CD11b/c Products


Description

CD11b, also known as Integrin alpha M, is one half of the heterodimeric integrin alpha-M beta-2 molecule. This protein mediates inflammation by regulating leukocyte adhesion and migration and has been implicated in several immune processes such as phagocytosis, cell-mediated cytotoxicity, chemotaxis and cellular activation. CD11b is expressed on the surface of many leukocytes involved in the innate immune system, including monocytes, granulocytes, macrophages, and natural killer cells. Mutations in the CD11b protein have been assosicated with the autoimmune disease lupus, and CD11b antibodies are therefore commonly in immunology studies.

CD11c, also known as Integrin alpha X, is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Mouse
Product By Gene ID 3684
Alternate Names
  • Neutrophil adherence receptor
  • SLEB6
  • CD11b antigen
  • MAC1A
  • neutrophil adherence receptor alpha-M subunit
  • CR-3 alpha chain
  • macrophage antigen alpha polypeptide
  • CD11 antigen-like family member B
  • integrin alpha-M
  • Leukocyte adhesion receptor MO1
  • antigen CD11b (p170)
  • Cell surface glycoprotein MAC-1 subunit alpha
  • MO1A
  • MAC-1
  • CR3AMGC117044
  • CD11Bintegrin, alpha M (complement component receptor 3, alpha; also known as CD11b(p170), macrophage antigen alpha polypeptide)
  • CD11b
  • integrin, alpha M (complement component 3 receptor 3 subunit)

Research Areas for CD11b/c

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
CD Markers
Cellular Markers
Glia Markers
Immunology
Microglia Markers
Neuronal Cell Markers
Neuroscience
Signal Transduction

Bioinformatics Tool for CD11b/c

Discover related pathways, diseases and genes to CD11b/c. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related CD11b/c Blog Posts

Check out the latest blog posts on CD11b/c.
Adhesion Receptor Molecule CD11b/c is the Point of Entry for many Infectious Diseases
Pathogenic microorganisms utilize a variety of cell surface receptors to gain entry into host cells and to bypass the natural defense mechanisms. One of the most prominent receptors used in this fashion is the leukocyte adhesion receptor CD11b/c. This...    Read more.
Read more CD11b/c related blogs.