CD38 Products

Antibodies
CD38 Antibody (NIMR-5)
CD38 Antibody (NIMR-5)
NBP1-27951
Species: Mu
Applications: B/N, Flow, IHC-Fr, IP, BA
Host: Rat Monoclonal
Conjugate Catalog # Availability Size Price
Lysates
CD38 Overexpression Lysate (N ...
CD38 Overexpression Lysate (Native)
NBL1-08942
Applications: WB
Proteins
CD38 Recombinant Protein
CD38 Recombinant Protein
H00000952-P01
Species: Hu
Applications: WB, ELISA, PA
CD38 Partial Recombinant Prot ...
CD38 Partial Recombinant Protein
H00000952-Q01
Species: Hu
Applications: WB, ELISA, PA
CD38 Recombinant Protein Anti ...
CD38 Recombinant Protein Antigen
NBP1-86010PEP
Species: Hu
Applications: AC
RNAi
CD38 RNAi
CD38 RNAi
H00000952-R02
Species: Hu

Description

CD38 (T10) is a single chain 42 to 46 kDa type II integral transmembrane glycoprotein with a short N terminal cytoplasmic tail. CD38 is highly expressed on thymocytes. It is also expressed by early cells of B and T lineages, NK cells, plasma cells, monocytes and macrophages and may be detected on cells from multiple myeloma, ALL (B and T) and some AML. It is expressed by murine, but not human, hematopoietic progenitors. In normal lymph nodes and tonsils the antigen is detected mainly on B cells in germinal centers and in plasma cells. The extracellular domain of the molecule shares a high homology sequence with Aplysia ADP ribosyl cyclase. CD38 functions as a multicatalytic ectoenzyme serving as ADP ribosyl cyclase, ADPR hydrolase and possibly NAD+ glycohydrolase, or as a surface receptor. In mice, CD38 is expressed by follicular B cells, is down regulated on germinal centre B cells, and is not expressed by mature plasma cells. Murine CD38 is also expressed by all Mac1+ macrophages in the peritoneal cavities of unimmunized mice, but not by unstimulated bone marrow derived macrophages. This pattern of expression contrasts strikingly with that seen in the human. Monoclonal antibodies to CD38 have been shown to be useful in subtyping of lymphomas and leukemias, inhibition of B lymphopoiesis, detection of plasma cells, protection of B cells from apoptosis, and as a marker for activated B and T cell proliferation.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Mouse
Product By Gene ID 952
Alternate Names
  • CD38 antigen
  • cADPr hydrolase 1
  • EC 3.2.2.5
  • T10
  • NAD(+) nucleosidase
  • Cyclic ADP-ribose hydrolase 1
  • ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
  • CD38 antigen (p45)
  • ADP-ribosyl cyclase 1
  • CD38 molecule

Research Areas for CD38

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cell Biology
Hematopoietic Stem Cell Markers
Immunology
Stem Cell Markers

Bioinformatics Tool for CD38

Discover related pathways, diseases and genes to CD38. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related CD38 Blog Posts

Check out the latest blog posts on CD38.
Transferrin and the blood brain barrier
Transferrin, an iron binding protein that facilitates iron uptake in cells, is an integral part of a mechanism that may introduce antibody therapies to the central nervous system. Currently, the brain’s ability to take in antibody therapies i...    Read more.
Multifunctional CD38
CD38 is a 42 kD type II transmembrane glycoprotein that uses nicotinamide adenine dinucleotide (NAD) as a substrate to form cyclic adenosine diphosphate ribose (cADPR). This novel multifunctional ectoenzyme has both cyclase and hydrolase enzymatic act...    Read more.
Read more CD38 related blogs.