Species: Hu
Applications: WB, ELISA, Flow, ICC/IF, IHC, CyTOF-ready
Host: Mouse Monoclonal
Species: Hu, Mu, Rt, Bv, Ch, RM, Xp
Applications: WB, IHC, KO
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IP, KO
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Description
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
|
| Product By Gene ID |
5781 |
| Alternate Names |
- BPTP3
- EC 3.1.3.48
- MGC14433
- protein tyrosine phosphatase, non-receptor type 11
- protein tyrosine phosphatase-2
- Protein-tyrosine phosphatase 1D
- Protein-tyrosine phosphatase 2C
- PTP1D
- PTP-1D
- PTP2C
- PTP-2C
- PTP2CNS1
- PTPN11
- SHP2
- SHP-2
- SHP2CFC
- SHPTP2
- SH-PTP2
- SH-PTP2Noonan syndrome 1
- SH-PTP3
- tyrosine-protein phosphatase non-receptor type 11
|
