Mouse IL-5 Quantikine ELISA Kit, 2 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: HRP

Mouse IL-5 Quantikine ELISA Kit, 2 Plate Summary

• Background: The Quantikine Mouse IL-5 Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse IL-5 in cell culture supernates and mouse serum. It contains Sf 21-expressed recombinant mouse IL-5 and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate recombinant mouse IL-5. Results obtained using natural mouse IL-5 showed linea...r curves that were parallel to the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse IL-5.
  Show More
• Specificity: Natural and recombinant mouse IL-5
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Il5

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse IL-5 Quantikine ELISA Kit, 2 Plate

• BCDF mu
• B-cell differentiation factor I
• BCGFII
• EDF
• Eo-CSF
• Eosinophil differentiation factor
• IL5
• IL-5
• IL-5T-cell replacing factor
• interleukin 5 (colony-stimulating factor, eosinophil)
• interleukin-5
• TRF
• TRFB cell differentiation factor I

Background

IL-5 (Interleukin-5) is a secreted cytokine that is expressed as a covalent dimer. It is produced by activated Th2 cells, eosinophils, mast cells, and iNKT cells and promotes eosinophilic and basophilic differentiation and activation. IL-5 signals through a receptor complex containing IL-5 R alpha and the Common beta Chain/CD131 on eosinophils and basophils. Naturally occurring soluble forms of IL-5 R alpha retain the ability to bind IL-5 and limit its bioavailability.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for IL-5 (M5000)(95)

Publications using M5000

• Arai, K;Toyonaga, H;Cheng, L;Tanaka, H; Th2 Suppression Through Antigen Liver Expression Using mRNA-LNP Technology Biomedicines 2025-09-19 [PMID: 41007857] (Mouse)
• Woo, JH;Song, MK;Baek, SH;Park, CJ;Kim, JW;Kim, B;Lee, K; Polystyrene particles induces asthma-like Th2-mediated lung injury through IL-33 secretion Environment international 2025-09-08 [PMID: 40926454] (Mouse)
• Fang, Y;Liu, Y;Chen, L;Wang, J;Zhang, J;Zhang, H;Tian, S;Zhang, A;Zhang, J;Zhang, JH;Wang, X;Yu, J;Chen, S; Cerebrospinal fluid markers of neuroinflammation and coagulation in severe cerebral edema and chronic hydrocephalus after subarachnoid hemorrhage: a prospective study Journal of neuroinflammation 2024-09-27 [PMID: 39334416] (Mouse)
• Cao, Z;Wang, J;Liu, X;Liu, Y;Li, F;Liu, M;Chiu, S;Jin, X; Helminth alleviates COVID-19-related cytokine storm in an IL-9-dependent way mBio 2024-05-10 [PMID: 38727220] (Mouse)
• Jin, J;Fan, YJ;Nguyen, TV;Yu, ZN;Song, CH;Lee, SY;Shin, HS;Chai, OH; Fallopia japonica Root Extract Ameliorates Ovalbumin-Induced Airway Inflammation in a CARAS Mouse Model by Modulating the IL-33/TSLP/NF-?B Signaling Pathway International journal of molecular sciences 2023-08-07 [PMID: 37569890] (Mouse)
• Irie, M;Kabata, H;Sasahara, K;Kurihara, M;Shirasaki, Y;Kamatani, T;Baba, R;Matsusaka, M;Koga, S;Masaki, K;Miyata, J;Araki, Y;Kikawada, T;Kabe, Y;Suematsu, M;Yamagishi, M;Uemura, S;Moro, K;Fukunaga, K; Annexin A1 is a cell-intrinsic metalloregulator of zinc in human ILC2s Cell reports 2023-06-07 [PMID: 37294636] (Mouse, Transgenic Mouse)
• Y Song, J Jiang, Q Bai, S Liu, Y Zhang, C Xu, H Piao, L Li, G Yan Gene expression profiles and bioinformatics analysis in lung samples from ovalbumin-induced asthmatic mice BMC pulmonary medicine, 2023-02-02;23(1):50. 2023-02-02 [PMID: 36726128] (Mouse)
• KE Block, K Iijima, MJ Pierson, DA Walsh, R Tei, TA Kucaba, J Xu, MH Khan, C Staley, TS Griffith, HJ McSorley, H Kita, SC Jameson Physiological microbial exposure transiently inhibits mouse lung ILC2 responses to allergens Nature Immunology, 2022-11-21;0(0):. 2022-11-21 [PMID: 36411381] (Mouse)
• W Chang, H Lv, L Tan, Z Gao, P Liu, D Qin, W Zhang, Y Xu Downregulation of deubiquitinating enzyme USP25 promotes the development of allergic rhinitis by enhancing TSLP signaling in the nasal epithelium Molecular Medicine Reports, 2022-09-30;26(5):. 2022-09-30 [PMID: 36177892] (Mouse, Transgenic Mouse)
• JO Lim, YH Kim, IS Lee, WI Kim, SJ Lee, SW Pak, IS Shin, T Kim Cinnamomum cassia (L.) J.Presl Alleviates Allergic Responses in Asthmatic Mice via Suppression of MAPKs and MMP-9 Frontiers in Pharmacology, 2022-08-11;13(0):906916. 2022-08-11 [PMID: 36034804] (Mouse)
• A Kanamori, F Tanaka, M Ominami, Y Nadatani, S Fukunaga, K Otani, S Hosomi, N Kamata, Y Nagami, K Taira, Y Fujiwara Psychological Stress Exacerbates Inflammation of the Ileum via the Corticotropin-Releasing Hormone-Mast Cell Axis in a Mouse Model of Eosinophilic Enteritis International Journal of Molecular Sciences, 2022-08-01;23(15):. 2022-08-01 [PMID: 35955675] (Mouse)
• DH Lee, HK Park, HR Lee, H Sohn, S Sim, HJ Park, YS Shin, YK Kim, Y Choi, HS Park Immunoregulatory effects of Lactococcus lactis-derived extracellular vesicles in allergic asthma Clinical and translational allergy, 2022-03-01;12(3):e12138. 2022-03-01 [PMID: 35344296] (Mouse)
• JH Chang, HC Chuang, G Hsiao, TY Hou, CC Wang, SC Huang, BY Li, YL Lee Acteoside exerts immunomodulatory effects on dendritic cells via aryl hydrocarbon receptor activation and ameliorates Th2-mediated allergic asthma by inducing Foxp3+ regulatory T cells International immunopharmacology, 2022-02-03;106(0):108603. 2022-02-03 [PMID: 35123286] (Mouse)
• JQ Liu, XR Geng, TY Hu, LH Mo, XQ Luo, SY Qiu, DB Liu, ZG Liu, JB Shao, ZQ Liu, PC Yang Glutaminolysis is required in maintaining immune regulatory functions in B cells Mucosal Immunology, 2022-01-10;0(0):. 2022-01-10 [PMID: 35013572] (Mouse)
• Y Lu, Y Huang, J Li, J Huang, L Zhang, J Feng, J Li, Q Xia, Q Zhao, L Huang, S Jiang, S Su Eosinophil extracellular traps drive asthma progression through neuro-immune signals Nature Cell Biology, 2021-10-06;23(10):1060-1072. 2021-10-06 [PMID: 34616019] (Mouse)
• S Lee, A Ishitsuka, T Kuroki, YH Lin, A Shibuya, T Hongu, Y Funakoshi, Y Kanaho, K Nagata, A Kawaguchi Arf6 exacerbates allergic asthma through cell-to-cell transmission of ASC inflammasomes JCI Insight, 2021-08-23;6(16):. 2021-08-23 [PMID: 34423792] (Mouse)
• Y Song, X Li, F Liu, H Zhu, Y Shen Isoalantolactone alleviates ovalbumin?induced asthmatic inflammation by reducing alternatively activated macrophage and STAT6/PPAR?gamma/KLF4 signals Molecular Medicine Reports, 2021-08-09;24(4):. 2021-08-09 [PMID: 34368878] (Mouse)
• W Wei, W Chen, N He HDAC4 induces the development of asthma by increasing Slug-upregulated CXCL12 expression through KLF5 deacetylation Journal of Translational Medicine, 2021-06-12;19(1):258. 2021-06-12 [PMID: 34118928] (Mouse)
• LT Wang, MH Lin, KY Liu, SS Chiou, SN Wang, CY Chai, LW Tseng, HC Chiou, HC Wang, KK Yokoyama, SH Hsu, SK Huang WLS/wntless is essential in controlling dendritic cell homeostasis via a WNT signaling-independent mechanism Autophagy, 2021-04-14;0(0):1-16. 2021-04-14 [PMID: 33853474] (Mouse)
• Á Rol, T Todorovski, P Martin-Mal, A Escolà, E Gonzalez-R, E Aragón, X Verdaguer, M Vallès-Mir, J Farrera-Si, E Puig, J Fernández-, B Ponsati, M Delgado, A Riera, MJ Macias Structure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease Nature Communications, 2021-03-25;12(1):1869. 2021-03-25 [PMID: 33767180] (Mouse)
• E Saba, YY Lee, MH Rhee, SD Kim Alleviation of Ulcerative Colitis Potentially through th1/th2 Cytokine Balance by a Mixture of Rg3-enriched Korean Red Ginseng Extract and Persicaria tinctoria Molecules, 2020-11-10;25(22):. 2020-11-10 [PMID: 33182623] (Mouse)
• W Zhou, J Zhang, S Toki, K Goleniewsk, AE Norlander, DC Newcomb, P Wu, KL Boyd, H Kita, RS Peebles COX Inhibition Increases Alternaria-Induced Pulmonary Group 2 Innate Lymphoid Cell Responses and IL-33 Release in Mice J. Immunol., 2020-07-20;0(0):. 2020-07-20 [PMID: 32690653] (Mouse)
• T Sasaki, K Moro, T Kubota, N Kubota, T Kato, H Ohno, S Nakae, H Saito, S Koyasu Innate Lymphoid Cells in the Induction of Obesity Cell Rep, 2019-07-02;28(1):202-217.e7. 2019-07-02 [PMID: 31269440] (Mouse)
• CT Wu, FH Lin, YT Lee, MS Ku, KH Lue Effect of Lactobacillus rhamnosus GG immunopathologic changes in chronic mouse asthma model J Microbiol Immunol Infect, 2019-03-23;0(0):. 2019-03-23 [PMID: 30952512] (Mouse)
• I Sulaiman, K Tan, N Mohtarrudi, JC Woei Lim, J Stanslas Andrographolide prevented toluene diisocyanate-induced occupational asthma and aberrant airway E-cadherin distribution via p38 MAPK-dependent Nrf2 induction Pulm Pharmacol Ther, 2018-09-21;0(0):. 2018-09-21 [PMID: 30244166] (Mouse)
• Z Dong, Y Yuan Accelerated inflammation and oxidative stress induced by LPS in acute lung injury: ?nhibition by ST1926 Int. J. Mol. Med., 2018-03-19;0(0):. 2018-03-19 [PMID: 29568857] (Mouse)
• N Malhotra, JM Leyva-Cast, U Jadhav, O Barreiro, C Kam, NK O'Neill, F Meylan, P Chambon, UH von Andria, RM Siegel, EC Wang, R Shivdasani, RS Geha ROR?-expressing T regulatory cells restrain allergic skin inflammation Sci Immunol, 2018-03-02;3(21):. 2018-03-02 [PMID: 29500225] (Mouse)
• M Yamaguchi, SK Samuchiwal, O Quehenberg, JA Boyce, B Balestrier Macrophages regulate lung ILC2 activation via Pla2g5-dependent mechanisms Mucosal Immunol, 2017-12-20;11(3):615-626. 2017-12-20 [PMID: 29346348] (Mouse)
• C Zhang, W Yi, F Li, X Du, H Wang, P Wu, C Peng, M Luo, W Hua, CC Wong, JJ Lee, W Li, Z Chen, S Ying, Z Ju, H Shen Eosinophil-derived CCL-6 impairs hematopoietic stem cell homeostasis Cell Res., 2018-01-12;0(0):. 2018-01-12 [PMID: 29327730] (Mouse)
• J Youm, H Lee, HB Chang, J Jeon, MH Yoon, JY Woo, MS Choi, Y Hwang, S Seong, K Na, J Yoon Justicia procumbens Extract (DW2008) Selectively Suppresses Th2 Cytokines in Splenocytes and Ameliorates Ovalbumin-Induced Airway Inflammation in a Mouse Model of Asthma Biol. Pharm. Bull., 2017-01-01;40(9):1416-1422. 2017-01-01 [PMID: 28867724] (Mouse)
• YT Lee, CT Wu, HL Sun, JL Ko, KH Lue Fungal immunomodulatory protein-fve could modulate airway remodel through by affect IL17 cytokine J Microbiol Immunol Infect, 2017-06-29;0(0):. 2017-06-29 [PMID: 28709839] (Mouse)
• MT Stier, K Goleniewsk, JY Cephus, DC Newcomb, TP Sherrill, KL Boyd, MH Bloodworth, ML Moore, K Chen, JK Kolls, RS Peebles STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral Infection J. Immunol., 2017-06-02;0(0):. 2017-06-02 [PMID: 28576981] (Mouse)
• Y Sato, H Kato, R Ebina-Shib, A Itoh-Nakad, R Okuyama, K Igarashi Bach2 Controls Homeostasis of Eosinophils by Restricting the Type-2 Helper Function of T Cells Tohoku J. Exp. Med, 2017-03-01;241(3):175-182. 2017-03-01 [PMID: 28216546] (Mouse)
• Beneficial effects of Galectin-9 on allergen-specific sublingual immunotherapy in a Dermatophagoides farinae-induced mouse model�of chronic asthma Allergol Int, 2016-11-19;0(0):. 2016-11-19 [PMID: 27876361] (Mouse)
• Itoga M, Konno Y, Moritoki Y, Saito Y, Ito W, Tamaki M, Kobayashi Y, Kayaba H, Kikuchi Y, Chihara J, Takeda M, Ueki S, Hirokawa M G-protein-coupled estrogen receptor agonist suppresses airway inflammation in a mouse model of asthma through IL-10. PLoS ONE, 2015-03-31;10(3):e0123210. 2015-03-31 [PMID: 25826377] (Mouse)
• Mishra , Amarjit, Brown , Alexandr, Yao , Xianglan, Yang , Shutong, Park , Sung-Jun, Liu , Chengyu, Dagur , Pradeep, McCoy , J Philip, Keeran , Karen J, Nugent , Gayle Z, Jeffries , Kenneth, Qu , Xuan, Yu , Zu-Xi, Levine , Stewart, Chung , Jay H Dendritic cells induce Th2-mediated airway inflammatory responses to house dust mite via DNA-dependent protein kinase. Nat Commun, 2015-02-18;6(0):6224. 2015-02-18 [PMID: 25692509] (Mouse)
• Besnard A, Guabiraba R, Niedbala W, Palomo J, Reverchon F, Shaw T, Couper K, Ryffel B, Liew F IL-33-mediated protection against experimental cerebral malaria is linked to induction of type 2 innate lymphoid cells, M2 macrophages and regulatory T cells. PLoS Pathog, 2015-02-06;11(2):e1004607. 2015-02-06 [PMID: 25659095] (Mouse)
• Zhou W, Goleniewska K, Zhang J, Dulek D, Toki S, Lotz M, Newcomb D, Boswell M, Polosukhin V, Milne G, Wu P, Moore M, FitzGerald G, Peebles R Cyclooxygenase inhibition abrogates aeroallergen-induced immune tolerance by suppressing prostaglandin I2 receptor signaling. J Allergy Clin Immunol, 2014-07-18;134(3):698-705.e5. 2014-07-18 [PMID: 25042746] (Mouse)
• Hara K, Iijima K, Elias M, Seno S, Tojima I, Kobayashi T, Kephart G, Kurabayashi M, Kita H Airway uric acid is a sensor of inhaled protease allergens and initiates type 2 immune responses in respiratory mucosa. J Immunol, 2014-03-24;192(9):4032-42. 2014-03-24 [PMID: 24663677] (Mouse)
• Wong , Tina W, Doyle , Alfred D, Lee , James J, Jelinek , Diane F Eosinophils regulate peripheral B cell numbers in both mice and humans. J Immunol, 2014-03-10;192(8):3548-58. 2014-03-10 [PMID: 24616476] (Mouse)
• Mizutani N, Nabe T, Yoshino S Interleukin-33 and alveolar macrophages contribute to the mechanisms underlying the exacerbation of IgE-mediated airway inflammation and remodelling in mice. Immunology, 2013-06-01;139(2):205-18. 2013-06-01 [PMID: 23323935] (Mouse)
• Bartemes KR, Iijima K, Kobayashi T, Kephart GM, McKenzie AN, Kita H IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs. J. Immunol., 2011-12-23;188(3):1503-13. 2011-12-23 [PMID: 22198948] (Mouse)
• Yamamoto Y, Otani S, Hirai H, Nagata K, Aritake K, Urade Y, Narumiya S, Yokozeki H, Nakamura M, Satoh T Dual functions of prostaglandin D2 in murine contact hypersensitivity via DP and CRTH2. Am. J. Pathol., 2011-05-10;179(1):302-14. 2011-05-10 [PMID: 21703412] (Mouse)
• Besnard AG, Togbe D, Guillou N, Erard F, Quesniaux V, Ryffel B IL-33-activated dendritic cells are critical for allergic airway inflammation. Eur. J. Immunol., 2011-05-25;41(6):1675-86. 2011-05-25 [PMID: 21469105] (Mouse)
• Hirata H, Arima M, Fukushima Y, Honda K, Sugiyama K, Tokuhisa T, Fukuda T Over-expression of the LTC4 synthase gene in mice reproduces human aspirin-induced asthma. Clin. Exp. Allergy, 2011-03-24;41(8):1133-42. 2011-03-24 [PMID: 21429049] (Mouse)
• Louten J, Rankin AL, Li Y Endogenous IL-33 enhances Th2 cytokine production and T-cell responses during allergic airway inflammation. Int. Immunol., 2011-03-21;23(5):307-15. 2011-03-21 [PMID: 21422152] (Mouse)
• Sang W, Zhou C, Cheng N, Li Z, Zeng L, Xu K Control of mouse graft-versus-host disease following allogeneic bone marrow transplantation by blocking the CD28/B7 signaling pathway with lentiviral vector-mediated RNA interference. Immunol. Lett., 2011-01-26;136(2):194-202. 2011-01-26 [PMID: 21277900] (Mouse)
• Wright PL, Yu J, Di YP Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation. J. Exp. Med., 2010-10-25;207(12):2595-607. 2010-10-25 [PMID: 20975041] (Mouse)
• Mizutani N, Nabe T, Yoshino S Complement C3a regulates late asthmatic response and airway hyperresponsiveness in mice. J. Immunol., 2009-08-14;183(6):4039-46. 2009-08-14 [PMID: 19684087] (Mouse)
• Page K, Ledford JR, Zhou P, Wills-Karp M A TLR2 agonist in German cockroach frass activates MMP-9 release and is protective against allergic inflammation in mice. J. Immunol., 2009-08-10;183(5):3400-8. 2009-08-10 [PMID: 19667087] (Mouse)
• Kottyan LC, Collier AR, Cao KH, Niese KA, Hedgebeth M, Radu CG, Witte ON, Khurana Hershey GK, Rothenberg ME, Zimmermann N Eosinophil viability is increased by acidic pH in a cAMP- and GPR65-dependent manner. Blood, 2009-07-29;114(13):2774-82. 2009-07-29 [PMID: 19641187] (Mouse)
• Park SJ, Lee KS, Kim SR, Min KH, Choe YH, Moon H, Chae HJ, Yoo WH, Lee YC Peroxisome proliferator-activated receptor gamma agonist down-regulates IL-17 expression in a murine model of allergic airway inflammation. J. Immunol., 2009-07-29;183(5):3259-67. 2009-07-29 [PMID: 19641141] (Mouse)
• Zhang X, Gao L, Lei L, Zhong Y, Dube P, Berton MT, Arulanandam B, Zhang J, Zhong G A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum. J. Immunol., 2009-06-19;183(2):1291-300. 2009-06-19 [PMID: 19542374] (Mouse)
• Gueders MM, Paulissen G, Crahay C, Quesada-Calvo F, Hacha J, Van Hove C, Tournoy K, Louis R, Foidart JM, Noel A, Cataldo DD Mouse models of asthma: a comparison between C57BL/6 and BALB/c strains regarding bronchial responsiveness, inflammation, and cytokine production. Inflamm. Res., 2009-06-09;58(12):845-54. 2009-06-09 [PMID: 19506803] (Mouse)
• Park SK, Cho MK, Park HK, Lee KH, Lee SJ, Choi SH, Ock MS, Jeong HJ, Lee MH, Yu HS Macrophage migration inhibitory factor homologs of anisakis simplex suppress Th2 response in allergic airway inflammation model via CD4+CD25+Foxp3+ T cell recruitment. J. Immunol., 2009-06-01;182(11):6907-14. 2009-06-01 [PMID: 19454687] (Mouse)
• Johnson TR, Rao S, Seder RA, Chen M, Graham BS TLR9 agonist, but not TLR7/8, functions as an adjuvant to diminish FI-RSV vaccine-enhanced disease, while either agonist used as therapy during primary RSV infection increases disease severity. Vaccine, 2009-04-03;27(23):3045-52. 2009-04-03 [PMID: 19428918] (Mouse)
• Kim DY, Park JW, Jeoung D, Ro JY Celastrol suppresses allergen-induced airway inflammation in a mouse allergic asthma model. Eur. J. Pharmacol., 2009-04-05;612(1):98-105. 2009-04-05 [PMID: 19356734] (Mouse)
• Shinagawa K, Ploplis VA, Castellino FJ A severe deficiency of coagulation factor VIIa results in attenuation of the asthmatic response in mice. Am. J. Physiol. Lung Cell Mol. Physiol., 2009-03-13;296(5):L763-70. 2009-03-13 [PMID: 19286924] (Mouse)
• Palmer G, Talabot-Ayer D, Lamacchia C, Toy D, Seemayer CA, Viatte S, Finckh A, Smith DE, Gabay C Inhibition of interleukin-33 signaling attenuates the severity of experimental arthritis. Arthritis Rheum., 2009-03-01;60(3):738-49. 2009-03-01 [PMID: 19248109] (Mouse)
• Vultaggio A, Nencini F, Fitch PM, Fili L, Maggi L, Fanti P, deVries A, Beccastrini E, Palandri F, Manuelli C, Bani D, Giudizi MG, Guarna A, Annunziato F, Romagnani S, Maggi E, Howie SE, Parronchi P Modified adenine (9-benzyl-2-butoxy-8-hydroxyadenine) redirects Th2-mediated murine lung inflammation by triggering TLR7. J. Immunol., 2009-01-15;182(2):880-9. 2009-01-15 [PMID: 19124731] (Mouse)
• Zhou W, Newcomb DC, Moore ML, Goleniewska K, O'Neal JF, Peebles RS Cyclooxygenase inhibition during allergic sensitization increases STAT6-independent primary and memory Th2 responses. J. Immunol., 2008-10-15;181(8):5360-7. 2008-10-15 [PMID: 18832692] (Mouse)
• Heckman KL, Radhakrishnan S, Peikert T, Iijima K, McGregor HC, Bell MP, Kita H, Pease LR T-bet expression by dendritic cells is required for the repolarization of allergic airway inflammation. Eur. J. Immunol., 2008-09-01;38(9):2464-74. 2008-09-01 [PMID: 18819071] (Mouse)
• Moon DO, Kim MO, Lee HJ, Choi YH, Park YM, Heo MS, Kim GY Curcumin attenuates ovalbumin-induced airway inflammation by regulating nitric oxide. Biochem. Biophys. Res. Commun., 2008-08-13;375(2):275-9. 2008-08-13 [PMID: 18706396] (Mouse)
• Hirose K, Wakashin H, Oki M, Kagami S, Suto A, Ikeda K, Watanabe N, Iwamoto I, Furuichi Y, Nakajima H GS143, an IkappaB ubiquitination inhibitor, inhibits allergic airway inflammation in mice. Biochem. Biophys. Res. Commun., 2008-07-24;374(3):507-11. 2008-07-24 [PMID: 18656449] (Mouse)
• Ren Y, Lu L, Guo TB, Qiu J, Yang Y, Liu A, Zhang JZ Novel immunomodulatory properties of berbamine through selective down-regulation of STAT4 and action of IFN-gamma in experimental autoimmune encephalomyelitis. J. Immunol., 2008-07-15;181(2):1491-8. 2008-07-15 [PMID: 18606704] (Mouse)
• Oku H, Shimizu T, Kawabata T, Nagira M, Hikita I, Ueyama A, Matsushima S, Torii M, Arimura A Antifibrotic action of pirfenidone and prednisolone: different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis. Eur. J. Pharmacol., 2008-06-16;590(1):400-8. 2008-06-16 [PMID: 18598692] (Mouse)
• Johnson TR, Rothenberg ME, Graham BS Pulmonary eosinophilia requires interleukin-5, eotaxin-1, and CD4+ T cells in mice immunized with respiratory syncytial virus G glycoprotein. J. Leukoc. Biol., 2008-06-02;84(3):748-59. 2008-06-02 [PMID: 18519743] (Mouse)
• O'Brien LM, Fitzpatrick E, Baird AW, Campion DP Eosinophil-nerve interactions and neuronal plasticity in rat gut associated lymphoid tissue (GALT) in response to enteric parasitism. J. Neuroimmunol., 2008-05-20;197(1):1-9. 2008-05-20 [PMID: 18495257] (Rat)
• Jacobsen EA, Ochkur SI, Pero RS, Taranova AG, Protheroe CA, Colbert DC, Lee NA, Lee JJ Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells. J. Exp. Med., 2008-03-03;205(3):699-710. 2008-03-03 [PMID: 18316417] (Mouse)
• Maret M, Ruffie C, Periquet B, Campo AM, Menevret M, Phelep A, Dziewiszek K, Druilhe A, Pretolani M Liposomal retinoic acids modulate asthma manifestations in mice. J. Nutr., 2007-12-01;137(12):2730-6. 2007-12-01 [PMID: 18029491] (Mouse)
• Radinger M, Bossios A, Alm AS, Jeurink P, Lu Y, Malmhall C, Sjostrand M, Lotvall J Regulation of allergen-induced bone marrow eosinophilopoiesis: role of CD4+ and CD8+ T cells. Allergy, 2007-12-01;62(12):1410-8. 2007-12-01 [PMID: 17983375] (Mouse)
• Yoshimoto T, Yoshimoto T, Yasuda K, Mizuguchi J, Nakanishi K IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation. J. Immunol., 2007-10-01;179(7):4415-23. 2007-10-01 [PMID: 17878337] (Mouse)
• Denis O, van den Brule S, Heymans J, Havaux X, Rochard C, Huaux F, Huygen K Chronic intranasal administration of mould spores or extracts to unsensitized mice leads to lung allergic inflammation, hyper-reactivity and remodelling. Immunology, 2007-05-16;122(2):268-78. 2007-05-16 [PMID: 17506853] (Mouse)
• Daniel C, Sartory NA, Zahn N FTY720 ameliorates oxazolone colitis in mice by directly affecting T helper type 2 functions. Mol. Immunol., 2007-05-01;44(13):3305-16. 2007-05-01 [PMID: 17475330] (Mouse)
• Van Hove CL, Maes T, Joos GF, Tournoy KG Prolonged inhaled allergen exposure can induce persistent tolerance. Am. J. Respir. Cell Mol. Biol., 2007-01-11;36(5):573-84. 2007-01-11 [PMID: 17218615] (Mouse)
• Oh SY, Zheng T, Bailey ML, Barber DL, Schroeder JT, Kim YK, Zhu Z Src homology 2 domain-containing inositol 5-phosphatase 1 deficiency leads to a spontaneous allergic inflammation in the murine lung. J. Allergy Clin. Immunol., 2006-10-23;119(1):123-31. 2006-10-23 [PMID: 17208593] (Mouse)
• Levy BD, Kohli P, Gotlinger K, Haworth O, Hong S, Kazani S, Israel E, Haley KJ, Serhan CN Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsiveness. J. Immunol., 2007-01-01;178(1):496-502. 2007-01-01 [PMID: 17182589] (Mouse)
• Kitamura K, Takeda K, Koya T, Miyahara N, Kodama T, Dakhama A, Takai T, Hirano A, Tanimoto M, Harada M, Gelfand EW Critical role of the Fc receptor gamma-chain on APCs in the development of allergen-induced airway hyperresponsiveness and inflammation. J. Immunol., 2007-01-01;178(1):480-8. 2007-01-01 [PMID: 17182587] (Mouse)
• Lee JS, Lee CM, Jeong YI, Jung ID, Kim BH, Seong EY, Kim JI, Choi IW, Chung HY, Park YM D-pinitol regulates Th1/Th2 balance via suppressing Th2 immune response in ovalbumin-induced asthma. FEBS Lett., 2006-12-11;581(1):57-64. 2006-12-11 [PMID: 17174308] (Mouse)
• Takahashi N, Kitazawa H, Iwabuchi N, Xiao JZ, Miyaji K, Iwatsuki K, Saito T Oral administration of an immunostimulatory DNA sequence from Bifidobacterium longum improves Th1/Th2 balance in a murine model. Biosci. Biotechnol. Biochem., 2006-08-01;70(8):2013-7. 2006-08-01 [PMID: 16926520] (Mouse)
• Alvarez D, Swirski FK, Yang TC, Fattouh R, Croitoru K, Bramson JL, Stampfli MR, Jordana M Inhalation tolerance is induced selectively in thoracic lymph nodes but executed pervasively at distant mucosal and nonmucosal tissues. J. Immunol., 2006-02-15;176(4):2568-80. 2006-02-15 [PMID: 16456019] (Mouse)
• Shibamori M, Ogino K, Kambayashi Y, Ishiyama H Intranasal mite allergen induces allergic asthma-like responses in NC/Nga mice. Life Sci., 2005-10-17;78(9):987-94. 2005-10-17 [PMID: 16229861] (Mouse)
• Trabattoni D, Clivio A, Bray DH, Bhagat L, Beltrami S, Maffeis G, Cesana E, Lowry P, Lissoni F, Kandimalla ER, Sullivan T, Agrawal S, Bartholomew R, Clerici M Immunization with gp120-depleted whole killed HIV immunogen and a second-generation CpG DNA elicits strong HIV-specific responses in mice. Vaccine, 2005-09-22;24(9):1470-7. 2005-09-22 [PMID: 16221513] (Mouse)
• Gueders MM, Balbin M, Rocks N, Foidart JM, Gosset P, Louis R, Shapiro S, Lopez-Otin C, Noel A, Cataldo DD Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation. J. Immunol., 2005-08-15;175(4):2589-97. 2005-08-15 [PMID: 16081833] (Mouse)
• Gegg ME, Harry R, Hankey D, Zambarakji H, Pryce G, Baker D, Adamson P, Calder V, Greenwood J Suppression of autoimmune retinal disease by lovastatin does not require Th2 cytokine induction. J. Immunol., 2005-02-15;174(4):2327-35. 2005-02-15 [PMID: 15699169] (Rat)
• Oumouna M, Mapletoft JW, Karvonen BC, Babiuk LA Formulation with CpG oligodeoxynucleotides prevents induction of pulmonary immunopathology following priming with formalin-inactivated or commercial killed bovine respiratory syncytial virus vaccine. J. Virol., 2005-02-01;79(4):2024-32. 2005-02-01 [PMID: 15681404] (Mouse)
• Piggott DA, Eisenbarth SC, Xu L, Constant SL, Huleatt JW, Herrick CA, Bottomly K MyD88-dependent induction of allergic Th2 responses to intranasal antigen. J. Clin. Invest., 2005-02-01;115(2):459-67. 2005-02-01 [PMID: 15650773] (Human)
• Megid J, Kaneno R, Nozaki CN, Brito CJ, Almeida MF Increased interleukin-10 associated with low IL-6 concentration correlated with greater survival rates in mice infected by rabies virus vaccinated against it and immunomodulated with P. acnes. Comp. Immunol. Microbiol. Infect. Dis., 2004-11-01;27(6):393-411. 2004-11-01 [PMID: 15325513] (Mouse)
• Johnson TR, Varga SM, Braciale TJ, Graham BS Vbeta14(+) T cells mediate the vaccine-enhanced disease induced by immunization with respiratory syncytial virus (RSV) G glycoprotein but not with formalin-inactivated RSV. J. Virol., 2004-08-01;78(16):8753-60. 2004-08-01 [PMID: 15280483] (Mouse)
• Virag L, Bai P, Bak I, Pacher P, Mabley JG, Liaudet L, Bakondi E, Gergely P, Kollai M, Szabo C Effects of poly(ADP-ribose) polymerase inhibition on inflammatory cell migration in a murine model of asthma. Med. Sci. Monit., 2004-03-01;10(3):BR77-83. 2004-03-01 [PMID: 14976461] (Mouse)
• Kobayashi T, Iijima K, Kita H Marked airway eosinophilia prevents development of airway hyper-responsiveness during an allergic response in IL-5 transgenic mice. J. Immunol., 2003-06-01;170(11):5756-63. 2003-06-01 [PMID: 12759459] (Mouse)
• Drouin SM, Corry DB, Hollman TJ, Kildsgaard J, Wetsel RA Absence of the complement anaphylatoxin C3a receptor suppresses Th2 effector functions in a murine model of pulmonary allergy. J. Immunol., 2002-11-15;169(10):5926-33. 2002-11-15 [PMID: 12421977] (Mouse)
• Tangri S, Ishioka GY, Huang X, Sidney J, Southwood S, Fikes J, Sette A Structural features of peptide analogs of human histocompatibility leukocyte antigen class I epitopes that are more potent and immunogenic than wild-type peptide. J. Exp. Med., 2001-09-17;194(6):833-46. 2001-09-17 [PMID: 11560998] (Mouse)
• de Bernardis F, Santoni G, Boccanera M, Spreghini E, Adriani D, Morelli L, Cassone A Local anticandidal immune responses in a rat model of vaginal infection by and protection against Candida albicans. Infect. Immun., 2000-06-01;68(6):3297-304. 2000-06-01 [PMID: 10816477] (Rat)
• Domachowske JB, Bonville CA, Dyer KD, Easton AJ, Rosenberg HF Pulmonary eosinophilia and production of MIP-1alpha are prominent responses to infection with pneumonia virus of mice. Cell. Immunol., 2000-03-15;200(2):98-104. 2000-03-15 [PMID: 10753501] (Mouse)

FAQs for IL-5 (M5000). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: Il5