CD11b/c Antibody [Biotin]

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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Biotin

Order Details

CD11b/c Antibody [Biotin] Summary

Immunogen
A synthetic peptide made to an internal region (within residues 500-600) of the mouse CD11 (b/c) protein. [Swiss-Prot: P05555]
Localization
Monocytes and granulocytes.
Marker
Microglia Marker, Macrophage Marker
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
ITGAM
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot
  • Flow Cytometry
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Readout System

Reactivity Notes

Rat reactivity reported in scientific literature (PMID: 25150592)

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for CD11b/c Antibody [Biotin]

  • antigen CD11b (p170)
  • CD11 antigen-like family member B
  • CD11b antigen
  • CD11b
  • CD11Bintegrin, alpha M (complement component receptor 3, alpha; also known as CD11b(p170), macrophage antigen alpha polypeptide)
  • Cell surface glycoprotein MAC-1 subunit alpha
  • CR-3 alpha chain
  • CR3AMGC117044
  • integrin alpha-M
  • integrin, alpha M (complement component 3 receptor 3 subunit)
  • Leukocyte adhesion receptor MO1
  • MAC-1
  • MAC1A
  • macrophage antigen alpha polypeptide
  • MO1A
  • neutrophil adherence receptor alpha-M subunit
  • Neutrophil adherence receptor
  • SLEB6

Background

CD11b is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement coated particles. It is identical to CR3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the RGD peptide in C3b. CD11b is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. The Mac1 CD11b antigen is present on macrophages, granulocytes, natural killer cells, blood monocytes. CD11b is expressed on 8% spleen cells, 44% bone marrow cells and less than 1% of thymocytes and is commonly used as a microglial marker in nervous tissue.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for CD11b/c Antibody (NB110-40766B) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NB110-40766AF350
Alexa Fluor 405 NB110-40766AF405
Alexa Fluor 488 NB110-40766AF488
Alexa Fluor 532 NB110-40766AF532
Alexa Fluor 594 NB110-40766AF594
Alexa Fluor 647 NB110-40766AF647
Alexa Fluor 700 NB110-40766AF700
Alexa Fluor 750 NB110-40766AF750
Allophycocyanin/Cy7 NB110-40766APCCY7
Biotin NB110-40766B
DyLight 350 NB110-40766UV
DyLight 405 NB110-40766V
DyLight 488 NB110-40766G
DyLight 550 NB110-40766R
DyLight 594 NB110-40766DL594
DyLight 650 NB110-40766C
DyLight 680 NB110-40766FR
DyLight 755 NB110-40766IR
FITC NB110-40766F
HRP NB110-40766H
Janelia Fluor 549 NB110-40766JF549
Janelia Fluor 646 NB110-40766JF646
PE NB110-40766PE
PE/Atto594 NB110-40766PEATT594
PE/Cy5.5 NB110-40766PECY55
PE/Cy7 NB110-40766PECY7

Additional CD11b/c Products

Array NB110-40766B

Bioinformatics Tool for CD11b/c Antibody (NB110-40766B)

Discover related pathways, diseases and genes to CD11b/c Antibody (NB110-40766B). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for CD11b/c Antibody (NB110-40766B)

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Blogs on CD11b/c.

Adhesion Receptor Molecule CD11b/c is the Point of Entry for many Infectious Diseases
Pathogenic microorganisms utilize a variety of cell surface receptors to gain entry into host cells and to bypass the natural defense mechanisms. One of the most prominent receptors used in this fashion is the leukocyte adhesion receptor CD11b/c. This...  Read full blog post.

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Contact Information

Learn the difference between western blot and simple western

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Calculators

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Bioinformatics

Gene Symbol ITGAM