Recombinant Human P-Selectin/CD62P Fc Chimera Protein, CF


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Product Details

Reactivity HuSpecies Glossary
Applications Bioactivity

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Recombinant Human P-Selectin/CD62P Fc Chimera Protein, CF Summary

Details of Functionality
Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells. P-Selectin/Fc Chimera, immobilized at 10 µg/mL, will induce greater than 50% adhesion on U937 cells (100 µL/well at 1 x 106 cells/mL).
Optimal dilutions should be determined be each laboratory for each application.
Mouse myeloma cell line, NS0-derived human P-Selectin/CD62P protein
Human P-Selectin
(Trp42 - Ala771)
Accession # P16109
(Pro100 - Lys330)
N-terminus C-terminus
Accession #
N-terminal Sequence
Structure / Form
Disulfide-linked homodimer
Protein/Peptide Type
Recombinant Proteins
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Note
<0.01 EU per 1 μg of the protein by the LAL method.


  • Bioactivity
Theoretical MW
106 kDa (monomer).
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
146-160 kDa, reducing conditions
Read Publications using
137-PS in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS.
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human P-Selectin/CD62P Fc Chimera Protein, CF

  • CD62P antigen
  • CD62P
  • FLJ45155
  • GMP140
  • GRMP
  • PADGEMantigen CD62)
  • PSEL
  • P-Selectin
  • selectin P (granule membrane protein 140kDa, antigen CD62)
  • SELP


Human P-Selectin (GMP-140, LECAM-3, PADGEM, CD62P), a member of the Selectin family, is a cell surface glycoprotein expressed by activated platelets and endothelial cells. P-Selectin is translocated to the cell surface within minutes, from alpha granules of platelets or Weibel-Palade bodies of endothelial cells, following stimulation with thrombin, histamine, PMA or peroxides. P-Selectin binds to a 106 kDa protein present on myeloid cells, neutrophils, monocytes and lymphocytes, termed PSGL-1 (P-Selectin glycoprotein ligand-1).

P-Selectin plays a role in the adhesion of leukocytes and neutrophils to the endothelium. Acting in cooperation with L-Selectin, P-Selectin mediates the initial interaction of circulating leukocytes with endothelial cells that produces a characteristic ‘rolling’ of the leukocytes on the endothelium. This initial interaction is followed by a stronger interaction involving E-Selectin, and later ICAM-1 and VCAM-1, that leads eventually to extravasation of the white blood cell through the blood vessel wall into the extracellular matrix tissue.

Human P-Selectin cDNA encodes an 830 amino acid (aa) residue type I transmembrane protein with a 41 aa signal peptide, a 730 aa extracellular domain, a transmembrane domain and a short (35 aa) cytoplasmic domain. The extracellular domain has an NH2-terminal C-type lectin domain and an EGF-like domain followed by a series of complement factor A repeat homology domains. The extracellular domains of human and mouse P-Selectin share approximately 73% sequence homology.

  1. Kansas, G.S. (1996) Blood 88:3259.
  2. McEver, R.P. and R.D. Cummings (1997) J. Clin. Invest. 100:485.

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Publications for P-Selectin/CD62P (137-PS)(41)

We have publications tested in 3 confirmed species: Human, Mouse, N/A.

We have publications tested in 8 applications: Binding Assay, Bioassay, ELISA (Capture), ELISA (Standard), ELISA Control, Flow Cytometry, ICC, Surface Plasmon Resonance.

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Binding Assay
ELISA (Capture)
ELISA (Standard)
ELISA Control
Flow Cytometry
Surface Plasmon Resonance
All Applications
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All Species
Showing Publications 1 - 10 of 41. Show All 41 Publications.
Publications using 137-PS Applications Species
K Taverner, Y Murad, AB Yasunaga, C Furrer, J Little, ITS Li The effect of type-2 diabetes conditions on neutrophil rolling adhesion Bmc Research Notes, 2022;15(1):355. 2022 [PMID: 36463286] (Bioassay, Human) Bioassay Human
S Wu, J Liu, Y Zhang, J Song, Z Zhang, Y Yang, M Wu, H Tong Structural characterization and antagonistic effect against P-selectin-mediated function of SFF-32, a fucoidan fraction from Sargassum fusiforme Journal of ethnopharmacology, 2022;295(0):115408. 2022 [PMID: 35659565] (Bioassay, Human) Bioassay Human
L Wen, A Marki, Z Wang, M Orecchioni, J Makings, M Billitti, E Wang, SSA Suthahar, K Kim, WB Kiosses, Z Mikulski, K Ley A humanized beta2 integrin knockin mouse reveals localized intra- and extravascular neutrophil integrin activation in�vivo Cell Reports, 2022;39(9):110876. 2022 [PMID: 35649374] (Bioassay, Human) Bioassay Human
SU Khan, Y Xia, D Goodale, G Schoettle, AL Allan Lung-Derived Selectins Enhance Metastatic Behavior of Triple Negative Breast Cancer Cells Biomedicines, 2021;9(11):. 2021 [PMID: 34829810] (Bioassay, Human) Bioassay Human
W Liu, AY Hsu, Y Wang, T Lin, H Sun, JS Pachter, A Groisman, M Imperioli, FW Yungher, L Hu, P Wang, Q Deng, Z Fan Mitofusin-2 regulates leukocyte adhesion and beta2 integrin activation Journal of leukocyte biology, 2021;0(0):. 2021 [PMID: 34494308] (Bioassay, Human) Bioassay Human
AB Yasunaga, ITS Li Quantification of fast molecular adhesion by fluorescence footprinting Science Advances, 2021;7(34):. 2021 [PMID: 34407937] (Bioassay, Human) Bioassay Human
FW Lam, CA Brown, C Valladolid, DC Emebo, TG Palzkill, MA Cruz The vimentin rod domain blocks P-selectin-P-selectin glycoprotein ligand 1 interactions to attenuate leukocyte adhesion to inflamed endothelium PLoS ONE, 2020;15(10):e0240164. 2020 [PMID: 33048962] (Bioassay, N/A) Bioassay N/A
U Valentiner, J Knips, R Pries, T Clauditz, A Münscher, G Sauter, B Wollenberg, U Schumacher Selectin Binding Sites Are Involved in Cell Adhesive Properties of Head and Neck Squamous Cell Carcinoma Cancers (Basel), 2019;11(11):. 2019 [PMID: 31661833] (Bioassay, Human) Bioassay Human
A Kelkar, Y Zhu, T Groth, G Stolfa, AB Stablewski, N Singhi, M Nemeth, S Neelamegha Doxycycline-Dependent Self-Inactivation of CRISPR-Cas9 to Temporally Regulate On- and Off-Target Editing Mol. Ther., 2019;0(0):. 2019 [PMID: 31601489] (Flow Cytometry, Human) Flow Cytometry Human
W Fu, C Lei, S Liu, Y Cui, C Wang, K Qian, T Li, Y Shen, X Fan, F Lin, M Ding, M Pan, X Ye, Y Yang, S Hu CAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity Nat Commun, 2019;10(1):4355. 2019 [PMID: 31554797] (ELISA Control, Human) ELISA Control Human
Show All 41 Publications.

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Gene Symbol SELP