CD31/PECAM-1 Antibody (MEC 7.46) [DyLight 550] Summary
mouse endothelial cell line T-end
Membrane; Single-pass type I membrane protein. Cell junction.
Protein G purified
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- Flow Cytometry
This CD31/PECAM1 antibody (clone MEC 7.46) is useful for Immunoprecipitation, Immunohistochemistry on frozen sections, Flow Cytometry and Immunofluorescence.
Packaging, Storage & Formulations
Store at 4C in the dark.
50mM Sodium Borate
0.05% Sodium Azide
Protein G purified
Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.
Alternate Names for CD31/PECAM-1 Antibody (MEC 7.46) [DyLight 550]
- adhesion molecule
- CD31 antigen
- PECAM-1, CD31/EndoCAM
- platelet endothelial cell adhesion molecule
- platelet/endothelial cell adhesion molecule
CD31/PECAM1 is commonly used as an endothelial marker, particularly in angiogenesis. CD31 is important in assisting placental and endometrial vascular development. However, CD31 is also associated with many negative angiogenic occurrences, particularly those within or related to tumors and other disease lesions. In MS, plasma microparticules carry CD31 and are important in the formation of brain lesions associated with MS. In cardiac angiosarcoma, CD31 presence is indicative of the severity of the disease. In prostate tumor cells, CD31 is upregulated and associated with increased levels of HIF1a, VEGF, and other hypoxic markers. This relationship seems to indicate that when prostate cancer reaches a sufficient state of development that intense angiogenesis must occur in order to support the ongoing growth and survival of the cancer cells. In all, CD31 is a great marker for normal and disease-induced angiogenesis.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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