Nanog Antibody [Unconjugated]

Western blot shows lysates of BG01V human embryonic stem cells and Tera‑2 human embryonic lung carcinoma cell line. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human Nanog Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1997) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). A specific band was detected for Nanog at approximately 40 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 9.

BG01V human embryonic stem cells were fixed using formaldehyde, resuspended in lysis buffer, and sonicated to shear chromatin. Nanog/DNA complexes were immunoprecipitated using 5 μg Goat Anti-Human Nanog Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1997) or control antibody (Catalog # AB-108-C) for 15 minutes in an ultrasonic bath, followed by Biotinylated Anti-Goat IgG Secondary Antibody (Catalog # BAF109). Immunocomplexes were captured using 50 μL of MagCellect Streptavidin Ferrofluid (Catalog # MAG999) and DNA was purified using chelating resin solution. The nanog promoter was detected by standard PCR.

Nanog was detected in immersion fixed BG01V human embryonic stem cells using 10 µg/mL Goat Anti-Human Nanog Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1997) for 3 hours at room temperature. Cells were stained with the Northern­Lights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # NL001) and counterstained with DAPI (blue). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Nanog was detected in immersion fixed BG01V human embryonic stem cells-derived embryoid body using 10 µg/mL Goat Anti-Human Nanog Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1997) for 3 hours at room temperature. Cells were stained with the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # NL001) and counterstained with DAPI (blue). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Nanog was detected in immersion fixed ADLF1 (top panel) and FAB2 (bottom panel) induced pluripotent stem cell lines using Goat Anti-Human Nanog Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1997) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # NL001) and counterstained with DAPI (blue). Specific staining was localized to nuclei. View our protocol for Fluorescent ICC Staining of Stem Cells on Coverslips.

Nanog was detected in immersion fixed paraffin-embedded sections of human testicular cancer using Goat Anti-Human Nanog Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1997) at 1 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (VC004). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cell nuclei. Staining was performed using our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Nanog was detected in immersion fixed paraffin-embedded sections of normal human testis using Goat Anti-Human Nanog Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1997) at 1 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (VC004). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm in developing sperm cells. Staining was performed using our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Nanog was detected in immersion fixed frozen sections of 13 d.p.c. mouse embryos using Goat Anti-Human Nanog Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1997) at 1 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (VC004). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cell nuclei in developing CNS. Staining was performed using our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Simple Western lane view shows lysates of iPSC, loaded at 0.2 mg/mL. A specific band was detected for Nanog at approximately 55 kDa (as indicated) using 10 µg/mL of Goat Anti-Human Nanog Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1997) . This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.

• Reactivity: Hu
• Applications: WB, IHC, ChIP, ICC/IF
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: LYOPH

Nanog Antibody [Unconjugated] Summary

• Immunogen: E. coli-derived recombinant human Nanog
  Trp153-Val305
  Accession # ABZ92376
• Specificity: Detects human Nanog in direct ELISAs and Western blots.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: NANOG
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Chromatin Immunoprecipitation (ChIP) 5 ug/5 x 10^6 cells
  • Immunocytochemistry 5-15 ug/mL
  • Immunohistochemistry 1-15 ug/mL
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Nanog Antibody [Unconjugated]

• FLJ12581
• FLJ40451
• hNanog
• homeobox protein NANOG
• Homeobox transcription factor Nanog
• homeobox transcription factor Nanog-delta 48
• Nanog homeobox
• Nanog

Background

Nanog is a member of the homeobox family of DNA binding transcription factors that has been shown to maintain pluripotency of embryonic stem cells. Its expression is high in undifferentiated embryonic stem cells is down-regulated during embryonic stem cell differentiation, concomitant with loss of pluripotency (1-3).

1. Mitsui, K. et al. (2003) Cell 11:631.
2. Chambers, I. et al. (2003) Cell 113:643.
3. Hart, A.H. et al. (2004) Dev. Dyn. 230:187.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Nanog Antibody (AF1997)(207)

Publications using AF1997

• Valtonen, J;Prajapati, C;Cherian, RM;Vanninen, S;Ojala, M;Leivo, K;Heliö, T;Koskenvuo, J;Aalto-Setälä, K; The Junctophilin-2 Mutation p.(Thr161Lys) Is Associated with Hypertrophic Cardiomyopathy Using Patient-Specific iPS Cardiomyocytes and Demonstrates Prolonged Action Potential and Increased Arrhythmogenicity Biomedicines 2023-05-27 [PMID: 37371654] (ICC, Human)
• S Teague, G Primavera, B Chen, E Freeburne, H Khan, K Jo, C Johnson, I Heemskerk The time integral of BMP signaling determines fate in a stem cell model for early human development bioRxiv : the preprint server for biology, 2023-04-10;0(0):. 2023-04-10 [PMID: 37090515] (ICC, Human)
• NM Schottmann, K Klug, E Klopocki, N Üçeyler Generation of induced pluripotent stem cell line (UKWNLi008) derived from a patient carrying a c.1678C>G variant in the transient receptor potential cation channel subfamily A member (TRPA1) gene potentially associated with small fiber neuropathy Stem Cell Research, 2023-04-12;69(0):103094. 2023-04-12 [PMID: 37079968] (ICC, Human)
• SD Sharma, BK Reddy, R Pal, TE Ritakari, JD Cooper, BT Selvaraj, PC Kind, S Chandran, DJA Wyllie, S Chattarji Astrocytes mediate cell non-autonomous correction of aberrant firing in human FXS neurons Cell Reports, 2023-04-04;42(4):112344. 2023-04-04 [PMID: 37018073] (Human)
• N Son, YS Son, CR Jung, MY Son Generation of a human fibroblast-derived induced pluripotent stem cell line KRIBBi009-A from a patient with breast cancer Stem Cell Research, 2023-03-14;68(0):103060. 2023-03-14 [PMID: 36925228] (Flow Cytometry, ICC, Human)
• Zuo Q, Yang Y, Lyu Y, Yang C, Chen C, Salman S, Huang T, Wicks E, Jackson W, Datan E, Qin W, Semenza G Plexin-B3 expression stimulates MET signaling, breast cancer stem cell specification, and lung metastasis. Cell Rep, 2023-02-28;42(3):112164. 2023-02-28 [PMID: 36857181] (Western Blot, Human)
• K Klug, M Breyer, E Klopocki, N Üçeyler Generation of two induced pluripotent stem cell lines UKWNLi006 and UKWNLi007 derived from two patients with an active site GLA mutation leading to a pain and no pain phenotype in Fabry disease Stem Cell Research, 2023-01-09;67(0):103025. 2023-01-09 [PMID: 36640471] (Flow Cytometry, ICC, Human)
• EY Akda?, S Turan, D Guhathakur, A Ekici, S Salar, DC Lie, B Winner, A Fejtova CRISPR/Cas9-mediated generation of hESC lines with homozygote and heterozygote p.R331W mutation in CTBP1 to model HADDTS syndrome Stem Cell Research, 2022-12-30;67(0):103012. 2022-12-30 [PMID: 36610307] (Flow Cytometry, ICC, Human)
• L Li, X Si, J Yang, M Lei, H Liu, J Ruan, H Fu, W Li, H Yang, X Lei, H Sang Generation of a human iPSC line (CIBi014-A) from a patient with Parkinson's disease carrying a novel heterozygotic PARK8 (LRRK2) mutation Stem Cell Research, 2022-12-09;66(0):102995. 2022-12-09 [PMID: 36528012] (ICC, Human)
• L Yang, S Lu, Z Yang, J Yao, P Zhou, M Zhao Generation of an induced pluripotent stem cell line (IPCASi001-A) from an autism spectrum disorder individual without intellectual disability Stem Cell Research, 2022-12-05;66(0):102994. 2022-12-05 [PMID: 36502620] (ICC, Human)
• D Choudhury, N Rong, I Ikhapoh, N Rajabian, G Tseropoulo, Y Wu, P Mehrotra, R Thiyagaraj, A Shahini, KL Seldeen, BR Troen, P Lei, ST Andreadis Inhibition of glutaminolysis restores mitochondrial function in senescent stem cells Cell Reports, 2022-11-29;41(9):111744. 2022-11-29 [PMID: 36450260] (ICC, Human)
• M Tongbaen, Y Matsumura, K Okita, K Leecharoen Generation of human induced pluripotent stem cells (CHULAi001-A) from peripheral blood mononuclear cells of a glucose-6-phosphate dehydrogenase (G6PD) deficient subject carrying the Viangchan mutation Stem Cell Research, 2022-10-28;65(0):102953. 2022-10-28 [PMID: 36334578] (ICC, Human)
• Y Han, L Tan, T Zhou, L Yang, L Carrau, LA Lacko, M Saeed, J Zhu, Z Zhao, BE Nilsson-Pa, FT Lira Neto, C Cahir, AM Giani, JC Chai, Y Li, X Dong, D Moroziewic, NYSCF Glob, D Paull, T Zhang, S Koo, C Tan, R Danziger, Q Ba, L Feng, Z Chen, A Zhong, GJ Wise, JZ Xiang, H Wang, RE Schwartz, BR tenOever, SA Noggle, CM Rice, Q Qi, T Evans, S Chen A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants Cell Stem Cell, 2022-10-06;29(10):1475-1490.e6. 2022-10-06 [PMID: 36206731] (ICC, Human)
• R Chimienti, T Baccega, S Torchio, F Manenti, S Pellegrini, A Cospito, A Amabile, MT Lombardo, P Monti, V Sordi, A Lombardo, M Malnati, L Piemonti Engineering of immune checkpoints B7-H3 and CD155 enhances immune compatibility of MHC-I-/- iPSCs for beta cell replacement Cell Reports, 2022-09-27;40(13):111423. 2022-09-27 [PMID: 36170817] (Flow Cytometry, Human)
• T Steiner, A Zink, MT Henke, G Cecchetto, M Buenning, A Rossi, M Schuelke, A Prigione RNA-based generation of iPSCs from a boy carrying the mutation m.9185�T>C in the mitochondrial gene MT-ATP6 and from his healthy mother Stem Cell Research, 2022-09-15;64(0):102920. 2022-09-15 [PMID: 36137325] (IHC, Human)
• R Rust, RZ Weber, M Generali, D Kehl, C Bodenmann, D Uhr, D Wanner, KJ Zürcher, H Saito, SP Hoerstrup, RM Nitsch, C Tackenberg Xeno-free induced pluripotent stem cell-derived neural progenitor cells for in vivo applications Journal of Translational Medicine, 2022-09-16;20(1):421. 2022-09-16 [PMID: 36114512] (IHC, Mouse)
• Z Ai, X Xiang, Y Xiang, I Szczerbins, Y Qian, X Xu, C Ma, Y Su, B Gao, H Shen, MN Bin Ramli, D Chen, Y Liu, JJ Hao, HH Ng, D Zhang, YS Chan, W Liu, H Liang Kr�ppel-like factor 5 rewires NANOG regulatory network to activate human naive pluripotency specific LTR7Ys and promote naive pluripotency Cell Reports, 2022-08-23;40(8):111240. 2022-08-23 [PMID: 36001968] (ChIP-Seq, ICC, Immunoprecipitation, Human)
• S Schmidt, MD Luecken, D Trümbach, S Hembach, KM Niedermeie, N Wenck, K Pflügler, C Stautner, A Böttcher, H Lickert, C Ramirez-Su, R Ahmad, MJ Ziller, JC Fitzgerald, V Ruf, WDJ van de Ber, AJ Jonker, T Gasser, B Winner, J Winkler, DM Vogt Weise, F Giesert, FJ Theis, W Wurst Primary cilia and SHH signaling impairments in human and mouse models of Parkinson's disease Nature Communications, 2022-08-16;13(1):4819. 2022-08-16 [PMID: 35974013] (IHC, Human)
• L László, H Maczelka, T Takács, A Kurilla, Á Tilajka, L Buday, V Vas, Á Apáti A Novel Cell-Based Model for a Rare Disease: The Tks4-KO Human Embryonic Stem Cell Line as a Frank-Ter Haar Syndrome Model System International Journal of Molecular Sciences, 2022-08-08;23(15):. 2022-08-08 [PMID: 35955935] (Flow Cytometry, Human)
• Z Jiang, XJ Gu, WM Su, QQ Duan, JY Lin, B Cao, HF Shang, YP Chen Production of a human iPSC line from an early-onset Parkinson's disease patient with a novel CHCHD2 gene truncated mutation Stem Cell Research, 2022-08-04;64(0):102881. 2022-08-04 [PMID: 35944313] (Flow Cytometry, ICC, Human)
• Y Sun, J Fu, J Yang, J Zhao, J Rong Generation of a RRAGA knockout human iPSC line GIBHi002-A-5 using CRISPR/Cas9 technology Oncogene, 2022-07-11;63(0):102859. 2022-07-11 [PMID: 35870248] (Flow Cytometry, ICC, Human)
• J Lotila, T Hyvärinen, H Skottman, L Airas, S Narkilahti, S Hagman Establishment of a human induced pluripotent stem cell line (TAUi008-A) derived from a multiple sclerosis patient Oncogene, 2022-07-11;63(0):102865. 2022-07-11 [PMID: 35843021] (Flow Cytometry, ICC, Human)
• M Ohgushi, N Taniyama, A Vandenbon, M Eiraku Delamination of trophoblast-like syncytia from the amniotic ectodermal analogue in human primed embryonic stem cell-based differentiation model Cell Reports, 2022-06-21;39(12):110973. 2022-06-21 [PMID: 35732132] (Flow Cytometry, ICC, Human)
• YH Chen, PS Huang, MH Wen, M Pan, DF Lee, TY Chen Generation of a homozygous knock-in human embryonic stem cell line expressing mEos4b-tagged CTR1 Oncogene, 2022-06-14;63(0):102845. 2022-06-14 [PMID: 35728441] (ICC, Human)
• M Simunovic, ED Siggia, AH Brivanlou In�vitro attachment and symmetry breaking of a human embryo model assembled from primed embryonic stem cells Cell Stem Cell, 2022-06-02;29(6):962-972.e4. 2022-06-02 [PMID: 35659878] (IHC, Human)
• H Jiao, MS Lee, A Sivapatham, EM Leiferman, WJ Li Epigenetic regulation of BAF60A determines efficiency of miniature swine iPSC generation Scientific Reports, 2022-05-31;12(1):9039. 2022-05-31 [PMID: 35641537] (ICC, Human)
• Y Shi, S Wu, B Yang, B Yu, Y Yan, J Yang, M Chu, X Hu Generation of a human iPSC line CIBi011-A from amniocytes of a healthy fetus Stem Cell Research, 2022-05-04;62(0):102801. 2022-05-04 [PMID: 35609349] (ICC, Human)
• J Fu, L Jiang, B Yu, Y Liu, R Wei, Y Hu, WI Ho, B Yang, M Chu, HF Tse, J Yang Generation of a human iPSC line CIBi010-A with a reporter for ASGR1 using CRISPR/Cas9 Stem Cell Research, 2022-05-05;62(0):102800. 2022-05-05 [PMID: 35561459] (ICC, Human)
• X Hu, S Xiong, X Zhou, L Sun Generation of a human induced pluripotent stem cell line FMUPDCi001-A from a patient with mental retardation, autosomal recessive 36 (MRT36) carrying the variants c.219dupA and c.587C�>�T in ADAT3 Stem Cell Research, 2022-04-04;61(0):102777. 2022-04-04 [PMID: 35405382] (ICC, Human)
• AJ Collier, A Bendall, C Fabian, AA Malcolm, K Tilgner, CI Semprich, K Wojdyla, PS Nisi, K Kishore, VN Roamio Fra, B Mirshekar-, C D'Santos, K Plath, K Yusa, PJ Rugg-Gunn Genome-wide screening identifies Polycomb repressive complex 1.3 as an essential regulator of human na�ve pluripotent cell reprogramming Science Advances, 2022-03-25;8(12):eabk0013. 2022-03-25 [PMID: 35333572] (ICC, Human)
• M Breyer, T Klein, K Klug, E Klopocki, N Üçeyler Generation of the induced pluripotent stem cell line UKWNLi005-A derived from a patient with the GLA mutation c.376A�>�G of unknown pathogenicity in Fabry disease Stem Cell Research, 2022-03-14;61(0):102747. 2022-03-14 [PMID: 35325818] (ICC, Human)
• C Lorenz, A Zink, MT Henke, S Staege, B Mlody, M Bünning, E Wanker, S Diecke, M Schuelke, A Prigione Generation of four iPSC lines from four patients with Leigh syndrome carrying homoplasmic mutations m.8993T�>�G or m.8993T�>�C in the mitochondrial gene MT-ATP6 Stem Cell Research, 2022-03-08;61(0):102742. 2022-03-08 [PMID: 35279592] (ICC, Human)
• I Fagerlund, A Dougalis, A Shakirzyan, M Gómez-Budi, A Pelkonen, H Konttinen, S Ohtonen, MF Fazaludeen, M Koskuvi, J Kuusisto, D Hernández, A Pebay, J Koistinaho, T Rauramaa, Š Lehtonen, P Korhonen, T Malm Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids Cells, 2021-12-30;11(1):. 2021-12-30 [PMID: 35011686] (ICC, Human)
• BE Jewell, A Xu, D Zhu, MF Huang, L Lu, M Liu, EL Underwood, JH Park, H Fan, JA Gingold, R Zhou, J Tu, Z Huo, Y Liu, W Jin, YH Chen, Y Xu, SH Chen, N Rainusso, NK Berg, DA Bazer, C Vellano, P Jones, HK Eltzschig, Z Zhao, BA Kaipparett, R Zhao, LL Wang, DF Lee Patient-derived iPSCs link elevated mitochondrial respiratory complex I function to osteosarcoma in Rothmund-Thomson syndrome PloS Genetics, 2021-12-29;17(12):e1009971. 2021-12-29 [PMID: 34965247] (ICC, Western Blot, Human)
• M Ozgencil, J Barwell, M Tischkowit, L Izatt, I Kesterton, M Simpson, P Sharpe, P de Sepulve, E Voisset, E Solomon Assessing BRCA1 activity in DNA damage repair using human induced pluripotent stem cells as an approach to assist classification of BRCA1 variants of uncertain significance PLoS ONE, 2021-12-02;16(12):e0260852. 2021-12-02 [PMID: 34855882] (ICC, Human)
• JR Valcourt, RE Huang, S Kundu, D Venkatasub, RE Kingston, S Ramanathan Modulating mesendoderm competence during human germ layer differentiation Cell Reports, 2021-11-09;37(6):109990. 2021-11-09 [PMID: 34758327] (IF, Human)
• L Pagliaroli, P Porazzi, AT Curtis, C Scopa, HMM Mikkers, C Freund, L Daxinger, S Deliard, SA Welsh, S Offley, CA Ott, B Calabretta, SA Brugmann, GWE Santen, M Trizzino Inability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest formation in ARID1B-related neurodevelopmental disorders Nature Communications, 2021-11-09;12(1):6469. 2021-11-09 [PMID: 34753942] (ChIP-Seq, ICC, Human)
• Y Shin, SJ Mun, J Lee, KS Chung, M Kim, C Kun Cheon, MJ Son Generation of human induced pluripotent stem cell line, KRIBBi003-A, from urinary cells of a patient with glycogen storage disease type IXa Stem Cell Research, 2021-10-22;57(0):102584. 2021-10-22 [PMID: 34740118] (Flow Cytometry, ICC, Human)
• HC Ting, HI Yang, HJ Harn, IM Chiu, HL Su, X Li, MF Chen, TJ Ho, CA Liu, YJ Tsai, TW Chiou, SZ Lin, CY Chang Coactivation of GSK3beta and IGF-1 Attenuates Amyotrophic Lateral Sclerosis Nerve Fiber Cytopathies in SOD1 Mutant Patient-Derived Motor Neurons Cells, 2021-10-16;10(10):. 2021-10-16 [PMID: 34685754] (ICC, Human)
• L Krumm, T Pozner, J Kaindl, M Regensburg, C Günther, S Turan, R Asadollahi, A Rauch, B Winner Generation and characterization of an endogenously tagged SPG11-human iPSC line by CRISPR/Cas9 mediated knock-in Stem Cell Research, 2021-08-26;56(0):102520. 2021-08-26 [PMID: 34479069] (ICC/IF, Human)
• X Huang, KM Park, P Gontarz, B Zhang, J Pan, Z McKenzie, LA Fischer, C Dong, S Dietmann, X Xing, PV Shliaha, J Yang, D Li, J Ding, T Lungjangwa, M Mitalipova, SA Khan, S Imsoonthor, N Jensen, T Wang, C Kadoch, R Jaenisch, J Wang, TW Theunissen OCT4 cooperates with distinct ATP-dependent chromatin remodelers in na�ve and primed pluripotent states in human Nature Communications, 2021-08-26;12(1):5123. 2021-08-26 [PMID: 34446700] (ICC, Human)
• Y Kang, Y Zhou, Y Li, Y Han, J Xu, W Niu, Z Li, S Liu, H Feng, W Huang, R Duan, T Xu, N Raj, F Zhang, J Dou, C Xu, H Wu, GJ Bassell, ST Warren, EG Allen, P Jin, Z Wen A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies Nature Neuroscience, 2021-08-19;0(0):. 2021-08-19 [PMID: 34413513] (ICC, Human)
• NJ Hogrebe, KG Maxwell, P Augsornwor, JR Millman Generation of insulin-producing pancreatic beta cells from multiple human stem cell lines Nature Protocols, 2021-08-04;0(0):. 2021-08-04 [PMID: 34349281] (Flow Cytometry, ICC, Human)
• CEM Aarts, E Varga, S Webbers, J Geissler, M von Linder, TW Kuijpers, E van den Ak Generation and characterization of a human iPSC line SANi006-A from a Gray Platelet Syndrome patient Stem Cell Research, 2021-06-29;55(0):102443. 2021-06-29 [PMID: 34237592] (ICC, Human)
• EC Pandolfi, TJ Hunt, S Goldsmith, K Hurlbut, SJ Silber, AT Clark Generation of three human induced pluripotent stem cell sublines (UCLAi004-A, UCLAi004-B, and UCLAi004-C) for reproductive science research Stem Cell Research, 2021-06-24;54(0):102446. 2021-06-24 [PMID: 34216981] (ICC, Human)
• L Ma, M Schmidt, EM Morrow Human iPSC lines from a Christianson syndrome patient with NHE6 W523X mutation, a biologically-related control, and CRISPR/Cas9 gene-corrected isogenic controls Stem Cell Research, 2021-06-18;54(0):102435. 2021-06-18 [PMID: 34182254] (ICC, Human)
• MS Lee, MJ Stebbins, H Jiao, HC Huang, EM Leiferman, BE Walczak, SP Palecek, EV Shusta, WJ Li Comparative evaluation of isogenic mesodermal and ectomesodermal chondrocytes from human iPSCs for cartilage regeneration Science Advances, 2021-05-19;7(21):. 2021-05-19 [PMID: 34138734] (Flow Cytometry, Human)
• EC Pandolfi, TJ Hunt, S Goldsmith, K Hurlbut, SJ Silber, AT Clark Generation of three human induced pluripotent stem cell sublines (UCLAi005-A, UCLAi005-B and UCLAi005-C) for reproductive science research Stem Cell Research, 2021-06-08;54(0):102409. 2021-06-08 [PMID: 34130154] (IHC, Human)
• PS Huang, MH Wen, X Xie, A Xu, DF Lee, TY Chen Generation of a homozygous knock-in human embryonic stem cell line expressing SNAP-tagged SOD1 Stem Cell Research, 2021-06-06;54(0):102415. 2021-06-06 [PMID: 34118566] (ICC, Human)
• R Yan, S Wu, W Wang, M Chu, P Liu Generation of a human induced pluripotent stem cell line (SMUSHi001-A) from a patient with 46, XX male sex reversal syndrome carrying the SRY gene Stem Cell Research, 2021-05-24;54(0):102397. 2021-05-24 [PMID: 34098200] (Flow Cytometry, Human)
• S Wu, Z Zhang, L Wang, J Yu Generation of a human iPSC line QDMHi001-A from a patient with Marfan syndrome carrying a heterozygous c.6772�T�>�C variant in FBN1 Stem Cell Research, 2021-05-16;54(0):102390. 2021-05-16 [PMID: 34087733] (Flow Cytometry, Human)
• DJ Truong, T Phlairahar, B E beta wein, C Gruber, D Tümen, E Baligács, N Armbrust, FL Vaccaro, EM Lederer, EM Beck, J Geilenkeus, S Göppert, L Krumwiede, C Grätz, G Raffl, D Schwarz, M Zirngibl, M Živani?, M Beyer, JD Körner, T Santl, V Evsyukov, T Strau beta , SC Schwarz, GU Höglinger, P Heutink, S Doll, M Conrad, F Giesert, W Wurst, GG Westmeyer Non-invasive and high-throughput interrogation of exon-specific isoform expression Nature Cell Biology, 2021-06-03;23(6):652-663. 2021-06-03 [PMID: 34083785] (ICC, Human)
• J Borsoi, M Morato-Mar, F de Araújo, L Assis Pere, LE Farinha-Ar, R Delgado Sa, AB Alvarez Pe, L Veiga Pere Generation of two human induced pluripotent stem cell (hiPSC) lines derived from unrelated Marfan Syndrome patients Stem Cell Research, 2021-05-25;54(0):102407. 2021-05-25 [PMID: 34062330] (ICC, Human)
• BSJ Low, CS Lim, SSL Ding, YS Tan, NHJ Ng, VG Krishnan, SF Ang, CWY Neo, CS Verma, S Hoon, SC Lim, ES Tai, AKK Teo Decreased GLUT2 and glucose uptake contribute to insulin secretion defects in MODY3/HNF1A hiPSC-derived mutant &beta cells Nature Communications, 2021-05-25;12(1):3133. 2021-05-25 [PMID: 34035238] (ICC, Human)
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Reviews for Nanog Antibody (AF1997) (5)

Average Rating: 3.8

(Based on 5 reviews)

We have 5 reviews tested in 2 species: Human, Other.

reviewed by: Verified Customer WB Human 12/02/2018

Summary

• Application: Western Blot
• Sample Tested: MCF7
• Species: Human
• Lot: KKJ061707

reviewed by: Verified Customer WB Human 01/06/2015

Summary

• Application: Western Blot
• Sample Tested: See PMID 24178749
• Species: Human

reviewed by: Verified Customer IF Human 01/06/2015

Summary

• Application: Immunofluorescence
• Sample Tested: See PMID 23910086
• Species: Human

reviewed by: Verified Customer IF Other 01/06/2015

Summary

• Application: Immunofluorescence
• Sample Tested: See PMID 22851508
• Species: Other

reviewed by: Verified Customer ICC Human 01/06/2015

Summary

• Application: Immunocytochemistry
• Sample Tested: See PMID 23778137
• Species: Human

Bioinformatics

• Gene Symbol: NANOG
• Uniprot:
  • ABZ92376()