NANOS1 Antibody

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Immunohistochemistry-Paraffin: NANOS1 Antibody [NBP2-27084] - analysis of NANOS1 in formalin-fixed, paraffin-embedded human brain tissue using this antibody at 5 ug/ml.

Product Details

Summary
Reactivity Hu, PmSpecies Glossary
Applications WB, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

NANOS1 Antibody Summary

Immunogen
This antibody was raised against NANOS1
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
NANOS1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot
  • Immunohistochemistry-Paraffin 5ug/ml

Reactivity Notes

The amino acid sequence used as immunogen is 100% homologous in human and chimpanzee.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
0.2 ml PBS and 0.05% BSA
Preservative
0.05% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for NANOS1 Antibody

  • nanos homolog 1 (Drosophila)
  • nanos homolog 1
  • NOS-1
  • NOS1EC_Rep1a

Background

NANOS1 is a protein that belongs to the nanos family. The C terminus contains a conserved RNA-binding domain that consists of two zinc fingers. Nanos-type zinc finger is composed of two C2HC motifs, each motif binds one molecule of zinc. It is essential for the translation repression activity of the protein. The zinc finger region of NANOS1 shares 62% identity with the zinc finger region of Drosophila Nanos. It is required for the development of germ stem cells in both the sexes. It may regulate translation of specific mRNAs by forming a complex with PUM2. A region of PUM2 that include the RNA-binding domain and 155 upstream amino acids interacted with the zinc finger domain of NANOS1. NANOS1 is expressed during meiosis in spermatocytes but is absent in late post meiotic-stage germ cells. Northern blot analysis shows its almost exclusive expression on testis. It is also expressed in fetal testis and fetal ovary. It is essential for both establishing and maintaining germline stem cells by preventing their precocious entry into oogenesis. Removing NANOS from germline stem cells or their precursors, the primordial germ cells, causes both cell types to differentiate into germline cysts.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol NANOS1