SHP-2/PTPN11 Products

Antibodies
SHP-2/PTPN11 [p Tyr542] Antib ...
SHP-2/PTPN11 [p Tyr542] Antibody
AF3790
Species: Hu, Mu
Applications: WB, Simple Western, ICC
Host: Rabbit Polyclonal
SHP-2/PTPN11 Antibody
SHP-2/PTPN11 Antibody
Species: V
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
SHP-2/PTPN11 Antibody (6D9)
SHP-2/PTPN11 Antibody (6D9)
NBP2-37454
Species: Hu
Applications: WB, ELISA, Flow, ICC/IF, IHC
Host: Mouse Monoclonal
Lysates
SHP-2/PTPN11 Overexpression L ...
SHP-2/PTPN11 Overexpression Lysate...
H00005781-T02
Species: Hu
Applications: WB
SHP-2/PTPN11 Overexpression L ...
SHP-2/PTPN11 Overexpression Lysate...
H00005781-T03
Species: Hu
Applications: WB
Proteins
SHP-2/PTPN11 Recombinant Prot ...
SHP-2/PTPN11 Recombinant Protein
H00005781-P02
Species: Hu
Applications: WB, ELISA, PA
SHP-2/PTPN11 Recombinant Prot ...
SHP-2/PTPN11 Recombinant Protein
H00005781-P01
Species: Hu
Applications: WB, ELISA, PA
SHP-2/PTPN11 Recombinant Prot ...
SHP-2/PTPN11 Recombinant Protein
H00005781-P03
Species: Hu
Applications: WB, ELISA, PA
RNAi
SHP-2/PTPN11 RNAi
SHP-2/PTPN11 RNAi
H00005781-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

SHP-2 (also called PTP2C, SH-PTP2, PTP1D, SH-PTP3, Syp and PTPN11) is a protein tyrosine phosphatase (PTP) expressed in most cell types (unlike SHP-1), (1). SHP-2 is involved in t the signal transduction stimulated by EGF, PDGF and Insulin. After cell stimulation, SHP-2 (as well as SHP-1), translocates from cytosol to the plasma membrane and binds to tyrosine-phosphorylated receptors through their SH2 domains, becoming activated in the process (2). When phosphorylated, SHP-2 has been shown to bind Grb2, EGFR, PDGFR, IRS-1 via its SH2 domain (3). Over expression of SHP-2 leads to Juvenile Myelo-monocytic Leukemia and Noonan syndrome (4-5).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 5781
Alternate Names
  • SH-PTP3
  • Shp2
  • PTP-2C
  • SHPTP2
  • PTP-1D
  • tyrosine-protein phosphatase non-receptor type 11
  • Protein-tyrosine phosphatase 2C
  • protein tyrosine phosphatase-2
  • Protein-tyrosine phosphatase 1D
  • SHP-2
  • MGC14433
  • BPTP3
  • SHP2CFC
  • SH-PTP2Noonan syndrome 1
  • PTP2CNS1
  • EC 3.1.3.48
  • protein tyrosine phosphatase, non-receptor type 11

Research Areas for SHP-2/PTPN11

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Cell Biology
Lipid and Metabolism
Phospho-Specific
Signal Transduction
Tyrosine Kinases

Bioinformatics Tool for SHP-2/PTPN11

Discover related pathways, diseases and genes to SHP-2/PTPN11. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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