SOX2 Antibody (4G8) [Janelia Fluor® 549]

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Product Details

Summary
Reactivity Hu, Mu, Ch, Pm, ShSpecies Glossary
Applications WB, IHC, IHC-P
Clone
4G8
Clonality
Monoclonal
Host
Mouse
Conjugate
Janelia Fluor 549

SOX2 Antibody (4G8) [Janelia Fluor® 549] Summary

Immunogen
Full length recombinant human SOX2 (NCBI NP_003097).
Localization
Nucleus, Cytoplasm
Marker
Embryonic Stem Cell Marker
Predicted Species
Mouse (96%), Primate (99%), Chicken (93%), Sheep (99%). Backed by our 100% Guarantee.
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
SOX2
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Human. Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (96%), Chicken (93%), Sheep (99%) and Monkey/Primate species (99%), Zebrafish (87%), Xenopus tropicalis (87%), Xenopus laevis (88%).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for SOX2 Antibody (4G8) [Janelia Fluor® 549]

  • ANOP3
  • MCOPS3
  • MGC2413
  • SOX2
  • SRY (sex determining region Y)-box 2
  • SRY-related HMG-box gene 2
  • transcription factor SOX2
  • transcription factor SOX-2

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for SOX2 Antibody (NBP2-29623JF549) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-29623AF350
Alexa Fluor 405 NBP2-29623AF405
Alexa Fluor 488 NBP2-29623AF488
Alexa Fluor 532 NBP2-29623AF532
Alexa Fluor 594 NBP2-29623AF594
Alexa Fluor 647 NBP2-29623AF647
Alexa Fluor 700 NBP2-29623AF700
Alexa Fluor 750 NBP2-29623AF750
Biotin NBP2-29623B
DyLight 350 NBP2-29623UV
DyLight 405 NBP2-29623V
DyLight 488 NBP2-29623G
DyLight 550 NBP2-29623R
DyLight 594 NBP2-29623DL594
DyLight 650 NBP2-29623C
DyLight 680 NBP2-29623FR
DyLight 755 NBP2-29623IR
HRP NBP2-29623H
Janelia Fluor 549 NBP2-29623JF549
Janelia Fluor 646 NBP2-29623JF646

Additional SOX2 Products

Array NBP2-29623JF549

Bioinformatics Tool for SOX2 Antibody (NBP2-29623JF549)

Discover related pathways, diseases and genes to SOX2 Antibody (NBP2-29623JF549). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for SOX2 Antibody (NBP2-29623JF549)

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PTMs for SOX2 Antibody (NBP2-29623JF549)

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Research Areas for SOX2 Antibody (NBP2-29623JF549)

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Blogs on SOX2. Showing 1-10 of 11 blog posts - Show all blog posts.

Breast cancer stem cells survive chemotherapy through S100A10-ANXA2-SPT6 interaction that epigenetically promotes OCT4-mediated stemness
By Jamshed Arslan, Pharm D, PhDBreast cancer is the most common cancer among women that causes the greatest number of cancer-related deaths worldwide. After radiotherapy or cytotoxic chemotherapy like paclitax...  Read full blog post.

Deriving neural precursor cells from human induced pluripotent stem cells
By Jennifer Sokolowski, MD, PhD.Human induced pluripotent stem cells (iPSCs) can be used to create models of human organ systems and are useful for a) ascertaining the mechanisms underlying pathological conditions...  Read full blog post.

Application Focus: New Methods for iPSC Differentiation, Inducing a Mammary Fate
Discovery of the Key to PluripotencyInduced pluripotent stem cells (iPSCs) may be generated from a wide range of fully differentiated cells, and under optimal conditions may be prompted to differentiate into virtu...  Read full blog post.

Stemness for Surviving Hypoxia: TGF-beta/Smad Signaling in Multiple Myeloma
By Jamshed Arslan Pharm.D. Multiple myeloma (MM) is a cancer of antibody-producing plasma cells. The bone marrow (BM) of MM patients is hypoxic, and MM cells overexpress many cancerous genes that are regulated by hy...  Read full blog post.

KLF4 as a transcription factor in stem cell differentiation
Kru¨ppel-like factors (KLFs) are evolutionarily conserved zinc finger transcription factors that play a role in cell differentiation, proliferation, and pluripotency. KLF4 has specifically been tied to many diverse cellular processes, including sel...  Read full blog post.

SOX2 - a stem cell transcription factor
The SOX gene family encodes a group of highly conserved transcription factors defined by the presence of a conserved high motility group (HMG) DNA-binding domain. They are involved in embryonic development regulation and cell fate determination. Al...  Read full blog post.

SOX2: an Important Stem Cell Transcription Factor
SOX2 is a transcription factor that is expressed by self-renewing and multipotent stem cells of the embryonic neuroepithelium. Sox-2 was found to be expressed by dividing neural progenitor cells. Constitutive expression of SOX2 has also been shown to...  Read full blog post.

Sox2 and Oct4: Roles in Embryonic Stem Cell Pluripotency
Embryonic stem (ES) cells are cells derived from the inner cell mass of the blastocyst, an early-stage embryo. ES cells are distinguished from other cells due to their pluripotency, which is the ability to differentiate into any different type of cell...  Read full blog post.

An Unlikely Pairing: The SOX2 Antibody and Breast Cancer
SOX2 encodes a member of the SOX (SRY-related HMG-box) family of transcription factors, which play a vital role in embryonic development. SOX2 antibody research has identified Sox2 as a key transcription factor in pluripotent stem cells. We at Novus B...  Read full blog post.

The Sox2 Antibody Aids Brain Cancer Research
The Sox2 antibody is widely used in sensory, neuroscience and stem cell marker research. Recently, Sox2 antibody preparations identified the Sox2 protein as a marker for malignant neural gliomas. We at Novus Biologicals offer a wide variety of highly...  Read full blog post.

Showing 1-10 of 11 blog posts - Show all blog posts.
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Bioinformatics

Gene Symbol SOX2