iNOS Antibody

Images

 
Immunohistochemistry-Paraffin: iNOS Antibody [NBP1-50606] - Human adrenal formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval concentration 5 ug/ml.
Immunohistochemistry-Paraffin: iNOS Antibody [NBP1-50606] - Human spleen formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval concentration 5 ug/ml.
Immunohistochemistry-Paraffin: iNOS Antibody [NBP1-50606] - Human testis formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval concentration 5 ug/ml.
Immunohistochemistry-Paraffin: iNOS Antibody [NBP1-50606] - Human pancreas, nerve formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval concentration 5 ug/ml.
Immunohistochemistry-Paraffin: iNOS Antibody [NBP1-50606] - Human prostate, nerve formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval concentration 5 ug/ml.

Product Details

Summary
Reactivity Hu, Mu, Rt, Po, BvSpecies Glossary
Applications IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

iNOS Antibody Summary

Immunogen
A synthetic peptide derived from the C-terminus of mouse iNOS and nNOS.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
NOS2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 5 ug/ml
Publications
Read Publications using
NBP1-50606 in the following applications:

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
10mM PBS (pH 7.4) and BSA
Preservative
Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for iNOS Antibody

  • EC 1.14.13.39
  • Hepatocyte NOS
  • HEP-NOSPeptidyl-cysteine S-nitrosylase NOS2
  • Inducible NO synthase
  • Inducible NOS
  • iNOS
  • nitric oxide synthase 2, inducible
  • nitric oxide synthase 2A (inducible, hepatocytes)
  • nitric oxide synthase, inducible
  • nitric oxide synthase, macrophage
  • NOS
  • NOS, type II
  • NOS2
  • NOS2A
  • NOS2ANOS type II

Background

Nitric oxide (NO) is an inorganic, gaseous free radical that carries a variety of messages between cells. Vasorelaxation, neurotransmission and cytotoxicity can all be potentiated through cellular response to NO. NO production is mediated by members of the nitric oxide synthase (NOS) family. NOS catalyzes the oxidization of L-arginine to produce L-citrulline and NO. Two constitutive isoforms, brain or neuronal NOS (b or nNOS, type I) & endothelial cell NOS (eNOS, type III), and one inducible isoform (iNOS, type II), have been cloned. All NOS isoforms contain calmodulin, nicotinamide adenine dinucleotide phosphate (NADPH), flavin adenine dinucleotide (FAD), and flavin mononucleotide (FMN) binding domains. Nitric oxide synthase is expressed in liver, macrophages, hepatocytes, synoviocytes, stimulated glial cells and smooth muscle cells. Cytokines such as interferon-gamma (IFN), tumor necrosis factor (TNF), interleukin-1 and -2, and lipopolysaccarides (LPS) cause an increase in iNOS mRNA, protein, and activity levels. Protein kinase C-stimulating agents exhibit the same effect on iNOS activity. After cytokine induction, iNOS exhibits a delayed activity response which is then followed by a significant increase in NO production over a long period of time. Human iNOS is regulated by calcium/calmodulin (in contrast with mouse NOS2).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Applications: IHC, IHC-P

Publications for iNOS Antibody (NBP1-50606)(2)

We have publications tested in 1 confirmed species: Rat.

We have publications tested in 2 applications: FLOW, IHC-P.


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FLOW
(1)
IHC-P
(1)
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(1)
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Product General Protocols

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FAQs for iNOS Antibody (NBP1-50606). (Showing 1 - 1 of 1 FAQs).

  1. We need to evaluate the level of iNOS in Rat sciatic nerve by westernblot. I see that you have few antibodies suitable for that, could you please recommend the best what you have for our purposes?
    • We have 4 iNOS antibodies that are suitable for your experiment. The best choice for you will depend on your specific preferences, in this case the main difference will be the immunogen location. If the immunogen is not important to you, then I would recommend choosing NB300-605 as it gives you the best value and we are able to provide the exact immunogen.

Secondary Antibodies

 

Isotype Controls

Additional iNOS Products

Bioinformatics Tool for iNOS Antibody (NBP1-50606)

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Diseases for iNOS Antibody (NBP1-50606)

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Research Areas for iNOS Antibody (NBP1-50606)

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Blogs on iNOS.

The effects of curcumin on IKB Alpha and the NFkB signaling pathway
The IKK complex, or inhibitor of NFkB kinase, is composed of IKK alpha and IKK beta.  These kinases are at the core of the NFkB signaling cascade.  The NFkB family is made up of transcription factors that are kept inactive in the cytoplasm through...  Read full blog post.

iNOS: The Nitric Oxide Boss
Nitric oxide (NO) is an inorganic, gaseous, and reactive free radical that acts as a biologic mediator in processes such as neurotransmission, vasorelaxation, and cytotoxicity. In addition, it has antimicrobial and anti-tumoral activities. NO producti...  Read full blog post.

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Bioinformatics

Gene Symbol NOS2
Entrez