Human C-Reactive Protein/CRP DuoSet ELISA, 15 Plate



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Reactivity HuSpecies Glossary
Applications ELISA

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Human C-Reactive Protein/CRP DuoSet ELISA, 15 Plate Summary

Assay Type
Solid Phase Sandwich ELISA
See PDF Datasheet for details
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details


Application Notes
No significant interference observed with available related molecules.
Read Publications using DY1707.

Packaging, Storage & Formulations

Store the unopened product at 2 - 8 °C. Do not use past expiration date.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human C-Reactive Protein/CRP DuoSet ELISA, 15 Plate

  • C-Reactive Protein
  • C-reactive protein, pentraxin-related
  • CRP
  • MGC88244
  • pentraxin 1
  • PTX1MGC149895


C-Reactive Protein (CRP), also known as Pentraxin 1, is a non-glycosylated protein in the Pentraxin family that also includes Pentraxin 2/SAP and Pentraxin 3/TSG-14. CRP functions as a sensor and activator of the innate immune response (1). In humans, it is a major acute-phase protein; its circulating concentration is dramatically elevated at the onset of inflammation (2). In mice, however, serum CRP levels increase only slightly during inflammation, and the analogous acute phase role is filled by Pentraxin 2 (3). CRP assembles non-covalently into a 110-120 kDa cyclical pentamer (4). Mature human CRP shares 71% and 64% amino acid (aa) sequence identity with mouse and rat CRP, respectively (5). 
CRP binds and opsonizes apoptotic cells (6-8) as well as bacteria such as S. pneumoniae (9, 10). It subsequently enhances the phagocytosis of these opsonized cells (6, 8-10). CRP additionally binds several proteins in the complement cascade including C1q, C4BP, and Factor H (8, 11-13). It enhances activation of the classical complement pathway and the deposition of C3b (9). In later stages of the response, CRP inhibits complement-mediated cell lysis through its binding to C4BP and Factor H (8, 12). These interactions induce the upregulation of complement inhibitory proteins CD46, CD59, and CD55/DAF and inhibit assembly of the membrane attack complex (MAC) (8, 14). 
CRP binds to Fc gamma RI, Fc gamma RIIA, and Fc gamma RIIB on macrophages and dendritic cells (15-17), and Fc receptors are required for the phagocytosis of CRP-opsonized target cells (6, 10, 18). CRP binding to Fc gamma RI induces Src activation which subsequently triggers the inhibitory Fc gamma RIIb and dampens the inflammatory response (15, 19). CRP additionally promotes dendritic cell maturation and humoral immunity (10). In cardiovascular disease, CRP binds to oxidized LDL, exacerbates tissue damage in coronary artery infarction, and inhibits the repair of injured vascular endothelium (7, 19, 20). 

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Publications for C-Reactive Protein/CRP (DY1707)(54)

We have publications tested in 2 confirmed species: Human, Porcine.

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Showing Publications 1 - 10 of 54. Show All 54 Publications.
Publications using DY1707 Applications Species
WJ Shon, MH Jung, Y Kim, GH Kang, EY Choi, DM Shin Sugar-sweetened beverages exacerbate high-fat diet-induced inflammatory bowel disease by altering the gut microbiome: Sweetened beverages enhance fat-induced IBD The Journal of nutritional biochemistry, 2022;0(0):109254. 2022 [PMID: 36572070] (Human) Human
MJM Silvis, EJ Demkes, L Timmers, F Arslan, SCA de Jager, JPG Sluijter, A Mosterd, DPV de Kleijn, L Bosch, GPJ van Hout NLRP3-Inflammasome Inhibition with IZD334 Does Not Reduce Cardiac Damage in a Pig Model of Myocardial Infarction Biomedicines, 2022;10(12):. 2022 [PMID: 36551811] (Porcine) Porcine
ML Sarangam, R Namazzi, D Datta, C Bond, CPB Vanderpool, RO Opoka, CC John, AL Conroy Intestinal Injury Biomarkers Predict Mortality in Pediatric Severe Malaria MBio, 2022;0(0):e0132522. 2022 [PMID: 36069443] (Human) Human
J Mohanraj, UJA D'Souza, SY Fong, IR Karkada, H Jaiprakash Association between Leptin (G2548A) and Leptin Receptor (Q223R) Polymorphisms with Plasma Leptin, BMI, Stress, Sleep and Eating Patterns among the Multiethnic Young Malaysian Adult Population from a Healthcare University Oncogene, 2022;19(14):. 2022 [PMID: 35886710] (Human) Human
HM Demerdash, AA Sabry, OE Arida Impact of Zinc to Copper Ratio and Lipocalin 2 in Obese Patients Undergoing Sleeve Gastrectomy Oncogene, 2022;2022(0):9278531. 2022 [PMID: 35722455] (Human) Human
R Palika, T Dasi, S Ghosh, R Peter, DJ Parasannan, AS Pradhan, AV Kurpad, HS Sachdev, B Kulkarni, R Pullakhand Efficacy of iron-folic acid treatment for reducing anemia prevalence and improving iron status in women of reproductive age: A one-year longitudinal study Clinical Nutrition ESPEN, 2022;49(0):390-397. 2022 [PMID: 35623842] (Human) Human
C Pham, S Bekkering, M O'Hely, D Burgner, S Thomson, P Vuillermin, F Collier, W Marx, T Mansell, C Symeonides, PD Sly, M Lk Tang, R Saffery, AL Ponsonby Infant inflammation predicts childhood emotional and behavioral problems and partially mediates socioeconomic disadvantage Brain, Behavior, and Immunity, 2022;0(0):. 2022 [PMID: 35618227] (Human) Human
T Mansell, R Saffery, S Burugupall, AL Ponsonby, MLK Tang, M O'Hely, S Bekkering, AAT Smith, R Rowland, S Ranganatha, PD Sly, P Vuillermin, F Collier, P Meikle, D Burgner, Barwon Inf Early life infection and proinflammatory, atherogenic metabolomic and lipidomic profiles in infancy: a population-based cohort study Elife, 2022;11(0):. 2022 [PMID: 35535496] (Human) Human
MH Schutte, R Kleemann, NM Nota, CM Wiepjes, JM Snabel, G T'Sjoen, A Thijs, M den Heijer The effect of transdermal gender-affirming hormone therapy on markers of inflammation and hemostasis PLoS ONE, 2022;17(3):e0261312. 2022 [PMID: 35290388] (Human) Human
S Hakki, EJ Robinson, MG Robson Circulating Interleukin-6 and CD16 positive monocytes increase following angioplasty of an arteriovenous fistula Scientific Reports, 2022;12(1):1427. 2022 [PMID: 35082332] (Human) Human
Show All 54 Publications.

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Gene Symbol CRP