Recombinant Human FGF basic/FGF2/bFGF (146 aa) Protein

Recombinant Human FGF basic/FGF2/bFGF (146 aa) (Catalog # 233-FB) stimulates cell proliferation of the NR6R‑3T3 mouse fibroblast cell line. The activity is approximately 3-fold greater than the top competitor's FGF basic (146 aa).

1 µg/lane of Recombinant Human FGF basic/FGF2/bFGF (146 aa) was resolved by SDS-PAGE with silver staining, under reducing (R) conditions, showing a band at 17 kDa.

Equivalent bioactivity of GMP (233-GMP), Animal-Free (AFL233) and RUO (Catalog # 233-FB) grades of Recombinant Human FGF basic as measured in a cell proliferation assay using NR6R‑3T3 mouse fibroblast cells (orange, green, red, respectively).

Equivalent bioactivity of E.coli-derived RUO (3718-FB) and Animal-Free (Catalog # 233-FB) grades of Recombinant Human FGF basic as measured in a cell proliferation assay using NR6R-3T3 mouse fibroblast cells (orange,green, respectively).

• Reactivity: Hu
• Applications: Bioactivity

Recombinant Human FGF basic/FGF2/bFGF (146 aa) Protein Summary

• Details of Functionality: Measured in a cell proliferation assay using NR6R‑3T3 mouse fibroblast cells. Raines, E.W. et al. (1985) Methods Enzymol. 109:749. The ED₅₀ for this effect is 0.1-0.6 ng/mL.
• Source: E. coli-derived human FGF basic/FGF2/bFGF protein
  Pro143-Ser288, with an N-terminal Ala
• Accession #: P09038
• N-terminal Sequence: Ala-Pro143
• Protein/Peptide Type: Recombinant Proteins
• Gene: FGF2
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Endotoxin Note: <0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 16.5 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• SDS-PAGE: 17 kDa, reducing conditions

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in Tris-HCl and NaCl with BSA as a carrier protein.
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution Instructions: Reconstitute at 100-250 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human FGF basic/FGF2/bFGF (146 aa) Protein

• basic fibroblast growth factor bFGF
• Basic fibroblast growth factor
• bFGF
• FGF basic
• FGF2
• FGF-2
• FGFBprostatropin
• fibroblast growth factor 2 (basic)
• HBGF-2
• heparin-binding growth factor 2
• Prostatropin

Background

FGF basic (also known as FGF-2 and HBGF-2) is a member of the FGF superfamily of mitogenic proteins which show 35-60% amino acid conservation. FGF acidic and basic are unique from other members of the family in that they lack classical secretory signal peptides. However, they are both readily secreted from cells by an alternative secretory pathway involving direct translocation and aided by several chaperones. FGF acidic (FGF-1) and FGF basic (FGF-2) were the first two identified FGFs, and the designations acidic and basic refer to their relative isoelectric points. The full length human FGF basic protein is 288 amino acids, but there are multiple start sites which produce various shorter forms. Further adding to the complexity, a variety of forms of FGF basic are produced as a result of N-terminal extensions. These extensions affect localization of FGF basic in cellular compartments but do not affect biological activity. FGF basic has been isolated from a number of sources, including neural tissue, adrenal cortex, pituitary gland, corpus luteum, and placenta. Binding of FGF to heparin or cell surface heparan sulfate proteoglycans is required for FGF binding with high affinity to FGF receptors. FGF basic stimulates proliferation of all cells of mesodermal origin as well as many cells of neuroectodermal, ectodermal, and endodermal origin. FGF basic also induces neuronal differentiation, survival, and regeneration, and modulates embryonic development and differentiation. These observed in vitro functions suggest FGF basic may play a role in vivo in the modulation of such normal processes as angiogenesis, wound healing and tissue repair, embryonic development and differentiation, and neuronal function and neural degeneration. Additionally, FGF basic may also participate in the development of several pathological conditions resulting from excessive cell proliferation and/or angiogenesis.

1. Coulier, F. et al. (1997) J. Mol. Evol. 44:43.
2. Chen, C.H. et al. (2004) Curr. Vasc. Pharmacol. 2:33.
3. Mohammadi, M. et al. (2005) Curr. Opin. Struct. Biol. 15:506.
4. Fernig, D. et al. (1994) Prog. Growth Factor Res. 5:353.

Publications for FGF basic/FGF2/bFGF (233-FB)(486)

Publications using 233-FB

• Y Fan, J Hackland, A Baggiolini, LY Hung, H Zhao, P Zumbo, P Oberst, AP Minotti, E Hergenrede, S Najjar, Z Huang, NM Cruz, A Zhong, M Sidharta, T Zhou, E de Stanchi, D Betel, RM White, M Gershon, KG Margolis, L Studer hPSC-derived sacral neural crest enables rescue in a severe model of Hirschsprung&#039;s disease Cell Stem Cell, 2023;30(3):264-282.e9. 2023 [PMID: 36868194] (Bioassay, Human)
• C Degorre, IC Sutton, SL Lehman, UT Shankavara, K Camphausen, PJ Tofilon Glioblastoma cells have increased capacity to repair radiation-induced DNA damage after migration to the olfactory bulb Cancer Cell International, 2022;22(1):389. 2022 [PMID: 36482431] (Cell Culture, Human)
• EF Cohn, BLL Clayton, M Madhavan, S Yacoub, Y Federov, K Paul-Fried, TJ Shafer, PJ Tesar Pervasive environmental chemicals impair oligodendrocyte development bioRxiv : the preprint server for biology, 2023;0(0):. 2023 [PMID: 36798415] (Bioassay, Human)
• RC Gimple, G Zhang, S Wang, T Huang, J Lee, S Taori, D Lv, D Dixit, ME Halbert, AR Morton, RL Kidwell, Z Dong, BC Prager, L Kim, Z Qiu, L Zhao, Q Xie, Q Wu, S Agnihotri, JN Rich Sorting-nexin-10 sustains platelet-derived growth factor receptor signaling in glioblastoma stem cells via endosomal protein sorting JCI Insight, 2023;0(0):. 2023 [PMID: 36795488] (Bioassay, Human)
• L Feige, T Kozaki, G Dias de Me, V Guillemot, F Larrous, F Ginhoux, H Bourhy Susceptibilities of CNS Cells towards Rabies Virus Infection Is Linked to Cellular Innate Immune Responses Viruses, 2022;15(1):. 2022 [PMID: 36680128] (Bioassay, Human)
• N Wang, J He, X Feng, S Liao, Y Zhao, F Tang, K Kee Single-cell profiling of lncRNAs in human germ cells and molecular analysis reveals transcriptional regulation of LNC1845 on LHX8 Elife, 2023;12(0):. 2023 [PMID: 36602025] (Bioassay, Human)
• SC Lin, YC Liao, PM Chen, YY Yang, YH Wang, SL Tung, CM Chuang, YW Sung, TH Jang, SE Chuang, LH Wang Periostin promotes ovarian cancer metastasis by enhancing M2 macrophages and cancer-associated fibroblasts via integrin-mediated NF-kappaB and TGF-beta2 signaling Journal of Biomedical Science, 2022;29(1):109. 2022 [PMID: 36550569] (Cell Culture, Human)
• JE Kaserman, RB Werder, F Wang, T Matte, MI Higgins, M Dodge, J Lindstrom-, P Bawa, A Hinds, E Bullitt, IS Caballero, X Shi, RE Gerszten, N Brunetti-P, M Liesa, C Villacorta, AN Hollenberg, DN Kotton, AA Wilson Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity Cell Reports, 2022;41(10):111775. 2022 [PMID: 36476855] (Bioassay, Human)
• AA Widjaja, S Viswanatha, SG Shekeran, E Adami, WW Lim, S Chothani, J Tan, JWT Goh, HM Chen, SY Lim, CM Boustany-K, J Hawkins, E Petretto, N Hübner, S Schafer, TM Coffman, SA Cook Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease Nature Communications, 2022;13(1):7497. 2022 [PMID: 36470928] (Bioassay, Human)
• HF Wu, W Yu, K Saito-Diaz, CW Huang, J Carey, F Lefcort, GW Hart, HX Liu, N Zeltner Norepinephrine transporter defects lead to sympathetic hyperactivity in Familial Dysautonomia models Nature Communications, 2022;13(1):7032. 2022 [PMID: 36396637] (Bioassay, Human)
• M Fujita, MM Chen, DR Siwak, S Sasagawa, A Oosawa-Tat, K Arihiro, A Ono, R Miura, K Maejima, H Aikata, M Ueno, S Hayami, H Yamaue, K Chayama, JS Lee, Y Lu, GB Mills, H Liang, SS Nishizuka, H Nakagawa Proteo-genomic characterization of virus-associated liver cancers reveals potential subtypes and therapeutic targets Nature Communications, 2022;13(1):6481. 2022 [PMID: 36309506] (Bioassay, Human)
• JH Song, J Choi, YJ Hong, H La, TK Hong, K Hong, JT Do Developmental Potency and Metabolic Traits of Extended Pluripotency Are Faithfully Transferred to Somatic Cells via Cell Fusion-Induced Reprogramming Cells, 2022;11(20):. 2022 [PMID: 36291134] (Bioassay, Human)
• AN Cho, F Bright, N Morey, C Au, LM Ittner, YD Ke Efficient Gene Expression in Human Stem Cell Derived-Cortical Organoids Using Adeno Associated Virus Cells, 2022;11(20):. 2022 [PMID: 36291062] (Bioassay, Human)
• VR Herrera Mi, B Canciani, L Mangiavini, JFS Filipe, L Aidos, M Pallaoro, GM Peretti, P Pocar, SC Modina, A Di Giancam Endostatin in 3D Fibrin Hydrogel Scaffolds Promotes Chondrogenic Differentiation in Swine Neonatal Meniscal Cells Biomedicines, 2022;10(10):. 2022 [PMID: 36289678] (Bioassay, Porcine)
• H Wang, B Keepers, Y Qian, Y Xie, M Colon, J Liu, L Qian Cross-lineage potential of Ascl1 uncovered by comparing diverse reprogramming regulatomes Cell Stem Cell, 2022;29(10):1491-1504.e9. 2022 [PMID: 36206732] (Bioassay, Mouse)
• P Dong, GE Hoffman, P Apontes, J Bendl, S Rahman, MB Fernando, B Zeng, JM Vicari, W Zhang, K Girdhar, KG Townsley, R Misir, CommonMind, KJ Brennand, V Haroutunia, G Voloudakis, JF Fullard, P Roussos Population-level variation in enhancer expression identifies disease mechanisms in the human brain Nature Genetics, 2022;54(10):1493-1503. 2022 [PMID: 36163279] (Bioassay, Human)
• D Yang, J Gomez-Garc, S Funakoshi, T Tran, I Fernandes, GD Bader, MA Laflamme, GM Keller Modeling human multi-lineage heart field development with pluripotent stem cells Cell Stem Cell, 2022;29(9):1382-1401.e8. 2022 [PMID: 36055193] (Bioassay, Human)
• S Martin, KC Allan, O Pinkard, T Sweet, PJ Tesar, J Coller Oligodendrocyte differentiation alters tRNA modifications and codon optimality-mediated mRNA decay Nature Communications, 2022;13(1):5003. 2022 [PMID: 36008413] (Bioassay, Mouse)
• K Kishimoto, K Iwasawa, A Sorel, C Ferran-Her, L Han, M Morimoto, JM Wells, T Takebe, AM Zorn Directed differentiation of human pluripotent stem cells into diverse organ-specific mesenchyme of the digestive and respiratory systems Nature Protocols, 2022;0(0):. 2022 [PMID: 35978039] (Cell Culture, Human)
• D Hao, L Lu, H Song, Y Duan, J Chen, R Carney, JJ Li, P Zhou, J Nolta, KS Lam, JK Leach, DL Farmer, A Panitch, A Wang Engineered extracellular vesicles with high collagen-binding affinity present superior in situ retention and therapeutic efficacy in tissue repair Theranostics, 2022;12(13):6021-6037. 2022 [PMID: 35966577] (Cell Culture, Human)
• Q Ma, Y Xiao, W Xu, M Wang, S Li, Z Yang, M Xu, T Zhang, ZN Zhang, R Hu, Q Su, F Yuan, T Xiao, X Wang, Q He, J Zhao, ZJ Chen, Z Sheng, M Chai, H Wang, W Shi, Q Deng, X Cheng, W Li ZnT8 loss-of-function accelerates functional maturation of hESC-derived beta cells and resists metabolic stress in diabetes Nature Communications, 2022;13(1):4142. 2022 [PMID: 35842441] (Bioassay, Human)
• CW Lee, YF Chen, AW Hsiao, AY Wang, OY Shen, BY Wang, LWC Ho, WT Lin, CHJ Choi, OK Lee Demystifying the long noncoding RNA landscape of small EVs derived from human mesenchymal stromal cells Journal of advanced research, 2022;39(0):73-88. 2022 [PMID: 35777918] (Bioassay, Human)
• MK Eltahir, M Nakamori, S Hattori, T Kimura, H Mochizuki, S Nagano Pharmacotherapy alleviates pathological changes in human direct reprogrammed neuronal cell model of myotonic dystrophy type 1 PLoS ONE, 2022;17(7):e0269683. 2022 [PMID: 35776705] (Bioassay, Human)
• Y Tsujisaka, T Hatani, C Okubo, R Ito, A Kimura, M Narita, K Chonabayas, S Funakoshi, A Lucena-Cac, T Toyoda, K Osafune, T Kimura, H Saito, Y Yoshida Purification of human iPSC-derived cells at large scale using microRNA switch and magnetic-activated cell sorting Stem Cell Reports, 2022;0(0):. 2022 [PMID: 35688152] (Bioassay, Human)
• MK Samanta, S Gayen, C Harris, E Maclary, Y Murata-Nak, RM Malcore, RS Porter, PM Garay, CN Vallianato, PB Samollow, S Iwase, S Kalantry Activation of Xist by an evolutionarily conserved function of KDM5C demethylase Nature Communications, 2022;13(1):2602. 2022 [PMID: 35545632] (Bioassay, Mouse)
• M Cloutier, S Kumar, E Buttigieg, L Keller, B Lee, A Williams, S Mojica-Per, I Erliandri, AMD Rocha, K Cadigan, GD Smith, S Kalantry Preventing erosion of X-chromosome inactivation in human embryonic stem cells Nature Communications, 2022;13(1):2516. 2022 [PMID: 35523820] (Bioassay, Mouse)
• C Rodriguez-, N Kale, MJ Carlini, N Shrivastav, AA Rodrigues, B Khalil, JJ Bravo-Cord, M Alexander, J Ji, Y Hong, F Behbod, MS Sosa NR2F1 is a barrier to dissemination of early stage breast cancer cells Cancer Research, 2022;0(0):. 2022 [PMID: 35471456] (Cell Culture, Mouse)
• Y Quan, M Wang, C Xu, X Wang, Y Wu, D Qin, Y Lin, X Lu, F Lu, L Li Cnot8 eliminates na�ve regulation networks and is essential for na�ve-to-formative pluripotency transition Nucleic Acids Research, 2022;0(0):. 2022 [PMID: 35390160] (Bioassay, Mouse)
• BK Gage, S Merlin, C Olgasi, A Follenzi, GM Keller Therapeutic correction of hemophilia A by transplantation of hPSC-derived liver sinusoidal endothelial cell progenitors Cell Reports, 2022;39(1):110621. 2022 [PMID: 35385743] (Bioassay, Human)
• I Kim, A Ghosh, N Bundschuh, L Hinte, E Petrosyan, F von Meyenn, O Bar-Nur Integrative molecular roadmap for direct conversion of fibroblasts into myocytes and myogenic progenitor cells Science Advances, 2022;8(14):eabj4928. 2022 [PMID: 35385316] (Cell Culture, Mouse)
• Y Shinmyo, K Saito, T Hamabe-Hor, N Kameya, A Ando, K Kawasaki, TAD Duong, M Sakashita, J Roboon, T Hattori, T Kannon, K Hosomichi, M Slezak, MG Holt, A Tajima, O Hori, H Kawasaki Localized astrogenesis regulates gyrification of the cerebral cortex Science Advances, 2022;8(10):eabi5209. 2022 [PMID: 35275722] (Bioassay, Mouse)
• J Chen, K Qiao, C Zhang, X Zhou, Q Du, Y Deng, L Cao VRK2 activates TNFalpha/NF-kappaB signaling by phosphorylating IKKbeta in pancreatic cancer International journal of biological sciences, 2022;18(3):1288-1302. 2022 [PMID: 35173553] (Bioassay, Human)
• K Zhao, Y Shi, J Yu, L Yu, A Mael, Y Li, A Kolton, T Joyce, J Odorico, PO Berggren, SN Yang Intracameral Microimaging of Maturation of Human iPSC Derivatives into Islet Endocrine Cells Cell Transplantation, 2022;31(0):9636897211066. 2022 [PMID: 35156411] (Bioassay, Human)
• G Iannello, A Patel, D Sirabella, B Corneo, VV Thaker Derivation and characterization of the induced pluripotent stem cell line CUIMCi004-A from a patient with a novel frameshift variant in exon 18a of OCRL Stem Cell Research, 2021;59(0):102635. 2021 [PMID: 35074682] (Bioassay, Human)
• Z Pan, R Zhao, B Li, Y Qi, W Qiu, Q Guo, S Zhang, S Zhao, H Xu, M Li, Z Gao, Y Fan, J Xu, H Wang, S Wang, J Qiu, Q Wang, X Guo, L Deng, P Zhang, H Xue, G Li EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3 Molecular Cancer, 2022;21(1):16. 2022 [PMID: 35031058] (Bioassay, Human)
• Y Miura, MY Li, O Revah, SJ Yoon, G Narazaki, SP Pa?ca Engineering brain assembloids to interrogate human neural circuits Nature Protocols, 2022;17(1):15-35. 2022 [PMID: 34992269] (Bioassay, Human)
• S Rezaei-Lot, F Vujovic, M Simonian, N Hunter, RM Farahani Programmed genomic instability regulates neural transdifferentiation of human brain microvascular pericytes Genome Biology, 2021;22(1):334. 2021 [PMID: 34886891] (Bioassay, Human)
• AK Eicher, DO Kechele, N Sundaram, HM Berns, HM Poling, LE Haines, JG Sanchez, K Kishimoto, M Krishnamur, L Han, AM Zorn, MA Helmrath, JM Wells Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells Cell Stem Cell, 2021;0(0):. 2021 [PMID: 34856121] (Bioassay, Human)
• AF de Souza, FF Bressan, NCG Pieri, RC Botigelli, T Revay, SK Haddad, DT Covas, ES Ramos, WA King, FV Meirelles Generation of Primordial Germ Cell-like Cells from iPSCs Derived from Turner Syndrome Patients Cells, 2021;10(11):. 2021 [PMID: 34831322] (Bioassay, Human)
• MA Fayaz, GDS Rosa, A Honaramooz Neonatal Porcine Germ Cells Dedifferentiate and Display Osteogenic and Pluripotency Properties Cells, 2021;10(11):. 2021 [PMID: 34831039] (Bioassay, Porcine)
• RS Kenchappa, Y Liu, MG Argenziano, MA Banu, AC Mladek, R West, A Luu, A Quiñones-H, D Hambardzum, V Justilien, M Leitges, JN Sarkaria, PA Sims, P Canoll, NR Murray, AP Fields, SS Rosenfeld Protein kinase C? and SRC signaling define reciprocally related subgroups of glioblastoma with distinct therapeutic vulnerabilities Cell Reports, 2021;37(8):110054. 2021 [PMID: 34818553] (Bioassay, Human)
• Y Gu, Y Chen, L Wei, S Wu, K Shen, C Liu, Y Dong, Y Zhao, Y Zhang, C Zhang, W Zheng, J He, Y Wang, Y Li, X Zhao, H Wang, J Tan, L Wang, Q Zhou, G Xie, H Liang, J Ou ABHD5 inhibits YAP-induced c-Met overexpression and colon cancer cell stemness via suppressing YAP methylation Nature Communications, 2021;12(1):6711. 2021 [PMID: 34795238] (Bioassay, Human)
• T Arad, N Fainstein, S Goldfarb, M Lachish, T Ganz, T Ben-Hur CD200 -dependent and -independent immune-modulatory functions of neural stem cells Stem Cell Research, 2021;56(0):102559. 2021 [PMID: 34634761] (Cell Culture, Mouse)
• R Linares-Sa, W Kim, NA Bolar, H Zhang, BA Koch-Bojal, S Yoon, PP Shah, A Karnay, DS Park, JM Luppino, SC Nguyen, A Padmanabha, CL Smith, A Poleshko, Q Wang, L Li, D Srivastava, G Vahedi, GH Eom, GA Blobel, EF Joyce, R Jain BRD4 orchestrates genome folding to promote neural crest differentiation Nature Genetics, 2021;53(10):1480-1492. 2021 [PMID: 34611363] (Bioassay, Human)
• de Rus Jacquet A, Tancredi J, Lemire A, DeSantis M, Li W, O'Shea E The LRRK2 G2019S mutation alters astrocyte-to-neuron communication via extracellular vesicles and induces neuron atrophy in a human iPSC-derived model of Parkinson&#039;s disease. Elife, 0;10(0):. 0 [PMID: 34590578] (Bioassay, Human)
• Q Heydt, C Xintaropou, A Clear, M Austin, I Pislariu, F Miraki-Mou, P Cutillas, K Korfi, M Calaminici, W Cawthorn, K Suchacki, A Nagano, JG Gribben, M Smith, JD Cavenagh, H Oakervee, A Castleton, D Taussig, B Peck, A Wilczynska, L McNaughton, D Bonnet, F Mardakheh, B Patel Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence Nature Communications, 2021;12(1):5507. 2021 [PMID: 34535653] (Cell Culture, Human)
• F Vujovic, S Rezaei-Lot, N Hunter, RM Farahani The fate of notch-1 transcript is linked to cell cycle dynamics by activity of a natural antisense transcript Nucleic Acids Research, 2021;0(0):. 2021 [PMID: 34520549] (Bioassay, Human)
• Y Aghazadeh, F Poon, F Sarangi, FTM Wong, ST Khan, X Sun, R Hatkar, BJ Cox, SS Nunes, MC Nostro Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models Cell Stem Cell, 2021;0(0):. 2021 [PMID: 34480863] (Bioassay, Human)
• M Restan Per, R Sharma, NZ Masri, SM Willerth 3D Bioprinting Mesenchymal Stem Cell-Derived Neural Tissues Using a Fibrin-Based Bioink Biomolecules, 2021;11(8):. 2021 [PMID: 34439916] (Bioassay, Human)
• T Jia, T Jacquet, F Dalonneau, P Coudert, E Vaganay, C Exbrayat-H, J Vollaire, V Josserand, F Ruggiero, JL Coll, B Eymin FGF-2 promotes angiogenesis through a SRSF1/SRSF3/SRPK1-dependent axis that controls VEGFR1 splicing in endothelial cells Bmc Biology, 2021;19(1):173. 2021 [PMID: 34433435] (Bioassay, Human)
• AV Parent, G Faleo, J Chavez, M Saxton, DI Berrios, NR Kerper, Q Tang, M Hebrok Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection Cell Reports, 2021;36(7):109538. 2021 [PMID: 34407395] (Bioassay, Human)
• N Shimamura, K Fujii, S Ohkoshi Detection and quantification of human-specific mRNA from hepatocyte-like cells derived from dental pulp using real-time polymerase chain reaction Journal of oral biosciences, 2021;0(0):. 2021 [PMID: 34311038] (Bioassay, Human)
• SM Dieter, C Siegl, PL Codó, M Huerta, AL Ostermann-, E Schulz, MK Zowada, S Martin, K Laaber, A Nowrouzi, M Blatter, S Kreth, F Westermann, A Benner, U Uhrig, K Putzker, J Lewis, A Haegebarth, D Mumberg, SJ Holton, J Weiske, LM Toepper, U Scheib, G Siemeister, CR Ball, B Kuster, G Stoehr, H Hahne, S Johannes, M Lange, F Herbst, H Glimm Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer Cell Reports, 2021;36(3):109394. 2021 [PMID: 34289372] (Bioassay, Human)
• D Boso, E Carraro, E Maghin, S Todros, A Dedja, M Giomo, N Elvassore, P De Coppi, PG Pavan, M Piccoli Porcine Decellularized Diaphragm Hydrogel: A New Option for Skeletal Muscle Malformations Biomedicines, 2021;9(7):. 2021 [PMID: 34206569] (Bioassay, Human)
• J Dong, J Li, Y Li, Z Ma, Y Yu, CY Wang Transcriptional super-enhancers control cancer stemness and metastasis genes in squamous cell carcinoma Nature Communications, 2021;12(1):3974. 2021 [PMID: 34172737] (Bioassay, Human)
• S Dvir, A Argoetti, C Lesnik, M Roytblat, K Shriki, M Amit, T Hashimshon, Y Mandel-Gut Uncovering the RNA-binding protein landscape in the pluripotency network of human embryonic stem cells Cell Reports, 2021;35(9):109198. 2021 [PMID: 34077720] (Bioassay, Human)
• R Bhattachar, SE Black, MS Lotlikar, RH Fenn, M Jorfi, DM Kovacs, RE Tanzi Axonal generation of amyloid-&amp;beta from palmitoylated APP in mitochondria-associated endoplasmic reticulum membranes Cell Reports, 2021;35(7):109134. 2021 [PMID: 34010653] (Bioassay, Human)
• C Wang, Y Li, L Jia, JK Kim, J Li, P Deng, W Zhang, PH Krebsbach, CY Wang CD276 expression enables squamous cell carcinoma stem cells to evade immune surveillance Cell Stem Cell, 2021;0(0):. 2021 [PMID: 33945793] (Bioassay, Human)
• A Abdullah, C Herdenberg, H Hedman Netrin-1 functions as a suppressor of bone morphogenetic protein (BMP) signaling Scientific Reports, 2021;11(1):8585. 2021 [PMID: 33883596] (Bioassay, Human)
• T Distler, I Lauria, R Detsch, CM Sauter, F Bendt, J Kapr, S Rütten, AR Boccaccini, E Fritsche Neuronal Differentiation from Induced Pluripotent Stem Cell-Derived Neurospheres by the Application of Oxidized Alginate-Gelatin-Laminin Hydrogels Biomedicines, 2021;9(3):. 2021 [PMID: 33808044] (Bioassay, Human)
• RM Agoglia, D Sun, F Birey, SJ Yoon, Y Miura, K Sabatini, SP Pa?ca, HB Fraser Primate cell fusion disentangles gene regulatory divergence in neurodevelopment Nature, 2021;0(0):. 2021 [PMID: 33731928] (Bioassay, Human)
• CV Latchouman, MI Betancur, GA Simchick, MK Sun, R Forghani, CE Lenear, A Ahmed, R Mohankumar, N Balaji, HD Mason, SA Archer-Har, P Azadi, PV Holmes, Q Zhao, RV Bellamkond, L Karumbaiah Engineered glycomaterial implants orchestrate large-scale functional repair of brain tissue chronically after severe traumatic brain injury Science Advances, 2021;7(10):. 2021 [PMID: 33674306] (Bioassay, Rat)
• X Dong, L Yang, K Liu, X Ji, C Tang, W Li, L Ma, Y Mei, T Peng, B Feng, Z Wu, Q Tang, Y Gao, K Yan, W Zhou, M Xiong Transcriptional networks identify synaptotagmin-like 3 as a regulator of cortical neuronal migration during early neurodevelopment Cell Reports, 2021;34(9):108802. 2021 [PMID: 33657377] (Bioassay, Human)
• AL Rodrigues, HY Liu, YW Chen, M Porotto, A Moscona, HW Snoeck The in vitro multilineage differentiation and maturation of lung and airway cells from human pluripotent stem cell-derived lung progenitors in 3D Nature Protocols, 2021;0(0):. 2021 [PMID: 33649566] (Bioassay, Human)
• A Gordon, SJ Yoon, SS Tran, CD Makinson, JY Park, J Andersen, AM Valencia, S Horvath, X Xiao, JR Huguenard, SP Pa?ca, DH Geschwind Long-term maturation of human cortical organoids matches key early postnatal transitions Nature Neuroscience, 2021;0(0):. 2021 [PMID: 33619405] (Bioassay, Human)
• W Yuan, Z Yao, V Veerapandi, X Yang, X Wang, D Chen, L Ma, C Li, Y Zheng, F Luo, XY Zhao The histone demethylase KDM2B regulates human primordial germ cell-like cells specification International journal of biological sciences, 2021;17(2):527-538. 2021 [PMID: 33613110] (Bioassay, Human)
• X Wang, Y Xiang, Y Yu, R Wang, Y Zhang, Q Xu, H Sun, ZA Zhao, X Jiang, X Wang, X Lu, D Qin, Y Quan, J Zhang, N Shyh-Chang, H Wang, N Jing, W Xie, L Li Formative pluripotent stem cells show features of epiblast cells poised for gastrulation Cell Research, 2021;0(0):. 2021 [PMID: 33608671] (Bioassay, Mouse)
• J Li, A Wuethrich, AAI Sina, HH Cheng, Y Wang, A Behren, PN Mainwaring, M Trau A digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapy Nature Communications, 2021;12(1):1087. 2021 [PMID: 33597530] (Human)
• S Hao, X Zhu, Z Liu, X Wu, S Li, P Jiang, L Jiang Chronic intermittent hypoxia promoted lung cancer stem cell-like properties via enhancing Bach1 expression Respiratory Research, 2021;22(1):58. 2021 [PMID: 33596919] (Bioassay, Human)
• T Wang, AR Pine, AG Kotini, H Yuan, L Zamparo, DT Starczynow, C Leslie, EP Papapetrou Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets Cell Stem Cell, 2021;0(0):. 2021 [PMID: 33571445] (Bioassay, Human)
• PP Shah, W Lv, JH Rhoades, A Poleshko, D Abbey, MA Caporizzo, R Linares-Sa, JG Heffler, N Sayed, D Thomas, Q Wang, LJ Stanton, K Bedi, MP Morley, TP Cappola, AT Owens, KB Margulies, DB Frank, JC Wu, DJ Rader, W Yang, BL Prosser, K Musunuru, R Jain Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes Cell Stem Cell, 2021;0(0):. 2021 [PMID: 33529599] (Bioassay, Human)
• T Otsuka, PY Mengsteab, CT Laurencin Control of mesenchymal cell fate via application of FGF-8b in vitro Stem Cell Research, 2021;51(0):102155. 2021 [PMID: 33445073] (Bioassay, Rat)
• CL Wu, A Dicks, N Steward, R Tang, DB Katz, YR Choi, F Guilak Single cell transcriptomic analysis of human pluripotent stem cell chondrogenesis Nature Communications, 2021;12(1):362. 2021 [PMID: 33441552] (Bioassay, Human)
• JP Russell, X Lim, A Santambrog, V Yianni, Y Kemkem, B Wang, M Fish, S Haston, A Grabek, S Hallang, EJ Lodge, AL Patist, A Schedl, P Mollard, R Nusse, CL Andoniadou Pituitary stem cells produce paracrine WNT signals to control the expansion of their descendant progenitor cells Elife, 2021;10(0):. 2021 [PMID: 33399538] (Bioassay, Mouse)
• C Zhong, P Li, S Argade, L Liu, A Chilla', W Liang, H Xin, B Eliceiri, B Choudhury, N Ferrara Inhibition of protein glycosylation is a novel pro-angiogenic strategy that acts via activation of stress pathways Nature Communications, 2020;11(1):6330. 2020 [PMID: 33303737] (Cell Culture, Human)
• Y Na, A Hall, K Choi, L Hu, J Rose, RA Coover, A Miller, RF Hennigan, E Dombi, MO Kim, S Subramania, N Ratner, J Wu MicroRNA-155 contributes to plexiform neurofibroma growth downstream of MEK Oncogene, 2020;0(0):. 2020 [PMID: 33293695] (Bioassay, Mouse)
• N Zhang, J Mendieta-E, A Magli, KC Lilja, RCR Perlingeir, MA Marti-Reno, A Tsirigos, BD Dynlacht Muscle progenitor specification and myogenic differentiation are associated with changes in chromatin topology Nature Communications, 2020;11(1):6222. 2020 [PMID: 33277476] (Cell Culture, Mouse)
• J Qiu, S Nordling, HH Vasavada, EC Butcher, KK Hirschi Retinoic Acid Promotes Endothelial Cell Cycle Early G1 State to Enable Human Hemogenic Endothelial Cell Specification Cell Rep, 2020;33(9):108465. 2020 [PMID: 33264627] (Cell Culture, Human)
• T Chitiashvi, I Dror, R Kim, FM Hsu, R Chaudhari, E Pandolfi, D Chen, S Liebscher, K Schenke-La, K Plath, A Clark Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation Nature Cell Biology, 2020;22(12):1436-1446. 2020 [PMID: 33257808] (Cell Culture, Human)
• F Rajabi, WY Liu-Bordes, M Pinskaya, F Dominika, G Kratassiou, G Pinna, S Nanni, A Farsetti, C Gespach, A Londoño-Va, I Groisman CPEB1 orchestrates a fine-tuning of miR-145-5p tumor-suppressive activity on TWIST1 translation in prostate cancer cells Oncotarget, 2020;11(45):4155-4168. 2020 [PMID: 33227047] (Bioassay, Human)
• T Matsumura, T Fujimoto, A Futakuchi, Y Takihara, F Watanabe-K, E Takahashi, M Inoue-Moch, H Tanihara, T Inoue TGF-&amp;beta-induced activation of conjunctival fibroblasts is modulated by FGF-2 and substratum stiffness PLoS ONE, 2020;15(11):e0242626. 2020 [PMID: 33206726] (Cell Culture, Human)
• C Malkmus, S Jawahar, N Tricoche, S Lustigman, J Hansmann Preliminary evaluations of 3-dimensional human skin models for their ability to facilitate in vitro the long-term development of the debilitating obligatory human parasite Onchocerca volvulus PLoS Negl Trop Dis, 2020;14(11):e0008503. 2020 [PMID: 33151944] (Cell Culture, Human)
• FJ Hawkins, S Suzuki, ML Beermann, C Barillà, R Wang, C Villacorta, A Berical, JC Jean, J Le Suer, T Matte, C Simone-Roa, Y Tang, TM Schlaeger, AM Crane, N Matthias, SXL Huang, SH Randell, J Wu, JR Spence, G Carraro, BR Stripp, A Rab, EJ Sorsher, A Horani, SL Brody, BR Davis, DN Kotton Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells Cell Stem Cell, 2020;0(0):. 2020 [PMID: 33098807] (Bioassay, Human)
• KC Allan, LR Hu, MA Scavuzzo, AR Morton, AS Gevorgyan, EF Cohn, BLL Clayton, IR Bederman, S Hung, CF Bartels, M Madhavan, PJ Tesar Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function Cell Stem Cell, 2020;0(0):. 2020 [PMID: 33091368] (Bioassay, Human)
• SY Yin, BM Sun, T Xu, X Liu, LJ Huo, X Zhang, J Zhou, YL Miao CHIR99021 and rpIL6 promote porcine parthenogenetic embryo development and blastocyst quality Theriogenology, 2020;158(0):470-476. 2020 [PMID: 33049572] (Bioassay, Porcine)
• KH Elliott, X Chen, J Salomone, P Chaturvedi, PA Schultz, SK Balchand, JD Servetas, A Zuniga, R Zeller, B Gebelein, MT Weirauch, KA Peterson, SA Brugmann Gli3 utilizes Hand2 to synergistically regulate tissue-specific transcriptional networks Elife, 2020;9(0):. 2020 [PMID: 33006313] (Bioassay, Mouse)
• T Nicotra, A Desnos, J Halimi, H Antonot, L Reppel, T Belmas, A Freton, F Stranieri, M Mebarki, J Larghero, A Cras, L Faivre Mesenchymal stem/stromal cell quality control: validation of mixed lymphocyte reaction assay using flow cytometry according to ICH Q2(R1) Stem Cell Res Ther, 2020;11(1):426. 2020 [PMID: 33004063] (Cell Culture, Human)
• J Xiao, JR McGill, K Stanton, JD Kassner, S Choudhury, R Schlegel, ZE Sauna, PR Pohlmann, S Agarwal Efficient Propagation of Circulating Tumor Cells: A First Step for Probing Tumor Metastasis Cancers (Basel), 2020;12(10):. 2020 [PMID: 32998338] (Bioassay, Human)
• D Garbett, A Bisaria, C Yang, DG McCarthy, A Hayer, WE Moerner, TM Svitkina, T Meyer T-Plastin reinforces membrane protrusions to bridge matrix gaps during cell migration Nat Commun, 2020;11(1):4818. 2020 [PMID: 32968060] (Bioassay, Human)
• Z Wei, R Schnellman, HC Pruitt, S Gerecht Hydrogel Network Dynamics Regulate Vascular Morphogenesis Cell Stem Cell, 2020;0(0):. 2020 [PMID: 32931729] (Bioassay, Human)
• W Chen, Z Zhang, C Chang, Z Yang, P Wang, H Fu, X Wei, E Chen, S Tan, W Huang, L Sun, T Ni, Y Yang, Y Wang A bioenergetic shift is required for spermatogonial differentiation Cell Discov, 2020;6(0):56. 2020 [PMID: 32864161] (Bioassay, Mouse)
• W Chen, Z Zhang, C Chang, Z Yang, P Wang, H Fu, X Wei, E Chen, S Tan, W Huang, L Sun, T Ni, Y Yang, Y Wang A bioenergetic shift is required for spermatogonial differentiation Cell Discov, 2020;6(0):56. 2020 [PMID: 32864161] (Bioassay, Mouse)
• HHM Le, D Vang, N Amer, T Vue, C Yee, H Kaou, JS Harrison, N Xiao, J Lin-Ceregh, GP Lin-Ceregh, Thor Enhancement of cell proliferation and motility of mammalian cells grown in co-culture with Pichia pastoris expressing recombinant human FGF-2 Protein Expr. Purif., 2020;176(0):105724. 2020 [PMID: 32846209] (Bioassay, Mouse)
• F Duan, L Guo, L Yang, Y Han, A Thakur, BE Nilsson-Pa, P Wang, Z Zhang, CY Ma, X Zhou, T Han, T Zhang, X Wang, D Xu, X Duan, J Xiang, HF Tse, C Liao, W Luo, FP Huang, YW Chen, T Evans, RE Schwartz, B tenOever, DD Ho, S Chen, Q Lian, HJ Chen Modeling COVID-19 with Human Pluripotent Stem Cell-Derived Cells Reveals Synergistic Effects of Anti-inflammatory Macrophages with ACE2 Inhibition Against SARS-CoV-2 Res Sq, 2020;0(0):. 2020 [PMID: 32839764] (Bioassay, Human)
• S Zhou, W Zhang, G Cai, Y Ding, C Wei, S Li, Y Yang, J Qin, D Liu, H Zhang, X Shao, J Wang, H Wang, W Yang, H Wang, S Chen, P Hu, L Sun Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration Cell Res., 2020;0(0):. 2020 [PMID: 32839552] (Bioassay, Mouse)
• S Zhou, W Zhang, G Cai, Y Ding, C Wei, S Li, Y Yang, J Qin, D Liu, H Zhang, X Shao, J Wang, H Wang, W Yang, H Wang, S Chen, P Hu, L Sun Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration Cell Res., 2020;0(0):. 2020 [PMID: 32839552] (Bioassay, Mouse)
• S Eslava-Alc, MJ Extremera-, I Sanchez-Go, L Beltrán-Ca, A Rosal-Vela, J Muñoz, N Ibarz, JA Alonso-Piñ, M Rojas-Torr, M Jiménez-Pa, A González-R, R Conejero, E Doiz, M Rodriguez-, R Moreno-Lun, MC Durán-Ruiz Atherosclerotic Pre-Conditioning Affects the Paracrine Role of Circulating Angiogenic Cells Ex-Vivo Int J Mol Sci, 2020;21(15):. 2020 [PMID: 32722151] (Bioassay, Human)
• S Eslava-Alc, MJ Extremera-, I Sanchez-Go, L Beltrán-Ca, A Rosal-Vela, J Muñoz, N Ibarz, JA Alonso-Piñ, M Rojas-Torr, M Jiménez-Pa, A González-R, R Conejero, E Doiz, M Rodriguez-, R Moreno-Lun, MC Durán-Ruiz Atherosclerotic Pre-Conditioning Affects the Paracrine Role of Circulating Angiogenic Cells Ex-Vivo Int J Mol Sci, 2020;21(15):. 2020 [PMID: 32722151] (Bioassay, Human)
• T Nishimura, H Xu, M Iwasaki, D Karigane, B Saavedra, Y Takahashi, FP Suchy, S Monobe, RM Martin, M Ohtaka, M Nakanishi, SR Burrows, ML Cleary, R Majeti, A Shibuya, H Nakauchi Sufficiency for inducible Caspase-9 safety switch in human pluripotent stem cells and disease cells Gene Ther., 2020;0(0):. 2020 [PMID: 32704085] (Cell Culture, Human)
• H Yagi, AF Chen, D Hirsch, AC Rothenberg, J Tan, PG Alexander, RS Tuan Antimicrobial activity of mesenchymal stem cells against Staphylococcus aureus Stem Cell Res Ther, 2020;11(1):293. 2020 [PMID: 32680544] (Bioassay, Human)
• CE Eyler, H Matsunaga, V Hovestadt, SJ Vantine, P van Galen, BE Bernstein Single-cell lineage analysis reveals genetic and epigenetic interplay in glioblastoma drug resistance Genome Biol., 2020;21(1):174. 2020 [PMID: 32669109] (Cell Culture, Human)
• K Hirano, M Kubo, Y Fukuyama, M Namihira Indonesian Ginger (Bangle) Extract Promotes Neurogenesis of Human Neural Stem Cells through WNT Pathway Activation Int J Mol Sci, 2020;21(13):. 2020 [PMID: 32635647] (Cell Culture, Human)
• EJ Kim, YJ Kim, HI Lee, SH Jeong, HJ Nam, JH Cho NRF2 Knockdown Resensitizes 5-Fluorouracil-Resistant Pancreatic Cancer Cells by Suppressing HO-1 and ABCG2 Expression Int J Mol Sci, 2020;21(13):. 2020 [PMID: 32629871] (Cell Culture, Human)
• E Gronseth, A Gupta, C Koceja, S Kumar, RG Kutty, K Rarick, L Wang, R Ramchandra Astrocytes influence medulloblastoma phenotypes and CD133 surface expression PLoS ONE, 2020;15(7):e0235852. 2020 [PMID: 32628717] (Cell Culture, Zebrafish)
• LTP Khoa, YC Tsan, F Mao, DM Kremer, P Sajjakulnu, L Zhang, B Zhou, X Tong, NV Bhanu, C Choudhary, BA Garcia, L Yin, GD Smith, TL Saunders, SL Bielas, CA Lyssiotis, Y Dou Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation Cell Stem Cell, 2020;0(0):. 2020 [PMID: 32610040] (Bioassay, Human)
• J Wu, D Song, Z Li, B Guo, Y Xiao, W Liu, L Liang, C Feng, T Gao, Y Chen, Y Li, Z Wang, J Wen, S Yang, P Liu, L Wang, Y Wang, L Peng, GN Stacey, Z Hu, G Feng, W Li, Y Huo, R Jin, N Shyh-Chang, Q Zhou, L Wang, B Hu, H Dai, J Hao Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis Cell Res., 2020;0(0):. 2020 [PMID: 32546764] (Bioassay, Human)
• BN Sheikh, S Guhathakur, TH Tsang, M Schwabenla, G Renschler, B Herquel, V Bhardwaj, H Holz, T Stehle, O Bondareva, N Aizarani, O Mossad, O Kretz, W Reichardt, A Chatterjee, LJ Braun, J Thevenon, H Sartelet, T Blank, D Grün, D von Elverf, TB Huber, D Vestweber, S Avilov, M Prinz, JM Buescher, A Akhtar Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature Nat. Cell Biol., 2020;0(0):. 2020 [PMID: 32541879] (Bioassay, Mouse)
• JA Gregory, E Hoelzli, R Abdelaal, C Braine, M Cuevas, M Halpern, N Barretto, N Schrode, G Akbalik, K Kang, E Cheng, K Bowles, S Lotz, S Goderie, CM Karch, S Temple, A Goate, KJ Brennand, H Phatnani Cell Type-Specific In Vitro Gene Expression Profiling of Stem Cell-Derived Neural Models Cells, 2020;9(6):. 2020 [PMID: 32516938] (Cell Culture, Human)
• J Wesely, AG Kotini, F Izzo, H Luo, H Yuan, J Sun, M Georgomano, A Zviran, AG Deslaurier, N Dusaj, SD Nimer, C Leslie, DA Landau, MG Kharas, EP Papapetrou Acute Myeloid Leukemia iPSCs Reveal a Role for RUNX1 in the Maintenance of Human Leukemia Stem Cells Cell Rep, 2020;31(9):107688. 2020 [PMID: 32492433] (Cell Culture, Human)
• O Al-Dalahma, J Nicholson, S Draijer, LC Soares, FG Szele Galectin-3 diminishes Wnt signaling in the postnatal subventricular zone Stem Cells, 2020;0(0):. 2020 [PMID: 32442340] (Cell Culture, Mouse)
• L Nimtz, J Hartmann, J Tigges, S Masjosthus, M Schmuck, E Ke beta el, S Theiss, K Köhrer, P Petzsch, J Adjaye, C Wigmann, D Wieczorek, B Hildebrand, F Bendt, U Hübenthal, G Brockerhof, E Fritsche Characterization and application of electrically active neuronal networks established from human induced pluripotent stem cell-derived neural progenitor cells for neurotoxicity evaluation Stem Cell Res, 2020;45(0):101761. 2020 [PMID: 32244191] (Bioassay, Human)
• YH Fang, SPH Wang, ZH Gao, SN Wu, HY Chang, PJ Yang, PY Liu, YW Liu Efficient Cardiac Differentiation of Human Amniotic Fluid-Derived Stem Cells into Induced Pluripotent Stem Cells and Their Potential Immune Privilege Int J Mol Sci, 2020;21(7):. 2020 [PMID: 32235313] (Cell Culture, Human)
• SK Ryan, MV Gonzalez, JP Garifallou, FC Bennett, KS Williams, NP Sotuyo, E Mironets, K Cook, H Hakonarson, SA Anderson, KL Jordan-Sci Neuroinflammation and EIF2 Signaling Persist despite Antiretroviral Treatment in an hiPSC Tri-culture Model of HIV Infection Stem Cell Reports, 2020;0(0):. 2020 [PMID: 32220329] (Bioassay, Human)
• Z Chen, J Zhang, H Xue, M Qian, X Guo, X Gao, J Xu, Y Qi, X Sun, G Li Nitidine Chloride Is a Potential Alternative Therapy for Glioma Through Inducing Endoplasmic Reticulum Stress and Alleviating Epithelial-Mesenchymal Transition Integr Cancer Ther, 2020;19(0):1534735419900. 2020 [PMID: 32129091] (Bioassay, Human)
• HY Jo, HW Han, I Jung, JH Ju, SJ Park, S Moon, D Geum, H Kim, HJ Park, S Kim, GN Stacey, SK Koo, MH Park, JH Kim Development of genetic quality tests for good manufacturing practice-compliant induced pluripotent stem cells and their derivatives Sci Rep, 2020;10(1):3939. 2020 [PMID: 32127560] (Bioassay, Human)
• JS Kim, SI Hwang, JL Ryu, HS Hong, JM Lee, SM Lee, X Jin, C Han, JH Kim, J Han, MR Lee, DH Woo ER stress reliever enhances functionalities of in vitro cultured hepatocytes Stem Cell Res, 2020;43(0):101732. 2020 [PMID: 32087526] (Human)
• A Dicks, CL Wu, N Steward, SS Adkar, CA Gersbach, F Guilak Prospective isolation of chondroprogenitors from human iPSCs based on cell surface markers identified using a CRISPR-Cas9-generated reporter Stem Cell Res Ther, 2020;11(1):66. 2020 [PMID: 32070421] (Cell Culture, Human)
• J Venkatesh, SC Sekhar, VT Cheriyan, M Muthu, P Meister, E Levi, S Dzinic, JW Gauld, LA Polin, AK Rishi Antagonizing binding of cell cycle and apoptosis regulatory protein 1 (CARP-1) to the NEMO/IKKgamma protein enhances the anticancer effect of chemotherapy J. Biol. Chem., 2020;295(11):3532-3552. 2020 [PMID: 32024692] (Bioassay, Human)
• Y Kim, S Lee, H Zhang, S Lee, H Kim, Y Kim, MH Won, YM Kim, YG Kwon CLEC14A deficiency exacerbates neuronal loss by increasing blood-brain barrier permeability and inflammation J Neuroinflammation, 2020;17(1):48. 2020 [PMID: 32019570] (Cell Culture, Human)
• JH Lee, MR Shaker, E Lee, B Lee, W Sun NeuroCore formation during differentiation of neurospheres of mouse embryonic neural stem cells Stem Cell Res, 2020;43(0):101691. 2020 [PMID: 32018208] (Bioassay, Mouse)
• M Oatley, ÖV Bölükbas?, V Svensson, M Shvartsman, K Ganter, K Zirngibl, PV Pavlovich, V Milchevska, V Foteva, KN Natarajan, B Baying, V Benes, KR Patil, SA Teichmann, C Lancrin Single-cell transcriptomics identifies CD44 as a marker and regulator of endothelial to haematopoietic transition Nat Commun, 2020;11(1):586. 2020 [PMID: 31996681] (Cell Culture, Mouse)
• AR Nickolls, MM Lee, DF Espinoza, M Szczot, RM Lam, Q Wang, J Beers, J Zou, MQ Nguyen, HJ Solinski, AA AlJanahi, KR Johnson, ME Ward, AT Chesler, CG Bönnemann Transcriptional Programming of Human Mechanosensory Neuron Subtypes from Pluripotent Stem Cells Cell Rep, 2020;30(3):932-946.e7. 2020 [PMID: 31968264] (Dififerentiation, Human)
• Y Yang, L Ding, Q Zhou, L Fen, Y Cao, J Sun, X Zhou, A Liu Silencing of AURKA augments the antitumor efficacy of the AURKA inhibitor MLN8237 on neuroblastoma cells Cancer Cell Int., 2020;20(0):9. 2020 [PMID: 31920463] (Bioassay, Mouse)
• Yang Y, Ding L, Zhou Q, Fen L, Cao Y, Sun J, Zhou X, Liu A Silencing of AURKA augments the antitumor efficacy of the AURKA inhibitor MLN8237 on neuroblastoma cells. Cancer Cell Int, 0;20(0):9. 0 [PMID: 31920463] (Bioassay, Human)
• D Suzuki, C Flahou, N Yoshikawa, I Stirblyte, Y Hayashi, A Sawaguchi, M Akasaka, S Nakamura, N Higashi, H Xu, T Matsumoto, K Fujio, MG Manz, A Hotta, H Takizawa, K Eto, N Sugimoto iPSC-Derived Platelets Depleted of HLA Class I Are Inert to Anti-HLA Class I and Natural Killer Cell Immunity Stem Cell Reports, 2019;0(0):. 2019 [PMID: 31883921] (Bioassay, Human)
• B You, F Mercier, E Assenat, C Langlois-J, O Glehen, J Soulé, L Payen, V Kepenekian, M Dupuy, F Belouin, E Morency, V Saywell, M Flacelière, P Elies, P Liaud, T Mazard, D Maucort-Bo, W Tan, B Vire, L Villeneuve, M Ychou, M Kohli, D Joubert, A Prieur The oncogenic and druggable hPG80 (Progastrin) is overexpressed in multiple cancers and detected in the blood of patients EBioMedicine, 2019;51(0):102574. 2019 [PMID: 31877416] (Bioassay, Human)
• D Chen, N Sun, L Hou, R Kim, J Faith, M Aslanyan, Y Tao, Y Zheng, J Fu, W Liu, M Kellis, A Clark Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors Cell Rep, 2019;29(13):4568-4582.e5. 2019 [PMID: 31875561] (Cell Culture, Human)
• A Bonafina, MF Trinchero, AS Ríos, P Bekinschte, AF Schinder, G Paratcha, F Ledda GDNF and GFRalpha1 Are Required for Proper Integration of Adult-Born Hippocampal Neurons Cell Rep, 2019;29(13):4308-4319.e4. 2019 [PMID: 31875542] (Cell Culture, Mouse)
• C Fisher, G Obaid, C Niu, W Foltz, A Goldstein, T Hasan, L Lilge Liposomal Lapatinib in Combination with Low-Dose Photodynamic Therapy for the Treatment of Glioma J Clin Med, 2019;8(12):. 2019 [PMID: 31847378] (Bioassay, Human)
• C Peng, L Lu, Y Li, J Hu Neurospheres induced from human adipose-derived stem cells as a new source of neural progenitor cells Cell Transplant, 2019;0(0):9636897198886. 2019 [PMID: 31813268] (Bioassay, Human)
• M Ali, F Kabir, JJ Thomson, Y Ma, C Qiu, M Delannoy, SY Khan, SA Riazuddin Comparative transcriptome analysis of hESC- and iPSC-derived lentoid bodies Sci Rep, 2019;9(1):18552. 2019 [PMID: 31811247] (Bioassay, Human)
• S Weber, SE Koschade, CM Hoffmann, TD Dubash, KM Giessler, SM Dieter, F Herbst, H Glimm, CR Ball The notch target gene HEYL modulates metastasis forming capacity of colorectal cancer patient-derived spheroid cells in vivo BMC Cancer, 2019;19(1):1181. 2019 [PMID: 31796022] (Bioassay, Human)
• D Hao, C He, B Ma, L Lankford, L Reynaga, DL Farmer, F Guo, A Wang Hypoxic Preconditioning Enhances Survival and Proangiogenic Capacity of Human First Trimester Chorionic Villus-Derived Mesenchymal Stem Cells for Fetal Tissue Engineering Stem Cells Int, 2019;2019(0):9695239. 2019 [PMID: 31781252] (Tissue Culture, Human)
• M Vermeulen, F Del Vento, M Kanbar, S Pyr Dit Ru, D Vertommen, J Poels, C Wyns Generation of Organized Porcine Testicular Organoids in Solubilized Hydrogels from Decellularized Extracellular Matrix Int J Mol Sci, 2019;20(21):. 2019 [PMID: 31684200] (Bioassay, Porcine)
• Y Koutmani, IA Gampieraki, A Polissidis, M Ximerakis, PN Koutsoudak, A Polyzos, G Agrogianni, S Karaliota, D Thomaidou, LL Rubin, PK Politis, KP Karalis CRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult Hippocampus Cell Rep, 2019;29(4):932-945.e7. 2019 [PMID: 31644914] (Bioassay, Mouse)
• A Tripathi, C Volsko, JP Garcia, E Agirre, KC Allan, PJ Tesar, BD Trapp, G Castelo-Br, FJ Sim, R Dutta Oligodendrocyte Intrinsic miR-27a Controls Myelination and Remyelination Cell Rep, 2019;29(4):904-919.e9. 2019 [PMID: 31644912] (Bioassay, Mouse)
• J Chen, B Ananthanar, KS Springer, KJ Wolf, SM Sheyman, VD Tran, S Kumar Suppression of LIM Kinase 1 and LIM Kinase 2 Limits Glioblastoma Invasion Cancer Res., 2019;0(0):. 2019 [PMID: 31641031] (Bioassay, Human)
• F Inoue, A Kreimer, T Ashuach, N Ahituv, N Yosef Identification and Massively Parallel Characterization of Regulatory Elements Driving Neural Induction Cell Stem Cell, 2019;0(0):. 2019 [PMID: 31631012] (Bioassay, Human)
• T Yung, F Poon, M Liang, S Coquenlorg, EC McGaugh, CC Hui, MD Wilson, MC Nostro, TH Kim Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals Nat Commun, 2019;10(1):4647. 2019 [PMID: 31604927] (Bioassay, Human)
• R Liu, X Zhang, Z Fan, Y Wang, G Yao, X Wan, Z Liu, B Yang, L Yu Human amniotic mesenchymal stem cells improve the follicular microenvironment to recover ovarian function in premature ovarian failure mice Stem Cell Res Ther, 2019;10(1):299. 2019 [PMID: 31578152] (Bioassay, Human)
• T Tabata, M Petitt, J Fang-Hoove, DC Freed, F Li, Z An, D Wang, TM Fu, L Pereira Neutralizing Monoclonal Antibodies Reduce Human Cytomegalovirus Infection and Spread in Developing Placentas Vaccines (Basel), 2019;7(4):. 2019 [PMID: 31569508] (Bioassay, Human)
• Q Mei, A Bansal, MKG Jayakumar, Z Zhang, J Zhang, H Huang, D Yu, CJA Ramachandr, DJ Hausenloy, TW Soong, Y Zhang Manipulating energy migration within single lanthanide activator for switchable upconversion emissions towards bidirectional photoactivation Nat Commun, 2019;10(1):4416. 2019 [PMID: 31562321] (Bioassay, Human)
• V Lungova, X Chen, Z Wang, C Kendziorsk, SL Thibeault Human induced pluripotent stem cell-derived vocal fold mucosa mimics development and responses to smoke exposure Nat Commun, 2019;10(1):4161. 2019 [PMID: 31551422] (Bioassay, Human)
• CY Lee, TJ Huang, MH Wu, YY Li, KD Lee High Expression of Acid-Sensing Ion Channel 2 (ASIC2) in Bone Cells in Osteoporotic Vertebral Fractures Biomed Res Int, 2019;2019(0):4714279. 2019 [PMID: 31531354] (Bioassay, Human)
• Y Yuan, C Zhou, Q Yang, S Ma, X Wang, X Guo, Y Ding, J Tang, Y Zeng, D Li HIV-1 Tat protein inhibits the hematopoietic support function of human bone marrow mesenchymal stem cells Virus Res., 2019;273(0):197756. 2019 [PMID: 31521762] (Bioassay, Human)
• J Domingo-Pr, V Abad-Moral, M Riera, R Navarro, B Corcostegu, E Pomares Generation of an induced pluripotent stem cell line (FRIMOi007-A) derived from an incomplete achromatopsia patient carrying a novel homozygous mutation in PDE6C gene Stem Cell Res, 2019;40(0):101569. 2019 [PMID: 31520890] (Cell Culture, Human)
• J Domingo-Pr, M Riera, V Abad-Moral, S Ruiz-Nogal, B Corcostegu, E Pomares Generation of Best disease-derived induced pluripotent stem cell line (FRIMOi006-A) carrying a novel dominant mutation in BEST1 gene Stem Cell Res, 2019;40(0):101570. 2019 [PMID: 31518904] (Cell Culture, Human)
• KM Walter, K Dach, K Hayakawa, S Giersiefer, H Heuer, PJ Lein, E Fritsche Ontogenetic expression of thyroid hormone signaling genes: An in vitro and in vivo species comparison PLoS ONE, 2019;14(9):e0221230. 2019 [PMID: 31513589] (Bioassay, Human)
• Y Shen, K Pu, K Zheng, X Ma, J Qin, L Jiang, J Li Differentially Expressed microRNAs in MIA PaCa-2 and PANC-1 Pancreas Ductal Adenocarcinoma Cell Lines are Involved in Cancer Stem Cell Regulation Int J Mol Sci, 2019;20(18):. 2019 [PMID: 31510100] (Bioassay, Human)
• V Ravi, AB Madhankuma, T Abraham, B Slagle-Web, JR Connor Liposomal delivery of ferritin heavy chain 1 (FTH1) siRNA in patient xenograft derived glioblastoma initiating cells suggests different sensitivities to radiation and distinct survival mechanisms PLoS ONE, 2019;14(9):e0221952. 2019 [PMID: 31491006] (Bioassay, Human)
• SP Hong, TE Chan, Y Lombardo, G Corleone, N Rotmensz, S Bravaccini, A Rocca, G Pruneri, KR McEwen, RC Coombes, I Barozzi, L Magnani Single-cell transcriptomics reveals multi-step adaptations to endocrine therapy Nat Commun, 2019;10(1):3840. 2019 [PMID: 31477698] (Cell Culture, Human)
• J Tiihonen, M Koskuvi, M Lähteenvuo, PLJ Virtanen, I Ojansuu, O Vaurio, Y Gao, I Hyötyläine, KA Puttonen, E Repo-Tiiho, T Paunio, MR Rautiainen, S Tyni, J Koistinaho, Š Lehtonen Neurobiological roots of psychopathy Mol. Psychiatry, 2019;0(0):. 2019 [PMID: 31455857] (Bioassay, Human)
• L Messerschm, S Fischer, P Wiedemann, A Bringmann, M Hollborn Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation Mol. Vis., 2019;25(0):329-344. 2019 [PMID: 31341381] (Bioassay, Human)
• SB Yoon, YH Park, SA Choi, HJ Yang, PS Jeong, JJ Cha, S Lee, SH Lee, JH Lee, BW Sim, BS Koo, SJ Park, Y Lee, YH Kim, JJ Hong, JS Kim, YB Jin, JW Huh, SR Lee, BS Song, SU Kim Real-time PCR quantification of spliced X-box binding protein 1 (XBP1) using a universal primer method PLoS ONE, 2019;14(7):e0219978. 2019 [PMID: 31329612] (Cell Culture, Bovine)
• S Tongkobpet, R Rungsiwiwu, K Pruksanano, K Suphapeeti, V Shotelersu Generation of two human iPSC lines (MDCUi001-A and MDCUi001-B) from dermal fibroblasts of a Thai patient with X-linked osteogenesis imperfecta using integration-free Sendai virus Stem Cell Res, 2019;39(0):101493. 2019 [PMID: 31326747] (Bioassay, Human)
• TC Lin, YY Lin, CC Hsu, YP Yang, CH Yang, DK Hwang, CY Wang, YY Liu, WL Lo, SH Chiou, CH Peng, SJ Chen, YL Chang Nanomedicine-based Curcumin Approach Improved ROS Damage in Best Dystrophy-specific Induced Pluripotent Stem Cells Cell Transplant, 2019;0(0):9636897198601. 2019 [PMID: 31313605] (Bioassay, Human)
• S Pecha, K Yorgan, M Röhl, B Geertz, A Hansen, F Weinberger, S Sehner, H Ehmke, H Reichenspu, T Eschenhage, AP Schwoerer Human iPS cell-derived engineered heart tissue does not affect ventricular arrhythmias in a guinea pig cryo-injury model Sci Rep, 2019;9(1):9831. 2019 [PMID: 31285568] (Cell Culture, Human)
• SH Yang, M Andrabi, R Biss, S Murtuza Ba, M Iqbal, AD Sharrocks ZIC3 Controls the Transition from Naive to Primed Pluripotency Cell Rep, 2019;27(11):3215-3227.e6. 2019 [PMID: 31189106] (Bioassay, Mouse)
• J Domingo-Pr, M Riera, A Burés-Jels, B Corcostegu, E Pomares Establishment of an induced pluripotent stem cell line (FRIMOi005-A) derived from a retinitis pigmentosa patient carrying a dominant mutation in RHO gene Stem Cell Res, 2019;38(0):101468. 2019 [PMID: 31146251] (Bioassay, Human)
• M Meijer, K Rehbach, JW Brunner, JA Classen, HCA Lammertse, LA van Linge, D Schut, T Krutenko, M Hebisch, LN Cornelisse, PF Sullivan, M Peitz, RF Toonen, O Brüstle, M Verhage A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons Cell Rep, 2019;27(7):2199-2211.e6. 2019 [PMID: 31091456] (neural differentiation, Human)
• N Kawai, Y Hirohashi, Y Ebihara, T Saito, A Murai, T Saito, T Shirosaki, T Kubo, M Nakatsugaw, T Kanaseki, T Tsukahara, T Shichinohe, L Li, S Hirano, T Torigoe ABCG2 expression is related to low 5-ALA photodynamic diagnosis (PDD) efficacy and cancer stem cell phenotype, and suppression of ABCG2 improves the efficacy of PDD PLoS ONE, 2019;14(5):e0216503. 2019 [PMID: 31083682] (Bioassay, Human)
• ML Shiao, C Yuan, AT Crane, JP Voth, M Juliano, LLH Stone, Z Nan, Y Zhang, N Kuzmin-Nic, PR Sanberg, AW Grande, WC Low Immunomodulation with Human Umbilical Cord Blood Stem Cells Ameliorates Ischemic Brain Injury - A Brain Transcriptome Profiling Analysis Cell Transplant, 2019;0(0):9636897198367. 2019 [PMID: 31066288] (Bioassay, Human)
• A Hall, K Choi, W Liu, J Rose, C Zhao, Y Yu, Y Na, Y Cai, RA Coover, Y Lin, E Dombi, M Kim, D Levanon, Y Groner, E Boscolo, D Pan, PP Liu, QR Lu, N Ratner, G Huang, J Wu RUNX represses Pmp22 to drive neurofibromagenesis Sci Adv, 2019;5(4):eaau8389. 2019 [PMID: 31032403] (Bioassay, Mouse)
• EE Mulkearns-, LA Torre-Heal, DJ Silver, JT Eurich, D Bayik, E Serbinowsk, M Hitomi, J Zhou, B Przychodze, R Zhang, SA Sprowls, JS Hale, TJ Alban, A Berezovsky, BA Bell, PR Lockman, BK Jha, JD Lathia Development of a Cx46 Targeting Strategy for Cancer Stem Cells Cell Rep, 2019;27(4):1062-1072.e5. 2019 [PMID: 31018124] (Bioassay, Xenograft)
• L Sun, F Wang, H Chen, D Liu, T Qu, X Li, D Xu, F Liu, Z Yin, Y Chen Co-Transplantation of Human Umbilical Cord Mesenchymal Stem Cells and Human Neural Stem Cells Improves the Outcome in Rats with Spinal Cord Injury Cell Transplant, 2019;0(0):9636897198445. 2019 [PMID: 31012325] (Bioassay, Human)
• M Urbischek, H Rannikmae, T Foets, K Ravn, M Hyvönen, M de la Roch Organoid culture media formulated with growth factors of defined cellular activity Sci Rep, 2019;9(1):6193. 2019 [PMID: 30996238] (Bioassay, Human)
• G MacLeod, DA Bozek, N Rajakulend, V Monteiro, M Ahmadi, Z Steinhart, MM Kushida, H Yu, FJ Coutinho, FMG Cavalli, I Restall, X Hao, T Hart, HA Luchman, S Weiss, PB Dirks, S Angers Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells Cell Rep, 2019;27(3):971-986.e9. 2019 [PMID: 30995489] (Bioassay, Human)
• B Mair, J Tomic, SN Masud, P Tonge, A Weiss, M Usaj, AHY Tong, JJ Kwan, KR Brown, E Titus, M Atkins, KSK Chan, L Munsie, A Habsid, H Han, M Kennedy, B Cohen, G Keller, J Moffat Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies Cell Rep, 2019;27(2):599-615.e12. 2019 [PMID: 30970261] (Differentiation, Human)
• T Ryynänen, A Pelkonen, K Grigoras, OME Ylivaara, T Hyvärinen, J Ahopelto, M Prunnila, S Narkilahti, J Lekkala Microelectrode Array With Transparent ALD TiN Electrodes Front Neurosci, 2019;13(0):226. 2019 [PMID: 30967754] (Bioassay, Human)
• SFB Fadhlullah, NBA Halim, JYT Yeo, RLY Ho, P Um, BT Ang, C Tang, WH Ng, DM Virshup, IAW Ho Pathogenic mutations in neurofibromin identifies a leucine-rich domain regulating glioma cell invasiveness Oncogene, 2019;38(27):5367-5380. 2019 [PMID: 30967630] (Bioassay, Human)
• S Varum, A Baggiolini, L Zurkirchen, ZK Atak, C Cantù, E Marzorati, R Bossart, J Wouters, J Häusel, E Tuncer, D Zingg, D Veen, N John, M Balz, MP Levesque, K Basler, S Aerts, N Zamboni, R Dummer, L Sommer Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation Cell Stem Cell, 2019;24(4):637-653.e9. 2019 [PMID: 30951662] (Bioassay, Mouse)
• M Matsushita, Y Mori, K Uchiumi, T Ogata, M Nakamura, H Yoda, H Soda, N Takiguchi, Y Nabeya, O Shimozato, T Ozaki PTPRK suppresses progression and chemo-resistance of colon cancer cells via direct inhibition of pro-oncogenic CD133 FEBS Open Bio, 2019;0(0):. 2019 [PMID: 30947381] (Bioassay, Human)
• M Rutgers, F Bach, L Vonk, M van Rijen, V Akrum, A van Boxtel, W Dhert, L Creemers PTH decreases in vitro human cartilage regeneration without affecting hypertrophic differentiation PLoS ONE, 2019;14(4):e0213483. 2019 [PMID: 30947269] (Bioassay, Human)
• HL Zhang, P Wang, MZ Lu, SD Zhang, L Zheng c-Myc maintains the self-renewal and chemoresistance properties of colon cancer stem cells Oncol Lett, 2019;17(5):4487-4493. 2019 [PMID: 30944638] (Bioassay, Human)
• K Itoh, S Masumori, D Mukai, H Sakakibara, M Yasuda, K Shimoi Dosage time affects alkylating agents induced micronuclei in mouse peripheral blood reticulocytes through the function of erythropoietin J Toxicol Sci, 2019;44(4):273-282. 2019 [PMID: 30944280] (In Vivo, Mouse)
• Z Shen, C Zhang, L Qu, C Lu, M Xiao, R Ni, J Liu MKP-4 suppresses hepatocarcinogenesis by targeting ERK1/2 pathway Cancer Cell Int., 2019;19(0):61. 2019 [PMID: 30923463] (Bioassay, Human)
• K Barber, L Studer, F Fattahi Derivation of enteric neuron lineages from human pluripotent stem cells Nat Protoc, 2019;14(4):1261-1279. 2019 [PMID: 30911172] (Bioassay, Human)
• Z Wang, L Kang, H Zhang, Y Huang, L Fang, M Li, PJ Brown, CH Arrowsmith, J Li, J Wong AKT drives SOX2 overexpression and cancer cell stemness in esophageal cancer by protecting SOX2 from UBR5-mediated degradation Oncogene, 2019;0(0):. 2019 [PMID: 30894683] (Bioassay, Human)
• MA Ajmone-Cat, A Onori, C Toselli, E Stronati, M Morlando, I Bozzoni, E Monni, Z Kokaia, G Lupo, L Minghetti, S Biagioni, E Cacci Increased FUS levels in astrocytes leads to astrocyte and microglia activation and neuronal death Sci Rep, 2019;9(1):4572. 2019 [PMID: 30872738] (Bioassay, Human)
• N Funk, M Munz, T Ott, K Brockmann, A Wenninger-, R Kühn, D Vogt-Weise, F Giesert, W Wurst, T Gasser, S Biskup The Parkinson&#039;s disease-linked Leucine-rich repeat kinase 2 (LRRK2) is required for insulin-stimulated translocation of GLUT4 Sci Rep, 2019;9(1):4515. 2019 [PMID: 30872638] (Bioassay, Mouse)
• H Xu, B Wang, M Ono, A Kagita, K Fujii, N Sasakawa, T Ueda, P Gee, M Nishikawa, M Nomura, F Kitaoka, T Takahashi, K Okita, Y Yoshida, S Kaneko, A Hotta Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility Cell Stem Cell, 2019;0(0):. 2019 [PMID: 30853558] (Bioassay, Human)
• N Naldaiz-Ga, M Goicoechea, IM Aragón, V Pérez-Lópe, S Fuertes-Al, B Herrera-Im, A López de M, R de Luna-Di, PM Baptista, MA Fernández, MF Lara, A Izeta Isolation and characterization of myogenic precursor cells from human cremaster muscle Sci Rep, 2019;9(1):3454. 2019 [PMID: 30837559] (Bioassay, Human)
• YP Xu, Y Qiu, B Zhang, G Chen, Q Chen, M Wang, F Mo, J Xu, J Wu, RR Zhang, ML Cheng, NN Zhang, B Lyu, WL Zhu, MH Wu, Q Ye, D Zhang, JH Man, XF Li, J Cui, Z Xu, B Hu, X Zhou, CF Qin Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids Cell Res., 2019;0(0):. 2019 [PMID: 30814679] (Bioassay, Human)
• J Ooi, SR Langley, X Xu, KH Utami, B Sim, Y Huang, NP Harmston, YL Tay, A Ziaei, R Zeng, D Low, F Aminkeng, RM Sobota, F Ginhoux, E Petretto, MA Pouladi Unbiased Profiling of Isogenic Huntington Disease hPSC-Derived CNS and Peripheral Cells Reveals Strong Cell-Type Specificity of CAG Length Effects Cell Rep, 2019;26(9):2494-2508.e7. 2019 [PMID: 30811996]
• M Riera, A Patel, A Burés-Jels, B Corcostegu, S Chang, E Pomares, B Corneo, JR Sparrow Generation of two iPS cell lines (FRIMOi003-A and FRIMOi004-A) derived from Stargardt patients carrying ABCA4 compound heterozygous mutations Stem Cell Res, 2019;36(0):101389. 2019 [PMID: 30798147] (Bioassay, Human)
• N Muraoka, K Nara, F Tamura, H Kojima, H Yamakawa, T Sadahiro, K Miyamoto, M Isomi, S Haginiwa, H Tani, S Kurotsu, R Osakabe, S Torii, S Shimizu, H Okano, Y Sugimoto, K Fukuda, M Ieda Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming Nat Commun, 2019;10(1):674. 2019 [PMID: 30787297] (Bioassay, Mouse)
• M Kunova Bos, A Nita, T Gregor, M Varecha, I Gudernova, B Fafilek, T Barta, N Basheer, SP Abraham, L Balek, M Tomanova, J Fialova Ku, J Bosak, D Potesil, J Zieba, J Song, P Konik, S Park, I Duran, Z Zdrahal, D Smajs, G Jansen, Z Fu, HW Ko, A Hampl, L Trantirek, D Krakow, P Krejci Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase Proc. Natl. Acad. Sci. U.S.A., 2019;0(0):. 2019 [PMID: 30782830] (Bioassay, Human)
• TS Winston, K Suddhapas, C Wang, R Ramos, P Soman, Z Ma Serum-Free Manufacturing of Mesenchymal Stem Cell Tissue Rings Using Human-Induced Pluripotent Stem Cells Stem Cells Int, 2019;2019(0):5654324. 2019 [PMID: 30766604] (Bioassay, Human)
• E Ito, S Miyagawa, M Takeda, A Kawamura, A Harada, H Iseoka, S Yajima, N Sougawa, N Mochizuki-, S Yasuda, Y Sato, Y Sawa Tumorigenicity assay essential for facilitating safety studies of hiPSC-derived cardiomyocytes for clinical application Sci Rep, 2019;9(1):1881. 2019 [PMID: 30760836] (Bioassay, Human)
• JH Wang, ST Huang, L Zhang, ZG Liu, RX Liang, SW Jiang, YN Jiang, XJ Yu, YC Jiang, XZ Li, PF Zhang, ZS Wen, M Zheng Combined prognostic value of the cancer stem cell markers CD47 and CD133 in esophageal squamous cell carcinoma Cancer Med, 2019;0(0):. 2019 [PMID: 30741466] (Bioassay, Human)
• S Bunda, P Heir, J Metcalf, ASC Li, S Agnihotri, S Pusch, M Yasin, M Li, K Burrell, S Mansouri, O Singh, M Wilson, A Alamsahebp, R Nejad, B Choi, D Kim, A von Deimli, G Zadeh, K Aldape CIC protein instability contributes to tumorigenesis in glioblastoma Nat Commun, 2019;10(1):661. 2019 [PMID: 30737375] (Bioassay, Human)
• S Ashraf, S Bell, C O'Leary, P Canning, I Micu, JA Fernandez, M O'Hare, P Barabas, H McCauley, DP Brazil, AW Stitt, JG McGeown, TM Curtis CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularisation JCI Insight, 2019;0(0):. 2019 [PMID: 30721154] (Bioassay, Human)
• JH Jo, SB Park, S Park, HS Lee, C Kim, DE Jung, SY Song Novel Gastric Cancer Stem Cell-Related Marker LINGO2 Is Associated with Cancer Cell Phenotype and Patient Outcome Int J Mol Sci, 2019;20(3):. 2019 [PMID: 30696080] (Bioassay, Human)
• M Riera, A Patel, B Corcostegu, S Chang, B Corneo, JR Sparrow, E Pomares Generation of an induced pluripotent stem cell line (FRIMOi002-A) from a retinitis pigmentosa patient carrying compound heterozygous mutations in USH2A gene Stem Cell Res, 2019;35(0):101386. 2019 [PMID: 30685615] (Bioassay, Human)
• M Riera, A Patel, B Corcostegu, S Chang, JR Sparrow, E Pomares, B Corneo Establishment and characterization of an iPSC line (FRIMOi001-A) derived from a retinitis pigmentosa patient carrying PDE6A mutations Stem Cell Res, 2019;35(0):101385. 2019 [PMID: 30685614] (Bioassay, Human)
• A Montel-Hag, CS Seet, S Li, B Chick, Y Zhu, P Chang, S Tsai, V Sun, S Lopez, HC Chen, C He, CJ Chin, D Casero, GM Crooks Organoid-Induced Differentiation of Conventional T Cells from Human Pluripotent Stem Cells Cell Stem Cell, 2019;0(0):. 2019 [PMID: 30661959] (Bioassay, Humane)
• SZ Kuo, CO Honda, WT Li, TK Honda, E Kim, X Altuna, E Abhold, J Wang-Rodri, WM Ongkeko Metformin Results in Diametrically Opposed Effects by Targeting Non-Stem Cancer Cells but Protecting Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma Int J Mol Sci, 2019;20(1):. 2019 [PMID: 30621095] (Bioassay, Human)
• JA Maguire, AL Gagne, P Gonzalez-A, BL Davidson, V Shakkottai, P Gadue, DL French Generation of Spinocerebellar Ataxia Type 2 induced pluripotent stem cell lines, CHOPi002-A and CHOPi003-A, from patients with abnormal CAG repeats in the coding region of the ATXN2 gene Stem Cell Res, 2018;34(0):101361. 2018 [PMID: 30611021] (Bioassay, Human)
• D Chen, W Liu, J Zimmerman, WA Pastor, R Kim, L Hosohama, J Ho, M Aslanyan, JJ Gell, SE Jacobsen, AT Clark The TFAP2C-Regulated OCT4 Naive Enhancer Is Involved in Human Germline Formation Cell Rep, 2018;25(13):3591-3602.e5. 2018 [PMID: 30590035] (Bioassay, Human)
• SJ Yoon, LS Elahi, AM Pa?ca, RM Marton, A Gordon, O Revah, Y Miura, EM Walczak, GM Holdgate, HC Fan, JR Huguenard, DH Geschwind, SP Pa?ca Reliability of human cortical organoid generation Nat. Methods, 2019;16(1):75-78. 2019 [PMID: 30573846] (Bioassay, Human)
• S Schwager, S Renner, T Hemmerle, S Karaman, ST Proulx, R Fetz, AM Golding-Oc, P Probst, C Halin, D Neri, M Detmar Antibody-mediated delivery of VEGF-C potently reduces chronic skin inflammation JCI Insight, 2018;3(23):. 2018 [PMID: 30518687] (Bioassay, Human)
• J Park, JH Lee, BS Yoon, EK Jun, G Lee, IY Kim, S You Additive effect of bFGF and selenium on expansion and paracrine action of human amniotic fluid-derived mesenchymal stem cells Stem Cell Res Ther, 2018;9(1):293. 2018 [PMID: 30409167] (Bioassay, Human)
• K Huang, Y Zhu, Y Ma, B Zhao, N Fan, Y Li, H Song, S Chu, Z Ouyang, Q Zhang, Q Xing, C Lai, N Li, T Zhang, J Gu, B Kang, Y Shan, K Lai, W Huang, Y Mai, Q Wang, J Li, A Lin, Y Zhang, X Zhong, B Liao, L Lai, J Chen, D Pei, G Pan BMI1 enables interspecies chimerism with human pluripotent stem cells Nat Commun, 2018;9(1):4649. 2018 [PMID: 30405129] (Bioassay, Human)
• IF LaRocque-d, JDB Rocha, MP Nunes, PAV Oliveira, DO Nascimento, L Freire-de-, CM Takiya, A Morrot, D Decote-Ric, JO Previato, GA DosReis, L Mendonça-P, CG Freire-de- Involvement of the capsular GalXM-induced IL-17 cytokine in the control of Cryptococcus neoformans infection Sci Rep, 2018;8(1):16378. 2018 [PMID: 30401972] (Bioassay, Human)
• H Takeuchi, S Inagaki, W Morozumi, Y Nakano, Y Inoue, Y Kuse, T Mizoguchi, S Nakamura, M Funato, H Kaneko, H Hara, M Shimazawa VGF nerve growth factor inducible is involved in retinal ganglion cells death induced by optic nerve crush Sci Rep, 2018;8(1):16443. 2018 [PMID: 30401804] (Bioassay, Human)
• JY Yeon, JY Hwang, HW Lee, HJ Pyeon, JS Won, YJ Noh, H Nam, KM Joo Optimized Clump Culture Methods for Adult Human Multipotent Neural Cells Int J Mol Sci, 2018;19(11):. 2018 [PMID: 30380605] (Bioassay, Human)
• SS Adkar, CL Wu, VP Willard, A Dicks, A Ettyreddy, N Steward, N Bhutani, CA Gersbach, F Guilak Step-Wise Chondrogenesis of Human Induced Pluripotent Stem Cells and Purification Via a Reporter Allele Generated by CRISPR-Cas9 Genome Editing Stem Cells, 2018;0(0):. 2018 [PMID: 30378731] (Bioassay, Human)
• B Readhead, BJ Hartley, BJ Eastwood, DA Collier, D Evans, R Farias, C He, G Hoffman, P Sklar, JT Dudley, EE Schadt, R Savi?, KJ Brennand Expression-based drug screening of neural progenitor cells from individuals with schizophrenia Nat Commun, 2018;9(1):4412. 2018 [PMID: 30356048] (Bioassay, Human)
• A Omer Javed, Y Li, J Muffat, KC Su, MA Cohen, T Lungjangwa, P Aubourg, IM Cheeseman, R Jaenisch Microcephaly Modeling of Kinetochore Mutation Reveals a Brain-Specific Phenotype Cell Rep, 2018;25(2):368-382.e5. 2018 [PMID: 30304678] (Bioassay, Human)
• Y Zhang, Y Yang, M Jiang, SX Huang, W Zhang, D Al Alam, S Danopoulos, M Mori, YW Chen, R Balasubram, SM Chuva de S, C Serra, M Bialecka, E Kim, S Lin, ALR Toste de C, PN Riccio, WV Cardoso, X Zhang, HW Snoeck, J Que 3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling Cell Stem Cell, 2018;0(0):. 2018 [PMID: 30244870] (Bioassay, Human)
• A Skrzypczyk, S Kehr, I Krystel, SH Bernhart, S Giri, A Bader, PF Stadler Noncoding RNA Transcripts during Differentiation of Induced Pluripotent Stem Cells into Hepatocytes Stem Cells Int, 2018;2018(0):5692840. 2018 [PMID: 30210551] (Bioassay, Human)
• SA Sloan, J Andersen, AM Pa?ca, F Birey, SP Pa?ca Generation and assembly of human brain region-specific three-dimensional cultures Nat Protoc, 2018;0(0):. 2018 [PMID: 30202107] (Cell Culture, Human)
• D Kim, BH Choi, IG Ryoo, MK Kwak High NRF2 level mediates cancer stem cell-like properties of aldehyde dehydrogenase�(ALDH)-high ovarian cancer cells: inhibitory role of all-trans retinoic acid in ALDH/NRF2 signaling Cell Death Dis, 2018;9(9):896. 2018 [PMID: 30166520] (Bioassay, Human)
• LS Pane, FG Fulcoli, A Cirino, A Altomonte, R Ferrentino, M Bilio, A Baldini Tbx1 represses Mef2c gene expression and is correlated with histone 3 deacetylation of the anterior heart field enhancer Dis Model Mech, 2018;11(9):. 2018 [PMID: 30166330] (Bioassay, Human)
• Z Liu, Y Wei, L Zhang, PP Yee, M Johnson, X Zhang, M Gulley, JM Atkinson, M Trebak, HG Wang, W Li Induction of store-operated calcium entry (SOCE) suppresses glioblastoma growth by inhibiting the Hippo pathway transcriptional coactivators YAP/TAZ Oncogene, 2019;38(1):120-139. 2019 [PMID: 30082911] (Bioassay, Human)
• P Nikolakopo, A Chatzigeor, I Kourtzelis, L Toutouna, J Masjkur, C Arps-Forke, SW Poser, J Rozman, B Rathkolb, JA Aguilar-Pi, , E Wolf, M Klingenspo, M Ollert, C Schmidt-We, H Fuchs, V Gailus-Dur, M Hrabe de A, V Tsata, LS Monasor, M Troullinak, A Witt, V Anastasiou, G Chrousos, CX Yi, C García-Các, MH Tschöp, SR Bornstein, A Androutsel Streptozotocin-induced ?-cell damage, high fat diet, and metformin administration regulate Hes3 expression in the adult mouse brain Sci Rep, 2018;8(1):11335. 2018 [PMID: 30054579] (Bioassay, Mouse)
• Z Hubler, D Allimuthu, I Bederman, MS Elitt, M Madhavan, KC Allan, HE Shick, E Garrison, M T Karl, DC Factor, ZS Nevin, JL Sax, MA Thompson, Y Fedorov, J Jin, WK Wilson, M Giera, F Bracher, RH Miller, PJ Tesar, DJ Adams Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination Nature, 2018;0(0):. 2018 [PMID: 30046109] (Bioassay, Human)
• KH Lee, HJ Pyeon, H Nam, JS Won, JY Hwang, KA Lee, JY Yeon, SC Hong, DH Nam, K Lee, SH Lee, KM Joo Significant therapeutic effects of adult human multipotent neural cells on spinal cord injury Stem Cell Res, 2018;31(0):71-78. 2018 [PMID: 30031233] (Bioassay, Human)
• M Sladkova, R Alawadhi, R Jaragh Alh, A Esmael, S Alansari, M Saad, J Mulla Yous, L Alqaoud, GM de Peppo Segmental Additive Tissue Engineering Sci Rep, 2018;8(1):10895. 2018 [PMID: 30022102] (Bioassay, Human)
• SS Chan, RW Arpke, A Filareto, N Xie, MP Pappas, JS Penaloza, RCR Perlingeir, M Kyba Skeletal Muscle Stem Cells from PSC-Derived Teratomas Have Functional Regenerative Capacity Cell Stem Cell, 2018;23(1):74-85.e6. 2018 [PMID: 29979993] (Bioassay, Mouse)
• X Meng, W Su, X Tao, M Sun, R Ying, W Wei, B Wang Oxidation Prevents HMGB1 Inhibition on PDGF-Induced Differentiation of Multipotent Vascular Stem Cells to Smooth Muscle Cells: A Possible Mechanism Linking Oxidative Stress to Atherosclerosis Biomed Res Int, 2018;2018(0):4019814. 2018 [PMID: 29951536] (Bioassay, Rat)
• CH Peng, LC Woung, KH Lu, CY Tsai, SD Lee, CS Huang, TC Lin, KH Chien, DK Hwang Acoustic waves improves retroviral transduction in human retinal stem cells J Chin Med Assoc, 2018;0(0):. 2018 [PMID: 29941298] (Bioassay, Human)
• J Li, F Xing, F Chen, L He, KF So, Y Liu, J Xiao Functional 3D Human Liver Bud Assembled from MSC-Derived Multiple Liver Cell Lineages Cell Transplant, 2018;0(0):9636897187803. 2018 [PMID: 29895168] (Bioassay, Human)
• K Skrzypek, A Kusienicka, E Trzyna, B Szewczyk, A Ulman, P Konieczny, T Adamus, B Badyra, M Kortylewsk, M Majka SNAIL is a key regulator of alveolar rhabdomyosarcoma tumor growth and differentiation through repression of MYF5 and MYOD function Cell Death Dis, 2018;9(6):643. 2018 [PMID: 29844345] (Bioassay, Human)
• H Yang, C Wang, H Chen, L Li, S Ma, H Wang, Y Fu, T Qu Neural Stem Cell-Conditioned Medium Ameliorated Cerebral Ischemia-Reperfusion Injury in Rats Stem Cells Int, 2018;2018(0):4659159. 2018 [PMID: 29765412] (Bioassay, Rat)
• X Guo, Y Xu, Z Wang, Y Wu, J Chen, G Wang, C Lu, W Jia, J Xi, S Zhu, Z Jiapaer, X Wan, Z Liu, S Gao, J Kang A Linc1405/Eomes Complex Promotes Cardiac Mesoderm Specification and Cardiogenesis Cell Stem Cell, 2018;0(0):. 2018 [PMID: 29754779] (Bioassay, Mouse)
• B Roy, S Venkatacha, P Ratna, Y Wang, DS Jokhun, M Nagarajan, GV Shivashank Laterally confined growth of cells induces nuclear reprogramming in the absence of exogenous biochemical factors Proc. Natl. Acad. Sci. U.S.A., 2018;0(0):. 2018 [PMID: 29735717] (Bioassay, Human)
• LR Penke, JM Speth, VL Dommeti, ES White, IL Bergin, M Peters-Gol FOXM1 is a critical driver of lung fibroblast activation and fibrogenesis J. Clin. Invest., 2018;0(0):. 2018 [PMID: 29733296] (Bioassay, Human)
• IG Ryoo, BH Choi, SK Ku, MK Kwak High CD44 expression mediates p62-associated NFE2L2/NRF2 activation in breast cancer stem cell-like cells: Implications for cancer stem cell resistance Redox Biol, 2018;17(0):246-258. 2018 [PMID: 29729523] (Bioassay, Human)
• M Li, D Khong, LY Chin, A Singleton, B Parekkadan Therapeutic Delivery Specifications Identified Through Compartmental Analysis of a Mesenchymal Stromal Cell-Immune Reaction Sci Rep, 2018;8(1):6816. 2018 [PMID: 29717209] (Bioassay, Human)
• M Zaim, S Isik DNA topoisomerase II? stimulates neurite outgrowth in neural differentiated human mesenchymal stem cells through regulation of Rho-GTPases (RhoA/Rock2 pathway) and Nurr1 expression Stem Cell Res Ther, 2018;9(1):114. 2018 [PMID: 29695291] (Bioassay, Human)
• F Ihler, R Gratz, HA Wolff, BG Weiss, M Bertlich, J Kitz, G Salinas, M Rave-Fränk, M Canis Epithelial-Mesenchymal Transition during Metastasis of HPV-Negative Pharyngeal Squamous Cell Carcinoma Biomed Res Int, 2018;2018(0):7929104. 2018 [PMID: 29693014] (Bioassay, Human)
• JE Shin, K Jung, M Kim, K Hwang, H Lee, IS Kim, BH Lee, IS Lee, KI Park Brain and spinal cord injury repair by implantation of human neural progenitor cells seeded onto polymer scaffolds Exp. Mol. Med., 2018;50(4):39. 2018 [PMID: 29674624] (Bioassay, Human)
• JX Liu, D Bravo, J Buza, T Kirsch, O Kennedy, A Rokito, JD Zuckerman, MS Virk Topical vancomycin and its effect on survival and migration of osteoblasts, fibroblasts, and myoblasts: An in vitro study J Orthop, 2018;15(1):53-58. 2018 [PMID: 29657439] (Bioassay, Human)
• V Pursani, D Bhartiya, V Tanavde, M Bashir, P Sampath Transcriptional activator DOT1L putatively regulates human embryonic stem cell differentiation into the cardiac lineage Stem Cell Res Ther, 2018;9(1):97. 2018 [PMID: 29631608] (Bioassay, Human)
• N Guzzi, M Cie?la, PCT Ngoc, S Lang, S Arora, M Dimitriou, K Pimková, MNE Sommarin, R Munita, M Lubas, Y Lim, K Okuyama, S Soneji, G Karlsson, J Hansson, G Jönsson, AH Lund, M Sigvardsso, E Hellström-, AC Hsieh, C Bellodi Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells Cell, 2018;0(0):. 2018 [PMID: 29628141] (Bioassay, Human)
• SM Planchon, KT Lingas, J Reese Koç, BM Hooper, B Maitra, RM Fox, PB Imrey, KM Drake, MA Aldred, HM Lazarus, JA Cohen Feasibility of mesenchymal stem cell culture expansion for a phase I clinical trial in multiple sclerosis Mult Scler J Exp Transl Clin, 2018;4(1):2055217318765. 2018 [PMID: 29623216] (Bioassay, Human)
• M Kim, K Jung, IS Kim, IS Lee, Y Ko, JE Shin, KI Park TNF-? induces human neural progenitor cell survival after oxygen-glucose deprivation by activating the NF-?B pathway Exp. Mol. Med., 2018;50(4):14. 2018 [PMID: 29622770] (Bioassay, Human)
• D Poppe, J Doerr, M Schneider, R Wilkens, JA Steinbeck, J Ladewig, A Tam, DE Paschon, PD Gregory, A Reik, CE Müller, P Koch, O Brüstle Genome Editing in Neuroepithelial Stem Cells to Generate Human Neurons with High Adenosine-Releasing Capacity Stem Cells Transl Med, 2018;0(0):. 2018 [PMID: 29589874] (Bioassay, Human)
• J Ou, JM Ball, Y Luan, T Zhao, KJ Miyagishim, Y Xu, H Zhou, J Chen, DK Merriman, Z Xie, BS Mallon, W Li iPSCs from a Hibernator Provide a Platform for Studying Cold Adaptation and Its Potential Medical Applications Cell, 2018;0(0):. 2018 [PMID: 29576452] (Bioassay, Squirrel)
• FN Vögtle, B Brändl, A Larson, M Pendziwiat, MW Friederich, SM White, A Basinger, C Kücükköse, H Muhle, JA Jähn, O Keminer, KL Helbig, CF Delto, L Myketin, D Mossmann, N Burger, N Miyake, A Burnett, A van Baalen, MA Lovell, N Matsumoto, M Walsh, HC Yu, DN Shinde, U Stephani, JLK Van Hove, FJ Müller, I Helbig Mutations in PMPCB Encoding the Catalytic Subunit of the Mitochondrial Presequence Protease Cause Neurodegeneration in Early Childhood Am. J. Hum. Genet., 2018;0(0):. 2018 [PMID: 29576218] (Bioassay, Human)
• S Gillotin, JD Davies, A Philpott Subcellular localisation modulates ubiquitylation and degradation of Ascl1 Sci Rep, 2018;8(1):4625. 2018 [PMID: 29545540] (Bioassay, Human)
• M Zhang, J Ngo, F Pirozzi, YP Sun, A Wynshaw-Bo Highly efficient methods to obtain homogeneous dorsal neural progenitor cells from human and mouse embryonic stem cells and induced pluripotent stem cells Stem Cell Res Ther, 2018;9(1):67. 2018 [PMID: 29544541] (Bioassay, Human)
• C Zarouchlio, B Sanchez-Pi, NJ Hafford Te, P Klein, P Liskova, K Dulla, M Semo, AA Vugler, K Muthusamy, L Dudakova, HJ Levis, P Skalicka, P Hysi, ME Cheetham, SJ Tuft, P Adamson, AJ Hardcastle, AE Davidson Antisense Therapy for a Common Corneal Dystrophy Ameliorates TCF4 Repeat Expansion-Mediated Toxicity Am. J. Hum. Genet., 2018;0(0):. 2018 [PMID: 29526280] (Bioassay, Human)
• R Tang, L Jing, VP Willard, CL Wu, F Guilak, J Chen, LA Setton Differentiation of human induced pluripotent stem cells into nucleus pulposus-like cells Stem Cell Res Ther, 2018;9(1):61. 2018 [PMID: 29523190] (Bioassay, Human)
• EM André, N Daviaud, L Sindji, J Cayon, R Perrot, CN Montero-Me A novel ex vivo Huntington&#039;s disease model for studying GABAergic neurons and cell grafts by laser microdissection PLoS ONE, 2018;13(3):e0193409. 2018 [PMID: 29505597] (Bioassay, Human)
• G Zhao, CG Bailey, Y Feng, J Rasko, FJ Lovicu Negative regulation of lens fiber cell differentiation by RTK antagonists Spry and Spred Exp. Eye Res., 2018;170(0):148-159. 2018 [PMID: 29501879] (Bioassay, Rat)
• W Wang, D Chen, K Zhu SOX2OT variant 7 contributes to the synergistic interaction between EGCG and Doxorubicin to kill osteosarcoma via autophagy and stemness inhibition J. Exp. Clin. Cancer Res., 2018;37(1):37. 2018 [PMID: 29475441] (Bioassay, Human)
• YG Kim, YN Yoon, HS Choi, JH Kim, H Seol, JK Lee, MK Seong, IC Park, KI Kim, HA Kim, JS Kim, WC Noh Breast cancer stem cells in HER2-negative breast cancer cells contribute to HER2-mediated radioresistance and molecular subtype conversion: clinical implications for serum HER2 in recurrent HER2-negative breast cancer Oncotarget, 2018;9(5):5811-5822. 2018 [PMID: 29464036] (Bioassay, Human)
• ME Katt, RM Linville, LN Mayo, ZS Xu, PC Searson Functional brain-specific microvessels from iPSC-derived human brain microvascular endothelial cells: the role of matrix composition on monolayer formation Fluids Barriers CNS, 2018;15(1):7. 2018 [PMID: 29463314] (Bioassay, Human)
• EJ Ostrin, DR Little, KN Gerner-Mau, EA Sumner, R Ríos-Corzo, E Ambrosio, SE Holt, NR Forcioli-C, H Akiyama, SM Hanash, S Kimura, SXL Huang, J Chen Beta-Catenin maintains lung epithelial progenitors after lung specification Development, 2018;0(0):. 2018 [PMID: 29440304] (Bioassay, Human)
• T Speck, JP Heidbueche, R Veinalde, D Jaeger, C von Kalle, CR Ball, G Ungerechts, CE Engeland Targeted BiTE expression by an oncolytic vector augments therapeutic efficacy against solid tumors Clin. Cancer Res., 2018;0(0):. 2018 [PMID: 29437789] (Bioassay, Human)
• A Wahba, MC Ryan, UT Shankavara, K Camphausen, PJ Tofilon Radiation-induced alternative transcripts as detected in total and polysome-bound mRNA Oncotarget, 2018;9(1):691-705. 2018 [PMID: 29416646] (Bioassay, Human)
• C Laterza, N Uoshima, D Tornero, U Wilhelmsso, A Stokowska, R Ge, M Pekny, O Lindvall, Z Kokaia Attenuation of reactive gliosis in stroke-injured mouse brain does not affect neurogenesis from grafted human iPSC-derived neural progenitors PLoS ONE, 2018;13(2):e0192118. 2018 [PMID: 29401502] (Bioassay, Human)
• G Zhou, H Jiang, Z Yin, Y Liu, Q Zhang, C Zhang, B Pan, J Zhou, X Zhou, H Sun, D Li, A He, Z Zhang, W Zhang, W Liu, Y Cao In Vitro Regeneration of Patient-specific Ear-shaped Cartilage and Its First Clinical Application for Auricular Reconstruction EBioMedicine, 2018;28(0):287-302. 2018 [PMID: 29396297] (Bioassay, Human)
• J Catry, M Luong-Nguy, L Arakelian, T Poghosyan, P Bruneval, T Domet, L Michaud, R Sfeir, F Gottrand, J Larghero, V Vanneaux, P Cattan Circumferential Esophageal Replacement by a Tissue-engineered Substitute Using Mesenchymal Stem Cells: An Experimental Study in Mini Pigs Cell Transplant, 2017;26(12):1831-1839. 2017 [PMID: 29390879] (Bioassay, Porcine)
• M Stromecki, N Tatari, LC Morrison, R Kaur, J Zagozewski, G Palidwor, V Ramaswamy, P Skowron, M Wölfl, T Milde, MR Del Bigio, MD Taylor, TE Werbowetsk Characterization of a novel OTX2-driven stem cell program in Group 3 and Group 4 medulloblastoma Mol Oncol, 2018;12(4):495-513. 2018 [PMID: 29377567] (Bioassay, Human)
• S Miyamoto, V Kochin, T Kanaseki, A Hongo, S Tokita, Y Kikuchi, A Takaya, Y Hirohashi, T Tsukahara, T Terui, K Ishitani, F Hata, I Takemasa, A Miyazaki, H Hiratsuka, N Sato, T Torigoe The antigen ASB4 on cancer stem cells serves as a target for CTL immunotherapy of colorectal cancer Cancer Immunol Res, 2018;0(0):. 2018 [PMID: 29371260] (Bioassay, Human)
• N Dreyer-And, AS Almeida, P Jensen, M Kamand, J Okarmus, T Rosenberg, SD Friis, A Martínez S, M Blaabjerg, BW Kristensen, T Skrydstrup, JB Gramsberge, HLA Vieira, M Meyer Intermittent, low dose carbon monoxide exposure enhances survival and dopaminergic differentiation of human neural stem cells PLoS ONE, 2018;13(1):e0191207. 2018 [PMID: 29338033] (Bioassay, Human)
• V Sobrino, P González-R, V Annese, J López-Barn, R Pardal Fast neurogenesis from carotid body quiescent neuroblasts accelerates adaptation to hypoxia EMBO Rep., 2018;0(0):. 2018 [PMID: 29335248] (Cell Culture, Human)
• G Detela, OW Bain, HW Kim, DJ Williams, C Mason, A Mathur, IB Wall Donor variability in growth kinetics of healthy hMSCs using manual processing: considerations for manufacture of cell therapies Biotechnol J, 2018;0(0):. 2018 [PMID: 29334181] (Bioassay, Human)
• CL Duran, CA Abbey, KJ Bayless Establishment of a three-dimensional model to study human uterine angiogenesis Mol. Hum. Reprod., 2017;0(0):. 2017 [PMID: 29329415] (Bioassay, Human)
• JJ Gell, J Zhao, D Chen, TJ Hunt, AT Clark PRDM14 is expressed in germ cell tumors with constitutive overexpression altering human germline differentiation and proliferation Stem Cell Res, 2018;27(0):46-56. 2018 [PMID: 29324254] (Bioassay, Human)
• CJ Drummond, JA Hanna, MR Garcia, DJ Devine, AJ Heyrana, D Finkelstei, JE Rehg, ME Hatley Hedgehog Pathway Drives Fusion-Negative Rhabdomyosarcoma Initiated From Non-myogenic Endothelial Progenitors Cancer Cell, 2018;33(1):108-124.e5. 2018 [PMID: 29316425] (Bioassay, Mouse)
• VT Cheriyan, HO Alsaab, S Sekhar, C Stieber, P Kesharwani, S Sau, M Muthu, LA Polin, E Levi, AK Iyer, AK Rishi A CARP-1 functional mimetic loaded vitamin E-TPGS micellar nano-formulation for inhibition of renal cell carcinoma Oncotarget, 2017;8(62):104928-104945. 2017 [PMID: 29285223] (Bioassay)
• JJ Song, SM Oh, OC Kwon, N Wulnansari, HS Lee, MY Chang, E Lee, W Sun, SE Lee, S Chang, H An, CJ Lee, SH Lee Cografting astrocytes improves cell therapeutic outcomes in a Parkinson&#039;s disease model J. Clin. Invest., 2017;0(0):. 2017 [PMID: 29227284] (Bioassay, Mouse)
• J Dietrich, N Baryawno, N Nayyar, YK Valtis, B Yang, I Ly, A Besnard, N Severe, KU Gustafsson, OC Andronesi, TT Batchelor, A Sahay, DT Scadden Bone marrow drives central nervous system regeneration after radiation injury J. Clin. Invest., 2017;0(0):. 2017 [PMID: 29202481] (Bioassay, Mouse)
• T Johansen, C Krabbe, SI Schmidt, AM Serrano, M Meyer Comparative Analysis of Spontaneous and Stimulus-Evoked Calcium Transients in Proliferating and Differentiating Human Midbrain-Derived Stem Cells Stem Cells Int, 2017;2017(0):9605432. 2017 [PMID: 29201062] (Bioassay, Human)
• SD Muthukrish, S Ryzhov, M Karolak, L Oxburgh Nephron progenitor cell death elicits a limited compensatory response associated with interstitial expansion in the neonatal kidney Dis Model Mech, 2017;0(0):. 2017 [PMID: 29196442] (Bioassay, Mouse)
• L Todd, L Suarez, C Quinn, AJ Fischer Retinoic Acid-Signaling Regulates the Proliferative and Neurogenic Capacity of M�ller Glia-Derived Progenitor Cells in the Avian Retina Stem Cells, 2017;0(0):. 2017 [PMID: 29193451] (In Vivo, Chicken)
• A Taguchi, R Nishinakam Higher-Order Kidney Organogenesis from Pluripotent Stem Cells Cell Stem Cell, 2017;0(0):. 2017 [PMID: 29129523] (Differentiation, Human)
• HM Lee, JW Joh, SR Seo, WT Kim, MK Kim, HS Choi, SY Kim, YJ Jang, DH Sinn, GS Choi, JM Kim, CHD Kwon, HJ Chang, DS Kim, CJ Ryu Cell-surface major vault protein promotes cancer progression through harboring mesenchymal and intermediate circulating tumor cells in hepatocellular carcinomas Sci Rep, 2017;7(1):13201. 2017 [PMID: 29038587] (Bioassay, Human)
• M Bhogal, CN Lwin, XY Seah, E Murugan, K Adnan, SJ Lin, G Peh, JS Mehta Real-time assessment of corneal endothelial cell damage following graft preparation and donor insertion for DMEK PLoS ONE, 2017;12(10):e0184824. 2017 [PMID: 28977017] (Bioassay, Human)
• F Wang, AY Wang, C Chesnelong, Y Yang, A Nabbi, S Thalappill, V Alekseev, K Riabowol ING5 activity in self-renewal of glioblastoma stem cells via calcium and follicle stimulating hormone pathways Oncogene, 2018;37(3):286-301. 2018 [PMID: 28925404] (Bioassay, Human)
• J Xing, Y Cao, Y Yu, H Li, Z Song, H Yu In Vitro Micropatterned Human Pluripotent Stem Cell Test (�P-hPST) for Morphometric-Based Teratogen Screening Sci Rep, 2017;7(1):8491. 2017 [PMID: 28819231] (Bioassay, Human)
• JH Lee, SI Protze, Z Laksman, PH Backx, GM Keller Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations Cell Stem Cell, 2017;21(2):179-194.e4. 2017 [PMID: 28777944] (Bioassay, Human)
• S Mahati, D Bolati, Y Yang, R Mao, H Zhang, Y Bao TMPRSS4 promotes cancer stem cell traits by regulating CLDN1 in hepatocellular carcinoma Biochem. Biophys. Res. Commun., 2017;0(0):. 2017 [PMID: 28651932] (Bioassay, Human)
• J Kuusela, K Larsson, D Shah, C Prajapati, K Aalto-Setä Low extracellular potassium prolongs repolarization and evokes early afterdepolarization in human induced pluripotent stem cell-derived cardiomyocytes Biol Open, 2017;6(6):777-784. 2017 [PMID: 28619993] (Bioassay, Human)
• A De Pauw, E Andre, B Sekkali, C Bouzin, H Esfahani, N Barbier, A Loriot, C De Smet, L Vanhoutte, S Moniotte, B Gerber, V di Mauro, D Catalucci, O Feron, D Hilfiker-K, JL Balligand Dnmt3a-mediated inhibition of Wnt in cardiac progenitor cells improves differentiation and remote remodeling after infarction JCI Insight, 2017;2(12):. 2017 [PMID: 28614798] (Bioassay, Mouse)
• RO Pereira, SM Tadinada, FM Zasadny, KJ Oliveira, KMP Pires, A Olvera, J Jeffers, R Souvenir, R Mcglauflin, A Seei, T Funari, H Sesaki, MJ Potthoff, CM Adams, EJ Anderson, ED Abel OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance EMBO J., 2017;0(0):. 2017 [PMID: 28607005] (Bioassay, Human)
• KG Wong, SD Ryan, K Ramnarine, SA Rosen, SE Mann, A Kulick, E De Stanchi, FJ Müller, TJ Kacmarczyk, C Zhang, D Betel, MJ Tomishima CryoPause: A New Method to Immediately Initiate Experiments after Cryopreservation of Pluripotent Stem Cells Stem Cell Reports, 2017;0(0):. 2017 [PMID: 28602613] (Bioassay, Human)
• A Prieur, M Cappellini, G Habif, MP Lefranc, T Mazard, E Morency, JM Pascussi, M Flaceliere, N Cahuzac, B Vire, B Dubuc, A Durochat, P Liaud, J Ollier, C Pfeiffer, S Poupeau, V Saywell, C Planque, E Assenat, F Bibeau, JF Bourgaux, P Pujol, A Sézeur, M Ychou, D Joubert Targeting the Wnt pathway and cancer stem cells with anti-progastrin humanized antibodies: a major breakthrough for K-RAS mutated colorectal cancer treatment Clin. Cancer Res., 2017;0(0):. 2017 [PMID: 28600477] (Bioassay, Human)
• N Rahman, PM Brauer, L Ho, T Usenko, M Tewary, JC Zúñiga-Pfl, PW Zandstra Engineering the haemogenic niche mitigates endogenous inhibitory signals and controls pluripotent stem cell-derived blood emergence Nat Commun, 2017;8(0):15380. 2017 [PMID: 28541275] (Bioassay, Human)
• JR Chao, DA Lamba, TR Klesert, A Torre, A Hoshino, RJ Taylor, A Jayabalu, AL Engel, TH Khuu, RK Wang, M Neitz, J Neitz, TA Reh Transplantation of Human Embryonic Stem Cell-Derived Retinal Cells into the Subretinal Space of a Non-Human Primate Transl Vis Sci Technol, 2017;6(3):4. 2017 [PMID: 28516002] (Bioassay, Human)
• JK Hu, W Du, SJ Shelton, MC Oldham, CM DiPersio, OD Klein An FAK-YAP-mTOR Signaling Axis Regulates Stem Cell-Based Tissue Renewal in Mice Cell Stem Cell, 2017;0(0):. 2017 [PMID: 28457749] (Bioassay, Mouse)
• DJ Tischfield, J Kim, SA Anderson Atypical PKC and Notch Inhibition Differentially Modulate Cortical Interneuron Subclass Fate from Embryonic Stem Cells Stem Cell Reports, 2017;0(0):. 2017 [PMID: 28416285] (Bioassay, Mouse)
• H Zhang, F Sun, J Wang, L Xie, C Yang, M Pan, B Shao, GY Yang, SH Yang, Q ZhuGe, K Jin Combining Injectable Plasma Scaffold with Mesenchymal Stem/Stromal Cells for Repairing Infarct Cavity after Ischemic Stroke Aging Dis, 2017;8(2):203-214. 2017 [PMID: 28400986] (Bioassay, Human)
• R Allison, JR Edgar, G Pearson, T Rizo, T Newton, S Günther, F Berner, J Hague, JW Connell, J Winkler, J Lippincott, C Beetz, B Winner, E Reid Defects in ER-endosome contacts impact lysosome function in hereditary spastic paraplegia J. Cell Biol., 2017;0(0):. 2017 [PMID: 28389476] (Bioassay, Human)
• EE Pashos, Y Park, X Wang, A Raghavan, W Yang, D Abbey, DT Peters, J Arbelaez, M Hernandez, N Kuperwasse, W Li, Z Lian, Y Liu, W Lv, SL Lytle-Gabb, DH Marchadier, P Rogov, J Shi, KJ Slovik, IM Stylianou, L Wang, R Yan, X Zhang, S Kathiresan, SA Duncan, TS Mikkelsen, EE Morrisey, DJ Rader, CD Brown, K Musunuru Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci Cell Stem Cell, 2017;20(4):558-570.e10. 2017 [PMID: 28388432] (Bioassay, Human)
• F Chen, Y Ni, B Liu, T Zhou, C Yu, Y Su, X Zhu, X Yu, Y Zhou Self-crosslinking and injectable hyaluronic acid/RGD-functionalized pectin hydrogel for cartilage tissue engineering Carbohydr Polym, 2017;166(0):31-44. 2017 [PMID: 28385238] (Bioassay, Porcine)
• Y Pan, LJ Smithson, Y Ma, D Hambardzum, DH Gutmann Ccl5 establishes an autocrine high-grade glioma growth regulatory circuit critical for mesenchymal glioblastoma survival Oncotarget, 2017;0(0):. 2017 [PMID: 28380429] (Bioassay, Mouse)
• LA Ahrens, D Vonwil, J Christense, VP Shastri Gelatin device for the delivery of growth factors involved in endochondral ossification PLoS ONE, 2017;12(4):e0175095. 2017 [PMID: 28380024] (Bioassay, Chicken)
• KB McCauley, F Hawkins, M Serra, DC Thomas, A Jacob, DN Kotton Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling Cell Stem Cell, 2017;0(0):. 2017 [PMID: 28366587] (Bioassay, Human)
• NA Guadagno, C Moriconi, V Licursi, E D'Acunto, PS Nisi, N Carucci, A De Jaco, E Cacci, R Negri, G Lupo, E Miranda Neuroserpin polymers cause oxidative stress in a neuronal model of the dementia FENIB Neurobiol. Dis., 2017;103(0):32-44. 2017 [PMID: 28363799] (Bioassay, Human)
• DC Thomas, S Clare, JM Sowerby, M Pardo, JK Juss, DA Goulding, L van der We, D Storistean, A Prakash, M Espéli, S Flint, JC Lee, K Hoenderdos, L Kane, K Harcourt, S Mukhopadhy, Y Umrania, R Antrobus, JA Nathan, DJ Adams, A Bateman, JS Choudhary, PA Lyons, AM Condliffe, ER Chilvers, G Dougan, KG Smith Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity J. Exp. Med, 2017;0(0):. 2017 [PMID: 28351984] (Bioassay, Human)
• PH Vincent, E Benedikz, P Uhlen, O Hovatta, E Sundström Expression of Pluripotency Markers in Non-pluripotent Human Neural Stem and Progenitor Cells Stem Cells Dev., 2017;0(0):. 2017 [PMID: 28351210] (Bioassay, Human)
• F Sampazioti, MC de Brito, I Geti, A Bertero, NR Hannan, L Vallier Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells Nat Protoc, 2017;12(4):814-827. 2017 [PMID: 28333915] (Bioassay, Human)
• K Eun, HM Jeon, SO Kim, SH Choi, SY Lee, X Jin, SC Kim, H Kim A cell-autonomous positive-signaling circuit associated with the PDGF-NO-ID4-regulatory axis in glioblastoma cells Biochem. Biophys. Res. Commun, 2017;0(0):. 2017 [PMID: 28327358] (Bioassay, Human)
• AR Bonilla-Po, C Velez-Pard, M Jimenez-De Fast transdifferentiation of human Wharton&#039;s jelly mesenchymal stem cells into neurospheres and nerve-like cells J. Neurosci. Methods, 2017;0(0):. 2017 [PMID: 28286110] (Bioassay, Human)
• D Chen, M Wu, Y Li, I Chang, Q Yuan, M Ekimyan-Sa, P Deng, B Yu, Y Yu, J Dong, JM Szymanski, S Ramadoss, J Li, CY Wang Targeting BMI1(+) Cancer Stem Cells Overcomes Chemoresistance and Inhibits Metastases in Squamous Cell Carcinoma Cell Stem Cell, 2017;0(0):. 2017 [PMID: 28285905] (Bioassay, Human)
• I Rudnik-Jan, S Colen, J Berard, S Plomp, I Que, M van Rijen, N Woike, A Egas, G van Osch, E van Maarse, K Messier, A Chan, J Thies, L Creemers Prolonged inhibition of inflammation in osteoarthritis by triamcinolone acetonide released from a polyester amide microsphere platform J Control Release, 2017;0(0):. 2017 [PMID: 28284832] (Bioassay, Human)
• H He, AE Kuriyan, CW Su, M Mahabole, Y Zhang, YT Zhu, HW Flynn, JM Parel, SC Tseng Inhibition of Proliferation and Epithelial Mesenchymal Transition in Retinal Pigment Epithelial Cells by Heavy Chain-Hyaluronan/Pentraxin 3 Sci Rep, 2017;7(0):43736. 2017 [PMID: 28252047] (Bioassay, Human)
• R Horibe, Y Hirohashi, T Asano, T Mariya, T Suzuki, A Takaya, H Saijo, Y Shionoya, T Kubo, M Nakatsugaw, T Kanaseki, T Tsukahara, K Watanabe, E Atsuyama, S Toji, H Hirano, T Hasegawa, H Takahashi, N Sato, T Torigoe Brother of the regulator of the imprinted site (BORIS) variant subfamily 6 is a novel target of lung cancer stem-like cell immunotherapy PLoS ONE, 2017;12(3):e0171460. 2017 [PMID: 28248963] (Bioassay, Human)
• L Wang, Y Hirohashi, T Ogawa, M Shen, R Takeda, A Murai, E Yamamoto, T Kubo, M Nakatsugaw, T Kanaseki, T Tsukahara, T Nishidate, K Okita, G Kutomi, N Sato, I Takemasa, T Torigoe LY6/PLAUR domain containing 3 has a role in the maintenance of colorectal cancer stem-like cells Biochem. Biophys. Res. Commun, 2017;0(0):. 2017 [PMID: 28238780] (Bioassay, Human)
• H Koike, RR Zhang, Y Ueno, K Sekine, YW Zheng, T Takebe, H Taniguchi Nutritional modulation of mouse and human liver bud growth through a branched-amino acid metabolism Development, 2017;0(0):. 2017 [PMID: 28219950] (Bioassay, Human)
• AG Kotini, CJ Chang, A Chow, H Yuan, TC Ho, T Wang, S Vora, A Solovyov, C Husser, M Olszewska, J Teruya-Fel, D Perumal, VM Klimek, A Spyridonid, RK Rampal, L Silverman, EP Reddy, E Papaemmanu, S Parekh, BD Greenbaum, CS Leslie, MG Kharas, EP Papapetrou Stage-Specific Human Induced Pluripotent Stem Cells Map the Progression of Myeloid Transformation to Transplantable Leukemia Cell Stem Cell, 2017;0(0):. 2017 [PMID: 28215825] (Bioassay, Human)
• JC Niclis, C Turner, J Durnall, S McDougal, JA Kauhausen, B Leaw, M Dottori, CL Parish, LH Thompson Long-Distance Axonal Growth and Protracted Functional Maturation of Neurons Derived From Human Induced Pluripotent Stem Cells After Intracerebral Transplantation Stem Cells Transl Med, 2017;0(0):. 2017 [PMID: 28198124] (Bioassay, Human)
• E Ercan, JM Han, A Di Nardo, K Winden, MJ Han, L Hoyo, A Saffari, A Leask, DH Geschwind, M Sahin Neuronal CTGF/CCN2 negatively regulates myelination in a mouse model of tuberous sclerosis complex J. Exp. Med, 2017;0(0):. 2017 [PMID: 28183733] (Bioassay, Rat)
• HK Voges, RJ Mills, DA Elliott, RG Parton, ER Porrello, JE Hudson Development of a human cardiac organoid injury model reveals innate regenerative potential Development, 2017;0(0):. 2017 [PMID: 28174241] (Bioassay, Human)
• JS Saini, B Corneo, JD Miller, TR Kiehl, Q Wang, NC Boles, TA Blenkinsop, JH Stern, S Temple Nicotinamide Ameliorates Disease Phenotypes in a Human iPSC Model of Age-Related Macular Degeneration Cell Stem Cell, 2017;0(0):. 2017 [PMID: 28132833] (Bioassay, Human)
• Enrique Armijo Increased susceptibility to a? toxicity in neuronal cultures derived from familial Azheimer&#039;s disease (PSEN1-A246E) induced pluripotent stem cells Neurosci. Lett, 2016;0(0):. 2016 [PMID: 28034781] (Bioassay, Human)
• Ivan Carcamo-Or Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity Cell Stem Cell, 2016;0(0):. 2016 [PMID: 28017796] (Bioassay, Human)
• E Jacobs Biomimetic Calcium Phosphate/Polyelectrolyte Multilayer Coatings for Sequential Delivery of Multiple Biological Factors J Biomed Mater Res A, 2016;0(0):. 2016 [PMID: 28002652]
• Young Dong Yoo Glioma-derived cancer stem cells are hypersensitive to proteasomal inhibition EMBO Rep, 2016;0(0):. 2016 [PMID: 27993939] (Bioassay, Human)
• Kyungshin Shin Skeletal muscle atrophy is induced by Fbxw7? via atrogene upregulation Cell Biol. Int, 2016;0(0):. 2016 [PMID: 27925341] (Bioassay, Human)
• Xiaoguang Fang Deubiquitinase USP13 maintains glioblastoma stem cells by antagonizing FBXL14-mediated Myc ubiquitination J. Exp. Med, 2016;0(0):. 2016 [PMID: 27923907] (Bioassay, Human)
• Leonardo Susta Derivation of chicken induced pluripotent stem cells tolerant to Newcastle disease virus-induced lysis through multiple rounds of infection Virol. J, 2016;13(1):205. 2016 [PMID: 27919263] (Bioassay, Chicken)
• T Toimela Intra-laboratory validated human cell-based in vitro vasculogenesis/angiogenesis test with serum-free medium Reprod. Toxicol, 2016;0(0):. 2016 [PMID: 27915012] (Human)
• Amber N Stratman Mural-Endothelial cell-cell interactions stabilize the developing zebrafish dorsal aorta Development, 2016;0(0):. 2016 [PMID: 27913637] (Bioassay, Human)
• Xiu Li Ju Angiopoietin-1 Modified Human Umbilical Cord Mesenchymal Stem Cell Therapy for Endotoxin-Induced Acute Lung Injury in Rats Yonsei Med. J., 2017;58(1):206-216. 2017 [PMID: 27873515] (Bioassay, Human)
• Stephen J Crocker iPS-derived neural progenitor cells from PPMS patients reveal defect in myelin injury response Exp. Neurol., 2016;288(0):114-121. 2016 [PMID: 27865736] (Bioassay, Human)
• Wout Feitz Ureteral reconstruction with reinforced collagen scaffolds in a porcine model J Tissue Eng Regen Med, 2016;0(0):. 2016 [PMID: 27860431] (Bioassay)
• Engulfed cadherin fingers are polarized junctional structures between collectively migrating endothelial�cells Nat. Cell Biol., 2016;0(0):. 2016 [PMID: 27842057] (Bioassay, Human)
• N Zeltner, F Fattahi, NC Dubois, N Saurat, F Lafaille, L Shang, B Zimmer, J Tchieu, MA Soliman, G Lee, JL Casanova, L Studer Capturing the biology of disease severity in a PSC-based model of familial dysautonomia Nat. Med., 2016;22(12):1421-1427. 2016 [PMID: 27841875] (Bioassay, Human)
• L Zhu, A Gomez-Dura, G Saretzki, S Jin, K Tilgner, D Melguizo-S, G Anyfantis, J Al-Aama, L Vallier, P Chinnery, M Lako, L Armstrong The mitochondrial protein CHCHD2 primes the differentiation potential of human induced pluripotent stem cells to neuroectodermal lineages J. Cell Biol., 2016;215(2):187-202. 2016 [PMID: 27810911] (Bioassay, Human)
• Fibroblast growth factor (FGF) signaling regulates transforming growth factor beta (TGF?)-dependent smooth muscle cell phenotype modulation Sci Rep, 2016;6(0):33407. 2016 [PMID: 27634335] (Bioassay, Human)
• The Semaphorin 4D-RhoA-Akt Signal Cascade Regulates Enamel Matrix Secretion in Coordination with Cell Polarization During Ameloblast Differentiation J Bone Miner Res, 2016;0(0):. 2016 [PMID: 27218883] (Bioassay, Mouse)
• Deverman B, Pravdo P, Simpson B, Kumar S, Chan K, Banerjee A, Wu W, Yang B, Huber N, Pasca S, Gradinaru V Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain. Nat Biotechnol, 2015;34(2):204-9. 2015 [PMID: 26829320] (Bioassay, Human)
• Robert Thomas Automated image analysis with the potential for process quality control applications in stem cell maintenance and differentiation Biotechnol. Prog., 2016;32(1):215-23. 2016 [PMID: 26560993] (Bioassay, Human)
• Bradshaw J, McFarland J, Paavilainen V, Bisconte A, Tam D, Phan V, Romanov S, Finkle D, Shu J, Patel V, Ton T, Li X, Loughhead D, Nunn P, Karr D, Gerritsen M, Funk J, Owens T, Verner E, Brameld K, Hill R, Goldstein D, Taunton J Prolonged and tunable residence time using reversible covalent kinase inhibitors. Nat Chem Biol, 2015;11(7):525-31. 2015 [PMID: 26006010] (Bioassay, Human)
• Siegert S, Seo J, Kwon E, Rudenko A, Cho S, Wang W, Flood Z, Martorell A, Ericsson M, Mungenast A, Tsai L The schizophrenia risk gene product miR-137 alters presynaptic plasticity. Nat Neurosci, 2015;18(7):1008-16. 2015 [PMID: 26005852] (Bioassay, Human)
• Kumorek M, Kubies D, Filova E, Houska M, Kasoju N, Mazl Chanova E, Matejka R, Kryslova M, Bacakova L, Rypacek F Cellular Responses Modulated by FGF-2 Adsorbed on Albumin/Heparin Layer-by-Layer Assemblies. PLoS ONE, 2015;10(5):e0125484. 2015 [PMID: 25945799] (Bioassay, Bovine)
• Chen C, Cheng F, Su H, Sheu M, Lu Z, Chiang C, Yang D, Sheehan J, Pan H Improved neurological outcome by intramuscular injection of human amniotic fluid derived stem cells in a muscle denervation model. PLoS ONE, 2015;10(5):e0124624. 2015 [PMID: 25945496] (Bioassay, Human)
• Ilkow C, Marguerie M, Batenchuk C, Mayer J, Ben Neriah D, Cousineau S, Falls T, Jennings V, Boileau M, Bellamy D, Bastin D, de Souza C, Alkayyal A, Zhang J, Le Boeuf F, Arulanandam R, Stubbert L, Sampath P, Thorne S, Paramanthan P, Chatterjee A, Strieter R, Burdick M, Addison C, Stojdl D, Atkins H, Auer R, Diallo J, Lichty B, Bell J Reciprocal cellular cross-talk within the tumor microenvironment promotes oncolytic virus activity. Nat Med, 2015;21(5):530-6. 2015 [PMID: 25894825] (Bioassay, Human)
• Majumder A, Syed K, Joseph S, Scambler P, Dutta D Histone Chaperone HIRA in Regulation of Transcription Factor RUNX1. J Biol Chem, 2015;290(21):13053-63. 2015 [PMID: 25847244] (Bioassay, Mouse)
• Iyer D, Gambardella L, Bernard W, Serrano F, Mascetti V, Pedersen R, Talasila A, Sinha S Robust derivation of epicardium and its differentiated smooth muscle cell progeny from human pluripotent stem cells. Development, 2015;142(8):1528-41. 2015 [PMID: 25813541] (Bioassay, Human)
• Salvucci O, Ohnuki H, Maric D, Hou X, Li X, Yoon S, Segarra M, Eberhart C, Acker-Palmer A, Tosato G EphrinB2 controls vessel pruning through STAT1-JNK3 signalling. Nat Commun, 2015;6(0):6576. 2015 [PMID: 25807892] (Bioassay, Human)
• Pezzolla D, Lopez-Beas J, Lachaud C, Dominguez-Rodriguez A, Smani T, Hmadcha A, Soria B Resveratrol ameliorates the maturation process of beta-cell-like cells obtained from an optimized differentiation protocol of human embryonic stem cells. PLoS ONE, 2015;10(3):e0119904. 2015 [PMID: 25774684] (Bioassay, Human)
• Xie Q, Wu Q, Horbinski C, Flavahan W, Yang K, Zhou W, Dombrowski S, Huang Z, Fang X, Shi Y, Ferguson A, Kashatus D, Bao S, Rich J Mitochondrial control by DRP1 in brain tumor initiating cells. Nat Neurosci, 2015;18(4):501-10. 2015 [PMID: 25730670] (Bioassay, Human)
• Scheller , T, Hellerbrand , C, Moser , C, Schmidt , K, Kroemer , A, Brunner , S M, Schlitt , H J, Geissler , E K, Lang , S A mTOR inhibition improves fibroblast growth factor receptor targeting in hepatocellular carcinoma. Br J Cancer, 2015;112(5):841-50. 2015 [PMID: 25688743] (Bioassay, Human)
• Huang S, Green M, de Carvalho A, Mumau M, Chen Y, D'Souza S, Snoeck H The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells. Nat Protoc, 2015;10(3):413-25. 2015 [PMID: 25654758] (Bioassay, Human)
• Han K, Kim S, Kim D, Choi J, Im I, Hwang K, Kim C, Lee B, Yoo H, Han Y Enhanced SMAD1 Signaling Contributes to Impairments of Early Development in CFC-iPSCs. Stem Cells, 2015;33(5):1447-55. 2015 [PMID: 25639853] (Bioassay, Human)
• All A, Gharibani P, Gupta S, Bazley F, Pashai N, Chou B, Shah S, Resar L, Cheng L, Gearhart J, Kerr C Early intervention for spinal cord injury with human induced pluripotent stem cells oligodendrocyte progenitors. PLoS ONE, 2015;10(1):e0116933. 2015 [PMID: 25635918] (Bioassay, Human)
• Wu , Bo, Cao , Xiaoming, Liang , Xuezhi, Zhang , Xuhui, Zhang , Wei, Sun , Guang, Wang , Dongwen Epigenetic regulation of Elf5 is associated with epithelial-mesenchymal transition in urothelial cancer. PLoS ONE, 2015;10(1):e0117510. 2015 [PMID: 25629735] (Bioassay, Human)
• Soeda , Akio, Hara , Akira, Kunisada , Takahiro, Yoshimura , Shin-ich, Iwama , Toru, Park , Deric M The evidence of glioblastoma heterogeneity. Sci Rep, 2015;5(0):7979. 2015 [PMID: 25623281] (Bioassay, Human)
• Chen X, Wales P, Quinti L, Zuo F, Moniot S, Herisson F, Rauf N, Wang H, Silverman R, Ayata C, Maxwell M, Steegborn C, Schwarzschild M, Outeiro T, Kazantsev A The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson&#039;s disease but not amyotrophic lateral sclerosis and cerebral ischemia. PLoS ONE, 2015;10(1):e0116919. 2015 [PMID: 25608039] (Bioassay, Human)
• Bayin , N Sumru, Modrek , Aram S, Dietrich , August, Lebowitz , Jonathan, Abel , Tobias, Song , Hae-Ri, Schober , Markus, Zagzag , David, Buchholz , Christia, Chao , Moses V, Placantonakis , Dimitris Selective lentiviral gene delivery to CD133-expressing human glioblastoma stem cells. PLoS ONE, 2014;9(12):e116114. 2014 [PMID: 25541984] (Bioassay, Human)
• Granata A, Bernard W, Zhao N, McCafferty J, Lilly B, Sinha S Temporal and embryonic lineage-dependent regulation of human vascular SMC development by NOTCH3. Stem Cells Dev, 2015;24(7):846-56. 2015 [PMID: 25539150] (Bioassay, Human)
• Wee S, Niklasson M, Marinescu V, Segerman A, Schmidt L, Hermansson A, Dirks P, Forsberg-Nilsson K, Westermark B, Uhrbom L, Linnarsson S, Nelander S, Andang M Selective calcium sensitivity in immature glioma cancer stem cells. PLoS ONE, 2014;9(12):e115698. 2014 [PMID: 25531110] (Bioassay, Human)
• Boucrot E, Ferreira A, Almeida-Souza L, Debard S, Vallis Y, Howard G, Bertot L, Sauvonnet N, McMahon H Endophilin marks and controls a clathrin-independent endocytic pathway. Nature, 2015;517(7535):460-5. 2015 [PMID: 25517094] (Bioassay, Human)
• Sandberg C, Vik-Mo E, Behnan J, Helseth E, Langmoen I Transcriptional profiling of adult neural stem-like cells from the human brain. PLoS ONE, 2014;9(12):e114739. 2014 [PMID: 25514637] (Bioassay, Human)
• Shen K, Luk S, Hicks D, Elman J, Bohr S, Iwamoto Y, Murray R, Pena K, Wang F, Seker E, Weissleder R, Yarmush M, Toner M, Sgroi D, Parekkadan B Resolving cancer-stroma interfacial signalling and interventions with micropatterned tumour-stromal assays. Nat Commun, 2014;5(0):5662. 2014 [PMID: 25489927] (Bioassay, Human)
• Poehler A, Xiang W, Spitzer P, May V, Meixner H, Rockenstein E, Chutna O, Outeiro T, Winkler J, Masliah E, Klucken J Autophagy modulates SNCA/alpha-synuclein release, thereby generating a hostile microenvironment. Autophagy, 2014;10(12):2171-92. 2014 [PMID: 25484190] (Bioassay, Rat)
• Flierl A, Oliveira L, Falomir-Lockhart L, Mak S, Hesley J, Soldner F, Arndt-Jovin D, Jaenisch R, Langston J, Jovin T, Schule B Higher vulnerability and stress sensitivity of neuronal precursor cells carrying an alpha-synuclein gene triplication. PLoS ONE, 2014;9(11):e112413. 2014 [PMID: 25390032] (Bioassay, Human)
• Sundaram S, One J, Siewert J, Teodosescu S, Zhao L, Dimitrievska S, Qian H, Huang A, Niklason L Tissue-engineered vascular grafts created from human induced pluripotent stem cells. Stem Cells Transl Med, 2014;3(12):1535-43. 2014 [PMID: 25378654] (Bioassay, Human)
• Jin H, Kanthasamy A, Harischandra D, Kondru N, Ghosh A, Panicker N, Anantharam V, Rana A, Kanthasamy A Histone hyperacetylation up-regulates protein kinase Cdelta in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of neurodegeneration in Parkinson disease. J Biol Chem, 2014;289(50):34743-67. 2014 [PMID: 25342743] (Bioassay, Human)
• Tomellini E, Touil Y, Lagadec C, Julien S, Ostyn P, Ziental-Gelus N, Meignan S, Lengrand J, Adriaenssens E, Polakowska R, Le Bourhis X Nerve growth factor and proNGF simultaneously promote symmetric self-renewal, quiescence, and epithelial to mesenchymal transition to enlarge the breast cancer stem cell compartment. Stem Cells, 2015;33(2):342-53. 2015 [PMID: 25286822] (Bioassay, Human)
• Hirata , Naoya, Yamada , Shigeru, Shoda , Takuji, Kurihara , Masaaki, Sekino , Yuko, Kanda , Yasunari Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation. Nat Commun, 2014;5(0):4806. 2014 [PMID: 25254944] (Bioassay, Human)
• Falcon B, Swearingen M, Gough W, Lee L, Foreman R, Uhlik M, Hanson J, Lee J, McClure D, Chintharlapalli S An in vitro cord formation assay identifies unique vascular phenotypes associated with angiogenic growth factors. PLoS ONE, 2014;9(9):e106901. 2014 [PMID: 25210890] (Bioassay, Human)
• Lee , Rimi, Kim , Il-Sun, Han , Nalae, Yun , Seokhwan, Park , Kook In, Yoo , Kyung-Hw Real-time discrimination between proliferation and neuronal and astroglial differentiation of human neural stem cells. Sci Rep, 2014;4(0):6319. 2014 [PMID: 25204726] (Bioassay, Human)
• Gerhardt J, Zaninovic N, Zhan Q, Madireddy A, Nolin S, Ersalesi N, Yan Z, Rosenwaks Z, Schildkraut C Cis-acting DNA sequence at a replication origin promotes repeat expansion to fragile X full mutation. J Cell Biol, 2014;206(5):599-607. 2014 [PMID: 25179629] (Bioassay, Human)
• Tani , Hidenori, Onuma , Yasuko, Ito , Yuzuru, Torimura , Masaki Long non-coding RNAs as surrogate indicators for chemical stress responses in human-induced pluripotent stem cells. PLoS ONE, 2014;9(8):e106282. 2014 [PMID: 25171338] (Bioassay, Human)
• van Gastel N, Stegen S, Stockmans I, Moermans K, Schrooten J, Graf D, Luyten F, Carmeliet G Expansion of murine periosteal progenitor cells with fibroblast growth factor 2 reveals an intrinsic endochondral ossification program mediated by bone morphogenetic protein 2. Stem Cells, 2014;32(9):2407-18. 2014 [PMID: 24989687] (Bioassay, Mouse)
• Mathur , Anjili, Ware , Christop, Davis , Lenora, Gazdar , Adi, Pan , Bo-Sheng, Lutterbach , Bart FGFR2 is amplified in the NCI-H716 colorectal cancer cell line and is required for growth and survival. PLoS ONE, 2014;9(6):e98515. 2014 [PMID: 24968263] (Bioassay, Human)
• Ao , Ying, Mich-Basso , Jocelyn, Lin , Bo, Yang , Lei High efficient differentiation of functional hepatocytes from porcine induced pluripotent stem cells. PLoS ONE, 2014;9(6):e100417. 2014 [PMID: 24949734] (Bioassay, Porcine)
• Lopez-Sanchez L, Jimenez C, Valverde A, Hernandez V, Penarando J, Martinez A, Lopez-Pedrera C, Munoz-Castaneda J, De la Haba-Rodriguez J, Aranda E, Rodriguez-Ariza A CoCl2, a mimic of hypoxia, induces formation of polyploid giant cells with stem characteristics in colon cancer. PLoS ONE, 2014;9(6):e99143. 2014 [PMID: 24932611] (Bioassay, Human)
• Park , Chul-Yon, Kim , Jungeun, Kweon , Jiyeon, Son , Jeong Sa, Lee , Jae Souk, Yoo , Jeong-Eu, Cho , Sung-Rae, Kim , Jong-Hoo, Kim , Jin-Soo, Kim , Dong-Woo Targeted inversion and reversion of the blood coagulation factor 8 gene in human iPS cells using TALENs. Proc Natl Acad Sci U S A, 2014;111(25):9253-8. 2014 [PMID: 24927536] (Bioassay, Human)
• Ye K, Felimban R, Traianedes K, Moulton S, Wallace G, Chung J, Quigley A, Choong P, Myers D Chondrogenesis of infrapatellar fat pad derived adipose stem cells in 3D printed chitosan scaffold. PLoS ONE, 2014;9(6):e99410. 2014 [PMID: 24918443] (Bioassay, Human)
• Rouhani , Foad, Kumasaka , Natsuhik, de Brito , Miguel C, Bradley , Allan, Vallier , Ludovic, Gaffney , Daniel Genetic background drives transcriptional variation in human induced pluripotent stem cells. PLoS Genet, 2014;10(6):e1004432. 2014 [PMID: 24901476] (Bioassay, Human)
• Kanehira M, Kikuchi T, Santoso A, Tode N, Hirano T, Ohkouchi S, Tamada T, Sugiura H, Harigae H, Ichinose M Human marrow stromal cells downsize the stem cell fraction of lung cancers by fibroblast growth factor 10. Mol Cell Biol, 2014;34(15):2848-56. 2014 [PMID: 24865969] (Bioassay, Human)
• Brady M, Hilchey S, Hyrien O, Spence S, Bernstein S Mesenchymal stromal cells support the viability and differentiation of follicular lymphoma-infiltrating follicular helper T-cells. PLoS ONE, 2014;9(5):e97597. 2014 [PMID: 24836297] (Bioassay, Human)
• Stein L, Imai S Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging. EMBO J, 2014;33(12):1321-40. 2014 [PMID: 24811750] (Bioassay, Mouse)
• Yan K, Wu Q, Yan D, Lee C, Rahim N, Tritschler I, DeVecchio J, Kalady M, Hjelmeland A, Rich J Glioma cancer stem cells secrete Gremlin1 to promote their maintenance within the tumor hierarchy. Genes Dev, 2014;28(10):1085-100. 2014 [PMID: 24788093] (Bioassay, Human)
• Nakamura I, Zakharia K, Banini B, Mikhail D, Kim T, Yang J, Moser C, Shaleh H, Thornburgh S, Walters I, Roberts L Brivanib attenuates hepatic fibrosis in vivo and stellate cell activation in vitro by inhibition of FGF, VEGF and PDGF signaling. PLoS ONE, 2014;9(4):e92273. 2014 [PMID: 24710173] (Bioassay, Human)
• Zheng G, Huang L, Tong H, Shu Q, Hu Y, Ge M, Deng K, Zhang L, Zou B, Cheng B, Xu J Treatment of acute respiratory distress syndrome with allogeneic adipose-derived mesenchymal stem cells: a randomized, placebo-controlled pilot study. Respir Res, 2014;15(0):39. 2014 [PMID: 24708472] (Bioassay, Human)
• Ronaghi , Mohammad, Nasr , Marjan, Ealy , Megan, Durruthy-Durruthy , Robert, Waldhaus , Joerg, Diaz , Giovanni, Joubert , Lydia-Ma, Oshima , Kazuo, Heller , Stefan Inner ear hair cell-like cells from human embryonic stem cells. Stem Cells Dev, 2014;23(11):1275-84. 2014 [PMID: 24512547] (Bioassay, Human)
• Rodin S, Antonsson L, Niaudet C, Simonson O, Salmela E, Hansson E, Domogatskaya A, Xiao Z, Damdimopoulou P, Sheikhi M, Inzunza J, Nilsson A, Baker D, Kuiper R, Sun Y, Blennow E, Nordenskjold M, Grinnemo K, Kere J, Betsholtz C, Hovatta O, Tryggvason K Clonal culturing of human embryonic stem cells on laminin-521/E-cadherin matrix in defined and xeno-free environment. Nat Commun, 2014;5(0):3195. 2014 [PMID: 24463987] (Bioassay, Human)
• Takebe , Takanori, Zhang , Ran-Ran, Koike , Hiroyuki, Kimura , Masaki, Yoshizawa , Emi, Enomura , Masahiro, Koike , Naoto, Sekine , Keisuke, Taniguchi , Hideki Generation of a vascularized and functional human liver from an iPSC-derived organ bud transplant. Nat Protoc, 2014;9(2):396-409. 2014 [PMID: 24457331] (Bioassay, Human)
• Kamat V, Paluru P, Myint M, French D, Gadue P, Diamond S MicroRNA screen of human embryonic stem cell differentiation reveals miR-105 as an enhancer of megakaryopoiesis from adult CD34+ cells. Stem Cells, 2014;32(5):1337-46. 2014 [PMID: 24446170] (Bioassay, Human)
• Gericota B, Anderson J, Mitchell G, Borjesson D, Sturges B, Nolta J, Sieber-Blum M Canine epidermal neural crest stem cells: characterization and potential as therapy candidate for a large animal model of spinal cord injury. Stem Cells Transl Med, 2014;3(3):334-45. 2014 [PMID: 24443004] (Bioassay, Canine)
• Jun E, Zhang Q, Yoon B, Moon J, Lee G, Park G, Kang P, Lee J, Kim A, You S Hypoxic conditioned medium from human amniotic fluid-derived mesenchymal stem cells accelerates skin wound healing through TGF-beta/SMAD2 and PI3K/Akt pathways. Int J Mol Sci, 2014;15(1):605-28. 2014 [PMID: 24398984] (Bioassay, Human)
• Smith A, Bowers S, Stratman A, Davis G Hematopoietic stem cell cytokines and fibroblast growth factor-2 stimulate human endothelial cell-pericyte tube co-assembly in 3D fibrin matrices under serum-free defined conditions. PLoS ONE, 2013;8(12):e85147. 2013 [PMID: 24391990] (Bioassay, Human)
• Adini , Irit, Ghosh , Kaustabh, Adini , Avner, Chi , Zai-Long, Yoshimura , Takeru, Benny , Ofra, Connor , Kip M, Rogers , Michael, Bazinet , Lauren, Birsner , Amy E, Bielenberg , Diane R, D'Amato , Robert J Melanocyte-secreted fibromodulin promotes an angiogenic microenvironment. J Clin Invest, 2014;124(1):425-36. 2014 [PMID: 24355922] (Cell Culture, Human)
• Lotti , Fiorenza, Jarrar , Awad M, Pai , Rish K, Hitomi , Masahiro, Lathia , Justin, Mace , Adam, Gantt , Gerald A, Sukhdeo , Kumar, DeVecchio , Jennifer, Vasanji , Amit, Leahy , Patrick, Hjelmeland , Anita B, Kalady , Matthew, Rich , Jeremy N Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A. J Exp Med, 2013;210(13):2851-72. 2013 [PMID: 24323355] (Bioassay, Human)
• Tolar J, McGrath J, Xia L, Riddle M, Lees C, Eide C, Keene D, Liu L, Osborn M, Lund T, Blazar B, Wagner J Patient-specific naturally gene-reverted induced pluripotent stem cells in recessive dystrophic epidermolysis bullosa. J Invest Dermatol, 2014;134(5):1246-54. 2014 [PMID: 24317394] (Bioassay, Human)
• Bas E, Van De Water T, Lumbreras V, Rajguru S, Goss G, Hare J, Goldstein B Adult human nasal mesenchymal-like stem cells restore cochlear spiral ganglion neurons after experimental lesion. Stem Cells Dev, 2014;23(5):502-14. 2014 [PMID: 24172073] (Bioassay, Human)
• Chen Y, Huang W, Chang S, Chang K, Kao S, Lo J, Su P Enhanced filopodium formation and stem-like phenotypes in a novel metastatic head and neck cancer cell model. Oncol Rep, 2013;30(6):2829-37. 2013 [PMID: 24100418] (Bioassay, Human)
• Palla , A R, Piazzolla , D, Abad , M, Li , H, Dominguez , O, Schonthaler , H B, Wagner , E F, Serrano , M Reprogramming activity of NANOGP8, a NANOG family member widely expressed in cancer. Oncogene, 2014;33(19):2513-9. 2014 [PMID: 23752184] (Bioassay, Human)
• Prots I, Veber V, Brey S, Campioni S, Buder K, Riek R, Bohm K, Winner B alpha-Synuclein oligomers impair neuronal microtubule-kinesin interplay. J Biol Chem, 2013;288(30):21742-54. 2013 [PMID: 23744071] (Bioassay, Human)
• Hong , Weimin C, Amara , Susan G Differential targeting of the dopamine transporter to recycling or degradative pathways during amphetamine- or PKC-regulated endocytosis in dopamine neurons. FASEB J, 2013;27(8):2995-3007. 2013 [PMID: 23612789] (Bioassay, Rat)
• Frohlich C, Klitgaard M, Noer J, Kotzsch A, Nehammer C, Kronqvist P, Berthelsen J, Blobel C, Kveiborg M, Albrechtsen R, Wewer U ADAM12 is expressed in the tumour vasculature and mediates ectodomain shedding of several membrane-anchored endothelial proteins. Biochem J, 2013;452(1):97-109. 2013 [PMID: 23458101] (Bioassay, Human)
• Hannan , Nicholas, Segeritz , Charis-P, Touboul , Thomas, Vallier , Ludovic Production of hepatocyte-like cells from human pluripotent stem cells. Nat Protoc, 2013;8(2):430-7. 2013 [PMID: 23370178] (Bioassay, Human)
• Ehnman M, Missiaglia E, Folestad E, Selfe J, Strell C, Thway K, Brodin B, Pietras K, Shipley J, Ostman A, Eriksson U Distinct effects of ligand-induced PDGFRalpha and PDGFRbeta signaling in the human rhabdomyosarcoma tumor cell and stroma cell compartments. Cancer Res, 2013;73(7):2139-49. 2013 [PMID: 23338608] (Bioassay, Human)
• Shim , Joong Hy, Lee , Tae Ryon, Shin , Dong Woo Enrichment and characterization of human dermal stem/progenitor cells by intracellular granularity. Stem Cells Dev, 2013;22(8):1264-74. 2013 [PMID: 23336432] (Bioassay, Human)
• Maston G, Zhu L, Chamberlain L, Lin L, Fang M, Green M Non-canonical TAF complexes regulate active promoters in human embryonic stem cells. Elife, 2012;1(0):e00068. 2012 [PMID: 23150797] (Bioassay, Mouse)
• Segarra , Marta, Ohnuki , Hidetaka, Maric , Dragan, Salvucci , Ombretta, Hou , Xu, Kumar , Anil, Li , Xuri, Tosato , Giovanna Semaphorin 6A regulates angiogenesis by modulating VEGF signaling. Blood, 2012;120(19):4104-15. 2012 [PMID: 23007403] (Bioassay, Human)
• Ferreras , Cristina, Rushton , Graham, Cole , Claire L, Babur , Muhammad, Telfer , Brian A, van Kuppevelt , Toin H, Gardiner , John M, Williams , Kaye J, Jayson , Gordon C, Avizienyte , Egle Endothelial heparan sulfate 6-o-sulfation levels regulate angiogenic responses of endothelial cells to fibroblast growth factor 2 and vascular endothelial growth factor. J Biol Chem, 2102;287(43):36132-46. 2102 [PMID: 22927437] (Bioassay, Human)
• Zhang J, Shan L, Koussih L, Redhu NS, Halayko AJ, Chakir J, Gounni AS Pentraxin 3 (PTX3) expression in allergic asthmatic airways: role in airway smooth muscle migration and chemokine production. PLoS ONE, 2012;7(4):e34965. 2012 [PMID: 22529962] (Bioassay, Human)
• Di Maggio N, Mehrkens A, Papadimitropoulos A, Schaeren S, Heberer M, Banfi A, Martin I Fibroblast growth factor-2 maintains a niche-dependent population of self-renewing highly potent non-adherent mesenchymal progenitors through FGFR2c. Stem Cells, 2012;30(7):1455-64. 2012 [PMID: 22495904] (Bioassay, Human)
• Cheung C, Bernardo AS, Trotter MW Generation of human vascular smooth muscle subtypes provides insight into embryological origin-dependent disease susceptibility. Nat. Biotechnol., 2012;30(2):165-73. 2012 [PMID: 22252507] (Bioassay, Human)
• Joubin , Katherin, Richardson , Amelia, Novoa , Natalia, Tu , Edmund, Tomishima , Mark J The endothelial cell line bEnd.3 maintains human pluripotent stem cells. Stem Cells Dev, 2012;21(12):2312-21. 2012 [PMID: 22224974] (Bioassay, Human)
• Walter D, Satheesha S, Albrecht P, Bornhauser BC, D'Alessandro V, Oesch SM, Rehrauer H, Leuschner I, Koscielniak E, Gengler C, Moch H, Bernasconi M, Niggli FK, Schafer BW CD133 positive embryonal rhabdomyosarcoma stem-like cell population is enriched in rhabdospheres. PLoS ONE, 2011;6(5):e19506. 2011 [PMID: 21602936] (Bioassay, Human)
• Krencik R, Weick JP, Liu Y, Zhang ZJ, Zhang SC Specification of transplantable astroglial subtypes from human pluripotent stem cells. Nat. Biotechnol., 2011;29(6):528-34. 2011 [PMID: 21602806] (Bioassay, Human)
• Roobrouck VD, Clavel C, Jacobs SA, Ulloa-Montoya F, Crippa S, Sohni A, Roberts SJ, Luyten FP, Van Gool SW, Sampaolesi M, Delforge M, Luttun A, Verfaillie CM Differentiation potential of human postnatal mesenchymal stem cells, mesoangioblasts, and multipotent adult progenitor cells reflected in their transcriptome and partially influenced by the culture conditions. Stem Cells, 2011;29(5):871-82. 2011 [PMID: 21433224] (Bioassay, Human)
• Pirotte S, Lamour V, Lambert V, Alvarez Gonzalez ML, Ormenese S, Noel A, Mottet D, Castronovo V, Bellahcene A Dentin matrix protein 1 induces membrane expression of VE-cadherin on endothelial cells and inhibits VEGF-induced angiogenesis by blocking VEGFR-2 phosphorylation. Blood, 2011;117(8):2515-26. 2011 [PMID: 21190990] (Bioassay, Human)
• Fang JD, Chou HC, Tung HH Endogenous expression of matriptase in neural progenitor cells promotes cell migration and neuron differentiation. J. Biol. Chem., 2011;286(7):5667-79. 2011 [PMID: 21149451] (Bioassay, Mouse)
• Yang MH, Hsu DS, Wang HW Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition. Nat. Cell Biol., 2010;12(10):982-92. 2010 [PMID: 20818389] (Bioassay, Human)
• Roelandt P, Pauwelyn KA, Sancho-Bru P Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells. PLoS ONE, 2010;5(8):e12101. 2010 [PMID: 20711405] (Cell Culture, Human)
• Jones JL, Anderson JM, Phuah CL, Fox EJ, Selmaj K, Margolin D, Lake SL, Palmer J, Thompson SJ, Wilkins A, Webber DJ, Compston DA, Coles AJ Improvement in disability after alemtuzumab treatment of multiple sclerosis is associated with neuroprotective autoimmunity. Brain, 2010;133(0):2232-47. 2010 [PMID: 20659956] (Bioassay, Rat)
• Carvajal-Vergara X, Sevilla A, D'Souza SL Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome. Nature, 2010;465(7299):808-12. 2010 [PMID: 20535210] (Bioassay, Human)
• Tao J, Xiang JJ, Li D, Deng N, Wang H, Gong YP Selection and characterization of a human neutralizing antibody to human fibroblast growth factor-2. Biochem. Biophys. Res. Commun., 2010;394(3):767-73. 2010 [PMID: 20227391] (Bioassay, Human)
• Chng Z, Teo A, Pedersen RA, Vallier L SIP1 mediates cell-fate decisions between neuroectoderm and mesendoderm in human pluripotent stem cells. Cell Stem Cell, 2010;6(1):59-70. 2010 [PMID: 20074535] (Bioassay, Human)
• Floer M, Gotte M, Wild MK, Heidemann J, Gassar ES, Domschke W, Kiesel L, Luegering A, Kucharzik T Enoxaparin improves the course of dextran sodium sulfate-induced colitis in syndecan-1-deficient mice. Am. J. Pathol., 2010;176(1):146-57. 2010 [PMID: 20008145] (Bioassay, Human)
• Darby S, Murphy T, Thomas H, Robson CN, Leung HY, Mathers ME, Gnanapragasam VJ Similar expression to FGF (Sef) inhibits fibroblast growth factor-induced tumourigenic behaviour in prostate cancer cells and is downregulated in aggressive clinical disease. Br. J. Cancer, 2009;101(11):1891-9. 2009 [PMID: 19888221] (Bioassay, Human)
• Cattaruzza L, Gloghini A, Olivo K, Di Francia R, Lorenzon D, De Filippi R, Carbone A, Colombatti A, Pinto A, Aldinucci D Functional coexpression of Interleukin (IL)-7 and its receptor (IL-7R) on Hodgkin and Reed-Sternberg cells: Involvement of IL-7 in tumor cell growth and microenvironmental interactions of Hodgkin&#039;s lymphoma. Int. J. Cancer, 2009;125(5):1092-101. 2009 [PMID: 19391137] (Bioassay, Human)
• Fischer AJ, Scott MA, Ritchey ER, Sherwood P Mitogen-activated protein kinase-signaling regulates the ability of Muller glia to proliferate and protect retinal neurons against excitotoxicity. Glia, 2009;57(14):1538-52. 2009 [PMID: 19306360] (In Vivo, Chicken)
• Riekstina U, Muceniece R, Cakstina I, Muiznieks I, Ancans J Characterization of human skin-derived mesenchymal stem cell proliferation rate in different growth conditions. Cytotechnology, 2008;58(3):153-62. 2008 [PMID: 19219561] (Bioassay, Human)
• Shi S, Mercer S, Eckert GJ, Trippel SB Growth factor regulation of growth factors in articular chondrocytes. J. Biol. Chem., 2009;284(11):6697-704. 2009 [PMID: 19136669] (Bioassay, Human)
• Ma LH, Webb SE, Chan CM, Zhang J, Miller AL Establishment of a transitory dorsal-biased window of localized Ca2+ signaling in the superficial epithelium following the mid-blastula transition in zebrafish embryos. Dev. Biol., 2009;327(1):143-57. 2009 [PMID: 19133253] (Bioassay, Zebrafish)
• Bernardo AS, Cho CH, Mason S, Docherty HM, Pedersen RA, Vallier L, Docherty K Biphasic induction of Pdx1 in mouse and human embryonic stem cells can mimic development of pancreatic beta-cells. Stem Cells, 2009;27(2):341-51. 2009 [PMID: 19056911] (Bioassay, Mouse)
• Chojnacki A, Kelly JJ, Hader W, Weiss S Distinctions between fetal and adult human platelet-derived growth factor-responsive neural precursors. Ann. Neurol., 2008;64(2):127-42. 2008 [PMID: 18756507] (Bioassay, Human)
• Nedeau AE, Bauer RJ, Gallagher K, Chen H, Liu ZJ, Velazquez OC A CXCL5- and bFGF-dependent effect of PDGF-B-activated fibroblasts in promoting trafficking and differentiation of bone marrow-derived mesenchymal stem cells. Exp. Cell Res., 2008;314(11):2176-86. 2008 [PMID: 18570917] (Bioassay, Mouse)
• Desbordes SC, Placantonakis DG, Ciro A, Socci ND, Lee G, Djaballah H, Studer L High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell Stem Cell, 2008;2(6):602-12. 2008 [PMID: 18522853] (Bioassay, Human)
• Yang L, Soonpaa MH, Adler ED, Roepke TK, Kattman SJ, Kennedy M, Henckaerts E, Bonham K, Abbott GW, Linden RM, Field LJ, Keller GM Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. Nature, 2008;453(7194):524-8. 2008 [PMID: 18432194] (Bioassay, Human)
• Ladewig J, Koch P, Endl E, Meiners B, Opitz T, Couillard-Despres S, Aigner L, Brustle O Lineage selection of functional and cryopreservable human embryonic stem cell-derived neurons. Stem Cells, 2008;26(7):1705-12. 2008 [PMID: 18420830] (Bioassay, Human)
• Rao RC, Boyd J, Padmanabhan R, Chenoweth JG, McKay RD Efficient Serum-Free Derivation of Oligodendrocyte Precursors from Neural Stem Cell-Enriched Cultures. Stem Cells, 2008;0(0):. 2008 [PMID: 18403757] (Bioassay, Mouse)
• Kiprilov EN, Awan A, Desprat R, Velho M, Clement CA, Byskov AG, Andersen CY, Satir P, Bouhassira EE, Christensen ST, Hirsch RE Human embryonic stem cells in culture possess primary cilia with hedgehog signaling machinery. J. Cell Biol., 2008;180(5):897-904. 2008 [PMID: 18332216] (Bioassay, Human)
• Keshet GI, Goldstein I, Itzhaki O, Cesarkas K, Shenhav L, Yakirevitch A, Treves AJ, Schachter J, Amariglio N, Rechavi G MDR1 expression identifies human melanoma stem cells. Biochem. Biophys. Res. Commun., 2008;368(4):930-6. 2008 [PMID: 18279661] (Bioassay, Human)
• Patel VN, Likar KM, Zisman-Rozen S, Cowherd SN, Lassiter KS, Sher I, Yates EA, Turnbull JE, Ron D, Hoffman MP Specific heparan sulfate structures modulate FGF10-mediated submandibular gland epithelial morphogenesis and differentiation. J. Biol. Chem., 2008;283(14):9308-17. 2008 [PMID: 18230614] (Bioassay, Mouse)
• Elkabetz Y, Panagiotakos G, Al Shamy G, Socci ND, Tabar V, Studer L Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage. Genes Dev., 2008;22(2):152-65. 2008 [PMID: 18198334] (Bioassay, Human)
• Schulz TC, Swistowska AM, Liu Y A large-scale proteomic analysis of human embryonic stem cells. BMC Genomics, 2007;8(0):478. 2007 [PMID: 18162134] (Bioassay, Human)
• Dobson NR, Zhou YX, Flint NC, Armstrong RC Musashi1 RNA-binding protein regulates oligodendrocyte lineage cell differentiation and survival. Glia, 2008;56(3):318-30. 2008 [PMID: 18098125] (Bioassay, Rat)
• Shojaei F, Wu X, Zhong C, Yu L, Liang XH, Yao J, Blanchard D, Bais C, Peale FV, van Bruggen N, Ho C, Ross J, Tan M, Carano RA, Meng YG, Ferrara N Bv8 regulates myeloid-cell-dependent tumour angiogenesis. Nature, 2007;450(7171):825-31. 2007 [PMID: 18064003] (Bioassay, Mouse)
• Zhang P, Li J, Tan Z, Wang C, Liu T, Chen L, Yong J, Jiang W, Sun X, DU L, Ding M, Deng H Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells. Blood, 2007;111(4):1933-41. 2007 [PMID: 18042803] (Bioassay, Human)
• You JJ, Yang CH, Huang JS, Chen MS, Yang CM Fractalkine, a CX3C chemokine, as a mediator of ocular angiogenesis. Invest. Ophthalmol. Vis. Sci., 2007;48(11):5290-8. 2007 [PMID: 17962485] (Bioassay, Bovine)
• Lu J, Jiang W, Yang JH, Chang PY, Walterscheid JP, Chen HH, Marcelli M, Tang D, Lee YT, Liao WS, Yang CY, Chen CH Electronegative LDL impairs vascular endothelial cell integrity in diabetes by disrupting fibroblast growth factor 2 (FGF2) autoregulation. Diabetes, 2007;57(1):158-66. 2007 [PMID: 17959932] (Bioassay, Bovine)
• Patel VN, Knox SM, Likar KM, Lathrop CA, Hossain R, Eftekhari S, Whitelock JM, Elkin M, Vlodavsky I, Hoffman MP Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis. Development, 2007;134(23):4177-86. 2007 [PMID: 17959718] (Bioassay, Mouse)
• Wang L, Schulz TC, Sherrer ES, Dauphin DS, Shin S, Nelson AM, Ware CB, Zhan M, Song CZ, Chen X, Brimble SN, McLean A, Galeano MJ, Uhl EW, D'Amour KA, Chesnut JD, Rao MS, Blau CA, Robins AJ Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling. Blood, 2007;110(12):4111-9. 2007 [PMID: 17761519] (Bioassay, Human)
• Watanabe K, Bianco C, Strizzi L, Hamada S, Mancino M, Bailly V, Mo W, Wen D, Miatkowski K, Gonzales M, Sanicola M, Seno M, Salomon DS Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration. J. Biol. Chem., 2007;282(43):31643-55. 2007 [PMID: 17720976] (Bioassay, Human)
• Inagaki A, Soeda A, Oka N, Kitajima H, Nakagawa J, Motohashi T, Kunisada T, Iwama T Long-term maintenance of brain tumor stem cell properties under at non-adherent and adherent culture conditions. Biochem. Biophys. Res. Commun., 2007;361(3):586-92. 2007 [PMID: 17673180] (Bioassay, Human)
• Tesar PJ, Chenoweth JG, Brook FA, Davies TJ, Evans EP, Mack DL, Gardner RL, McKay RD New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature, 2007;448(7150):196-9. 2007 [PMID: 17597760] (Bioassay, Human)
• Vallier L, Alexander M, Pedersen R Conditional gene expression in human embryonic stem cells. Stem Cells, 2007;25(6):1490-7. 2007 [PMID: 17322103] (Bioassay, Human)
• Salero E, Hatten ME Differentiation of ES cells into cerebellar neurons. Proc. Natl. Acad. Sci. U.S.A., 2007;104(8):2997-3002. 2007 [PMID: 17293457] (Bioassay, Mouse)
• Rajesh&lt;/LastName&gt;&lt;ForeNam D&lt;/Initial, Rajesh D, Chinnasamy N, Mitalipov SM, Wolf DP, Slukvin I, Thomson JA, Shaaban AF Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells. Stem Cells, 2007;25(2):490-9. 2007 [PMID: 17284653] (Bioassay, Human)
• Josephson R, Ording CJ, Liu Y, Shin S, Lakshmipathy U, Toumadje A, Love B, Chesnut JD, Andrews PW, Rao MS, Auerbach JM Qualification of embryonal carcinoma 2102Ep as a reference for human embryonic stem cell research. Stem Cells, 2007;25(2):437-46. 2007 [PMID: 17284651] (Bioassay, Human)
• Williamson D, Selfe J, Lu YJ, Pritchard-Jones K, Murai K, Jones P, Workman P, Shipley J Role for amplification and expression of glypican-5 in rhabdomyosarcoma. Cancer Res., 2007;67(1):57-65. 2007 [PMID: 17210683] (Bioassay, Human)
• McLean AB, D&amp;amp;apos;Amour KA, Jones KL, Krishnamoorthy M, Kulik MJ, Reynolds DM, Sheppard AM, Liu H, Xu Y, Baetge EE, Dalton S Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed. Stem Cells, 2007;25(1):29-38. 2007 [PMID: 17204604] (Bioassay, Human)
• Nakayama T, Mutsuga N, Tosato G FGF2 posttranscriptionally down-regulates expression of SDF1 in bone marrow stromal cells through FGFR1 IIIc. Blood, 2006;109(4):1363-72. 2006 [PMID: 17077327] (Bioassay, Mouse)
• Bartunek J, Croissant JD, Wijns W, Gofflot S, de Lavareille A, Vanderheyden M, Kaluzhny Y, Mazouz N, Willemsen P, Penicka M, Mathieu M, Homsy C, De Bruyne B, McEntee K, Lee IW, Heyndrickx GR Pretreatment of adult bone marrow mesenchymal stem cells with cardiomyogenic growth factors and repair of the chronically infarcted myocardium. Am. J. Physiol. Heart Circ. Physiol., 2006;292(2):H1095-104. 2006 [PMID: 17056665] (Bioassay, Canine)
• Porat Y, Porozov S, Belkin D, Shimoni D, Fisher Y, Belleli A, Czeiger D, Silverman WF, Belkin M, Battler A, Fulga V, Savion N Isolation of an adult blood-derived progenitor cell population capable of differentiation into angiogenic, myocardial and neural lineages. Br. J. Haematol., 2006;135(5):703-14. 2006 [PMID: 17052254] (Bioassay, Human)
• Benzing C, Segschneider M, Leinhaas A, Itskovitz-Eldor J, Brustle O Neural conversion of human embryonic stem cell colonies in the presence of fibroblast growth factor-2. Neuroreport, 2006;17(16):1675-81. 2006 [PMID: 17047452] (Bioassay, Human)
• Greber B, Lehrach H, Adjaye J Fibroblast growth factor 2 modulates transforming growth factor beta signaling in mouse embryonic fibroblasts and human ESCs (hESCs) to support hESC self-renewal. Stem Cells, 2006;25(2):455-64. 2006 [PMID: 17038665] (Bioassay, Human)
• Lake AC, Vassy R, Di Benedetto M, Lavigne D, Le Visage C, Perret GY, Letourneur D Low molecular weight fucoidan increases VEGF165-induced endothelial cell migration by enhancing VEGF165 binding to VEGFR-2 and NRP1. J. Biol. Chem., 2006;281(49):37844-52. 2006 [PMID: 17028197] (Bioassay, Human)
• Aghajanova L, Skottman H, Stromberg AM, Inzunza J, Lahesmaa R, Hovatta O Expression of leukemia inhibitory factor and its receptors is increased during differentiation of human embryonic stem cells. Fertil. Steril., 2006;86(4):1193-209. 2006 [PMID: 16949591] (Bioassay, Human)
• Lindsley RC, Gill JG, Kyba M, Murphy TL, Murphy KM Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm. Development, 2006;133(19):3787-96. 2006 [PMID: 16943279] (Bioassay, Mouse)
• Zeng L, Rahrmann E, Hu Q, Lund T, Sandquist L, Felten M, O'Brien TD, O'Brien TD, Zhang J, Verfaillie C Multipotent adult progenitor cells from swine bone marrow. Stem Cells, 2006;24(11):2355-66. 2006 [PMID: 16931778] (Bioassay, Porcine)
• Kobayashi T, Ahlenius H, Thored P, Kobayashi R, Kokaia Z, Lindvall O Intracerebral infusion of glial cell line-derived neurotrophic factor promotes striatal neurogenesis after stroke in adult rats. Stroke, 2006;37(9):2361-7. 2006 [PMID: 16873711] (Bioassay, Rat)
• Yamashita H, Nakamura T, Takahashi T, Nagano Y, Hiji M, Hirabayashi T, Amano T, Yagi T, Sakai N, Kohriyama T, Matsumoto M Embryonic stem cell-derived neuron models of Parkinson&apos;s disease exhibit delayed neuronal death. J. Neurochem., 2006;98(1):45-56. 2006 [PMID: 16805795] (Bioassay, Mouse)
• Murata T, Tsuboi M, Hikita K, Kaneda N Protective effects of neurotrophic factors on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis of murine adrenal chromaffin cell line tsAM5D. J. Biol. Chem., 2006;281(32):22503-16. 2006 [PMID: 16772303] (Bioassay, Mouse)
• Kurita R, Sasaki E, Yokoo T, Hiroyama T, Takasugi K, Imoto H, Izawa K, Dong Y, Hashiguchi T, Soda Y, Maeda T, Suehiro Y, Tanioka Y, Nakazaki Y, Tani K Tal1/Scl gene transduction using a lentiviral vector stimulates highly efficient hematopoietic cell differentiation from common marmoset (Callithrix jacchus) embryonic stem cells. Stem Cells, 2006;24(9):2014-22. 2006 [PMID: 16728561] (Bioassay, Primate - Callitrix jacchus (Common Marmoset))
• Yu H, Fang D, Kumar SM, Li L, Nguyen TK, Acs G, Herlyn M, Xu X Isolation of a novel population of multipotent adult stem cells from human hair follicles. Am. J. Pathol., 2006;168(6):1879-88. 2006 [PMID: 16723703] (Bioassay, Human)
• Li Y, Fan J, Chen M, Li W, Woodley DT Transforming growth factor-alpha: a major human serum factor that promotes human keratinocyte migration. J. Invest. Dermatol., 2006;126(9):2096-105. 2006 [PMID: 16691197] (Bioassay, Human)
• Moreno MJ, Ball M, Andrade MF, McDermid A, Stanimirovic DB Insulin-like growth factor binding protein-4 (IGFBP-4) is a novel anti-angiogenic and anti-tumorigenic mediator secreted by dibutyryl cyclic AMP (dB-cAMP)-differentiated glioblastoma cells. Glia, 2006;53(8):845-57. 2006 [PMID: 16586492] (Bioassay, Human)
• Lee YS, Lin CY, Robertson RT, Yu J, Deng X, Hsiao I, Lin VW Re-growth of catecholaminergic fibers and protection of cholinergic spinal cord neurons in spinal repaired rats. Eur. J. Neurosci., 2006;23(3):693-702. 2006 [PMID: 16487151] (In Vivo, Rat)
• Anghelina M, Krishnan P, Moldovan L, Moldovan NI Monocytes/macrophages cooperate with progenitor cells during neovascularization and tissue repair: conversion of cell columns into fibrovascular bundles. Am. J. Pathol., 2006;168(2):529-41. 2006 [PMID: 16436667] (In Vivo, Mouse)
• Narazaki M, Tosato G Ligand-induced internalization selects use of common receptor neuropilin-1 by VEGF165 and semaphorin3A. Blood, 2006;107(10):3892-901. 2006 [PMID: 16424390] (ELISA (Standard), N/A)
• Faraone D, Aguzzi MS, Ragone G, Russo K, Capogrossi MC, Facchiano A Heterodimerization of FGF-receptor 1 and PDGF-receptor-alpha: a novel mechanism underlying the inhibitory effect of PDGF-BB on FGF-2 in human cells. Blood, 2006;107(5):1896-902. 2006 [PMID: 16322476] (Bioassay, Human)
• Tsai MS, Hwang SM, Tsai YL, Cheng FC, Lee JL, Chang YJ Clonal amniotic fluid-derived stem cells express characteristics of both mesenchymal and neural stem cells. Biol. Reprod., 2005;74(3):545-51. 2005 [PMID: 16306422] (Bioassay, Human)
• Shin JW, Min M, Larrieu-Lahargue F, Canron X, Kunstfeld R, Nguyen L, Henderson JE, Bikfalvi A, Detmar M, Hong YK Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis. Mol. Biol. Cell, 2005;17(2):576-84. 2005 [PMID: 16291864] (Human)
• Bagley RG, Weber W, Rouleau C, Teicher BA Pericytes and endothelial precursor cells: cellular interactions and contributions to malignancy. Cancer Res., 2005;65(21):9741-50. 2005 [PMID: 16266995] (Bioassay, Human)
• Kim B, Lee S, Suvas S, Rouse BT Application of plasmid DNA encoding IL-18 diminishes development of herpetic stromal keratitis by antiangiogenic effects. J. Immunol., 2005;175(1):509-16. 2005 [PMID: 15972686] (Bioassay, Mouse)
• Schmidt-Ott KM, Yang J, Chen X, Wang H, Paragas N, Mori K, Li JY, Lu B, Costantini F, Schiffer M, Bottinger E, Barasch J Novel regulators of kidney development from the tips of the ureteric bud. J. Am. Soc. Nephrol., 2005;16(7):1993-2002. 2005 [PMID: 15917337] (Bioassay, Rat)
• Fischer AJ, Omar G Transitin, a nestin-related intermediate filament, is expressed by neural progenitors and can be induced in Muller glia in the chicken retina. J. Comp. Neurol., 2005;484(1):1-14. 2005 [PMID: 15717308] (In Vivo, Chicken)
• Steinberg Z, Myers C, Heim VM, Lathrop CA, Rebustini IT, Stewart JS, Larsen M, Hoffman MP FGFR2b signaling regulates ex vivo submandibular gland epithelial cell proliferation and branching morphogenesis. Development, 2005;132(6):1223-34. 2005 [PMID: 15716343] (Bioassay, Mouse)
• Fischer AJ, Omar G, Eubanks J, McGuire CR, Dierks BD, Reh TA Different aspects of gliosis in retinal Muller glia can be induced by CNTF, insulin, and FGF2 in the absence of damage. Mol. Vis., 2004;10(0):973-86. 2004 [PMID: 15623987] (In Vivo, Chicken)
• Nagineni CN, Kutty V, Detrick B, Hooks JJ Expression of PDGF and their receptors in human retinal pigment epithelial cells and fibroblasts: regulation by TGF-beta. J. Cell. Physiol., 2005;203(1):35-43. 2005 [PMID: 15368539] (Bioassay, Human)
• Ni HT, Hu S, Sheng WS, Olson JM, Cheeran MC, Chan AS, Lokensgard JR, Peterson PK High-level expression of functional chemokine receptor CXCR4 on human neural precursor cells. Brain Res. Dev. Brain Res., 2004;152(2):159-69. 2004 [PMID: 15351504] (Bioassay, Human)
• Tardif G, Hum D, Pelletier JP, Boileau C, Ranger P, Martel-Pelletier J Differential gene expression and regulation of the bone morphogenetic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes and synovial fibroblasts. Arthritis Rheum., 2004;50(8):2521-30. 2004 [PMID: 15334466] (Bioassay, Human)
• Oynebraten I, Bakke O, Brandtzaeg P, Johansen FE, Haraldsen G Rapid chemokine secretion from endothelial cells originates from 2 distinct compartments. Blood, 2004;104(2):314-20. 2004 [PMID: 15044249] (Bioassay, Human)
• Sharma MR, Tuszynski GP, Sharma MC Angiostatin-induced inhibition of endothelial cell proliferation/apoptosis is associated with the down-regulation of cell cycle regulatory protein cdk5. J. Cell. Biochem., 2004;91(2):398-409. 2004 [PMID: 14743398] (Bioassay, Bovine)
• Wang J, Roy SK Growth differentiation factor-9 and stem cell factor promote primordial follicle formation in the hamster: modulation by follicle-stimulating hormone. Biol. Reprod., 2004;70(3):577-85. 2004 [PMID: 14585807] (Bioassay, Hamster)
• Yi M, Sakai T, Fassler R, Ruoslahti E Antiangiogenic proteins require plasma fibronectin or vitronectin for in vivo activity. Proc. Natl. Acad. Sci. U.S.A., 2003;100(20):11435-8. 2003 [PMID: 13679585] (In Vivo, Mouse)
• Kovalenko D, Yang X, Nadeau RJ, Harkins LK, Friesel R Sef inhibits fibroblast growth factor signaling by inhibiting FGFR1 tyrosine phosphorylation and subsequent ERK activation. J. Biol. Chem., 2003;278(16):14087-91. 2003 [PMID: 12604616] (Bioassay, Human)
• Barbour AP, Reeder JA, Walsh MD, Fawcett J, Antalis TM, Gotley DC Expression of the CD44v2-10 isoform confers a metastatic phenotype: importance of the heparan sulfate attachment site CD44v3. Cancer Res., 2003;63(4):887-92. 2003 [PMID: 12591743] (Binding Assay, Human)
• Bandyopadhyay A, 2019, Zhu Y, Malik SN, Kreisberg J, Brattain MG, Sprague EA, Luo J, Lopez-Casillas F, Sun LZ Extracellular domain of TGFbeta type III receptor inhibits angiogenesis and tumor growth in human cancer cells. 101205, 2002;21(22):3541-51. 2002 [PMID: 12032856] (In Vivo, Mouse)

FAQs for FGF basic/FGF2/bFGF (233-FB). (Showing 1 - 1 of 1 FAQs).

1. I am looking for an ovine antibody for bFGF and PDGF-AB and ELISA Kits for both. It is for a research work on meniscus healing in sheep. Do you have anything suitable? How is the homology with sheep? Is it ever tested and/or published in papers?
   • Unfortunately, most of the products you are interested in have not yet been tested in sheep, but this should not be a problem, due to sequence homology, and our Innovators Reward Program. In terms of an antibody for bFGF, also called FGF-2, we have two antibodies that are validated to detect the bovine protein, which is almost identical to that from sheep (99% homology). Here is a link to those FGF-2 antibodies. We only have FGF2 ELISA kits that have been tested with human or mouse. Mouse FGF-2 has 94% homology with sheep; human has 98% homology for most of its sequence, but also has an additional stretch of amino acids that is not present in the sheep protein. I therefore think that the mouse kit would be most suitable, just in case the human kit targets the region of the human protein not present in mouse. We sell antibodies to PDGF-A or PDGF-B rather than PDGF-AB. We don't have any PDGF-A antibodies that have been tested in sheep but there are several options you may find of interest. There isn't a sheep PDGFA sequence in UniProt, so I can't comment on how similar it is to the PDGFA from other species. Nevertheless, our NBP1-52533 PDGFB antibody has been shown to work in sheep. We sell two PDGF-AB ELISA kits , but these are for human and rat. I'm not sure how well these would work with sheep. Note that if you test a product with a species (or application) that it has not yet been validated in, you are eligible for our Innovator's Reward: Novus would provide you a 50% refund on the purchased product as well as a 50% discount on a future product of equal or lesser value. You would email innovators@novusbio.com to apply for your award, and we

Bioinformatics

• Gene Symbol: FGF2
• Uniprot:
  • P09038()