CD31/PECAM-1 Antibody (MEC13.3) [PE]

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications Flow
Clone
MEC13.3
Clonality
Monoclonal
Host
Rat
Conjugate
PE

CD31/PECAM-1 Antibody (MEC13.3) [PE] Summary

Immunogen
mouse endothelial cell line T-end
Localization
Membrane; Single-pass type I membrane protein. Cell junction.
Isotype
IgG2a Kappa
Clonality
Monoclonal
Host
Rat
Gene
PECAM1
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry
Application Notes
This CD31/PECAM1 Antibody (MEC13.3) is useful for Flow Cytometry, Immunoprecipitation, Immunohistochemical staining of acetone-fixed frozen sections and zinc-fixed paraffin-embedded sections, and in vitro and in vivo blocking of CD31-mediated cell-cell interactions. Please Note: NB600-1475 works well on acetone-fixed frozen sections as well as zinc-fixed paraffin-embedded sections. However, it is not recommended for formalin-fixed paraffin-embedded sections due to inconsistent results. In vivo assay was reported in scientific literature.

Reactivity Notes

Mouse.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for CD31/PECAM-1 Antibody (MEC13.3) [PE]

  • adhesion molecule
  • CD31 antigen
  • CD31
  • CD31/EndoCAM
  • endoCAM
  • FLJ34100
  • FLJ58394
  • GPIIA'
  • PECA1
  • PECAM1
  • PECAM-1
  • PECAM-1, CD31/EndoCAM
  • platelet endothelial cell adhesion molecule
  • platelet/endothelial cell adhesion molecule

Background

CD31/PECAM1 is commonly used as an endothelial marker, particularly in angiogenesis. CD31 is important in assisting placental and endometrial vascular development. However, CD31 is also associated with many negative angiogenic occurrences, particularly those within or related to tumors and other disease lesions. In MS, plasma microparticules carry CD31 and are important in the formation of brain lesions associated with MS. In cardiac angiosarcoma, CD31 presence is indicative of the severity of the disease. In prostate tumor cells, CD31 is upregulated and associated with increased levels of HIF1a, VEGF, and other hypoxic markers. This relationship seems to indicate that when prostate cancer reaches a sufficient state of development that intense angiogenesis must occur in order to support the ongoing growth and survival of the cancer cells. In all, CD31 is a great marker for normal and disease-induced angiogenesis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Allophycocyanin Labeled NB600-1475APC
DyLight 350 Labeled NB600-1475UV
DyLight 405 Labeled NB600-1475V
DyLight 488 Labeled NB600-1475G
DyLight 550 Labeled NB600-1475R
DyLight 650 Labeled NB600-1475C
DyLight 680 Labeled NB600-1475FR
DyLight 755 Labeled NB600-1475IR
FITC Labeled NB600-1475F
PerCP Labeled NB600-1475PCP

Additional CD31/PECAM-1 Products

Bioinformatics Tool for CD31/PECAM-1 Antibody (NB600-1475PE)

Discover related pathways, diseases and genes to CD31/PECAM-1 Antibody (NB600-1475PE). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Research Areas for CD31/PECAM-1 Antibody (NB600-1475PE)

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Blogs on CD31/PECAM-1.

The application of CD31/Pecam-1 (MEC 7.46) in breast cancer research
CD31/PECAM-1, or platelet endothelial cell adhesion molecule 1, is a 130-kDa glycoprotein expressed on vascular and hematopoietic cells.  Depending on the cell type, CD31/PECAM-1 expression can be largely localized to cell junctions, playing a rol...  Read full blog post.

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Bioinformatics

Gene Symbol PECAM1
Entrez