SHP-2/PTPN11 Products

Description

SHP-2 (also called PTP2C, SH-PTP2, PTP1D, SH-PTP3, Syp and PTPN11) is a protein tyrosine phosphatase (PTP) expressed in most cell types (unlike SHP-1), (1). SHP-2 is involved in t the signal transduction stimulated by EGF, PDGF and Insulin. After cell stimulation, SHP-2 (as well as SHP-1), translocates from cytosol to the plasma membrane and binds to tyrosine-phosphorylated receptors through their SH2 domains, becoming activated in the process (2). When phosphorylated, SHP-2 has been shown to bind Grb2, EGFR, PDGFR, IRS-1 via its SH2 domain (3). Over expression of SHP-2 leads to Juvenile Myelo-monocytic Leukemia and Noonan syndrome (4-5).

Bioinformatics

Entrez	19247 Mouse 25622 Rat 5781 Human
Uniprot	AAH08692 Human AAH08692.1 Human AAH25181 Human NP_002825 Human NP_002825.3 Human Q06124 Human
Product By Gene ID	5781
Alternate Names	BPTP3 EC 3.1.3.48 MGC14433 protein tyrosine phosphatase, non-receptor type 11 protein tyrosine phosphatase-2 Protein-tyrosine phosphatase 1D Protein-tyrosine phosphatase 2C PTP-1D PTP-2C PTP2CNS1 Shp2 SHP-2 SHP2CFC SHPTP2 SH-PTP2Noonan syndrome 1 SH-PTP3 tyrosine-protein phosphatase non-receptor type 11

Research Areas for SHP-2/PTPN11

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Cell Biology
Lipid and Metabolism
Phospho-Specific
Signal Transduction
Tyrosine Kinases