Human C-Reactive Protein/CRP DuoSet ELISA, 15 Plate

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
Biotin

Order Details

Human C-Reactive Protein/CRP DuoSet ELISA, 15 Plate Summary

Source
N/A
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
CRP

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DY1707.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human C-Reactive Protein/CRP DuoSet ELISA, 15 Plate

  • C-Reactive Protein
  • C-reactive protein, pentraxin-related
  • CRP
  • MGC88244
  • pentraxin 1
  • PTX1MGC149895

Background

C-Reactive Protein (CRP), also known as Pentraxin 1, is a non-glycosylated protein in the Pentraxin family that also includes Pentraxin 2/SAP and Pentraxin 3/TSG-14. CRP functions as a sensor and activator of the innate immune response (1). In humans, it is a major acute-phase protein; its circulating concentration is dramatically elevated at the onset of inflammation (2). In mice, however, serum CRP levels increase only slightly during inflammation, and the analogous acute phase role is filled by Pentraxin 2 (3). CRP assembles non-covalently into a 110-120 kDa cyclical pentamer (4). Mature human CRP shares 71% and 64% amino acid (aa) sequence identity with mouse and rat CRP, respectively (5). 
CRP binds and opsonizes apoptotic cells (6-8) as well as bacteria such as S. pneumoniae (9, 10). It subsequently enhances the phagocytosis of these opsonized cells (6, 8-10). CRP additionally binds several proteins in the complement cascade including C1q, C4BP, and Factor H (8, 11-13). It enhances activation of the classical complement pathway and the deposition of C3b (9). In later stages of the response, CRP inhibits complement-mediated cell lysis through its binding to C4BP and Factor H (8, 12). These interactions induce the upregulation of complement inhibitory proteins CD46, CD59, and CD55/DAF and inhibit assembly of the membrane attack complex (MAC) (8, 14). 
CRP binds to Fc gamma RI, Fc gamma RIIA, and Fc gamma RIIB on macrophages and dendritic cells (15-17), and Fc receptors are required for the phagocytosis of CRP-opsonized target cells (6, 10, 18). CRP binding to Fc gamma RI induces Src activation which subsequently triggers the inhibitory Fc gamma RIIb and dampens the inflammatory response (15, 19). CRP additionally promotes dendritic cell maturation and humoral immunity (10). In cardiovascular disease, CRP binds to oxidized LDL, exacerbates tissue damage in coronary artery infarction, and inhibits the repair of injured vascular endothelium (7, 19, 20). 

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Publications for C-Reactive Protein/CRP (DY1707)(65)

We have publications tested in 2 confirmed species: Human, Porcine.


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Human
(64)
Porcine
(1)
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Showing Publications 1 - 10 of 65. Show All 65 Publications.
Publications using DY1707 Applications Species
Li, W;Pucka, AQ;Debats, C;Reyes, B;Syed, F;O'Brien, AR;Mehta, R;Manchanda, N;Jacob, SA;Hardesty, BM;Greist, A;Harte, SE;Harris, RE;Yu, Q;Wang, Y; Inflammation and autoimmunity are interrelated in patients with sickle cell disease at a steady-state condition: implications for vaso-occlusive crisis, pain, and sensory sensitivity medRxiv : the preprint server for health sciences 2023-09-05 [PMID: 37732268] (Human) Human
Wolny, M;Rozanova, S;Knabbe, C;Pfeiffer, K;Barkovits, K;Marcus, K;Birschmann, I; Changes in the Proteome of Platelets from Patients with Critical Progression of COVID-19 Cells 2023-09-01 [PMID: 37681923] (Human) Human
Ghosh, S;Palika, R;Dasi, T;Varshney, RK;Parasannanavar, DJ;Sen Gupta, S;Chitikineni, A;Banjara, SK;Pullakhandam, R;Thomas, T;Sachdev, HS;Kurpad, AV;Kulkarni, B; Haemoglobin diagnostic cut-offs for anaemia in Indian women of reproductive age European journal of clinical nutrition 2023-08-03 [PMID: 37537294] (Human) Human
Moore, LE;Brotto, AR;Fuhr, DP;Rosychuk, RJ;Wong, E;Bhutani, M;Stickland, MK; Impact of airway challenges on cardiovascular risk in asthma - a randomized controlled trial PloS one 2023-07-17 [PMID: 37459335] (Human) Human
Schmidt-Morgenroth, I;Michaud, P;Gasparini, F;Avrameas, A; Central and Peripheral Inflammation in Mild Cognitive Impairment in the Context of Alzheimer's Disease International journal of molecular sciences 2023-06-23 [PMID: 37445700] (Human) Human
Sominsky, L;O'Hely, M;Drummond, K;Cao, S;Collier, F;Dhar, P;Loughman, A;Dawson, S;Tang, ML;Mansell, T;Saffery, R;Burgner, D;Ponsonby, AL;Vuillermin, P;Barwon Infant Study Investigator Group, ; Pre-pregnancy obesity is associated with greater systemic inflammation and increased risk of antenatal depression Brain, behavior, and immunity 2023-07-10 [PMID: 37437818] (Human) Human
Chang, JP;Chang, SS;Chen, HT;Chien, YC;Yang, HT;Huang, SY;Tseng, PT;Chang, CH;Galecki, P;Su, KP; Omega-3 polyunsaturated fatty acids (n-3 PUFAs), somatic and fatigue symptoms in cardiovascular diseases comorbid major depressive disorder (MDD): A randomized controlled trial Brain, behavior, and immunity 2023-06-09 [PMID: 37301235] (Human) Human
Metz, CN;Xue, X;Chatterjee, PK;Adelson, R;Brines, M;Tracey, KJ;Gregersen, PK;Pavlov, VA; Increased plasma lipopolysaccharide-binding protein and altered inflammatory mediators in overweight women suggest a state of subclinical endotoxemia bioRxiv : the preprint server for biology 2023-05-22 [PMID: 37293028] (Human) Human
Meade, RD;Notley, SR;Akerman, AP;McCormick, JJ;King, KE;Sigal, RJ;Kenny, GP; Efficacy of Cooling Centers for Mitigating Physiological Strain in Older Adults during Daylong Heat Exposure: A Laboratory-Based Heat Wave Simulation Environmental health perspectives 2023-06-01 [PMID: 37262028] (Human) Human
N Balanza, C Erice, M Ngai, CR McDonald, AM Weckman, J Wright, M Richard-Gr, R Varo, E López-Vare, A Sitoe, P Vitorino, J Bramugy, M Lanaspa, S Acácio, L Madrid, B Baro, KC Kain, Q Bassat Prognostic accuracy of biomarkers of immune and endothelial activation in Mozambican children hospitalized with pneumonia PLOS global public health, 2023-02-23;3(2):e0001553. 2023-02-23 [PMID: 36963048] (Human) Human
Show All 65 Publications.

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Bioinformatics

Gene Symbol CRP