A genomic peptide made to an internal region of human CD31/PECAM1 (within residues 100-300). [Swiss-Prot P16284]
Membrane; Single-pass type I membrane protein. Cell junction. Note: Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.
Immunogen affinity purified
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This CD31/PECAM1 antibody is useful for Immunohistochemistry, Flow Cytometry, and Western Blot, where a band is seen ~ 150 kDa. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.
This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.
Alternate Names for CD31/PECAM-1 Antibody [FITC]
platelet endothelial cell adhesion molecule
platelet/endothelial cell adhesion molecule
CD31/PECAM1 (cluster of differentiation 31/platelet-endothelial cell adhesion molecule-1), is a transmembrane glycoprotein belonging to immunoglobulin (Ig)-superfamily of cell adhesion molecules and is expressed by platelets, megakaryocytes, endothelial cells, certain T cells etc., and has been shown to modulate cell adhesion, endothelial cell migration and angiogenesis. CD31/PECAM-1 undergoes phosphorylation at Tyr686 through SRC family members upon versatile stimuli that includes mechanical stress and oxidative stress also, and this phosphorylation facilitates its associations with a number of SH2 domain containing binding partners such as PI3K, SHIP, PLC gamma and SHP-2. Besides, exhibiting adhesive properties, CD31/PECAM-1 implicates in angiogenesis, platelet function, and thrombosis, mechanosensing of endothelial cell response to fluid shear stress, and control of multiple stages of leukocyte migration through venular walls. Importantly, CD31/PECAM-1 is the most commonly used pan-endothelial marker for blood vessels and due to its involvement in angiogenesis and vascular permeability, it plays important role in the growth as well as metastatic spread of several cancers.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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