CCR7 Antibody (150503) [Fluorescein]

Human peripheral blood lymphocytes were stained with Mouse Anti-Human CD4 APC-conjugated Monoclonal Antibody (Catalog # FAB3791A) and either (A) Mouse Anti-Human CCR7 Fluorescein-conjugated Monoclonal Antibody (Catalog # FAB197F) or (B) Mouse IgG2AFluorescein Isotype Control (Catalog # IC003F). View our protocol for Staining Membrane-associated Proteins.

The specificity of Mouse Anti-Human CCR7 Clone 150503 was demonstrated by its ability to react with (A) HEK293 human embryonic kidney cell line transfected with human CCR7 and not react with (B) irrelevant HEK293 transfectants. Antibody binding was monitored using Phycoerythrin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0102B).

Frequency of peripheral T lymphocytes in hip fracture patients with and without depressive symptoms versus healthy controls. (a) The percentage of CD3+ve T cells in healthy controls: n = 37; hip fracture patients without depression (HF): n = 38 and hip fracture patients with depressive symptoms (HF + D): n = 29.The solid bar represents the mean value. (b) The mean absolute number of T cells in healthy controls: n = 20; hip fracture patients without depression (HF): n = 19 and hip fracture patients with depressive symptoms (HF + D): n = 15. Data are mean ± SEM. *p < .05 and **p < .01. Representative flow cytometry plots and gating strategy of PBMCs from a young individual stained with anti-CD3 and (c) anti-CD4, and CD8, (d) and anti-CD45RA and -CCR7 (e and f). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/25628751), licensed under a CC-BY license. Not internally tested by R&D Systems.

• Reactivity: Hu
• Applications: Flow
• Clone: 150503
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Fluorescein

CCR7 Antibody (150503) [Fluorescein] Summary

• Additional Information: Clone 150503 was used by HLDA to establish CD designation
• Immunogen: Human CCR7 transfectants
  Met1-Pro378
  Accession # AAA58615
• Specificity: Detects human CCR7.
• Source: N/A
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: CCR7
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 10 uL/10^6 cells

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
• Buffer: Supplied in a saline solution containing BSA and Sodium Azide.
• Preservative: Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CCR7 Antibody (150503) [Fluorescein]

• BLR2
• BLR2C-C chemokine receptor type 7
• C-C CKR-7
• CC-CKR-7
• CCR7
• CCR-7
• CD197 antigen
• CD197
• CDw197
• CDw197CC chemokine receptor 7
• chemokine (C-C motif) receptor 7
• CMKBR7
• CMKBR7chemokine (C-C) receptor 7
• EBI1
• EBI1EBV-induced G protein-coupled receptor 1
• EBV-induced G-protein coupled receptor 1
• Epstein-Barr virus induced gene 1
• Epstein-Barr virus induced G-protein coupled receptor
• Epstein-Barr virus-induced G-protein coupled receptor 1
• EVI1
• lymphocyte-specific G protein-coupled peptide receptor
• MIP-3 beta receptor

Background

CCR7 (Chemokine Receptor 7; also CD197) is a 7 transmembrane (7TM) G protein-coupled chemokine receptor for the homeostatic chemokines CCL19/MIP-3 beta and CCL21/6Ckine. CCL19 and CCL21 are constitutively expressed by high endothelial venule epithelial cells or fibroblastic reticular cells in secondary lymphoid organs. CCR7 is upregulated on dendritic cells, naïve and memory T cells, Treg, NK cells, and B cells following inflammatory stimulation. Its expression enables the function of immune cell trafficking to and retention in regional lymph nodes for expansion of the adaptive immune response. Human CCR7 shares 87% amino acid sequence identity with mouse CCR7.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for CCR7 Antibody (FAB197F)(78)

Publications using FAB197F

• Lopes, N;Maia, ML;Pereira, CS;Mondragão-Rodrigues, I;Martins, E;Ribeiro, R;Gaspar, A;Aguiar, P;Garcia, P;Cardoso, MT;Rodrigues, E;Leão-Teles, E;Giugliani, R;Coutinho, MF;Alves, S;Macedo, MF; Leukocyte Imbalances in Mucopolysaccharidoses Patients Biomedicines 2023-06-13 [PMID: 37371793] (Flow Cytometry, Human)
• Yuqing Wang, Duolong Zhu, Laura C. Ortiz-Velez, Jacob L. Perry, Michael W. Pennington, Joseph M. Hyser et al. A bioengineered probiotic for the oral delivery of a peptide Kv1.3 channel blocker to treat rheumatoid arthritis Proceedings of the National Academy of Sciences 1/10/2023 [PMID: 36595694]
• Tatangelo V, Boncompagni G, Capitani N et al. p66Shc Deficiency in Chronic Lymphocytic Leukemia Promotes Chemokine Receptor Expression Through the ROS-Dependent Inhibition of NF-?B Frontiers in Oncology 2022-06-29 [PMID: 35847884]
• Tatangelo V, Boncompagni G, Capitani N et al. p66Shc Deficiency in Chronic Lymphocytic Leukemia Promotes Chemokine Receptor Expression Through the ROS-Dependent Inhibition of NF-?B Frontiers in Oncology 6/29/2022 [PMID: 35847884]
• MF Lammoglia, J Ritter, R Gary, V Seitz, J Mautner, M Aigner, S Völkl, S Schaffer, S Moi, A Seegebarth, H Bruns, W Rösler, K Amann, M Büttner-He, S Hennig, A Mackensen, M Hummel, A Moosmann, A Gerbitz Reconstitution of EBV-directed T cell immunity by adoptive transfer of peptide-stimulated T cells in a patient after allogeneic stem cell transplantation for AITL PloS Pathogens, 2022-04-22;18(4):e1010206. 2022-04-22 [PMID: 35452490] (Flow Cytometry, Human)
• P Agarwalla, EA Ogunnaike, S Ahn, KA Froehlich, A Jansson, FS Ligler, G Dotti, Y Brudno Bioinstructive implantable scaffolds for rapid in vivo manufacture and release of CAR-T cells Nature Biotechnology, 2022-03-24;0(0):. 2022-03-24 [PMID: 35332339] (Flow Cytometry, Human)
• Richard E. Beatson, Ana C. Parente-Pereira, Leena Halim, Domenico Cozzetto, Caroline Hull, Lynsey M. Whilding et al. TGF-beta 1 potentiates V gamma 9Vδ2 T cell adoptive immunotherapy of cancer Cell Reports Medicine 2021-12-21 [PMID: 35028614]
• Richard E. Beatson, Ana C. Parente-Pereira, Leena Halim, Domenico Cozzetto, Caroline Hull, Lynsey M. Whilding et al. TGF-beta 1 potentiates V gamma 9Vδ2 T cell adoptive immunotherapy of cancer Cell Reports Medicine 2021-12-21 [PMID: 35028614]
• S Hoyer, V Eberlein, G Schuler, C Berking, L Heinzerlin, N Schaft, J Dörrie BRAF and MEK Inhibitors Affect Dendritic-Cell Maturation and T-Cell Stimulation Oncogene, 2021-11-04;22(21):. 2021-11-04 [PMID: 34769379] (Flow Cytometry, Human)
• HM Parry, AC Dowell, J Zuo, K Verma, FAM Kinsella, J Begum, W Croft, A Sharma-Oat, G Pratt, P Moss PD-1 is imprinted on cytomegalovirus-specific CD4+ T cells and attenuates Th1 cytokine production whilst maintaining cytotoxicity PloS Pathogens, 2021-03-04;17(3):e1009349. 2021-03-04 [PMID: 33662046] (Flow Cytometry, Human)
• F Onodi, L Bonnet-Mad, L Meertens, L Karpf, J Poirot, SY Zhang, C Picard, A Puel, E Jouanguy, Q Zhang, J Le Goff, JM Molina, C Delaugerre, JL Casanova, A Amara, V Soumelis SARS-CoV-2 induces human plasmacytoid pre-dendritic cell diversification via UNC93B and IRAK4 bioRxiv : the preprint server for biology, 2021-01-08;0(0):. 2021-01-08 [PMID: 33442685] (Flow Cytometry, Human)
• RR Anderko, CR Rinaldo, RB Mailliard IL-18 Responsiveness Defines Limitations in Immune Help for Specialized FcR&amp;gamma- NK Cells J Immunol, 2020-11-13;0(0):. 2020-11-13 [PMID: 33188073] (Flow Cytometry, Human)
• R Peruzzo, A Mattarei, M Azzolini, KA Becker-Fle, M Romio, G Rigoni, A Carrer, L Biasutto, S Parrasia, S Kadow, A Managò, A Urbani, A Rossa, G Semenzato, ME Soriano, L Trentin, S Ahmad, M Edwards, E Gulbins, C Paradisi, M Zoratti, L Leanza, I Szabò Insight into the mechanism of cytotoxicity of membrane-permeant psoralenic Kv1.3 channel inhibitors by chemical dissection of a novel member of the family Redox Biol, 2020-09-06;37(0):101705. 2020-09-06 [PMID: 33007503] (ICC, Human)
• Pritha Agarwalla, Edikan A. Ogunnaike, Sarah Ahn, Frances S. Ligler, Gianpietro Dotti, Yevgeny Brudno Scaffold‐Mediated Static Transduction of T Cells for CAR‐T Cell Therapy Advanced Healthcare Materials 7/1/2020 [PMID: 32592454]
• JM Laufer, MA Hauser, I Kindinger, V Purvanov, A Pauli, DF Legler Chemokine Receptor CCR7 Triggers an Endomembrane Signaling Complex for Spatial Rac Activation Cell Rep, 2019-10-22;29(4):995-1009.e6. 2019-10-22 [PMID: 31644919] (Flow Cytometry, Human)
• J Mouillaux, C Allam, M Gossez, T Uberti, B Delwarde, J Hayman, T Rimmelé, J Textoris, G Monneret, E Peronnet, F Venet TCR activation mimics CD127lowPD-1high phenotype and functional alterations of T lymphocytes from septic shock patients Crit Care, 2019-04-17;23(1):131. 2019-04-17 [PMID: 30995946] (Flow Cytometry, Human)
• J Kristoff, ML Palma, TM Garcia-Bat, C Shen, N Sluis-Crem, P Gupta, CR Rinaldo, RB Mailliard Type 1-programmed dendritic cells drive antigen-specific latency reversal and immune elimination of persistent HIV-1 EBioMedicine, 2019-04-02;0(0):. 4/2/2019 [PMID: 30952614]
• S Ahn, J Li, C Sun, K Gao, K Hirabayash, H Li, B Savoldo, R Liu, G Dotti Cancer immunotherapy with T cells carrying bispecific receptors that mimic antibodies Cancer Immunol Res, 2019-03-06;0(0):. 2019-03-06 [PMID: 30842091] (CAR-T (Flow Cytometry), Human)
• J Fourcade, Z Sun, JM Chauvin, M Ka, D Davar, O Pagliano, H Wang, S Saada, C Menna, R Amin, C Sander, JM Kirkwood, AJ Korman, HM Zarour CD226 opposes TIGIT to disrupt Tregs in melanoma JCI Insight, 2018-07-26;3(14):. 2018-07-26 [PMID: 30046006] (Flow Cytometry, Human)
• NA Duggal, C Snelson, U Shaheen, V Pearce, JM Lord Innate and adaptive immune dysregulation in critically ill ICU patients Sci Rep, 2018-07-05;8(1):10186. 2018-07-05 [PMID: 29976949] (Flow Cytometry, Human)
• A Wagner, E Garner-Spi, J Jasinska, H Kollaritsc, K Stiasny, M Kundi, U Wiedermann Age-related differences in humoral and cellular immune responses after primary immunisation: indications for stratified vaccination schedules Sci Rep, 2018-06-29;8(1):9825. 2018-06-29 [PMID: 29959387] (Flow Cytometry, Human)
• R Gary, M Aigner, S Moi, S Schaffer, A Gottmann, S Maas, R Zimmermann, J Zingsem, J Strobel, A Mackensen, J Mautner, A Moosmann, A Gerbitz Clinical-grade generation of peptide-stimulated CMV/EBV-specific T cells from G-CSF mobilized stem cell grafts J Transl Med, 2018-05-09;16(1):124. 2018-05-09 [PMID: 29743075] (Flow Cytometry, Human)
• YM Chiu, CL Tsai, JT Kao, CT Hsieh, DC Shieh, YJ Lee, GJ Tsay, KS Cheng, YY Wu PD-1 and PD-L1 Up-regulation Promotes T-cell Apoptosis in Gastric Adenocarcinoma Anticancer Res., 2018-04-01;38(4):2069-2078. 2018-04-01 [PMID: 29599324] (Flow Cytometry, Human)
• C Gavegnano, JH Brehm, FP Dupuy, A Talla, SP Ribeiro, DA Kulpa, C Cameron, S Santos, SJ Hurwitz, VC Marconi, JP Routy, L Sabbagh, RF Schinazi, RP Sékaly Novel mechanisms to inhibit HIV reservoir seeding using Jak inhibitors PLoS Pathog., 2017-12-21;13(12):e1006740. 2017-12-21 [PMID: 29267399] (Flow Cytometry, Human)
• BA Kansy, F Concha-Ben, RM Srivastava, HB Jie, G Shayan, Y Lei, J Moskovitz, J Moy, J Li, S Brandau, S Lang, NC Schmitt, GJ Freeman, WE Gooding, DA Clump, RL Ferris PD-1 status in CD8(+) T cells associates with survival and anti-PD-1 therapeutic outcomes in head and neck cancer Cancer Res., 2017-09-13;0(0):. 2017-09-13 [PMID: 28904066] (Flow Cytometry, Human)
• L Stenberg, M Stö beta el, G Ronchi, S Geuna, Y Yin, S Mommert, L Mårtensson, J Metzen, C Grothe, LB Dahlin, K Haastert-T Regeneration of long-distance peripheral nerve defects after delayed reconstruction in healthy and diabetic rats is supported by immunomodulatory chitosan nerve guides BMC Neurosci, 2017-07-18;18(1):53. 2017-07-18 [PMID: 28720074] (Flow Cytometry, Human)
• J Hazeldine, DN Naumann, E Toman, D Davies, JRB Bishop, Z Su, P Hampson, RJ Dinsdale, N Crombie, NA Duggal, P Harrison, A Belli, JM Lord Prehospital immune responses and development of multiple organ dysfunction syndrome following traumatic injury: A prospective cohort study PLoS Med., 2017-07-18;14(7):e1002338. 2017-07-18 [PMID: 28719602] (Flow Cytometry, Human)
• L Huang, NHR Litjens, NM Kannegiete, M Klepper, CC Baan, MGH Betjes pERK-dependent defective TCR-mediated activation of CD4(+) T cells in end-stage renal disease patients Immun Ageing, 2017-06-19;14(0):14. 2017-06-19 [PMID: 28642802] (Flow Cytometry, Human)
• D Rea, G Henry, Z Khaznadar, G Etienne, F Guilhot, F Nicolini, J Guilhot, P Rousselot, F Huguet, L Legros, M Gardembas, V Dubruille, A Guerci-Bre, A Charbonnie, F Maloisel, JC Ianotto, B Villemagne, FX Mahon, H Moins-Teis, N Dulphy, A Toubert Natural killer cell counts are associated with molecular relapse-free survival after imatinib discontinuation in chronic myeloid leukemia: the IMMUNOSTIM study Haematologica, 2017-05-18;0(0):. 2017-05-18 [PMID: 28522576] (Flow Cytometry, Human)
• C Godbersen, TA Coupet, AM Huehls, T Zhang, MB Battles, JL Fisher, MS Ernstoff, CL Sentman NKG2D ligand targeted Bispecific T Cell Engagers lead to robust antitumor activity against diverse human tumors Mol. Cancer Ther., 2017-05-12;0(0):. 2017-05-12 [PMID: 28500232] (Flow Cytometry, Human)
• Lynsey M. Whilding, Ana C. Parente-Pereira, Tomasz Zabinski, David M. Davies, Roseanna M.G. Petrovic, Y. Vincent Kao et al. Targeting of Aberrant alpha v beta 6 Integrin Expression in Solid Tumors Using Chimeric Antigen Receptor-Engineered T Cells Molecular Therapy 2017-01-01 [PMID: 28129120] (Flow Cytometry, Human)
• Lynsey M. Whilding, Ana C. Parente-Pereira, Tomasz Zabinski, David M. Davies, Roseanna M.G. Petrovic, Y. Vincent Kao et al. Targeting of Aberrant alpha v beta 6 Integrin Expression in Solid Tumors Using Chimeric Antigen Receptor-Engineered T Cells Molecular Therapy 1/1/2017 [PMID: 28129120]
• Robert L Ferris Tumor-infiltrating Tim-3(+) T cells proliferate avidly except when PD-1 is co-expressed: Evidence for intracellular cross talk Oncoimmunology, 2016-09-22;5(10):e1200778. 2016-09-22 [PMID: 27853635] (Flow Cytometry, Human)
• Zaidoon Al-Jaderi Glatiramer Acetate, Dimethyl Fumarate, and Monomethyl Fumarate Upregulate the Expression of CCR10 on the Surface of Natural Killer Cells and Enhance Their Chemotaxis and Cytotoxicity Front Immunol, 2016-10-19;7(0):437. 2016-10-19 [PMID: 27807435] (Flow Cytometry, Human)
• Yang Xu Glycolysis determines dichotomous regulation of T cell subsets in hypoxia J Clin Invest, 2016-06-13;0(0):. 2016-06-13 [PMID: 27294526] (Flow Cytometry, Human)
• Hui Li Envelope residue 375 substitutions in simian-human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques Proc Natl Acad Sci USA, 2016-05-31;113(24):E3413-22. 2016-05-31 [PMID: 27247400] (Flow Cytometry, Human, Primate - Macaca mulatta (Rhesus Macaque))
• Kellie N Smith Effective Cytotoxic T Lymphocyte Targeting of Persistent HIV-1 during Antiretroviral Therapy Requires Priming of Naive CD8+ T Cells MBio, 2016-05-31;7(3):. 2016-05-31 [PMID: 27247230] (Flow Cytometry, Human)
• Veronica De Rosa, Mario Galgani, Antonio Porcellini, Alessandra Colamatteo, Marianna Santopaolo, Candida Zuchegna et al. Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants Nature Immunology 11/1/2015 [PMID: 26414764]
• Hudspeth K, Donadon M, Cimino M, Pontarini E, Tentorio P, Preti M, Hong M, Bertoletti A, Bicciato S, Invernizzi P, Lugli E, Torzilli G, Gershwin M, Mavilio D Human liver-resident CD56(bright)/CD16(neg) NK cells are retained within hepatic sinusoids via the engagement of CCR5 and CXCR6 pathways. J Autoimmun, 2015-08-30;66(0):40-50. 2015-08-30 [PMID: 26330348] (Flow Cytometry, Human)
• Santra S, Tomaras G, Warrier R, Nicely N, Liao H, Pollara J, Liu P, Alam S, Zhang R, Cocklin S, Shen X, Duffy R, Xia S, Schutte R, Pemble Iv C, Dennison S, Li H, Chao A, Vidnovic K, Evans A, Klein K, Kumar A, Robinson J, Landucci G, Forthal D, Montefiori D, Kaewkungwal J, Nitayaphan S, Pitisuttithum P, Rerks-Ngarm S, Robb M, Michael N, Kim J, Soderberg K, Giorgi E, Blair L, Korber B, Moog C, Shattock R, Letvin N, Schmitz J, Moody M, Gao F, Ferrari G, Shaw G, Haynes B Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques. PLoS Pathog, 2015-08-03;11(8):e1005042. 2015-08-03 [PMID: 26237403] (Flow Cytometry, Human)
• Thomas S, Klobuch S, Podlech J, Plachter B, Hoffmann P, Renzaho A, Theobald M, Reddehase M, Herr W, Lemmermann N Evaluating Human T-Cell Therapy of Cytomegalovirus Organ Disease in HLA-Transgenic Mice. PLoS Pathog, 2015-07-16;11(7):e1005049. 2015-07-16 [PMID: 26181057] (Flow Cytometry, Human)
• de Mare-Bredemeijer E, Shi X, Mancham S, van Gent R, van der Heide-Mulder M, de Boer R, Heemskerk M, de Jonge J, van der Laan L, Metselaar H, Kwekkeboom J Cytomegalovirus-Induced Expression of CD244 after Liver Transplantation Is Associated with CD8+ T Cell Hyporesponsiveness to Alloantigen. J Immunol, 2015-07-13;195(4):1838-48. 2015-07-13 [PMID: 26170387] (Flow Cytometry, Human)
• Wilson R, Ives M, Rao G, Lau A, Payne K, Kobayashi M, Arkwright P, Peake J, Wong M, Adelstein S, Smart J, French M, Fulcher D, Picard C, Bustamante J, Boisson-Dupuis S, Gray P, Stepensky P, Warnatz K, Freeman A, Rossjohn J, McCluskey J, Holland S, Casanova J, Uzel G, Ma C, Tangye S, Deenick E STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function. J Exp Med, 2015-05-04;212(6):855-64. 2015-05-04 [PMID: 25941256] (Flow Cytometry, Human)
• Costa M, Cruz E, Oliveira S, Benes V, Ivacevic T, Silva M, Vieira I, Dias F, Fonseca S, Goncalves M, Lima M, Leitao C, Muckenthaler M, Pinto J, Porto G Lymphocyte gene expression signatures from patients and mouse models of hereditary hemochromatosis reveal a function of HFE as a negative regulator of CD8+ T-lymphocyte activation and differentiation in vivo. PLoS ONE, 2015-04-16;10(4):e0124246. 2015-04-16 [PMID: 25880808] (Flow Cytometry, Human)
• Zaccard C, Watkins S, Kalinski P, Fecek R, Yates A, Salter R, Ayyavoo V, Rinaldo C, Mailliard R CD40L induces functional tunneling nanotube networks exclusively in dendritic cells programmed by mediators of type 1 immunity. J Immunol, 2014-12-29;194(3):1047-56. 2014-12-29 [PMID: 25548234] (Flow Cytometry, Human)
• Nitschke K, Flecken T, Schmidt J, Gostick E, Marget M, Neumann-Haefelin C, Blum H, Price D, Thimme R Tetramer enrichment reveals the presence of phenotypically diverse hepatitis C virus-specific CD8+ T cells in chronic infection. J Virol, 2014-10-15;89(1):25-34. 2014-10-15 [PMID: 25320295] (Flow Cytometry, Human)
• Perreau M, Vigano S, Bellanger F, Pellaton C, Buss G, Comte D, Roger T, Lacabaratz C, Bart P, Levy Y, Pantaleo G Exhaustion of bacteria-specific CD4 T cells and microbial translocation in common variable immunodeficiency disorders. J Exp Med, 2014-09-15;211(10):2033-45. 2014-09-15 [PMID: 25225461] (Flow Cytometry, Human)
• Hoyer S, Prommersberger S, Pfeiffer I, Schuler-Thurner B, Schuler G, Dorrie J, Schaft N Concurrent interaction of DCs with CD4(+) and CD8(+) T cells improves secondary CTL expansion: It takes three to tango. Eur J Immunol, 2014-10-27;44(12):3543-59. 2014-10-27 [PMID: 25211552] (Flow Cytometry, Human)
• Killig M, Friedrichs B, Meisig J, Gentilini C, Bluthgen N, Loddenkemper C, Labopin M, Basara N, Pfrepper C, Niederwieser D, Uharek L, Romagnani C Tracking in vivo dynamics of NK cells transferred in patients undergoing stem cell transplantation. Eur J Immunol, 2014-06-30;44(9):2822-34. 2014-06-30 [PMID: 24895051] (Flow Cytometry, Human)
• Osuna C, Gonzalez A, Chang H, Hung A, Ehlinger E, Anasti K, Alam S, Letvin N TCR affinity associated with functional differences between dominant and subdominant SIV epitope-specific CD8+ T cells in Mamu-A*01+ rhesus monkeys. PLoS Pathog, 2014-04-17;10(4):e1004069. 2014-04-17 [PMID: 24743648] (Flow Cytometry, Human)
• Romano E, Michielin O, Voelter V, Laurent J, Bichat H, Stravodimou A, Romero P, Speiser D, Triebel F, Leyvraz S, Harari A MART-1 peptide vaccination plus IMP321 (LAG-3Ig fusion protein) in patients receiving autologous PBMCs after lymphodepletion: results of a Phase I trial. J Transl Med, 2014-04-12;12(0):97. 2014-04-12 [PMID: 24726012] (Flow Cytometry, Human)
• Clay C, Donart N, Fomukong N, Knight J, Overheim K, Tipper J, Van Westrienen J, Hahn F, Harrod K Severe acute respiratory syndrome-coronavirus infection in aged nonhuman primates is associated with modulated pulmonary and systemic immune responses. Immun Ageing, 2014-03-19;11(1):4. 2014-03-19 [PMID: 24642138] (Flow Cytometry, Primate - Chlorocebus pygerythrus (Vervet Monkey))
• Morandi , Fabio, Di Carlo , Emma, Ferrone , Soldano, Petretto , Andrea, Pistoia , Vito, Airoldi , Irma IL-27 in human secondary lymphoid organs attracts myeloid dendritic cells and impairs HLA class I-restricted antigen presentation. J Immunol, 2014-02-19;192(6):2634-42. 2014-02-19 [PMID: 24554774] (Flow Cytometry, Human)
• Alejenef A, Pachnio A, Halawi M, Christmas S, Moss P, Khan N Cytomegalovirus drives Vdelta2neg gammadelta T cell inflation in many healthy virus carriers with increasing age. Clin Exp Immunol, 2014-06-01;176(3):418-28. 2014-06-01 [PMID: 24547915] (Flow Cytometry, Human)
• Lehmann , Dorit, Spanholtz , Jan, Sturtzel , Caterina, Tordoir , Marleen, Schlechta , Bernhard, Groenewegen , Dirk, Hofer , Erhard IL-12 directs further maturation of ex vivo differentiated NK cells with improved therapeutic potential. PLoS ONE, 2014-01-31;9(1):e87131. 2014-01-31 [PMID: 24498025] (Flow Cytometry, Human)
• Wong J, Muthuswamy R, Bartlett D, Kalinski P IL-18-based combinatorial adjuvants promote the intranodal production of CCL19 by NK cells and dendritic cells of cancer patients. Oncoimmunology, 2013-09-12;2(9):e26245. 2013-09-12 [PMID: 24228233] (Flow Cytometry, Human)
• Pradier A, Tabone-Eglinger S, Huber V, Bosshard C, Rigal E, Wehrle-Haller B, Roosnek E Peripheral blood CD56(bright) NK cells respond to stem cell factor and adhere to its membrane-bound form after upregulation of c-kit. Eur J Immunol, 2013-11-20;44(2):511-20. 2013-11-20 [PMID: 24150691] (Flow Cytometry, Human)
• Lecuroux C, Saez-Cirion A, Girault I, Versmisse P, Boufassa F, Avettand-Fenoel V, Rouzioux C, Meyer L, Pancino G, Lambotte O, Sinet M, Venet A Both HLA-B*57 and plasma HIV RNA levels contribute to the HIV-specific CD8+ T cell response in HIV controllers. J Virol, 2013-10-16;88(1):176-87. 2013-10-16 [PMID: 24131719] (Flow Cytometry, Human)
• Pritz T, Landgraf-Rauf K, Herndler-Brandstetter D, Rauf R, Lair J, Gassner R, Weinberger B, Krismer M, Grubeck-Loebenstein B Bone marrow T cells from the femur are similar to iliac crest derived cells in old age and represent a useful tool for studying the aged immune system. Immun Ageing, 2013-05-04;10(1):17. 2013-05-04 [PMID: 23642143] (Flow Cytometry, Human)
• Alonzo , Francis, Kozhaya , Lina, Rawlings , Stephen, Reyes-Robles , Tamara, DuMont , Ashley L, Myszka , David G, Landau , Nathanie, Unutmaz , Derya, Torres , Victor J CCR5 is a receptor for Staphylococcus aureus leukotoxin ED. Nature, 2012-12-12;493(7430):51-5. 2012-12-12 [PMID: 23235831] (Human)
• Le Friec G, Sheppard D, Whiteman P, Karsten C, Shamoun S, Laing A, Bugeon L, Dallman M, Melchionna T, Chillakuri C, Smith R, Drouet C, Couzi L, Fremeaux-Bacchi V, Kohl J, Waddington S, McDonnell J, Baker A, Handford P, Lea S, Kemper C The CD46-Jagged1 interaction is critical for human TH1 immunity. Nat Immunol, 2012-10-21;13(12):1213-21. 2012-10-21 [PMID: 23086448] (Flow Cytometry, Human)
• Sato W, Tomita A, Ichikawa D, Lin Y, Kishida H, Miyake S, Ogawa M, Okamoto T, Murata M, Kuroiwa Y, Aranami T, Yamamura T CCR2+CCR5+ T Cells Produce Matrix Metalloproteinase-9 and Osteopontin in the Pathogenesis of Multiple Sclerosis. J Immunol, 2012-10-15;189(10):5057-65. 2012-10-15 [PMID: 23071279] (Flow Cytometry, Human)
• Wang W, Yu D, Sarnaik A, Yu B, Hall M, Morelli D, Zhang Y, Zhao X, Weber J Biomarkers on melanoma patient T cells associated with ipilimumab treatment. J Transl Med, 2012-07-12;10(0):146. 2012-07-12 [PMID: 22788688] (Flow Cytometry, Human)
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Bioinformatics

• Gene Symbol: CCR7
• Uniprot:
  • AAA58615()