Immunocytochemistry/ Immunofluorescence: CD31/PECAM-1 Antibody (MEC 7.46) [NB100-1642] - MS1 cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X TBS + 0.5% Triton-X100. The ...read more
Flow (Cell Surface): CD31/PECAM-1 Antibody (MEC 7.46) [NB100-1642] - A surface stain was performed on MS-1 Cells with CD31 (MEC 7.46) antibody NB100-1642(blue) and a matched isotype control (orange). Cells were ...read more
Flow Cytometry: CD31/PECAM-1 Antibody (MEC 7.46) [NB100-1642] - CD31/PECAM1 Antibody (MEC 7.46) [NB100-1642] - CD31/PECAM1 (MEC 7.46) antibody was tested at 1:250 in WEHI-3 cells with DyLight 488 (green) alongside a ...read more
Immunohistochemistry-Frozen: CD31/PECAM-1 Antibody (MEC 7.46) [NB100-1642] - Frozen mouse lung tissues of WT B6 and IL1R--/- (knockout) mice were blocked with 1% BSA in PBS and were double stained with ...read more
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Tris-Glycine and 0.15M NaCl
0.05% Sodium Azide
Protein G purified
Alternate Names for CD31/PECAM-1 Antibody (MEC 7.46)
mec 7.46 cd31
mec 7.46 clone
platelet endothelial cell adhesion molecule
platelet/endothelial cell adhesion molecule
CD31/PECAM1 is commonly used as an endothelial marker, particularly in angiogenesis. CD31/PECAM1 is important in assisting placental and endometrial vascular development. However, CD31/PECAM1 is also associated with many negative angiogenic occurrences, particularly those within or related to tumors and other disease lesions. In MS, plasma microparticules carry CD31/PECAM1 and are important in the formation of brain lesions associated with MS. In cardiac angiosarcoma, CD31/PECAM1 presence is indicative of the severity of the disease. In prostate tumor cells, CD31/PECAM1 is upregulated and associated with increased levels of HIF1a, VEGF, and other hypoxic markers. This relationship seems to indicate that when prostate cancer reaches a sufficient state of development that intense angiogenesis must occur in order to support the ongoing growth and survival of the cancer cells. In all, CD31/PECAM1 is a great marker for normal and disease-induced angiogenesis.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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