CD11b/c Products

Description

CD11b, also known as Integrin alpha M, is one half of the heterodimeric integrin alpha-M beta-2 molecule. This protein mediates inflammation by regulating leukocyte adhesion and migration and has been implicated in several immune processes such as phagocytosis, cell-mediated cytotoxicity, chemotaxis and cellular activation. CD11b is expressed on the surface of many leukocytes involved in the innate immune system, including monocytes, granulocytes, macrophages, and natural killer cells. Mutations in the CD11b protein have been assosicated with the autoimmune disease lupus, and CD11b antibodies are therefore commonly in immunology studies.

CD11c, also known as Integrin alpha X, is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias.

Bioinformatics

Entrez	16409 Mouse 3684 Human
Uniprot	P05555 Mouse P11215 Human
Product By Gene ID	3684
Alternate Names	antigen CD11b (p170) CD11 antigen-like family member B CD11b antigen CD11b CD11Bintegrin, alpha M (complement component receptor 3, alpha; also known as CD11b(p170), macrophage antigen alpha polypeptide) Cell surface glycoprotein MAC-1 subunit alpha CR-3 alpha chain CR3AMGC117044 integrin alpha-M integrin, alpha M (complement component 3 receptor 3 subunit) Leukocyte adhesion receptor MO1 MAC-1 MAC1A macrophage antigen alpha polypeptide MO1A neutrophil adherence receptor alpha-M subunit Neutrophil adherence receptor SLEB6

Research Areas for CD11b/c

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
CD Markers
Cellular Markers
Glia Markers
Immunology
Microglia Markers
Neuronal Cell Markers
Neuroscience
Signal Transduction

Related CD11b/c Blog Posts

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Adhesion Receptor Molecule CD11b/c is the Point of Entry for many Infectious Diseases Pathogenic microorganisms utilize a variety of cell surface receptors to gain entry into host cells and to bypass the natural defense mechanisms. One of the most prominent receptors used in this fashion is the leukocyte adhesion receptor CD11b/c. This...    Read more.

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