SOX3 Antibody

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SOX3 was detected in immersion fixed NTera‑2 human testicular embryonic carcinoma cell line differentiation with retinoic acid using Goat Anti-Human SOX3 Antigen Affinity-purified Polyclonal Antibody (Catalog # ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ICC/IF
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

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Catalog# & Formulation Size Price

SOX3 Antibody Summary

Immunogen
E. coli-derived recombinant human SOX3
Met1-Leu230
Accession # P41225
Specificity
Detects human SOX3 in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant human (rh) SOX2, rhSOX7, rhSOX10, and rhSOX17 is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
SOX3
Purity
Immunogen affinity purified
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry 5-15 ug/mL
  • Western Blot 0.1 ug/mL
Publications
Read Publications using
AF2569 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Immunogen affinity purified
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SOX3 Antibody

  • GHDX
  • MRGH
  • panhypopituitarism
  • PHP
  • PHPX
  • SOX3
  • SOXB
  • SRY (sex determining region Y)-box 3
  • transcription factor SOX-3

Background

SOX3 belongs to the SOX family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The SOX3 gene is localized on the X chromosome and is expressed in the brain and gonads. It has been suggested that SOX3 plays a role in brain formation and function. Human and mouse SOX3 share 92% amino acid sequence identity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for SOX3 Antibody (AF2569)(6)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 5 applications: Flow Cytometry, ICC, IHC, IHC-Fr, Immunoprecipitation.


Filter By Application
Flow Cytometry
(1)
ICC
(1)
IHC
(2)
IHC-Fr
(1)
Immunoprecipitation
(1)
All Applications
Filter By Species
Mouse
(6)
All Species
Showing Publications 1 - 6 of 6.
Publications using AF2569 Applications Species
Y Sun, L Wang, T Zhu, B Wu, G Wang, Z Luo, C Li, W Wei, Z Liu Single-cell transcriptomic landscapes of the otic neuronal lineage at multiple early embryonic ages Cell Reports, 2022;38(12):110542. 2022 [PMID: 35320729] (ICC, Mouse) ICC Mouse
E Thomson, R Dawson, CH H'ng, F Adikusuma, S Piltz, PQ Thomas The Nestin neural enhancer is essential for normal levels of endogenous Nestin in neuroprogenitors but is not required for embryo development PLoS ONE, 2021;16(11):e0258538. 2021 [PMID: 34739481] (IHC, Mouse) IHC Mouse
S Suzuki, JR McCarrey, BP Hermann An mTORC1-dependent switch orchestrates the transition between mouse spermatogonial stem cells and clones of progenitor spermatogonia Cell Reports, 2021;34(7):108752. 2021 [PMID: 33596419] (Flow Cytometry, Mouse) Flow Cytometry Mouse
D McAninch, JA Mäkelä, HM La, JN Hughes, R Lovell-Bad, RM Hobbs, PQ Thomas SOX3 promotes generation of committed spermatogonia in postnatal mouse testes Sci Rep, 2020;10(1):6751. 2020 [PMID: 32317665] (Immunoprecipitation, Mouse) Immunoprecipitation Mouse
HM La, JA Mäkelä, AL Chan, FJ Rossello, CM Nefzger, JMD Legrand, M De Seram, JM Polo, RM Hobbs Identification of dynamic undifferentiated cell states within the male germline Nat Commun, 2018;9(1):2819. 2018 [PMID: 30026551] (IHC, Mouse) IHC Mouse
Sutton E, Hughes J, White S Identification of SOX3 as an XX male sex reversal gene in mice and humans. J. Clin. Invest., 2011;121(1):328-41. 2011 [PMID: 21183788] (IHC-Fr, Mouse) IHC-Fr Mouse

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Product General Protocols

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Video Protocols

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol SOX3
Uniprot