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LC3

Autophagy and Metastasis

EpCAM/TROP1 is localized by immunohistochemical analysis of human breast carcinoma tissue to the cell membrane and intercellular spaces.
 

By Christina Towers, PhD

Tags: 
Autophagy
Cancer
EMT
LC3
LC3-II
LC3B
p62/SQSTM1
Paxillin
Twist-1
epcam-trop1
Christina Towers

Optogenetic Control of Mitophagy: AMBRA1 based mitophagy switch

sAmbra1 expression and localization to mitochondria in human U-2 OS cell line, ICC

By Christina Towers, PhD

Tags: 
Autophagy
Mitophagy
LC3
LC3-II
LC3B
p62/SQSTM1
Parkin
AMBRA1
Christina Towers

Autophagic flux: Is p62 a good indicator?

p62 detection via IHC-Paraffin, Novus Biologicals

By Christina Towers, PhD

Tags: 
Autophagy
autophagosome
LC3
LC3-II
LC3B
p62/SQSTM1
alpha Tubulin
mCherry
Autophagic flux
Chloroquine
Bafilomycin-A1
ATG5
ATG7
PKC zeta
NFkB
Keap1
NRF2
ERK1
Christina Towers

Best genes to knockout to control autophagic flux

Autophagy interactive signaling pathway, Novus Biologicals, macroautophagy induction, autophagosome maturation, microautophagy, autolysosome, elongation

By Christina Towers, PhD

Tags: 
Autophagy
Autophagic flux
LC3
LC3B
LC3-II
Chloroquine
Bafilomycin
Autophagy Inhibitors
ATGs
ATG5
ATG7
Atg3
ATG12
stx17
p62-sqstm1
ATG13
Apoptosis
Christina Towers
autophagosome
Autophagy flux

Make each cell count: How to assess autophagy using flow cytometry

LC3B expression in HeLa cells treated with chloroquine overnight, ICC. Novus Biologicals

Kristy R. Howell, PhD

Tags: 
Autophagy
autophagosome
LC3
LC3B
alpha Tubulin
GFP
mCherry
Autophagy flux
Chloroquine
rapamycin
Flow cytometry
Kristy Howell
Jurkat cell
MIFC
puncta
fluorescence
Immunocytochemistry
Immunofluorescence

How to visualize autophagy by microscopy

LC3B and alpha tubulin expression in HeLa cells treated with Chloroquine, ICC, immunocytochemistry, immunofluorescence

By Christina Towers, PhD

Tags: 
Autophagy
autophagosome
LC3
LC3B
p62/SQSTM1
alpha Tubulin
GFP
Mitophagy
mCherry
Autophagic flux
Chloroquine
Christina Towers
Autophagy flux
microscopy

Microglia: pruning shears for homeostatic maintenance in the brain

Iba1 expression in mouse fore brain, IHC

By Jennifer Sokolowski, MD, PhD.

Tags: 
Neuroscience
Microglia
Macrophage
resident macrophages
myeloid lineage cells
immune cells
polycomb repressive complex 2
AIF-1/ iba1
MMR
AXL
LC3
CD68
EZH2
SUZ12
EED
RbAp48
JARID2
PHF1
EBP2
Jennifer Sokolowski

The LC3 A, B, C’s and 1, 2, 3’s

Atg5 expression in HeLa cells, ICC, immunocytochemistry, immunofluorescence

By Christina Towers, PhD

Tags: 
Autophagy flux
LC3
LC3B
LC3-II
Autophagy
Autophagy Inhibitors
ATG4
ATG5
ATG12
LC3A
LC3C
GABARAP
GABARAPL1
GABARAPL2
Chloroquine
Bafilomycin-A1
ATG7
ATG8
Christina Towers
autophagosome

Best way to quantitatively measure Autophagic Flux

LC3B expression in HeLa cells, ICC, immunocytochemistry, immunofluorescence

By Christina Towers, PhD

Tags: 
Autophagy flux
LC3
LC3B
LC3-II
Chloroquine
Bafilomycin
Autophagy
Autophagy Inhibitors
Christina Towers
autophagosome
GFP
Flow cytometry
ratiometric
RFP
mCherry

Best Methods to Induce and Inhibit Autophagy Pharmacologically

VPS35 expression in endosomes and lysosomes of human U-2 OS cells, ICC

By Christina Towers, PhD

Tags: 
Autophagy
autophagosome
LC3
LC3B
Bafilomycin
Chloroquine
Lysosome
Western blot
Beclin 1
VPS34
ULK1
ATG4B
mTOR
autophagy induction
autophagy inhibition
Christina Towers
Cancer
rapamycin
Autophagic flux

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