New pricing — Effective July 1, 2022 -

Amidst rising costs across all areas of our business, and aggressive attempts to implement cost savings without sacrificing quality, we announce the need to implement a cost increase starting July 1, 2022. If you have questions, please contact your sales representative.

IL-1 beta/IL-1F2 Products

Antibodies
IL-1 beta/IL-1F2 Antibody [Un ...
IL-1 beta/IL-1F2 Antibody [Unconju...
AF-401-NA
Species: Mu
Applications: WB, Simple Western, IHC, B/N, ICC/IF
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Formulation Catalog # Availability Price  
IL-1 beta/IL-1F2 Antibody
IL-1 beta/IL-1F2 Antibody
Species: Hu, Mu, Rt, Po, Ca, Pm, SyHa, RM
Applications: WB, ELISA, EM, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, IHC-WhMt
Host: Rabbit Polyclonal
IL-1 beta/IL-1F2 Antibody [Un ...
IL-1 beta/IL-1F2 Antibody [Unconju...
AF-201-NA
Species: Hu
Applications: WB, Simple Western, IHC, B/N, Dual ISH-IHC, ICC/IF
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Formulation Catalog # Availability Price  
ELISA Kits
Mouse IL-1 beta/IL-1F2 Quanti ...
Mouse IL-1 beta/IL-1F2 Quantikine ...
MLB00C
Species: Mu
Applications: ELISA
Conjugate Catalog # Availability Size Price
Formulation Catalog # Availability Price  
Mouse IL-1 beta/IL-1F2 DuoSet ...
Mouse IL-1 beta/IL-1F2 DuoSet ELIS...
DY401
Species: Mu
Applications: ELISA
Conjugate Catalog # Availability Size Price
Human IL-1 beta/IL-1F2 Quanti ...
Human IL-1 beta/IL-1F2 Quantikine ...
DLB50
Species: Hu
Applications: ELISA
Conjugate Catalog # Availability Size Price
Lysates
IL-1 beta/IL-1F2 Overexpressi ...
IL-1 beta/IL-1F2 Overexpression Ly...
NBP2-04165
Species: Hu
Applications: WB
Proteins
Recombinant Human IL-1 beta/I ...
Recombinant Human IL-1 beta/IL-1F2...
201-LB
Species: Hu
Applications: Bioactivity
Recombinant Mouse IL-1 beta/I ...
Recombinant Mouse IL-1 beta/IL-1F2...
401-ML
Species: Mu
Applications: Bioactivity
Recombinant Rat IL-1 beta/IL- ...
Recombinant Rat IL-1 beta/IL-1F2 P...
501-RL
Species: Rt
Applications: Bioactivity
Formulation Catalog # Availability Price  

Description

Interleukin-1 beta (IL-1 beta), also called IL-1F2, is a proinflammatory cytokine that functions in host defense following injury or inflammation (1-5). IL-1 beta is expressed by cells of the immune system such as monocytes, macrophage, neutrophils, and hepatocytes (1-3). Human IL-1 beta protein is expressed in the cytoplasm in an inactive precursor form (pro-IL-1 beta) which is 269 amino acids in length with a theoretical molecular weight of 31 kDa (1,4,6). Pro-IL-1 beta is cleaved by IL-1 converting enzyme (ICE), also called caspase-1, generating the 18 kDa mature, active protein that is secreted from cells (1,4,6). Pro-IL-1 beta is produced as a cellular response to molecular signals from pathogens and other processes termed pathogen associated molecular patterns (PAMPs) and damage associated molecular patterns (DAMPs) (1,2). PAMPs and DAMPs signal through pattern recognition receptors (PRRs) to induce formation of the inflammasome (1,2). The inflammasome is a multi-protein complex made of a PRR, such as Nod-like receptor family, pyrin domain containing 3(NLRP3), an adaptor, such as apoptosis-associated spec-like protein containing a CARD (ASC), and pro-caspase-1 (1-3,5). Assembly of the inflammasome enables cleavage of pro-caspase-1 into active caspase 1, followed by secretion of activate IL-1 beta (1-3,5).

IL-1 beta binding to its receptor IL-1RI and the downstream signaling contributes to a dual pathophysiological role (3). On one hand, IL-1 beta signaling activates immune cells and drives CD4+ T cell polarization to T helper type 1 (Th1) and Th17 cells, resulting in anti-tumor responses and mediation of acute inflammation (2,3). However, IL-1 beta also supports tumor growth and metastasis driven by multiple mechanisms including chronic inflammation, an immunosuppressive tumor microenvironment (TME), and angiogenesis (3). Additionally, IL-1 beta signaling been implicated in the pathogenesis of neuroinflammatory diseases of the central nervous system (CNS) such as multiple sclerosis (MS), Alzheimer's disease, and diabetic retinopathy (DR) (2). Mouse studies have shown regression of tumors treated with IL-1 as well as protective effects of IL-1 beta in instances of induced colitis and colon carcinoma (3). Conversely, blocking IL-1 beta has also shown promising effect in cancer treatment, especially when combined with chemotherapeutics (2,3). Approved IL-1 beta monoclonal antibody canakinumab has shown significant therapeutic promise in the treatment of DR (2). Given its multifaceted role in disease, IL-1 beta is a promising therapeutic target.

References

1. Lopez-Castejon G, Brough D. Understanding the mechanism of IL-1beta secretion. Cytokine Growth Factor Rev. 2011;22(4):189-195. https://doi.org/10.1016/j.cytogfr.2011.10.001

2. Mendiola AS, Cardona AE. The IL-1beta phenomena in neuroinflammatory diseases. J Neural Transm (Vienna). 2018;125(5):781-795. https://doi.org/10.1007/s00702-017-1732-9

3. Bent R, Moll L, Grabbe S, Bros M. Interleukin-1 Beta-A Friend or Foe in Malignancies?. Int J Mol Sci. 2018;19(8):2155. https://doi.org/doi:10.3390/ijms19082155

4. Krumm B, Xiang Y, Deng J. Structural biology of the IL-1 superfamily: key cytokines in the regulation of immune and inflammatory responses. Protein Sci. 2014;23(5):526-538. https://doi.org/10.1002/pro.2441

5. He Y, Hara H, Nunez G. Mechanism and Regulation of NLRP3 Inflammasome Activation. Trends Biochem Sci. 2016;41(12):1012-1021. https://doi.org/10.1016/j.tibs.2016.09.002

6. Uniprot (P01584)

Bioinformatics

Entrez Mouse
Rat
Human
Uniprot Human
Human
Human
Human
Human
Mouse
Product By Gene ID 3553
Alternate Names
  • Catabolin
  • catabolin
  • IL-1 beta
  • IL-1
  • IL-1B
  • IL1-BETA
  • IL1F2IL-1 beta
  • interleukin 1, beta
  • interleukin-1 beta
  • preinterleukin 1 beta
  • pro-interleukin-1-beta

Research Areas for IL-1 beta/IL-1F2

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Apoptosis
Cancer
Cytokine Research
Diabetes Research
Immune System Diseases
Immunology
Innate Immunity

PTMs for IL-1 beta/IL-1F2

Learn more about PTMs related to IL-1 beta/IL-1F2.

Phosphorylation
Cleavage
Methylation
Demethylation
Glycosylation
Acetylation
Ubiquitination
Sumoylation
Oxidation

Bioinformatics Tool for IL-1 beta/IL-1F2

Discover related pathways, diseases and genes to IL-1 beta/IL-1F2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related IL-1 beta/IL-1F2 Blog Posts

Check out the latest blog posts on IL-1 beta/IL-1F2.
IL-1 beta (interleukin 1 beta, lymphocyte activating factor (LAF))
IL-1 was originally identified and cloned as a lymphocyte mitogen and much later, was found to be comprised of two closely related but distinct proteins, interleukin 1 alpha (IL-1 alpha) and interleukin 1 beta (IL-1 beta). Both these proteins bind ...    Read more.
Pyroptosis: Mechanisms mediating cell death and pro-inflammatory cytokine release
By Victoria OsinskiPyroptosis is an inflammatory form of programmed cell death characterized by the release of pro-inflammatory cytokines IL-1 beta and IL-18.1,10 It is a process distinct from apoptosis and necrosis (T...    Read more.
Immune Cell Metabolic Flux Influences Type I Diabetes
By Hunter MartinezWhat is Immunometabolism?It is well established that abnormal metabolic environments can be a risk factor for disease development. One characteristic example is the role of dyslipidemia (high lev...    Read more.
Read more IL-1 beta/IL-1F2 related blogs.