Neurovascular signaling for repair enhances brain metastasis

Mechanisms of Neurodegeneration: Protein aggregation and failure of autophagy

Best Methods to Induce and Inhibit Autophagy Pharmacologically

mTOR Signaling and the Tumor Microenvironment

Epigenetic Control of Autophagy

Brain size matters: MTOR regulates autophagy and number of cortical interneurons

How to switch from apoptotic to necroptotic cell death? Answer: Autophagy!

By Christina Towers, PhD.

Autophagy as a Therapeutic Target: The Double-edged Sword

The use of the autophagy marker LC3 in western blot, immunocytochemistry and flow cytometry research applications as an indicator of autophagy

The process of autophagy, or lysosome-mediated degradation of damaged proteins and organelles in the cytosol, is a vital cellular process that acts as a quality control mechanism for proteins and organelles. The misregulation of autophagy can lead to an imbalance of cellular homeostasis and the subsequent development of disease.  Therefore, the study of autophagy is at the forefront of neuroscience and cancer research, among others.

4EBP1 and skeletal muscle protein synthesis

Eukaryotic translation initiation factor 4E binding protein 1, or 4EBP1, is an mRNA translational repressor protein that negatively regulates eukaryotic translation initiation factor 4E, or EIF4E.  EIF4E is a protein that forms a complex necessary to block the 5’ ends of mRNA with a 7-methyl-guanosine five-prime cap structure, which is important for normal translation of mRNA.  Specifically, the EIF4E complex recruits 40s ribosome subunits to scan mRNA in order to regulate protein synthesis.  When EIF4E is bound to 4EBP1, it is held in an