CD31/PECAM-1 Products

Antibodies
CD31/PECAM-1 Antibody
CD31/PECAM-1 Antibody
NB100-2284
Species: Hu, Mu, Rt, Po, Xp
Applications: WB, ICC/IF, IHC, IHC-Fr, IHC-P
Host: Rabbit Polyclonal
Antibody Pairs
CD31/PECAM-1 Antibody Pair [H ...
CD31/PECAM-1 Antibody Pair [HRP]
NBP2-79451
Species: Hu
Applications: S-ELISA
Host: Mouse Monoclonal
Conjugate Catalog # Availability Size Price
ELISA Kits
Human CD31/PECAM-1 Quantikine ...
Human CD31/PECAM-1 Quantikine ELIS...
DCD310
Species: Hu
Applications: ELISA
Human CD31/PECAM-1 DuoSet ELI ...
Human CD31/PECAM-1 DuoSet ELISA, 5...
DY806-05
Species: Hu
Applications: ELISA
Monkey CD31/PECAM-1 ELISA Kit ...
Monkey CD31/PECAM-1 ELISA Kit (Col...
NBP1-92720
Species: Pm
Applications: ELISA
Lysates
CD31/PECAM-1 Overexpression L ...
CD31/PECAM-1 Overexpression Lysate
NBP2-10670
Species: Hu
Applications: WB
Proteins
Recombinant Mouse CD31/PECAM- ...
Recombinant Mouse CD31/PECAM-1 Pro...
3628-PC
Species: Mu
Applications: Bioactivity
Formulation Catalog # Availability Price  
Recombinant Human CD31/PECAM- ...
Recombinant Human CD31/PECAM-1 Pro...
ADP6
Species: Hu
Applications: Bioactivity
Formulation Catalog # Availability Price  
Recombinant Human CD31/PECAM- ...
Recombinant Human CD31/PECAM-1 Fc ...
8636-PC
Species: Hu
Applications: Bioactivity
Formulation Catalog # Availability Price  

Description

Cluster of differentiation (CD31), Platelet Endothelial Cell Adhesion Molecule 1 (PECAM-1), is a 30kDa type I transmembrane glycoprotein expressed by endothelial cells, platelets, leukocytes and some lymphocytes (e.g., B and T-cell subsets). Structurally, PECAM-1 consists of six extracellular immunoglobulin-like domains which serve to support various functions including homophilic binding, maintaining high expression of PECAM-1 within endothelial intercellular junctions, and supporting endothelial cell migration (1,2). PECAM's homophilic binding underscores its role in vascular barrier integrity and leukocyte trans-endothelial movement. However, PECAM may also engage in heterophilic interactions with molecules such as glycosaminoglycans (GAG), integrin alpha 5 beta 3, CD38 in lymphocytes and CD177/PR3 in neutrophils (2).

PECAM's intracellular cytoplasmic domain consists of a sequence of 118 amino acids and contains serine and tyrosine (also referred to as immunoreceptor tyrosine-based inhibitory motifs-ITIMs) residues, which may be phosphorylated upon cellular stimulation (3). ITIMs are phosphorylated by Src-family kinases and non-Src family kinases (e.g., Csk), leading to a conformational change which supports interactions with Src homology 2 (SH2) domain containing proteins such as protein-tyrosine phosphatase, SHP-2 (1,2). Formation of SHP-2/PECAM-1 complexes induces endothelial cell migration through the dephosphorylation of focal adhesion kinase and regulation of RhoA activity (1). Signaling downstream of ITIM tyrosine phosphorylations also plays a role in PECAM's anti-apoptotic activity, a function which is independent of its interaction with SHP-2. In platelets and leukocytes, phosphorylation of PECAM's cytosolic domain is inhibitory, preventing their activation.

References

1. Lertkiatmongkol, P., Liao, D., Mei, H., Hu, Y., & Newman, P. J. (2016). Endothelial functions of PECAM-1 (CD31). Current Opinion in Hematology. https://doi.org/10.1097/MOH.0000000000000239.Endothelial

2. Privratsky, J. R., & Newman, P. J. (2014). PECAM-1: Regulator of endothelial junctional integrity. Cell and Tissue Research. https://doi.org/10.1007/s00441-013-1779-3

3. Newman, P. J., & Newman, D. K. (2003). Signal transduction pathways mediated by PECAM-1: New roles for an old molecule in platelet and vascular cell biology. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/01.ATV.0000071347.69358.D9

Bioinformatics

Entrez Human
Mouse
Mouse
Rat
Porcine
Uniprot Human
Human
Human
Human
Mouse
Rat
Porcine
Product By Gene ID 5175
Alternate Names
  • platelet endothelial cell adhesion molecule-1
  • EndoCAM
  • CD31/EndoCAM
  • platelet endothelial cell adhesion molecule
  • CD31 antigen
  • PECAM-1, CD31/EndoCAM
  • PECAM-1
  • endoCAM
  • PECA1
  • adhesion molecule
  • GPIIA'
  • FLJ58394
  • CD31
  • FLJ34100
  • platelet/endothelial cell adhesion molecule

PTMs for CD31/PECAM-1

Learn more about PTMs related to CD31/PECAM-1.

Phosphorylation
Cleavage

Bioinformatics Tool for CD31/PECAM-1

Discover related pathways, diseases and genes to CD31/PECAM-1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related CD31/PECAM-1 Blog Posts

Check out the latest blog posts on CD31/PECAM-1.
The application of CD31/Pecam-1 (MEC 7.46) in breast cancer research
CD31/PECAM-1, or platelet endothelial cell adhesion molecule 1, is a 130-kDa glycoprotein expressed on vascular and hematopoietic cells.  Depending on the cell type, CD31/PECAM-1 expression can be largely localized to cell junctions, playing a rol...    Read more.
Read more CD31/PECAM-1 related blogs.