Beclin 1

Autophagy and RAS signaling: Clinical implications

Best Methods to Induce and Inhibit Autophagy Pharmacologically

E-syt in Autophagosome biogenesis: What is the source of it all?

Autophagy Inhibition in Cancer: Clinical Trials Update

Lysosomal Dysfunction is Linked to Exosomal Secretion

CaMKII stimulates autophagic degradation of 'ID', a new frontier against cancer

Brain size matters: MTOR regulates autophagy and number of cortical interneurons

Polyglutamine Tracts as Autophagy Regulators

Autophagy: Pro or Anti-tumorigenic? And the role of epigenetics in this debate

By Christina Towers, PhD

Key Targets in Apoptosis, Necroptosis, and Autophagy

Cell death/recycling pathways such as apoptosis, necroptosis, and autophagy are an integral part of the growth, development, homeostasis as well as the pathophysiology in the life of living organisms. These signaling pathways are highly regulated and some of their key regulatory targets are discussed below.


Apoptosis, programmed cell death, is primarily characterized by the activation of caspases which further regulate the mass cleavage of proteins and DNA. Some of major the proteins responsible for various apoptotic events are: