TNF-alpha Products

Antibodies
TNF-alpha Antibody [Unconjuga ...
TNF-alpha Antibody [Unconjugated]
AF-410-NA
Species: Hu, Mu
Applications: WB, B/N, CyTOF-ready, ELISA(Cap), Flow, ICC/IF
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Formulation Catalog # Availability Price  
Antibody Pairs
TNF-alpha Antibody Pair [HRP] ...
TNF-alpha Antibody Pair [HRP]
NBP2-79568
Species: Mu
Applications: S-ELISA
Host: Rabbit
Conjugate Catalog # Availability Size Price
TNF-alpha Antibody Pair [HRP] ...
TNF-alpha Antibody Pair [HRP]
NBP2-79675
Species: Hu
Applications: S-ELISA
Host: Mouse Monoclonal
Conjugate Catalog # Availability Size Price
TNF-alpha Antibody Pair [HRP] ...
TNF-alpha Antibody Pair [HRP]
NBP2-79390
Species: Ma
Applications: S-ELISA
Host: Monoclonal
Conjugate Catalog # Availability Size Price
ELISA Kits
Mouse TNF-alpha DuoSet ELISA, ...
Mouse TNF-alpha DuoSet ELISA, 15 P...
DY410
Species: Mu
Applications: ELISA
Conjugate Catalog # Availability Size Price
Human TNF-alpha Quantikine EL ...
Human TNF-alpha Quantikine ELISA Kit
DTA00D
Species: Hu
Applications: ELISA
Conjugate Catalog # Availability Size Price
Formulation Catalog # Availability Price  
Human TNF-alpha DuoSet ELISA, ...
Human TNF-alpha DuoSet ELISA, 15 P...
DY210
Species: Hu
Applications: ELISA
Conjugate Catalog # Availability Size Price
Lysates
TNF-alpha Overexpression Lysa ...
TNF-alpha Overexpression Lysate
NBL1-17134
Species: Hu
Applications: WB
Proteins
Recombinant Human TNF-alpha P ...
Recombinant Human TNF-alpha Protein
210-TA
Species: Hu
Applications: Bioactivity
Recombinant Mouse TNF-alpha ( ...
Recombinant Mouse TNF-alpha (aa 80...
410-MT
Species: Mu
Applications: Bioactivity
Recombinant Rat TNF-alpha Pro ...
Recombinant Rat TNF-alpha Protein
510-RT
Species: Rt
Applications: Bioactivity
Formulation Catalog # Availability Price  

Description

TNF-alpha (Tumor necrosis factor, alpha), a member of the TNF ligand superfamily, is among others, secreted by macrophages, activated monocytes, neutrophils, T-cells, B-cells and natural killer cells stimulated by bacterial lipopolysaccharides. TNF-alpha shows approximately 30% homology with TNF-beta. TNF-alpha plays an important role in the regulation of immune cells. TNF-alpha has many biological activities, including a cytotoxic effect to various tumor cells, causes inflammation, cellular proliferation and plays a critical role in mediating resistance to bacterial infections. Human and murine TNF-alpha show approximately 79% homology and human TNF-alpha is active on murine cells with a slightly reduced specific activity.

Bioinformatics

Entrez Human
Mouse
Rat
Rat
Rabbit
Uniprot Human
Human
Human
Human
Human
Human
Mouse
Mouse
Rat
Product By Gene ID 7124
Alternate Names
  • Cachectin
  • tumor necrosis factor (TNF superfamily, member 2)
  • tumor necrosis factor-alpha
  • TNF-a
  • tumor necrosis factor alpha
  • Tumor necrosis factor ligand superfamily member 2
  • TNF, monocyte-derived
  • DIF
  • TNFATNF, macrophage-derived
  • TNFSF2TNF superfamily, member 2
  • TNF-alphacachectin
  • APC1 protein
  • tumor necrosis factor

Research Areas for TNF-alpha

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Asthma
Autophagy
Biologically Active Proteins
Cancer
Cytokine Research
Diabetes Research
Immune System Diseases
Immunology
Innate Immunity

Bioinformatics Tool for TNF-alpha

Discover related pathways, diseases and genes to TNF-alpha. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related TNF-alpha Blog Posts

Check out the latest blog posts on TNF-alpha.
Liver ASK1 activates autophagy to protect against hepatic fat accumulation, non-alcoholic steatohepatitis and fibrosis
By Jamshed Arslan, Pharm. D., PhD. The most common chronic liver disorder worldwide is non-alcoholic fatty liver disease (NAFLD). This obesity-linked disorder can manifest as hepatic fat accumulation (steatosis) wit...    Read more.
Metabolic Syndrome: Symptoms and associated disease states
By Jamshed Arslan, Pharm. D., PhD. What is metabolic syndrome?It was 1988 when, after decades of research, Dr. GM Reaven    of the Stanford University, CA, explained the relationship between four diseases:...    Read more.
Increased wild type FUS levels in ALS patients lead to a toxic microenvironment and motor neuron neurodegeneration
By Michalina Hanzel, PhDFUS mutations in Amyotrophic Lateral SclerosisFused in sarcoma (FUS) is a ribonucleoprotein that continuously shuttles between the nucleus and the cytoplasm to regulate pre-mRNA splicing, mRN...    Read more.
You complete me: Natural killer cells need TGF-beta inhibition to effectively combat cancers
By Jamshed Arslan Pharm.D. Natural killer (NK) cells are lymphocytes of the innate immune system that were first discovered for their “natural” ability to kill cancer cells. To use NK cells as anti-cancer therapy, t...    Read more.
Friends become Foes: Molecular Chaperons, Hsp70 and Hsp90, Cause Muscle Wasting in Cancers
By Jamshed Arslan Pharm.D. Muscle atrophy is a common feature of many tumors. Cancer-induced muscle wasting, or cancer cachexia, results from pro-in?ammatory cytokines (TNFa and IL-6) and/or agonists of type IIB ac...    Read more.
cIAP2 - balancing cell death and cell survival
The inhibitor of apoptosis proteins (IAPs) are important regulators of cell death and inflammation. The cellular inhibitor of apoptosis protein 2 (cIAP2) contains three Baculovirus IAP repeat (BIR) domains, a Ubiquitin associated (UBA) domain, and...    Read more.
CD86 - I work in tandem with CD80
CD86 belongs to the immunoglobulin superfamily of proteins that drive innate and adaptive immune responses. It is an 80kD co-stimulatory molecule for the priming and activation of naive and memory T-cells, respectively. CD86 is expressed on activated...    Read more.
Read more TNF-alpha related blogs.