This Blimp-1 (3H2-E8) antibody is useful for ELISA, Immunocytochemistry/Immunofluorescence, Western Blot, Immunohistochemistry on paraffin-embedded sections and Flow Cytometry. Immunohistochemistry-Frozen was reported in scientific literature. By WB, this antibody recognizes a band at ~98 kDa and may recognize one at ~80 kDa (the beta form). Antigen retrieval is recommended (EDTA buffer, microwave) prior to IHC on paraffin tissues. This antibody demonstrates nuclear staining. This antibody does not immunoprecipitate. For IHC and ICC/IF a dilution of 1:200 is recommended with tyramide amplification.
beta-interferon gene positive-regulatory domain I binding factor
B-lymphocyte-induced maturation protein 1
Positive regulatory domain I-binding factor 1
PR domain containing 1, with ZNF domain
PR domain zinc finger protein 1
PR domain-containing protein 1
PRDI-binding factor 1
PR-domain zinc finger protein 1
Blimp-1 (B lymphocyte maturation protein-1) is a nuclear protein with five zinc fingers in its carboxy terminus. It is a transcriptional repressor that is both required and sufficient to trigger terminal differentiation of B lymphocytes and monocyte/macrophages. Blimp-1 is expressed in, and may be required for terminally differentiated epithelial cells, retinal neurons and other lineage cells. It has also been implicated in the repression of beta-interferon (IFN-beta) and c-myc gene expression.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.