hESC self-renewal. Stem Cells, 2006-10-12;25(2):455-64. 2006-10-12 [PMID: 17038665] (Bioassay, Human)
• Lake AC, Vassy R, Di Benedetto M, Lavigne D, Le Visage C, Perret GY, Letourneur D Low molecular weight fucoidan increases VEGF165-induced endothelial cell migration by enhancing VEGF165 binding to VEGFR-2 and NRP1. J. Biol. Chem., 2006-10-06;281(49):37844-52. 2006-10-06 [PMID: 17028197] (Bioassay, Human)
• Aghajanova L, Skottman H, Stromberg AM, Inzunza J, Lahesmaa R, Hovatta O Expression of leukemia inhibitory factor and its receptors is increased during differentiation of human embryonic stem cells. Fertil. Steril., 2006-09-01;86(4):1193-209. 2006-09-01 [PMID: 16949591] (Bioassay, Human)
• Lindsley RC, Gill JG, Kyba M, Murphy TL, Murphy KM Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm. Development, 2006-08-30;133(19):3787-96. 2006-08-30 [PMID: 16943279] (Bioassay, Mouse)
• Zeng L, Rahrmann E, Hu Q, Lund T, Sandquist L, Felten M, O'Brien TD, O'Brien TD, Zhang J, Verfaillie C Multipotent adult progenitor cells from swine bone marrow. Stem Cells, 2006-08-24;24(11):2355-66. 2006-08-24 [PMID: 16931778] (Bioassay, Porcine)
• Kobayashi T, Ahlenius H, Thored P, Kobayashi R, Kokaia Z, Lindvall O Intracerebral infusion of glial cell line-derived neurotrophic factor promotes striatal neurogenesis after stroke in adult rats. Stroke, 2006-07-27;37(9):2361-7. 2006-07-27 [PMID: 16873711] (Bioassay, Rat)
• Yamashita H, Nakamura T, Takahashi T, Nagano Y, Hiji M, Hirabayashi T, Amano T, Yagi T, Sakai N, Kohriyama T, Matsumoto M Embryonic stem cell-derived neuron models of Parkinson&apos;s disease exhibit delayed neuronal death. J. Neurochem., 2006-07-01;98(1):45-56. 2006-07-01 [PMID: 16805795] (Bioassay, Mouse)
• Murata T, Tsuboi M, Hikita K, Kaneda N Protective effects of neurotrophic factors on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis of murine adrenal chromaffin cell line tsAM5D. J. Biol. Chem., 2006-06-13;281(32):22503-16. 2006-06-13 [PMID: 16772303] (Bioassay, Mouse)
• Kurita R, Sasaki E, Yokoo T, Hiroyama T, Takasugi K, Imoto H, Izawa K, Dong Y, Hashiguchi T, Soda Y, Maeda T, Suehiro Y, Tanioka Y, Nakazaki Y, Tani K Tal1/Scl gene transduction using a lentiviral vector stimulates highly efficient hematopoietic cell differentiation from common marmoset (Callithrix jacchus) embryonic stem cells. Stem Cells, 2006-05-25;24(9):2014-22. 2006-05-25 [PMID: 16728561] (Bioassay, Primate - Callitrix jacchus (Common Marmoset))
• Yu H, Fang D, Kumar SM, Li L, Nguyen TK, Acs G, Herlyn M, Xu X Isolation of a novel population of multipotent adult stem cells from human hair follicles. Am. J. Pathol., 2006-06-01;168(6):1879-88. 2006-06-01 [PMID: 16723703] (Bioassay, Human)
• Li Y, Fan J, Chen M, Li W, Woodley DT Transforming growth factor-alpha: a major human serum factor that promotes human keratinocyte migration. J. Invest. Dermatol., 2006-05-11;126(9):2096-105. 2006-05-11 [PMID: 16691197] (Bioassay, Human)
• Moreno MJ, Ball M, Andrade MF, McDermid A, Stanimirovic DB Insulin-like growth factor binding protein-4 (IGFBP-4) is a novel anti-angiogenic and anti-tumorigenic mediator secreted by dibutyryl cyclic AMP (dB-cAMP)-differentiated glioblastoma cells. Glia, 2006-06-01;53(8):845-57. 2006-06-01 [PMID: 16586492] (Bioassay, Human)
• Lee YS, Lin CY, Robertson RT, Yu J, Deng X, Hsiao I, Lin VW Re-growth of catecholaminergic fibers and protection of cholinergic spinal cord neurons in spinal repaired rats. Eur. J. Neurosci., 2006-02-01;23(3):693-702. 2006-02-01 [PMID: 16487151] (In Vivo, Rat)
• Anghelina M, Krishnan P, Moldovan L, Moldovan NI Monocytes/macrophages cooperate with progenitor cells during neovascularization and tissue repair: conversion of cell columns into fibrovascular bundles. Am. J. Pathol., 2006-02-01;168(2):529-41. 2006-02-01 [PMID: 16436667] (In Vivo, Mouse)
• Narazaki M, Tosato G Ligand-induced internalization selects use of common receptor neuropilin-1 by VEGF165 and semaphorin3A. Blood, 2006-01-19;107(10):3892-901. 2006-01-19 [PMID: 16424390] (ELISA (Standard))
• Faraone D, Aguzzi MS, Ragone G, Russo K, Capogrossi MC, Facchiano A Heterodimerization of FGF-receptor 1 and PDGF-receptor-alpha: a novel mechanism underlying the inhibitory effect of PDGF-BB on FGF-2 in human cells. Blood, 2005-12-01;107(5):1896-902. 2005-12-01 [PMID: 16322476] (Bioassay, Human)
• Tsai MS, Hwang SM, Tsai YL, Cheng FC, Lee JL, Chang YJ Clonal amniotic fluid-derived stem cells express characteristics of both mesenchymal and neural stem cells. Biol. Reprod., 2005-11-23;74(3):545-51. 2005-11-23 [PMID: 16306422] (Bioassay, Human)
• Shin JW, Min M, Larrieu-Lahargue F, Canron X, Kunstfeld R, Nguyen L, Henderson JE, Bikfalvi A, Detmar M, Hong YK Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis. Mol. Biol. Cell, 2005-11-16;17(2):576-84. 2005-11-16 [PMID: 16291864] (Bioassay, Human)
• Bagley RG, Weber W, Rouleau C, Teicher BA Pericytes and endothelial precursor cells: cellular interactions and contributions to malignancy. Cancer Res., 2005-11-01;65(21):9741-50. 2005-11-01 [PMID: 16266995] (Bioassay, Human)
• Kim B, Lee S, Suvas S, Rouse BT Application of plasmid DNA encoding IL-18 diminishes development of herpetic stromal keratitis by antiangiogenic effects. J. Immunol., 2005-07-01;175(1):509-16. 2005-07-01 [PMID: 15972686] (Bioassay, Mouse)
• Schmidt-Ott KM, Yang J, Chen X, Wang H, Paragas N, Mori K, Li JY, Lu B, Costantini F, Schiffer M, Bottinger E, Barasch J Novel regulators of kidney development from the tips of the ureteric bud. J. Am. Soc. Nephrol., 2005-05-25;16(7):1993-2002. 2005-05-25 [PMID: 15917337] (Bioassay, Rat)
• Fischer AJ, Omar G Transitin, a nestin-related intermediate filament, is expressed by neural progenitors and can be induced in Muller glia in the chicken retina. J. Comp. Neurol., 2005-03-28;484(1):1-14. 2005-03-28 [PMID: 15717308] (In Vivo, Chicken)
• Steinberg Z, Myers C, Heim VM, Lathrop CA, Rebustini IT, Stewart JS, Larsen M, Hoffman MP FGFR2b signaling regulates ex vivo submandibular gland epithelial cell proliferation and branching morphogenesis. Development, 2005-02-16;132(6):1223-34. 2005-02-16 [PMID: 15716343] (Bioassay, Mouse)
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FAQs for FGF basic/FGF2/bFGF (233-FB). (Showing 1 - 1 of 1 FAQs).

1. I am looking for an ovine antibody for bFGF and PDGF-AB and ELISA Kits for both. It is for a research work on meniscus healing in sheep. Do you have anything suitable? How is the homology with sheep? Is it ever tested and/or published in papers?
   • Unfortunately, most of the products you are interested in have not yet been tested in sheep, but this should not be a problem, due to sequence homology, and our Innovators Reward Program. In terms of an antibody for bFGF, also called FGF-2, we have several antibodies that are validated to detect the bovine protein, which is almost identical to that from sheep (99% homology). We only have FGF2 ELISA kits that have been tested with human or mouse. Mouse FGF-2 has 94% homology with sheep; human has 98% homology for most of its sequence, but also has an additional stretch of amino acids that is not present in the sheep protein. I therefore think that the mouse kit would be most suitable, just in case the human kit targets the region of the human protein not present in mouse. We sell antibodies to PDGF-A or PDGF-B rather than PDGF-AB. We don't have any PDGF-A antibodies that have been tested in sheep but there are several options you may find of interest. There isn't a sheep PDGFA sequence in UniProt, so I can't comment on how similar it is to the PDGFA from other species. Nevertheless, our NBP1-52533 PDGFB antibody has been shown to work in sheep. We sell two PDGF-AB ELISA kits , but these are for human and rat. I'm not sure how well these would work with sheep. Note that if you test a product with a species (or application) that it has not yet been validated in, you are eligible for our Innovator's Reward: Novus would provide you a 50% refund on the purchased product as well as a 50% discount on a future product of equal or lesser value. You would email innovators@novusbio.com to apply for your award, and we

Bioinformatics

• Gene Symbol: FGF2
• Uniprot:
  • P09038()