Recombinant Human P-Selectin/CD62P Fc Chimera Protein, CF


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Reactivity HuSpecies Glossary
Applications Bioactivity

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Recombinant Human P-Selectin/CD62P Fc Chimera Protein, CF Summary

Details of Functionality
Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells. P-Selectin/Fc Chimera, immobilized at 10 µg/mL, will induce greater than 50% adhesion on U937 cells (100 µL/well at 1 x 106 cells/mL).
Optimal dilutions should be determined be each laboratory for each application.
Mouse myeloma cell line, NS0-derived human P-Selectin/CD62P protein
Human P-Selectin
(Trp42 - Ala771)
Accession # P16109
(Pro100 - Lys330)
N-terminus C-terminus
Accession #
N-terminal Sequence
Structure / Form
Disulfide-linked homodimer
Protein/Peptide Type
Recombinant Proteins
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Note
<0.01 EU per 1 μg of the protein by the LAL method.


Theoretical MW
106 kDa (monomer).
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
146-160 kDa, reducing conditions
Read Publications using
137-PS in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS.
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human P-Selectin/CD62P Fc Chimera Protein, CF

  • CD62P antigen
  • CD62P
  • FLJ45155
  • GMP140
  • GRMP
  • PADGEMantigen CD62)
  • PSEL
  • P-Selectin
  • selectin P (granule membrane protein 140kDa, antigen CD62)
  • SELP


Human P-Selectin (GMP-140, LECAM-3, PADGEM, CD62P), a member of the Selectin family, is a cell surface glycoprotein expressed by activated platelets and endothelial cells. P-Selectin is translocated to the cell surface within minutes, from alpha granules of platelets or Weibel-Palade bodies of endothelial cells, following stimulation with thrombin, histamine, PMA or peroxides. P-Selectin binds to a 106 kDa protein present on myeloid cells, neutrophils, monocytes and lymphocytes, termed PSGL-1 (P-Selectin glycoprotein ligand-1).

P-Selectin plays a role in the adhesion of leukocytes and neutrophils to the endothelium. Acting in cooperation with L-Selectin, P-Selectin mediates the initial interaction of circulating leukocytes with endothelial cells that produces a characteristic ‘rolling’ of the leukocytes on the endothelium. This initial interaction is followed by a stronger interaction involving E-Selectin, and later ICAM-1 and VCAM-1, that leads eventually to extravasation of the white blood cell through the blood vessel wall into the extracellular matrix tissue.

Human P-Selectin cDNA encodes an 830 amino acid (aa) residue type I transmembrane protein with a 41 aa signal peptide, a 730 aa extracellular domain, a transmembrane domain and a short (35 aa) cytoplasmic domain. The extracellular domain has an NH2-terminal C-type lectin domain and an EGF-like domain followed by a series of complement factor A repeat homology domains. The extracellular domains of human and mouse P-Selectin share approximately 73% sequence homology.

  1. Kansas, G.S. (1996) Blood 88:3259.
  2. McEver, R.P. and R.D. Cummings (1997) J. Clin. Invest. 100:485.

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Publications for P-Selectin/CD62P (137-PS)(28)

We have publications tested in 3 confirmed species: Human, Mouse, N/A.

We have publications tested in 7 applications: Binding Assay, Bioassay, ELISA Standard, ELISA capture, Flow, ICC, Surface Plasmon Resonance.

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Showing Publications 1 - 10 of 28. Show All 28 Publications.
Publications using 137-PS Applications Species
K Kitamura, K Sato, M Sawabe, M Yoshida, N Hagiwara P-Selectin Glycoprotein Ligand-1 (PSGL-1) Expressing CD4 T Cells Contribute Plaque Instability in Acute Coronary Syndrome Circ. J., 2018;0(0):. 2018 [PMID: 29962384] (Human) Human
CH Lee, HH Zhang, SP Singh, L Koo, J Kabat, H Tsang, TP Singh, JM Farber C/EBP? drives interactions between human MAIT cells and endothelial cells that are important for extravasation Elife, 2018;7(0):. 2018 [PMID: 29469805] (Bioassay, Human) Bioassay Human
FW Lam, Q Da, B Guillory, MA Cruz Recombinant Human Vimentin Binds to P-Selectin and Blocks Neutrophil Capture and Rolling on Platelets and Endothelium J. Immunol., 2018;0(0):. 2018 [PMID: 29335256] (Bioassay, Human) Bioassay Human
Y Seong, NH Lazarus, L Sutherland, A Habtezion, T Abramson, XS He, HB Greenberg, EC Butcher Trafficking receptor signatures define blood plasmablasts responding to tissue-specific immune challenge JCI Insight, 2017;2(6):e90233. 2017 [PMID: 28352656] (Flow, Human) Flow Human
IT Li, T Ha, YR Chemla Mapping cell surface adhesion by rotation tracking and adhesion footprinting Sci Rep, 2017;7(0):44502. 2017 [PMID: 28290531] (Bioassay, Human) Bioassay Human
EE Edwards, SN Thomas P-Selectin and ICAM-1 synergy in mediating THP-1 monocyte adhesion in hemodynamic flow is length dependent Integr Biol (Camb), 2017;9(4):313-327. 2017 [PMID: 28262902] (Bioassay, Human) Bioassay Human
Bo Li Development of Polymer Microcapsules Functionalized with Fucoidan to Target P-Selectin Overexpressed in Cardiovascular Diseases Adv Healthc Mater, 2016;0(0):. 2016 [PMID: 27943662] (Bioassay) Bioassay
Simon N Robinson Non-fucosylated CB CD34(+) cells represent a good target for enforced fucosylation to improve engraftment following cord blood transplantation Cytotherapy, 2016;0(0):. 2016 [PMID: 27919572] (Bioassay, Human) Bioassay Human
Using CRISPR-Cas9 to quantify the contributions of O-glycans, N-glycans and Glycosphingolipids to human leukocyte-endothelium adhesion Sci Rep, 2016;6(0):30392. 2016 [PMID: 27458028] (Bioassay, Human) Bioassay Human
Krishnamurthy V, Sardar M, Ying Y, Song X, Haller C, Dai E, Wang X, Hanjaya-Putra D, Sun L, Morikis V, Simon S, Woods R, Cummings R, Chaikof E Glycopeptide analogues of PSGL-1 inhibit P-selectin in vitro and in vivo. Nat Commun, 2015;6(0):6387. 2015 [PMID: 25824568] (Bioassay, Human) Bioassay Human
Show All 28 Publications.

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Gene Symbol SELP