IFN-gamma Products

Description

IFN-gamma, a type II interferon and an acid-labile interferon, is mainly produced by CD4 and CD8 T-lymphocytes and natural killer cells activated by antigens, mitogens or alloantigens. IFN-gamma shows no significant homology with IFN-beta or IFN-alpha. IFN-gamma has antiviral and antiparasitic activities and exhibits also immunoregulatory and proinflammatory activities. IFN-gamma induces cytokine production and promotes antigen presentation by up regulating the expression of MHC proteins as well as other antigen proteins. In contrast to other interferons, which are mostly antiviral, the main activity of IFN-gamma seems to be immunomodulatory. Human IFN-gamma is species-specific and is only biologically active in human and primate cells.

Bioinformatics

Entrez	15978 Mouse 25712 Rat 3458 Human
Uniprot	AAH70256.1 Human AAP20098.1 Human CAA31639 Human NM_000619 Human NP_000610 Human P01579 Human P01580 Mouse P01581 Rat P15260.1 Human
Product By Gene ID	3458
Alternate Names	IFG IFI IFN-gamma Immune interferon interferon gamma interferon, gamma

Diseases related to IFN-gamma

Discover more about diseases related to IFN-gamma.

Inflammation
Neoplasms
Infective Disorder
Tuberculosis
Malignant Neoplasms
Autoimmune Reaction
Sclerosis
Dysequilibrium Syndrome
Innate Immune Response
Multiple Sclerosis
Diabetes Mellitus
Virus Diseases
Hepatitis
Asthma
Autoimmune Diseases
Diabetes Mellitus, Insulin-dependent
Inflammatory Response
Cholangiocarcinoma
Tuberculosis, Pulmonary
Leukemia

Pathways for IFN-gamma

View related products by pathway and learn more about each of the pathways below.

Immune Response
Pathogenesis
Secretion
Cell Differentiation
Methylation
Cytokine Production
Inflammatory Response
Innate Immune Response
Histone Acetylation
Cell Cycle
Localization
Cell Death
Cell Proliferation
Dna Methylation
Cell Activation
Luteolysis
Macrophage Activation
T Cell Differentiation
Chromatin Remodeling
Cytokine Secretion

Research Areas for IFN-gamma

Find related products by research area and learn more about each of the different research areas below.

Biologically Active Proteins
Cytokine Research
Immunology
Innate Immunity
Stem Cell Markers

PTMs for IFN-gamma

Learn more about PTMs related to IFN-gamma.

Acetylation
Methylation
Phosphorylation
Demethylation

Bioinformatics Tool for IFN-gamma

Discover related pathways, diseases and genes to IFN-gamma. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 

Related IFN-gamma Blog Posts

Check out the latest blog posts on IFN-gamma.

You complete me: Natural killer cells need TGF-beta inhibition to effectively combat cancers By Jamshed Arslan Pharm.D. Natural killer (NK) cells are lymphocytes of the innate immune system that were first discovered for their “natural” ability to kill cancer cells. To use NK cells as anti-cancer therapy, t...    Read more.

iNOS: The Nitric Oxide Boss Nitric oxide (NO) is an inorganic, gaseous, and reactive free radical that acts as a biologic mediator in processes such as neurotransmission, vasorelaxation, and cytotoxicity. In addition, it has antimicrobial and anti-tumoral activities. NO producti...    Read more.

Success of combined IL-10 and IL-12 therapy in colon cancer depends on IFN-gamma and gut barrier integrity By Jamshed Arslan, Pharm. D., PhD. Colon cancer is responsible for over 600,000 deaths per year worldwide. Colon cancer can be classified into two categories: mismatch repair (MMR)-deficient and MMR-proficient cancers...    Read more.

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Early T cell response is associated with mild COVID-19 and rapid SARS-CoV-2 clearance Jamshed Arslan, Pharm D, PhD SARS-CoV-2 induces both humoral and cellular immunity. A vaccine or natural infection invokes SARS-CoV-2-specific humoral components (antibodies from activated B cells) and cellular resp...    Read more.

Tired T cells: Hypoxia Drives T cell Exhaustion in the Tumor Microenvironment By Hunter MartinezThe paradigm shifting view of the immune system being leveraged to target cancer has led to numerous therapeutic breakthroughs. One major cell group responsible for this revelation is a T cell. ...    Read more.

Read more IFN-gamma related blogs.