TNF-alpha Products

Antibodies
TNF-alpha Antibody [Unconjuga ...
TNF-alpha Antibody [Unconjugated]
AF-410-NA
Species: Hu, Mu
Applications: WB, IHC, B/N, CyTOF-ready, ELISA(Cap), Flow, ICC/IF
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
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Antibody Pairs
TNF-alpha Antibody Pair [HRP] ...
TNF-alpha Antibody Pair [HRP]
NBP2-79390
Species: Ma
Applications: ELISA, S-ELISA
Host: Monoclonal
Conjugate Catalog # Availability Size Price
TNF-alpha Antibody Pair [HRP] ...
TNF-alpha Antibody Pair [HRP]
NBP2-79675
Species: Hu
Applications: ELISA, S-ELISA
Host: Mouse Monoclonal
Conjugate Catalog # Availability Size Price
TNF-alpha Antibody Pair [HRP] ...
TNF-alpha Antibody Pair [HRP]
NBP2-79568
Species: Mu
Applications: ELISA, S-ELISA
Host: Rabbit
Conjugate Catalog # Availability Size Price
ELISA Kits
Mouse TNF-alpha DuoSet ELISA, ...
Mouse TNF-alpha DuoSet ELISA, 15 P...
DY410
Species: Mu
Applications: ELISA
Conjugate Catalog # Availability Size Price
Human TNF-alpha Quantikine EL ...
Human TNF-alpha Quantikine ELISA Kit
DTA00D
Species: Hu
Applications: ELISA
Conjugate Catalog # Availability Size Price
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Human TNF-alpha DuoSet ELISA, ...
Human TNF-alpha DuoSet ELISA, 15 P...
DY210
Species: Hu
Applications: ELISA
Conjugate Catalog # Availability Size Price
Lysates
TNF-alpha Overexpression Lysa ...
TNF-alpha Overexpression Lysate
NBL1-17134
Species: Hu
Applications: WB
Proteins
Recombinant Human TNF-alpha P ...
Recombinant Human TNF-alpha Protein
210-TA
Species: Hu
Applications: Bioactivity
Recombinant Mouse TNF-alpha ( ...
Recombinant Mouse TNF-alpha (aa 80...
410-MT
Species: Mu
Applications: Bioactivity
Recombinant Rat TNF-alpha Pro ...
Recombinant Rat TNF-alpha Protein
510-RT
Species: Rt
Applications: Bioactivity
Formulation Catalog # Availability Price  

Description

Tumor necrosis factor (TNF)-alpha is a pro-inflammatory cytokine belonging to the TNF superfamily that is secreted by monocytes/macrophages, T cell, and natural killer (NK), among others (1). TNF-alpha is synthesized as a 233 amino acid (aa) transmembrane protein (mTNF-alpha) with a theoretical molecular weight (MW) of 26 kDa (1,2) that forms a homotrimer. mTNF-alpha is cleaved by TNF-alpha converting enzyme (TACE) and released in its 157 aa, 17 kDa soluble form (sTNF-alpha) (1-5). Both mTNF-alpha and sTNF-alpha are capable of binding type 1 TNF receptors (TNFR1), whereas mTNF-alpha predominately binds to TNFR2 (1,2). TNF-alpha binding to its receptors causes receptor recruitment of adaptor proteins, formation of signaling complexes, and downstream signaling cascades (e.g. MAPK, NF-kappaB, and Caspase-8), leading to distinct cellular responses such as survival, proliferation, inflammation, necroptosis, and apoptosis (1-5).

TNF-alpha is critical for normal immune response; however, dysregulation of TNF-alpha production can result in various pathologies (2,4,5). Excessive production of pro-inflammatory cytokines including interleukin 1 (IL-1), IL-6, and TNF-alpha has been implicated in an array of autoimmune diseases like rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and psoriasis (2,4,5). Anti-TNF monoclonal antibodies, including Infliximab, and soluble TNFR have been approved for the treatment of autoimmune and TNF-mediated diseases (5). Additionally, data suggests that TNF inhibitors can be beneficial for treating patients experiencing immune-related adverse events associated with immune checkpoint inhibitor cancer treatment (6).

References

1. Holbrook J, Lara-Reyna S, Jarosz-Griffiths H, McDermott M. Tumour necrosis factor signalling in health and disease. F1000Res. 2019;8:F1000 Faculty Rev-111. https://doi.org/10.12688/f1000research.17023.1

2. Jang DI, Lee AH, Shin HY, et al. The Role of Tumor Necrosis Factor Alpha (TNF-alpha) in Autoimmune Disease and Current TNF-alpha Inhibitors in Therapeutics. Int J Mol Sci. 2021;22(5):2719. https://doi.org/10.3390/ijms22052719

3. Horiuchi T, Mitoma H, Harashima S, Tsukamoto H, Shimoda T. Transmembrane TNF-alpha: structure, function and interaction with anti-TNF agents. Rheumatology (Oxford). 2010;49(7):1215-1228. https://doi.org/10.1093/rheumatology/keq031

4. Webster JD, Vucic D. The Balance of TNF Mediated Pathways Regulates Inflammatory Cell Death Signaling in Healthy and Diseased Tissues. Front Cell Dev Biol. 2020;8:365. https://doi.org/10.3389/fcell.2020.00365

5. Kalliolias GD, Ivashkiv LB. TNF biology, pathogenic mechanisms and emerging therapeutic strategies. Nat Rev Rheumatol. 2016; 12(1):49-62. https://doi.org/10.1038/nrrheum.2015.169

6. Chen AY, Wolchok JD, Bass AR. TNF in the era of immune checkpoint inhibitors: friend or foe?. Nat Rev Rheumatol. 2021;17(4):213-223. doi:10.1038/s41584-021-00584-4

Bioinformatics

Entrez Rabbit
Mouse
Rat
Rat
Human
Uniprot Human
Human
Human
Mouse
Human
Human
Mouse
Rat
Human
Product By Gene ID 7124
Alternate Names
  • APC1 protein
  • Cachectin
  • DIF
  • TNF, monocyte-derived
  • TNF-a
  • TNF-alphacachectin
  • TNFATNF, macrophage-derived
  • TNFSF2TNF superfamily, member 2
  • tumor necrosis factor (TNF superfamily, member 2)
  • tumor necrosis factor alpha
  • Tumor necrosis factor ligand superfamily member 2
  • tumor necrosis factor
  • tumor necrosis factor-alpha

Research Areas for TNF-alpha

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Asthma
Autophagy
Biologically Active Proteins
Cancer
Cytokine Research
Diabetes Research
Immune System Diseases
Immunology
Innate Immunity

Bioinformatics Tool for TNF-alpha

Discover related pathways, diseases and genes to TNF-alpha. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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Related TNF-alpha Blog Posts

Check out the latest blog posts on TNF-alpha.
CD86 - I work in tandem with CD80
CD86 belongs to the immunoglobulin superfamily of proteins that drive innate and adaptive immune responses. It is an 80kD co-stimulatory molecule for the priming and activation of naive and memory T-cells, respectively. CD86 is expressed on activated ...    Read more.
Friends become Foes: Molecular Chaperons, Hsp70 and Hsp90, Cause Muscle Wasting in Cancers
By Jamshed Arslan Pharm.D. Muscle atrophy is a common feature of many tumors. Cancer-induced muscle wasting, or cancer cachexia, results from pro-in?ammatory cytokines (TNFa and IL-6) and/or agonists of type IIB ac...    Read more.
You complete me: Natural killer cells need TGF-beta inhibition to effectively combat cancers
By Jamshed Arslan Pharm.D. Natural killer (NK) cells are lymphocytes of the innate immune system that were first discovered for their “natural” ability to kill cancer cells. To use NK cells as anti-cancer therapy, t...    Read more.
Increased wild type FUS levels in ALS patients lead to a toxic microenvironment and motor neuron neurodegeneration
By Michalina Hanzel, PhDFUS mutations in Amyotrophic Lateral SclerosisFused in sarcoma (FUS) is a ribonucleoprotein that continuously shuttles between the nucleus and the cytoplasm to regulate pre-mRNA splicing, mRN...    Read more.
Metabolic Syndrome: Symptoms and associated disease states
By Jamshed Arslan, Pharm. D., PhD. What is metabolic syndrome?It was 1988 when, after decades of research, Dr. GM Reaven    of the Stanford University, CA, explained the relationship between four diseases:...    Read more.
Liver ASK1 activates autophagy to protect against hepatic fat accumulation, non-alcoholic steatohepatitis and fibrosis
By Jamshed Arslan, Pharm. D., PhD. The most common chronic liver disorder worldwide is non-alcoholic fatty liver disease (NAFLD). This obesity-linked disorder can manifest as hepatic fat accumulation (steatosis) wit...    Read more.
cIAP2 - balancing cell death and cell survival
The inhibitor of apoptosis proteins (IAPs) are important regulators of cell death and inflammation. The cellular inhibitor of apoptosis protein 2 (cIAP2) contains three Baculovirus IAP repeat (BIR) domains, a Ubiquitin associated (UBA) domain, and ...    Read more.

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Immune Cell Metabolic Flux Influences Type I Diabetes
By Hunter MartinezWhat is Immunometabolism?It is well established that abnormal metabolic environments can be a risk factor for disease development. One characteristic example is the role of dyslipidemia (high lev...    Read more.
Tired T cells: Hypoxia Drives T cell Exhaustion in the Tumor Microenvironment
By Hunter MartinezThe paradigm shifting view of the immune system being leveraged to target cancer has led to numerous therapeutic breakthroughs. One major cell group responsible for this revelation is a T cell. ...    Read more.
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