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p62/SQSTM1

Understanding Mitophagy Mechanisms: Canonical PINK1/Parkin, LC3-Dependent Piecemeal, and LC3-Independent Mitochondrial Derived Vesicles

Expression of the mitochondrial fission protein DRP1 in NH3T3 cells was analyzed by immunocytochemistry with knockout validated rabbit polyclonal anti-DRP1 antibody.

By Christina Towers, PhD

Tags: 
Autophagy
Selective Autophagy
Mitophagy
PINK1
p62/SQSTM1
NBR1
NDP52
OPTN
TAX1BP1
Parkin
DRP1
Christina Towers

Autophagy Research Update: What a difference a year makes!

Autophagy Handbook provides an overview of molecular players and regulatory mechanisms involved in the process of autophagy.

By Christina Towers, PhD

Tags: 
Autophagy
Selective Autophagy
Cancer
NDP25
TBK1
ULK1
VPS34
Beclin1
Bcl2
p62/SQSTM1
WIPI2B
alpha Tubulin
PTEN
Ras
Raf
MEK
ERK
Christina Towers

Autophagy and Metastasis

EpCAM/TROP1 is localized by immunohistochemical analysis of human breast carcinoma tissue to the cell membrane and intercellular spaces.
 

By Christina Towers, PhD

Tags: 
Autophagy
Cancer
EMT
LC3
LC3-II
LC3B
p62/SQSTM1
Paxillin
Twist-1
epcam-trop1
Christina Towers

Optogenetic Control of Mitophagy: AMBRA1 based mitophagy switch

sAmbra1 expression and localization to mitochondria in human U-2 OS cell line, ICC

By Christina Towers, PhD

Tags: 
Autophagy
Mitophagy
LC3
LC3-II
LC3B
p62/SQSTM1
Parkin
AMBRA1
Christina Towers

Autophagic flux: Is p62 a good indicator?

p62 detection via IHC-Paraffin, Novus Biologicals

By Christina Towers, PhD

Tags: 
Autophagy
autophagosome
LC3
LC3-II
LC3B
p62/SQSTM1
alpha Tubulin
mCherry
Autophagic flux
Chloroquine
Bafilomycin-A1
ATG5
ATG7
PKC zeta
NFkB
Keap1
NRF2
ERK1
Christina Towers

How to visualize autophagy by microscopy

LC3B and alpha tubulin expression in HeLa cells treated with Chloroquine, ICC, immunocytochemistry, immunofluorescence

By Christina Towers, PhD

Tags: 
Autophagy
autophagosome
LC3
LC3B
p62/SQSTM1
alpha Tubulin
GFP
Mitophagy
mCherry
Autophagic flux
Chloroquine
Christina Towers
Autophagy flux
microscopy

RNA-binding protein Staufen1 conspires with Atxn2 in stress granules to cause neurodegeneration by dysregulating RNA metabolism

PCP4 expression in mouse cerebellum Purkinje neurons, IHC

By Jamshed Arslan Pharm.D.

Tags: 
Neuroscience
Purkinje neurons
Staufen1
ATXN2
SCA2
PolyQ
Aldolase C
Pcp2
Calb1
ALS
neurodegeneration
motor deficit
Pcp4
Rgs8
Fam107b
Homer3
LC3
p62/SQSTM1
Autophagy
movement disorder

How a cell "reaches" out for help

Expression of alpha-synuclein in rat neuron-glial cultures ICCchloroquine-treated, ICC

By Christina Towers, PhD.

Tags: 
Autophagy
autophagosome
Lysosome
LC3
p62/SQSTM1
neurodegeneration
al2/SQSTM1
Parkinson's
F-actin
Lamp-1pha-synuclein
p6

Measuring Autophagic Flux with LC3 protein levels: The do's and don'ts

Expression of p62/SQSTM1 in HeLa cells mock- or chloroquine-treated, ICC

By Christina Towers, PhD.

Tags: 
Autophagy
autophagosome
Lysosome
LC3
p62/SQSTM1
Chloroquine
Autophagic flux

Crosstalk Between Oxidative Stress and Autophagy

Autophagosome and lysosome fusion, following macroautophagy to sequester cytosolic components within the autophagosome, forms autolysosome

By Christina Towers, PhD.

Tags: 
Autophagy
autophagosome
Lysosome
LC3B
p62/SQSTM1
Keap1
NRF2
Glutathione Peroxidase
SOD
Western blot
ROS
RNS
redoxstasis
Gpx
Oxidative Stress
Mitophagy
Christina Towers

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