Capicua Antibody


Immunocytochemistry/ Immunofluorescence: Capicua Antibody [NB110-59905] - Capicua antibody was tested in Neuro 2A cells with DyLight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight more
Immunoprecipitation: Capicua Antibody [NB110-59905] - Detection of Human CIC/Capicua by WB of IPs. Whole cell lysate from HeLa cells. Affinity purified rabbit NB110-59905 used for IP at 3 mcg/mg lysate. CIC was also more

Product Details

Reactivity Hu, Mu, Rt, CaSpecies Glossary
Applications ICC/IF, IP, WB (-)
1 mg/ml

Capicua Antibody Summary

The epitope recognized by this antibody maps to a region within residue 1150-1200 of human Capicua. [NP_055940.3]
Immunogen affinity purified
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  • Immunocytochemistry/Immunofluorescence 1:500
  • Immunoprecipitation 2-5 ug/mg lysate
Application Notes
This Capicua antibody is useful for Immunocytochemistry/Immunofluorescence and Immunoprecipitation. It is not recommended for Western blot analysis. With ICC/IF nuclear staining was observed in Neuro2A cells. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
164 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Positive Control
Capicua Lysate (NBP2-64848)

Reactivity Notes

Human, mouse, rat, canine.

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.02% Sodium Azide
1 mg/ml
Immunogen affinity purified

Alternate Names for Capicua Antibody

  • capicua homolog (Drosophila)
  • KIAA0306capicua (Drosophila) homolog
  • protein capicua homolog


Capicua is a transcriptional repressor protein belonging to HMG-box proteins which has been suggested to play a key role in CNS development and is expressed in foetal brain as well as medulloblastomas. Capicua protein expression levels are subject to posttranscriptional regulation by signaling downstream of two RTKs - EGFR and Torso (that propagate their signals through Ras-Raf-MAPK signaling cascade) and MAPK-mediated phosphorylation promotes capicua degradation. Capicua has been shown to act as a transcriptional repressor through interaction with a co-repressor Groucho. Moreover, Bantam which is a Hippo pathway player has recently been shown to acts in a feedback loop to limit Capicua expression for regulating EGFR signaling. Capicua is well conserved in mammals, and mediates RTK-dependent responses that are linked to cell proliferation, cell differentiation and cancer. Capicua can interact with ATXN1 as well as ATXN1L, and has been shown to be involved in Spinocerebellar Ataxia Type 1 (SCA-1).


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

View specific protocols for Capicua Antibody (NB110-59905): Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

ICC/IF Video Protocol

FAQs for Capicua Antibody (NB110-59905). (Showing 1 - 1 of 1 FAQ).

  1. Does this antibody work in Drosophila or Zebrafish?
    • I have checked the % homology between human capicua (which is what the Ab is raised to) and between drosophilia and Zebrafish capicua. The % homoloy with Drosophilia is only 27 % and our lab only recommends use if the % homology is 85% or above. The % homology with Zebrafish is only 42% so I would not recommend this either. Unfortunately all of our Capicua Anitbodies recognize the human protein therefore we do not have an antibody that would recognize Zebrafish or Drosophila Capicua.

Positive Control Lysate(s)

Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NB110-59905AF405
Alexa Fluor 488 Labeled NB110-59905AF488
Alexa Fluor 647 Labeled NB110-59905AF647
Alexa Fluor 700 Labeled NB110-59905AF700
Biotin Labeled NB110-59905B
DyLight 405 Labeled NB110-59905V
DyLight 488 Labeled NB110-59905G
DyLight 550 Labeled NB110-59905R
DyLight 650 Labeled NB110-59905C
FITC Labeled NB110-59905F
HRP Labeled NB110-59905H

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Gene Symbol CIC