Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, Mycoplasma
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt, Ca
Applications: ICC/IF, IP, WB (-)
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, IP
Host: Rabbit Polyclonal
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
CIC, a human homolog of Drosophila capicua, encodes a high mobility group box transcription factor and is fused to a double homeodomain gene DUX4 as a result of a recurrent chromosomal translocation. It is involved in epidermal growth factor receptor (EGFR) signaling, developmental patterning, and cell fate. In humans, CIC may be involved in granule cell lineage, cerebellar development, and medulloblastoma tumorigenesis. Recent evidence indicates that CIC is involved in Spinocerebellar Ataxia Type 1 (SCA-1) where it interacts directly with the product of the SCA-1 gene Ataxin-1.
Bioinformatics
| Entrez |
Human
Rat
Mouse
|
| Uniprot |
Human
|
| Product By Gene ID |
23152 |
| Alternate Names |
- capicua homolog (Drosophila)
- KIAA0306capicua (Drosophila) homolog
- protein capicua homolog
|
Research Areas for Capicua
Find related products by research area and learn more about each of the different research areas below.
CancerNeuroscience
