Neurovascular signaling for repair enhances brain metastasis

Bad news for stomach cancer: BAMBI protein inhibits gastric carcinoma via TGF-beta/epithelial-mesenchymal transition signaling

You complete me: Natural killer cells need TGF-beta inhibition to effectively combat cancers

TGF-beta for treating degenerative intervertebral disc disease

TGF-beta poster

By Jamshed Arslan Pharm.D.

Stemness for Surviving Hypoxia: TGF-beta/Smad Signaling in Multiple Myeloma

TGF-beta RIII - A multi-functional regulator of the TGF-beta signaling pathway

Transforming growth factor-beta receptor III (TGF-beta RIII) is one of three receptors for the secreted growth factor TGF-beta. Unlike type I and type II TGF-beta receptors, TGF-beta RIII does not participate directly in the propagation of intracellular signaling in response to TGF-beta binding (1). TGF-beta RIII typically functions as a coreceptor for TGF-beta by binding the ligand with high affinity in order to regulate signaling. TGF-beta RIII contains a large glycosylated extracellular domain and a small intracellular domain.

CCR2 or CD192

CCR2 is a receptor for several monocyte chemoattractant proteins (MCP1, MCP3, MCP4) that specifically govern monocyte chemotaxis. CCR2 transduces its downstream signals through increasing intracellular calcium ion levels. For example, MCP1 regulates the monocyte infiltration found in inflammatory diseases such as rheumatoid or the cellular inflammatory response to tumors. CCR2 is also an alternative co-receptor with CD4 for HIV1 infection.