While  not life threatening, blindness and retinal disease are profoundly debilitating  and greatly affect quality of life.  Understandably,  gene therapy has been subject to controversy given it’s potential effects on  the rest of our cellular processes.  However,  a genetically diseased eye being an isolated organ quickly becomes a promising  prospect for such therapies.  Specifically,  RPE antibodies are powerful diagnostic tools to test the viability of these clinical  treatments.